A next-generation Fab library platform directly yielding drug-like antibodies with high affinity, diversity, and developability by Fortunato Ferrara, Adeline Fanni, Andre A. R. Teixeira, Esteban Molina, Camila Leal-Lopes, Ashley DeAguero, Sara D’Angelo, M. Frank Erasmus, Laura Spector, Luis Antonio Rodriguez Carnero, Jianquan Li, Thomas J. Pohl, Nikolai Suslov, Klervi Desrumeaux, Conor McMahon, Sagar Kathuria, Andrew R. M. Bradbury

“…We previously described an in vitro single-chain fragment (scFv) library platform originally designed to generate antibodies with excellent developability properties. …”
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Unique Case Reports Associated with Ovarian Failure: Necessity of Two Intact X Chromosomes by Lakshmi Rao Kandukuri, Venkata Padmalatha, Murthy Kanakavalli, Raseswari Turlapati, Mangalipally Swapna, Metuku Vidyadhari, Govindaraghavan Saranaya, Kattera Himaja, Mamata Deenadayal, Bipin Kumar Sethi, Prasun Deb, Nalini Gupta, Baidyanath Chakraborthy, Pratibha Nallari, Lalji Singh

“…Interestingly, majority of the abnormalities involved the X-chromosome and we report two unique abnormalities, (46,XXdel(Xq21-22) and q28) and (mos,45XO/46,X+ringX) involving X chromosome in association with ovarian failure. …”
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A multidisciplinary collaborative care model involving family members in the treatment of type 2 diabetes mellitus and associated diabetes distress in young and middle-aged patient... by Wang Yan-Ping, Peng Lu-Yao, Yuan Xian-Ming, Chen Ting-Ting, Li Lin, Deng Kai-Qin

“…While both groups received standard care, IG additionally received FEC. We assessed and compared glycated hemoglobin (HbA1c) levels, Diabetes Distress Scale (DDS) scores, Summary of Diabetes Self-care Activities (SDSCA) scores, and body mass index (BMI) between the two groups be-fore the intervention and three months after. …”
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Parenting in the Digital Age: A Scoping Review of Digital Early Childhood Parenting Interventions in Low- and Middle-Income Countries (LMIC) by Lena Jäggi, Lena Jäggi, Stella M. Hartinger, Stella M. Hartinger, Stella M. Hartinger, Günther Fink, Günther Fink, Dana C. McCoy, Milagros Alvarado Llatance, Milagros Alvarado Llatance, Kristen Hinckley, Kristen Hinckley, Kristen Hinckley, Lucero Ramirez-Varela, Leonel Aguilar, Andreana Castellanos, Daniel Mäusezahl, Daniel Mäusezahl, Daniel Mäusezahl

“…ObjectivesThis scoping review examines the evidence and knowledge gaps regarding the effectiveness of digital early childhood parenting interventions in Low- and Middle-Income Countries (LMICs).MethodsUsing PRISMA-ScR and PICOS frameworks, we systematically reviewed studies published since 2010 from four databases, focusing on the impact of digital parenting interventions on Early Childhood Development and parent-level outcomes.ResultsOf 1,399 studies identified, 13 met inclusion criteria, evaluating digital interventions for parents of children aged 0–5 years. …”
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Analysing DNA methylation and transcriptomic signatures to predict prostate cancer recurrence risk by Fahad M. Aldakheel, Hadeel Alnajran, Shatha A. Alduraywish, Ayesha Mateen, Mohammed S. Alqahtani, Rabbani Syed

“…This study employs a machine learning approach to identify DNA methylation and RNA expression biomarkers predictive of PCa recurrence using datasets from The Cancer Genome Atlas (TCGA). We analyzed 49,133 genes, identifying 684 differentially methylated genes (DMGs) and 691 differentially expressed genes (DEGs) between recurrence and non-recurrence groups. …”
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Barriers and facilitators to data-based decision making in Australian early childhood education and care: A qualitative study by Shauna Sherker, Karen Villanueva, Ruth Beatson, Caitlin M. Macmillan, Wan Yi Lee, Olivia Hilton, Carly Molloy, Sharon Goldfeld

