Traumatic Blunt Force Renal Injury in a Diseased Horseshoe Kidney with Successful Embolization to Treat Active Bleeding: A Case Report and Literature Review by Chonlada Krutsri, Pongsasit Singhatas, Preeda Sumpritpradit, Chunlaches Chaijareenont, Wit Viseshsindh, Tharin Thampongsa, Pattawia Choikrua

“…Surgical reconstruction and preservation of a damaged horseshoe kidney is difficult because of variations in its vascular anatomy. We report successful nonoperative management of a blunt horseshoe kidney injury with active bleeding and review previous outcomes and complications. …”
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Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential by Wenhan Tian, Yuzeng Liu, Bo Han, Fengqi Cheng, Kang Yang, Weiyuan Hu, Dongdong Ye, Sujun Wu, Jiping Yang, Qi Chen, Yong Hai, Robert O. Ritchie, Guanping He, Juan Guan

“…During in vivo degradation, this material primarily undergoes host cell-mediated surface degradation, rather than bulk hydrolysis. We demonstrate significant capabilities of CFSCs in promoting vascularization and macrophage differentiation toward repair. …”
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Returning to the emergency department: a retrospective analysis of mental health re-presentations among young people in New South Wales, Australia by Rebecca Ivers, Michael Dinh, Patricia Cullen, Bette Liu, Katharine Steinbeck, Natasha Walker, Robert Neil Leong

“…Re-presentations were highest among young people <15 years (IRR 1.18 vs ≥20 years old), female (IRR=1.13 vs male), young people residing outside of major cities (IRR 1.08 vs major cities) and Aboriginal and Torres Strait Islander young people (IRR 1.27 vs non-Indigenous).Conclusions ED mental health re-presentation is high among young people. We demonstrate factors associated with re-presentation that EDs could target for timely, high-quality care that is youth friendly and culturally safe, with appropriate referral pathways into community-based primary and mental healthcare services.…”
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Short communication: Genomic prediction based on unbiased estimation of the genomic relationship matrix in pigs by M.Y. Li, L.Y. Shi, D.E. MacHugh, X.Q. Wang, J.J. Tian, L.G. Wang, Y.J. Deng, L.X. Wang, F.P. Zhao

“…The traditional genomic relationship matrix (GRM) has shown to be a biased estimation of true kinship, which can affect subsequent genetic analyses. In this study, we employed an unbiased kinship (UKin) estimation method within the genomic best linear unbiased prediction framework to evaluate its prediction performance on both a simulated dataset and a Large White pig dataset. …”
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Comparative Performance of Ante-Mortem Diagnostic Assays for the Identification of <i>Mycobacterium bovis</i>-Infected Domestic Dogs (<i>Canis lupus familiaris</i>) by Conor O’Halloran, Paul Burr, Danielle A. Gunn-Moore, Jayne C. Hope

“…The aim of this study was to compare the performance of ante mortem diagnostic tests across samples collected from dogs considered to be at a high or low risk of sub-clinical <i>M. bovis</i> infection. We previously tested a total of 164 dogs at a high risk of infection and here test 42 dogs at a low risk of infection and 77 presumed uninfected dogs with a combination of cell-based and/or serological diagnostic assays previously described for use in non-canid species. …”
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Cardiac Tamponade as an Initial Manifestation of Cervical Cancer by Yuridia Evangelina Rodríguez-Rosales, Carlos Eduardo Salazar-Mejía, Blanca Angélica Soto-Martínez, David Hernández-Barajas, Oscar Vidal-Gutiérrez, Gabriela Sofia Gómez-Macías

“…This type of cancer spreads mainly to the lung, the bone, and the brain; however, the pericardium is an unusual site of invasion, which is associated with a poor prognosis. We present a case of a 35-year-old woman with six months of leg edema and abnormal uterine bleeding. …”
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hnRNPH1 Inhibits Influenza Virus Replication by Binding Viral RNA by Ruixue Xue, Danqi Bao, Tianxin Ma, Shiqi Niu, Zihua Wu, Xuehua Lv, Yunxiang Zhang, Guanlong Xu, Dawei Yan, Zhifei Zhang, Xue Pan, Minghao Yan, Qiaoyang Teng, Chunxiu Yuan, Zejun Li, Qinfang Liu

