Serum levels of Wnt5a in Egyptian women with obesity and their association with toll like receptor 2 Arg753Gln gene polymorphism in a pilot case control study of obesity as a state... by Shaimaa H. Fouad, Mai Eldeeb, Shereen A. Baioumy, Sara I. Taha, Rehab Ali Ibrahim, Aya Elgendy, Azza Omran, Marwa Hamdy, Raed A. Alharbi, Abdulmajeed A. A. Sindi, Sylvia W. Roman

“…Abstract Female obesity is a worldwide health issue linked to chronic metabolic low-grade inflammation (metaflammation) causing multiple obesity-related co-morbid conditions. We aimed to assess the serum levels of wingless integration site family member 5 A (Wnt5a), leptin, and tumor necrosis factor-alpha (TNF-α) as markers of obesity-associated metaflammation and investigate the association with toll-like receptors2 (TLR2) gene (Arg753Gln) single nucleotide polymorphism (SNP) among Egyptian females. …”
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Deficit Irrigation and an IoT-Based System for Improving Yield and Water Use Efficiency of Winter Wheat Grown Under Semi-Arid Conditions by Salah Belkher, Basma Latrech, Wifak Bekri, Felix Markwordt, Mohamed Abdur Rahim, Corentin Dupont, Mohamed Ali Ben Abdallah, Hedi Daghari, Mourad Rezig

“…In the context of water restriction, the adoption of innovative technology and water saving strategies is crucial to sustainable agriculture production. Thus, we sought to emphasize the contribution of precision irrigation based on Internet of Things (IoT) technology and smart sensors for optimizing irrigation water use. …”
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Treatment of Miller I Mandibular Gingival Recessions Using PRF vs. Connective Graft by Hernan S. Garzon, Camilo Alfonso, Francisco J. Vega, Andrea García, Ana Muñoz, Gustavo Jaimes, Katherine Isaza, Katherine Rivera

“…Regarding the VSTT, better results were obtained using the CTG + CAF, suggesting eventually long-term stable clinical results. We suggest a combined technique for future investigations.…”
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Study of Radioclinical and Risk Factors of Cerebral Venous Thrombosis: A Retrospective Analysis of Patients Presenting to a Tertiary Hospital in Mogadishu, Somalia by Adam BA, Osman AA, Sheikh Hassan M, Sidow NO, Osman Hidig MF, Mohamed AA, Ibrahim AA, Mohamed SA, Mohamed YG, Ahmed SA, Jeele MOO, Hassan MO

“…Understanding regional variations and specific risk factors associated with CVT is crucial, especially in low-resource settings like Somalia, where epidemiological data is limited and healthcare resources are scarce.Objective: This study aims to investigate the clinical and risk factors associated with CVT in patients presenting to Mogadishu Somali-Turkey Recep Tayyip Erdogan Research and Training Hospital, a tertiary hospital in Mogadishu, Somalia.Methods: We conducted a retrospective observational study involving 68 patients diagnosed with CVT between January 2019 and December 2023. …”
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Association between white blood cell count and adverse pregnancy outcomes: a retrospective cohort study from a tertiary hospital in China by Yu Zhang, Xuesong Li, Zheng Hu, Yuping Song, Yiling Qian, Chuanwei Liu, Xiaofang Fan, Yujuan Fan, Jialin Yang

“…Due to acute infectious disease or other diseases, 1127 were excluded.Setting Minhang Hospital, China.Participants A total of 24 143 pregnant women were included in this study.Primary and secondary outcome measures The primary outcome was the adverse pregnancy outcomes.Results For the 24 143 participants, we calculated adjusted ORs for adverse pregnancy outcomes associated with an increased WBC count. …”
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Classification and Statistical Trend Analysis in Detecting Glaucomatous Visual Field Progression by Cristiana Valente, Elisa D’Alessandro, Michele Iester

“…For the statistical analysis, linear regression (r2) was calculated for mean deviation (MD), pattern standard deviation (PSD), and visual field index (VFI), and when it was significant, each series of visual field was considered progressive. We also used Progressor to look for a significant progression of each visual field series. …”
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The valve-sparing aortic root replacement: Results of the David I technique by B. M. Todurov, I. O. Stetsyuk, O. V. Zelenchuk, I. Yu. Mokryk, L. R. Stetsiuk, V. B. Demyanchuk, N. V. Malova