“…Yet there is little evidence that the ECEC sector is able to utilise lead indicators and data for this purpose. In this study, we used the Theoretical Domains Framework (TDF) and the Capability, Opportunity, and Motivation model of Behaviour (COM-B) to explore barriers and facilitators to data-utilisation behaviours (collecting, reporting, and using lead indicator data) by ECEC service providers. …”
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Assessment of Impact of Meteorology and Precursor in Long-term Trends of PM and Ozone in a Tropical City by Christian Mark G. Salvador, Angeles D. Alindajao, Karen B. Burdeos, Mark Anthony M. Lavapiez, Jhon Robin Yee, Angel T. Bautista, Preciosa Corazon B. Pabroa, Rey Y. Capangpangan

“…Abstract Long-term trends of atmospheric pollutants, particularly ozone (O3) and particulate matter (PM) provide a direct evaluation of the response of the atmosphere to the environmental policies and the variability of anthropogenic and biogenic emissions. Here, we report the assessment of the temporal evolution of the air quality in a tropical urban city (Butuan) in the southern Philippines by evaluating the trends of meteorological conditions (i.e., temperature, R.H., boundary layer height), air pollutants (i.e., PM2.5, NO2, O3) and their precursors (Benzene, Toluene, and Xylene) from 2014 to 2020. …”
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Plant Adaptation and Soil Shear Strength: Unraveling the Drought Legacy in <i>Amorpha fruticosa</i> by Hao Jiang, Xiaoqing Chen, Gang Xu, Jiangang Chen, Dongri Song, Ming Lv, Hanqing Guo, Jingyi Chen

“…Focusing on <i>Amorpha fruticosa</i>, a species known for its robust root system that plays a crucial role in soil consolidation and slope stabilization, thereby reducing soil and water erosion, we simulated a drought-rewetting event to assess the legacy effects of drought on the soil shear strength and the mechanical and hydrological traits associated with the reinforcement provided by <i>A. fruticosa</i>. …”
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A Retroperitoneal Isolated Enteric Duplication Cyst Mimicking a Teratoma: A Case Report and Literature Review by Daichi Momosaka, Yasuhiro Ushijima, Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Yukihisa Takayama, Daisuke Okamoto, Nobuhiro Fujita, Tetsuo Ikeda, Keiichiro Uchida, Masaaki Sugimoto, Kenichi Kohashi, Hiroshi Honda

“…Enteric duplication cysts lacking anatomic association with the gastrointestinal tract are called isolated enteric duplication cysts (IEDCs). We present an atypical case of a retroperitoneal IEDC with a tortuous tubular complex shape that enfolded the surrounding retroperitoneal fat and mimicked a retroperitoneal teratoma. …”
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Factors Associated with Medication Nonadherence among Hypertensives in Ghana and Nigeria by Vincent Boima, Adebowale Dele Ademola, Aina Olufemi Odusola, Francis Agyekum, Chibuike Eze Nwafor, Helen Cole, Babatunde L. Salako, Gbenga Ogedegbe, Bamidele O. Tayo

“…A potentially modifiable factor for control of BP is medication nonadherence (MNA); our study therefore aimed to determine factors associated with MNA among hypertensives in Ghana and Nigeria. Methodology. We conducted a multicenter cross-sectional study. …”
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Supportive functions of soil organic carbon for ecosystem services in karst desertification areas by Wang Xingfu, Liu Yi, Xiong Kangning, Huang Xianfei, Zhang Zhenming

“…In this study, we explored the supportive functions of soil organic carbon (SOC) for ecosystem services in karst rocky desertification areas. …”
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Analyzing Drivers of Tropical Moist Forest Dynamics in the Kahuzi-Biega National Park Landscape, Eastern Democratic Republic of Congo from 1990 to 2022 by Nadège Cizungu Cirezi, Jean-François Bastin, Yannick Mugumaarhahama, Yannick Sikuzani Useni, Katcho Karume, Raymond Sinsi Lumbuenamo, Jan Bogaert

“…Analyzing annual TMF dynamics from 1990 to 2022 using data classified by Vancutsem and his collaborators in 2021 from Landsat imagery alongside spatial datasets of deforestation and degradation drivers, we employed a comprehensive analytical approach. …”
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Electrocardiographic Frontal QRS-T Angle Is Independently Associated with the Presence of Celiac Disease and Disease Duration by Betül Ayça Yamak, İbrahim Ethem Güven, Mustafa Candemir

“…<b>Conclusions:</b> In this study, we demonstrated that chronic inflammation secondary to CD may have negative effects on cardiac repolarization and that this effect is closely related to disease duration.…”
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Outburst mechanism and hazard prevention technique of limestone aquifer under isolated island panels by Wei Wang, Wei Wang, Wei Wang, Yanjun Wu, Yanjun Wu, Yanjun Wu, Yongli Shi, Yongli Shi, Yongli Shi, Jingzhong Zhu