“…In this study, to explore the role of hnRNPH1 in influenza virus infection, we knocked down and over-expressed the hnRNPH1 proteins in 293T cells, then infected the cells with the influenza virus. …”
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Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis by Yunzhi Xu, Qi Zhu, Jinglve Song, Hongli Liu, Yutong Miao, Fan Yang, Feiyan Wang, Wenjing Cheng, Yebin Xi, Xiaoyin Niu, Dongyi He, Guangjie Chen

“…To expand upon the role of iguratimod (T-614) in the treatment of rheumatoid arthritis (RA), we investigated whether the Th1, Th17, follicular helper T cells (Tfh), and regulatory T cells (Treg) imbalance could be reversed by iguratimod and the clinical implications of this reversal. …”
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Usefulness of Routine Terminal Ileoscopy and Biopsy during Colonoscopy in a Tropical Setting: A Retrospective Record-Based Study by Hasitha Srimal Wijewantha, Arjuna Priyadarsin de Silva, Madunil Anuk Niriella, Nethini Wijesinghe, Prabahvi Waraketiya, Ravindu Sujeewa Kumarasena, Anuradha Supun Dassanayake, Janaki de Silva Hewawisenthi, Hithanadura Janaka de Silva

“…Available evidence for routine terminal ileoscopy during colonoscopy is equivocal. We investigated the place of routine terminal ileoscopy and biopsy during colonoscopy, in a tropical setting. …”
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Prognosis of premenopausal women with low-risk endometrial cancer but elevated CA125 levels by Jeong Min Song, Ala Aiob, Ala Aiob, Kidong Kim, Kidong Kim, Kwang Beom Lee, Sokbom Kang, Chae Hyeong Lee, Se Ik Kim, Nam Kyeong Kim, Dae Hoon Jeong

“…However, it is unclear whether lymphadenectomy should be performed in premenopausal women who meet the KGOG criteria other than elevated cancer antigen 125 (CA125) levels, because the CA125 level can be elevated by benign conditions. We investigated the patterns of metastasis and recurrence to assess the value of lymphadenectomy in this population.MethodsPremenopausal women with endometrial cancer meeting the KGOG criteria, except for those with elevated CA125 levels, were eligible. …”
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Impact of Prenatal Stress on Neuroendocrine Programming by Odile Viltart, Christel C. A. Vanbesien-Mailliot

“…Such prenatal stress-induced modifications of the phenotypic plasticity of the progeny might ultimately result in the development of long-term diseases, from metabolic syndromes to psychiatric disorders. Yet, we would like to consider the outcome of this neuroendocrine programming from an evolutionary perspective. …”
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Drug-induced autoimmune-like hepatitis: A disproportionality analysis based on the FAERS database. by Wangyu Ye, Yuan Ding, Meng Li, Zhihua Tian, Shaoli Wang, Zhen Liu

“…Food and Drug Administration's (FDA) Adverse Event Reporting System (FAERS) database.<h4>Methods</h4>We searched the FAERS database for the term "autoimmune hepatitis" and extracted DI-ALH reports from the first quarter of 2004 to the first quarter of 2024. …”
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Impact of non-invasive oxygen reserve index versus standard SpO2 monitoring on peripheral oxygen saturation during endotracheal intubation in the intensive care unit: Protocol for... by Hugo Hille, Aurélie Le Thuaut, Pierre Asfar, Quentin Quelven, Emmanuelle Mercier, Anthony Le Meur, Jean-Pierre Quenot, Virginie Lemiale, Grégoire Muller, Martin Cour, Alexis Ferré, Asael Berge, Anaïs Curtiaud, Maxime Touron, Gaetan Plantefeve, Jean-Charles Chakarian, Jean-Damien Ricard, Gwenhael Colin, Arthur Orieux, Patrick Girardie, Mathieu Jozwiak, Manon Rouaud, Camille Juhel, Jean Reignier, Jean-Baptiste Lascarrou, CRICS-TRIGGERSEP Network

“…No trial has assessed the potential effects of ORI monitoring to guide preoxygenation for ETI in unstable patients. We designed a multicenter, two-arm, parallel-group, randomized, superiority, open trial in 950 critically ill adults requiring ETI. …”
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Development and Evaluation of Aloperine-Loaded Nanostructured Lipid Carriers for the Treatment of Pulmonary Arterial Hypertension by Liu H, Liu S, Ma P, Ma L, Liu Y, Zhao F, Zhou R