“…The mean age of the 53 patients (among them, 47 (88.68 %) males) was 49.11 ± 1.54 years. We analyzed basic characteristics of the patients, intraoperative and postoperative data. …”
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Neoadjuvant Chemoradiotherapy Upregulates the Immunogenicity of Cold to Hot Tumors in Esophageal Cancer Patients by Yushi Nagaki, MD, PhD, Satoru Motoyama, MD, PhD, Yusuke Sato, MD, PhD, Akiyuki Wakita, MD, PhD, Hiromu Fujita, MD, PhD, Kohei Kemuriyama, MD, Ryohei Sasamori, MD, Shu Nozaki, MD, Kyoko Nomura, MD, PhD, Yoshihiro Minamiya, MD, PhD

“…Based on immunohistochemical analysis, tumors that were FOXA1 (+) and/or EYA2 (+) were defined as hot tumors, others were cold tumors. We then investigated the association between tumor immunogenicity and clinicopathological features. …”
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ASA Class Is a Stronger Predictor of Early Revision Risk Following Primary Total Knee Arthroplasty than BMI by Christopher J. Wall, MBBS, BMedSc, FRACS, FAOrthA, Richard N. de Steiger, MBBS, PhD, DipBiomech, FRACS, FAOrthA, Christopher J. Vertullo, MBBS, PhD, FRACS, FAOrthA, Dylan Harries, BSc(Hons), MBiostat, PhD, Srinivas Kondalsamy-Chennakesavan, MBBS, MPH, FRSPH

“…Although ASA class and BMI are theoretically interrelated variables, we found that a patient’s ASA class was more strongly associated with their risks of early all-cause revision and revision for PJI following primary TKA than their BMI. …”
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Population Pharmacokinetic of Epidural Sufentanil in Labouring Women: A Multicentric, Prospective, Observational Study by Nie Y, Sun X, Cao R, Tang S, Zhou Q, Zhou M, Chen Z, Huang S

“…However, there is little information regarding the time-dependent pharmacokinetic characteristics of sufentanil after epidural administration in laboring women. We aimed to develop a population PK model for epidural sufentanil in laboring women to evaluate the sufentanil placental transfer quantitatively.Patients and Methods: Forty-one participants who underwent epidural labor analgesia were recruited into this study. …”
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Ion beam induced secondary electron tomography of acrylonitrile-styrene-acrylate/polycarbonate polymer blends for fused filament fabrication and injection moulding by J. Hernández-Saz, D. Moreno-Sanchez, L. M. Valencia, Y. Gómez, S. I. Molina, M. Herrera

“…To understand the behaviour of the new materials obtained as well as the influence of the fabrication parameters used, methods to analyse the distribution of polymers in the blend with resolution below the micrometer are required. In this work, we demonstrate the capability of focused ion beam (FIB) tomography to provide 3D information of the polymer distribution in objects obtained by blending acrylonitrile-styrene-acrylate (ASA) with polycarbonate (PC) (50 wt%), fabricated by Fused Filament Fabrication (FFF) and by Injection Moulding (IM). …”
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Ni-kshay Poshan Yojana: receipt and utilization among persons with TB notified under the National TB Elimination Program in India, 2022 by Kathiresan Jeyashree, Jeromie W V Thangaraj, Devika Shanmugasundaram, G Sri Lakshmi Priya, Sumit Pandey, Venkateshprabhu Janagaraj, Prema Shanmugasundaram, Sabarinathan Ramasamy, Joshua Chadwick, Sivavallinathan Arunachalam, Rahul Sharma, Vaibhav Shah, Aniket Chowdhury, Swati Iyer, Raghuram Rao, Sanjay K Mattoo, Manoj V Murhekar, NPY Evaluation Group

“…Methods In our cross-sectional study, we used multi-stage sampling to select PwTB whose treatment outcome was declared between May 2022 and February 2023. …”
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Safety and Efficacy of Second-Generation Drug-Eluting Stents in Real-World Practice: Insights from the Multicenter Grand-DES Registry by You-Jeong Ki, Kyung Woo Park, Jeehoon Kang, Chee-Hoon Kim, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon-Kwon Koo, Hyo-Soo Kim

“…Objective. In this study, we sought to compare the efficacy and safety of the Xience Prime/Xience V/Promus EES and Biomatrix/Biomatrix Flex/Nobori BES with resolute integrity/resolute ZES using the grand drug-eluting stent (Grand-DES) registry. …”
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Pyogenic Granuloma of the Larynx: A Case Report by Moallim Hussein AA, Sheikh OA, Mukhtar AA, Abdi IA, Ahmed NM, Mohamed SS, Kahiye MA, Nur MA, Asseyr AF

