Lipoprotein Particle Predictors of Arterial Stiffness after 17 Years of Follow Up: The Malmö Diet and Cancer Study by Jacob Hartz, Ronald M. Krauss, Mikael Göttsater, Olle Melander, Peter Nilsson, Michele Mietus-Snyder

“…The results confirm that triglycerides (TG) and high-density lipoprotein cholesterol (HDL-c) but not low-density lipoprotein cholesterol (LDL-c) predict c-fPWV. We identify a positive predictive association for very small, small, and medium (high risk), but not large LDL particles. …”
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Moving to lower-poverty neighborhoods offers broad benefits for children with asthma, regardless of sex or other baseline characteristics by Torie L. Grant, MD, MHS, Laken C. Roberts Lavigne, PhD, MPH, Craig Evan Pollack, MD, MHS, Pete Cimbolic, BA, Susan Balcer-Whaley, MPH, Roger D. Peng, PhD, Elizabeth C. Matsui, MD, MHS, Corinne A. Keet, MD, PhD

“…Objective: Our aim was to determine whether the benefits of moving to lower-poverty/higher-opportunity neighborhoods were concentrated in subsets of participants with asthma. Methods: We conducted a secondary analysis of the participants in the Mobility Asthma Project. …”
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The impact of glucocorticoid receptor transactivation on context-dependent cell migration dynamics by Szonja Polett Pósa, Éva Saskői, Lili Bársony, Lőrinc Pongor, Fanni Fekete, János Papp, Anikó Bozsik, Attila Patócs, Henriett Butz

“…Positive correlation between the GR signature and migration signature at the single-cell level indicated an association between GR activity and cell migration. For the first time, we assessed altered time-lapse migration dynamics in TN breast cancer cells, potentially contributing to cancer progression and prognosis, highlighting that the effects of dexamethasone on breast cancer cell migration are influenced by ER status and treatment duration.…”
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Disease management teams in oncology: State of the art and the experience of a scientific institute of hospitalization and treatment (IRCCS) in Rome, Italy by Marialuisa Appetecchia, Carlotta Amantea, Marco Canfora, Fabrizio Petrone, Gennaro Ciliberto, Ermete Gallo, Laura Figorilli

“…The correct evaluation of the effectiveness of DMTs acquires great importance today, especially if we consider that empirical evidence is not yet in agreement on the real effectiveness of this tool with respect to both the qualitative dimension and the efficiency of interventions.…”
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Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers by Anca Negovan, Mihaela Iancu, Valeriu Moldovan, Septimiu Voidazan, Simona Bataga, Monica Pantea, Kinga Sarkany, Cristina Tatar, Simona Mocan, Claudia Banescu

“…The study included patients who underwent an upper digestive endoscopy and took low-dose aspirin treatment. Results. We recruited 51 patients with ulcer (ulcer group) and 108 patients with no mucosal lesions (control group). …”
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Black Soldier Fly (<i>Hermetia illucens</i>) Larvae as a Protein Substitute in Adverse Food Reactions for Canine Dermatitis: Preliminary Results Among Patients by Nuttawan Srifawattana, Yuthana Phimolsiripol, Pinpanit Boonchuay, Kannika Na-Lampang, Promporn Piboon, Sonthaya Umsumarng, Korakot Nganvongpanit

“…Can black soldier fly (BSF) larvae be a protein substitute for managing adverse food reactions (AFRs) in dogs, specifically those with dermatitis? We evaluated BSF larvae’s safety, tolerance, and effectiveness as a novel protein source in dogs with AFRs. …”
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Identification of a novel immunogenic cell death-related classifier to predict prognosis and optimize precision treatment in hepatocellular carcinoma by Dongjing Zhang, Bingyun Lu, Qianqian Ma, Wen Xu, Qi Zhang, Zhiqi Xiao, Yuanheng Li, Ren Chen, An-jiang Wang

“…However, the influence of ICD on tumor microenvironment (TME) formation and immune response in Hepatocellular carcinoma (HCC) remains largely unexplored. In this study, we systematically analyzed the mRNA profiles of ICD-related genes in 1847 HCC patients and identified three molecular subtypes with significantly different immune features and prognostic stratification. …”
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Exploring the potentials of indigenous Saccharomyces cerevisiae and Pichia kudriavzevii for enhancing flavour and aromatic characteristics in apricot wines by Yu Chen, Xingmeng Lei, Luxing Sun, Binghong Gao, Peng An, Dongqing Ye, Haibin Mu, Yi Qin, Yuyang Song, Yanlin Liu

“…In this study, we investigated the oenological performance of key yeast populations previously identified from apricot wine fermentation, aiming to obtain indigenous starters suitable for apricot wine production. …”
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Evaluation of reference genes for gene expression analysis in Japanese flounder (Paralichthys olivaceus) under temperature stress by Ping Han, Jianming Chen, Zhennan Sun, Shengjie Ren, Xubo Wang