“…Through a series of experiments including single-factor experimentation, transmission electron microscopy, high-performance liquid chromatography, in vivo pharmacokinetics, and tissue distribution studies, we assessed the physicochemical properties, drug release profiles, and in vitro and in vivo performance of this novel nanocarrier.Results: The prepared aloperine-loaded NLCs exhibited a milky white and translucent suspension appearance, presenting a quasi-spherical shape under a transmission electron microscope, with an average particle size of (509.48± 30.04) nm and an entrapment efficiency of (64.18± 1.14)%. …”
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Long-Term Outcomes of Mechanical Thrombectomy for Stroke: A Meta-Analysis by David J. McCarthy, Anthony Diaz, Dallas L. Sheinberg, Brian Snelling, Evan M. Luther, Stephanie H. Chen, Dileep R. Yavagal, Eric C. Peterson, Robert M. Starke

“…No difference in mortality at long-term follow-up was observed (OR 0.82; p = 0.12). We conclude that endovascular therapy results in favorable outcomes at long-term follow-up for patients with acute ischemic stroke compared to standard medical treatment alone and that the 90-day timepoint offers a fair representation of the long-term outcomes.…”
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From Natural Hosts to Agricultural Threats: The Evolutionary Journey of Phytopathogenic Fungi by Asanka Madhushan, Dulan Bhanuka Weerasingha, Evgeny Ilyukhin, Paul W. J. Taylor, Amila Sandaruwan Ratnayake, Jian-Kui Liu, Sajeewa S. N. Maharachchikumbura

“…., <i>Fusarium graminearum</i>, <i>F. oxysporum</i>, <i>Blumeria graminis</i>, <i>Zymoseptoria tritici</i>, and <i>Colletotrichum</i> spp. Also, we explore the mechanism used to understand evolutionary trends in these fungi. …”
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Characterisation of cardiovascular disease (CVD) incidence and machine learning risk prediction in middle-aged and elderly populations: data from the China health and retirement lo... by Qing Huang, Zihao Jiang, Bo Shi, Jiaxu Meng, Li Shu, Fuyong Hu, Jing Mi

“…The aim of this study was to analyse the incidence characteristics of CVD in these populations and develop a prediction model by using data from the China Health and Retirement Longitudinal Study (CHARLS). Methods We used follow-up data from the CHARLS to analyse CVD incidence in the Chinese middle-aged and elderly population over a time span of 9 years. …”
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Transcriptomics Analysis of Maize (<i>Zea mays</i> L.) in Response to the Infection by <i>Setosphaeria turcica</i> by Hui Jia, Pan Li, Bu Tao, Yuwei Liu, Zhihang Liu, Mengfang Zhu, He Zhou, Maocun Wang, Jingao Dong, Shouqin Gu, Xiaodong Gong

“…Previous research has predominantly centered on elucidating the infection strategy and process of the pathogen, but the molecular mechanism of maize response to the pathogen is still largely unknown. In this study, we employed transcriptomics technology to comprehensively analyze alterations in RNA expression profiles within maize leaves at critical time points (hours post-infestation, 24 hpi, and 72 hpi) during <i>S. turcica</i> infection. …”
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Photon-counting detector CTA to assess intracranial stents and flow diverters: an in vivo study with ultrahigh-resolution spectral reconstructions by Frederic De Beukelaer, Sophie De Beukelaer, Laura L. Wuyts, Omid Nikoubashman, Mohammed El Halal, Iliana Kantzeli, Martin Wiesmann, Hani Ridwan, Charlotte S. Weyland

“…Abstract Background To define optimal parameters for the evaluation of vessel visibility in intracranial stents (ICS) and flow diverters (FD) using photon-counting detector computed tomography angiography (PCD-CTA) with spectral reconstructions. Methods We retrospectively analyzed consecutive patients with implanted ICS or FD, who received a PCD-CTA between April 2023 and March 2024. …”
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Allopregnanolone relieves paclitaxel induced mechanical hypersensitivity via inhibiting spinal cord PGE2-EP2 mediated microglia-neuron signaling by Kunlin Guo, Lei Gao, Ping Li, Shanwu Feng, Liping Zhao, Xian Wang

“…Neurosteroid allopregnanolone is suggested to modulate the expression of various receptors or enzymes that involved in pain perception, presenting an analgesic potential. Here, we investigated if allopregnanolone attenuates extracellular signal-regulated kinase (ERK) and its downstream prostaglandin E2 (PGE2) expression in the dorsal spinal cord concomitant with neuropathic pain relief in paclitaxel (PTX)-induced neuropathic pain model rats. …”
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