“…Some of the conditions considered in the differential diagnosis include hemangioma, hemangioendothelioma, angiofibroma, angiosarcoma, Kaposi sarcoma, Wegener’s granuloma, Crohn’s disease, granulomatous infections such as tuberculosis and histoplasmosis, traumatic granuloma, carcinosarcoma, as well as verrucous and squamous cell carcinoma.Conclusion: We present a case report of lobular capillary hemangioma of the larynx, including its histopathological diagnosis and management course.Keywords: vocal cord, laryngoscope, hemangioma, bartonella…”
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Screening of necroptosis-related genes and evaluating the prognostic capacity, clinical value, and the effect of their copy number variations in acute myeloid leukemia by Dake Wen, Ru Yan, Lin Zhang, Haoyang Zhang, Xuyang Chen, Jian Zhou

“…Necroptosis has relationship with certain types of malignancies outcomes. Here, we evaluated the diagnostic ability, prognostic capacity of necroptosis-related genes (NRGs) and the effect of their copy number variations (CNVs) in AML. …”
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Evaluation of transcriptomic changes after photobiomodulation in spinal cord injury by Andrew R. Stevens, Mohammed Hadis, Hannah Alldrit, Michael R. Milward, Valentina Di Pietro, Deena M. A. Gendoo, Antonio Belli, William Palin, David J. Davies, Zubair Ahmed

“…However, the precise mechanism of action is yet to be determined. Here, we used an in-vivo model of SCI in adult rats that received daily PBM (660 nm, 24 mW/cm2, 1 min) and at three days post-injury, the injured spinal cord segment was harvested and subjected to whole transcriptome sequencing and subsequent pathway analysis (generally applicable gene-set enrichment (GAGE)). …”
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Low dose ATG-Fresenius for GVHD prophylaxis: a comparative study with ATG-Thymoglobulin by Itai Falicovich, Boaz Nachmias, Shlomo Elias, Eran Zimran, Adir Shaulov, Polina Stepensky, Batia Avni, Sigal Grisariu

“…BackgroundAnti-Thymocyte Globulin (ATG) is commonly used to prevent graft-versus-host disease (GVHD), but the optimal dosage and type of ATG remains to be determined.ObjectiveWe compared retrospectively the safety and efficacy outcomes of allogeneic transplantation using low-dose ATG-Fresenius (15mg/kg) and ATG-Thymoglobulin (10mg/kg) for GVHD prevention.Study designNinety-eight patients were included, with 46 in the ATG-T group and 52 in the ATG-F group. …”
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CD36 inhibition enhances the anti-proliferative effects of PI3K inhibitors in PTEN-loss anti-HER2 resistant breast cancer cells by You-Yu Liu, Wei-Lun Huang, Sin-Tian Wang, Hui-Ping Hsu, Tzu-Ching Kao, Wei-Pang Chung, Kung-Chia Young

“…Methods Since remodeling of fatty acid (FA) metabolism might contribute to HER-positive breast cancer and is triggered by the PI3K signal pathway, herein, we examined the effects of the inhibition of endogenous FA conversion, SCD-1 or exogenous FA transport, CD36, in combination with PI3K inhibitors (alpelisib and inavolisib) in anti-HER2 resistant PTEN-loss breast cancer cells. …”
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C3-VQA: Cryogenic Counter-Based Coprocessor for Variational Quantum Algorithms by Yosuke Ueno, Satoshi Imamura, Yuna Tomida, Teruo Tanimoto, Masamitsu Tanaka, Yutaka Tabuchi, Koji Inoue, Hiroshi Nakamura

“…Based on the workload analysis and domain-specific system design focused on variational quantum algorithms (VQAs), we propose the cryogenic counter-based coprocessor for VQAs (C3-VQA) to enhance the design scalability of cryogenic quantum computers under the thermal constraint. …”
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A New Antibody–Cytokine Construct Targeting Natural Killer Cells: An Immunotherapeutic Approach to Chronic Lymphocytic Leukemia by Michela Flego, Mauro Andreotti, Francesca Romana Mauro, Maria Beatrice Arasi, Silvia Zamboni, Zuleika Michelini, Sara Pepe, Clementina Maria Galluzzo, Roberta Amici, Diego Moricoli, Chiara Mazzei, Alessandro Ascione, Alessandra Mallano

“…Our aim was to restore NK cell functionality in CLL through a specifically targeted IL15-stimulating activity; IL15 targeting could, in fact, potentiate the activity of NK cells and reduce off-target effects. We designed and developed a cis-acting immunocytokine composed of an anti-CD56 single-chain Fragment variable (scFv) and IL15, labeled scFvB1IL15. scFvB1IL15 was tested in vitro on peripheral blood mononuclear cells (PBMCs) obtained from both different healthy donors (HDs) and CLL patients in order to evaluate its ability to target NK cells and enhance their activation and NK-mediated directed cytotoxicity. scFvB1IL15 specifically induced strong degranulation and cytokine and chemokine production in NK cells in both HD- and CLL patient-derived PBMC samples. …”
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