“…In this paper, the mechanism of water inrush from limestone aquifers under isolated island panels is discussed from theoretical mechanics analysis, numerical simulation, discriminant criterion, the variation law of surrounding rock stress and water pressure, and floor failure depth. Meanwhile, we take the coal mining of the isolated island shaft in the Zhuzhuang colliery, Huaibei mining area, as an application case and propose the key technique of limestone water disaster prevention and control. …”
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Development of a Cell-Based High-Throughput Screening Assay to Identify Porcine Host Defense Peptide-Inducing Compounds by Zhuo Deng, Jing Wang, Wentao Lyu, Xuwen Wieneke, Robert Matts, Xi Ma, Guolong Zhang

“…To facilitate the identification of HDP inducers for swine use, we developed a stable luciferase reporter cell line, IPEC-J2/PBD3-luc, through permanent integration of a luciferase reporter gene driven by a 1.1 kb porcine β-defensin 3 (PBD3) gene promoter in porcine IPEC-J2 intestinal epithelial cells. …”
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Real-world effectiveness of sofosbuvir/velpatasvir, glecaprevir/pibrentasvir, and sofosbuvir/velpatasvir/voxilaprevir against genotype 3 hepatitis C virus infection: a systematic r... by Liwei Zhuang, Liwei Zhuang, Junnan Li, Yu Zhang, Shibo Ji, Huichun Xing, Huichun Xing

“…The sustained virologic response (SVR) rates were analyzed using the Freeman–Tukey double arcsine transformation in a random-effects model in R4.1.0 software.ResultsWe recruited 3,177 patients with HCV GT3 in 19 studies from 9 countries. …”
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Lactococcus lactis NCC 2287 Alleviates Food Allergic Manifestations in Sensitized Mice by Reducing IL-13 Expression Specifically in the Ileum by Adrian W. Zuercher, Marietta Weiss, Sébastien Holvoet, Mireille Moser, Hélène Moussu, Laurence van Overtvelt, Stéphane Horiot, Philippe Moingeon, Sophie Nutten, Guénolée Prioult, Anurag Singh, Annick Mercenier

“…Utilizing a food allergy murine model, we have investigated the intrinsic antiallergic potential of the Lactococcus lactis NCC 2287 strain. …”
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En Balance: The Contribution of Physical Activity to the Efficacy of Spanish Diabetes Education of Hispanic Americans with Type 2 Diabetes by Dequina A. Nicholas, Lorena M. Salto, Kristen Lavelle, Joy Wilson, W. Lawrence Beeson, Anthony Firek, William H. R. Langridge, Zaida Cordero-MacIntyre, Marino De Leon

“…Half of the subjects had increased kynurenine levels at the end of the educational program. We found that the subjects in the active group with decreased kynurenine concentrations displayed statistically greater improvements in fasting blood glucose, A1C, cholesterol, and triglycerides despite weight loss being higher in the group with increased kynurenine concentrations. …”
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Evidences of +896 A/G TLR4 Polymorphism as an Indicative of Prevalence of Complications in T2DM Patients by Carmela Rita Balistreri, Anna Rita Bonfigli, Massimo Boemi, Fabiola Olivieri, Antonio Ceriello, Stefano Genovese, Claudio Franceschi, Liana Spazzafumo, Paolo Fabietti, Giuseppina Candore, Calogero Caruso, Domenico Lio, Roberto Testa

“…However, no conclusive findings have been reported until now about the role of this polymorphism in development of T2DM and its complications, even if a recent meta-analysis showed its T2DM association in Caucasians. In this study, we sought to evaluate the weight of rs4986790 polymorphism in the risk of the major T2DM complications, including 367 T2DM patients complicated for the 55.6%. …”
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On the Observational Solid Angle in Estimating the Moon-based Disk-integrated Earth Outgoing Longwave Radiation by Hanlin Ye, Huadong Guo, Dong Liang, Zhen Xu, Yin Jin, Guang Liu

“…Three critical issues are analyzed. (1) Comparing the observational solid angles calculated by using an Earth ellipsoidal model versus those obtained by adjusting the Earth’s radius. We find that adjusting the Earth’s radius can approximate the results based on an Earth ellipsoidal model, offering insights into parameterizing the observational solid angle. (2) Parameterizing the observational solid angle through series expansion, which is validated by comparing the associated results to those from numerical integrations. …”
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