“…Results In this study, we evaluated the suitability of eight genes including ribosomal protein L6 (rpl6), ribosomal protein L9 (rpl9), delta (4)-desaturase, sphingolipid 1 (degs1), cathepsin L (ctsl), eukaryotic translation elongation factor 1 gamma (eef1g), NSA2 ribosome biogenesis homolog (nsa2), eukaryotic translation initiation factor 3, subunit E, a (eif3ea), glutamine amidotransferase class 1 domain containing 1 (gatd1) analyzed from RNA sequencing (RNA-Seq) data and two genes including β-actin (actb) and 18S rRNA ribosomal RNA (18S RNA) selected from literature to obtain the best internal controls in qRT-PCR analysis of Japanese flounder under temperature stress. …”
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Evolution and Recent Radiation Therapy Advancement in Uganda: A Precedent on How to Increase Access to Quality Radiotherapy Services in Low- and Middle-Income Countries by Awusi Kavuma, Solomon Kibudde, Daniel Kanyike, Joseph Kigula-Mugambe, Tianyu Zhao, Hiram Gay, Baozhou Sun, Jackson Orem

“…With more support from the International Atomic Energy Agency, the acquisition of dosimetry equipment, treatment planning systems, and additional professional training signaled a new era in the fight against cancer. As we entered the second decade of the millennium, the Uganda Cancer Institute (UCI) witnessed a progression in sophisticated radiotherapy services, including high-dose-rate brachytherapy, initiation of intensity modulated radiation therapy (IMRT)/volumetric modulated arc therapy (VMAT), and use of artificial intelligence. …”
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Effects of Prognostic Nutrition Index, Neutrophil/Lymphocyte Ratio, and C-reactive Protein/Albumin Ratio on Prognosis Undergoing Open Heart Surgery by Anil Kilinc, Nilay Tas, Melih Urkmez, Ebru Canakci, Ilker Coskun, Merve Elif Demirhan

“…Aim: Deficiencies in preoperative nutritional status increase the incidence of negative postoperative events. In this study, we aimed to investigate the effect of the prognostic nutrition index (PNI), neutrophil-to-lymphocyte (N/L) ratio, and C-reactive protein (CRP)-to-albumin (CRP/Alb) ratio on postoperative prognosis in patients undergoing open-heart surgery. …”
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SPC25 upregulates CCND1 to promote the progression of esophageal squamous cell carcinoma by inhibiting MDM2-mediated E2F1 ubiquitination by Haoyao Jiang, Xiangfeng Jin, Haiyong Gu, Bin Li, Zhigang Li, Yifeng Sun

“…In addition, overexpression of CCND1 counteracted the effects of SPC25 silencing. Collectively, we demonstrated that the aberrant expression of SPC25 inhibited E2F1 ubiquitination and promoted CCND1 expression, thus accelerating the progression of ESCC. …”
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Evaluation of the Antitumor Effects of Platinum-Based [Pt(η1-C2H4-OR)(DMSO)(phen)]+ (R = Me, Et) Cationic Organometallic Complexes on Chemoresistant Pancreatic Cancer Cell Lines... by Erika Stefàno, Luca Giulio Cossa, Federica De Castro, Erik De Luca, Viviana Vergaro, Giulia My, Gianluca Rovito, Danilo Migoni, Antonella Muscella, Santo Marsigliante, Michele Benedetti, Francesco Paolo Fanizzi

“…Pancreatic cancer is one of the most lethal malignancies with an increasing incidence and a high mortality rate, due to its rapid progression, invasiveness, and resistance to anticancer therapies. In this work, we evaluated the antiproliferative and antimigratory activities of the two organometallic compounds, [Pt(η1-C2H4-OMe)(DMSO)(phen)]Cl (1) and [Pt(η1-C2H4-OEt)(DMSO)(phen)]Cl (2), on three human pancreatic ductal adenocarcinoma cell lines with different sensitivity to cisplatin (Mia PaCa-2, PANC-1, and YAPC). …”
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Efficacy of unified protocol for transdiagnostic treatment of emotional disorders in adolescents (UP-A) in China: protocol for a randomised controlled trial by Xue Gao, Lu Liu, Mei-Rong Pan, Hai-Mei Li, Yu-Feng Wang, Xue-Ying Liu, Zhong-Fang Fu, Qiujin Qian

“…Forty-eight participants will be randomly assigned to either the treatment as usual (TAU) group or the TAU combined with UP-A (UP-A+TAU) group. We will evaluate the efficacy of the UP-A, through the following primary and secondary outcomes: emotional disorder severity, emotional symptoms, emotion regulation, cognitive patterns, executive function, resilience, quality of life, social and family functioning. …”
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Economic impact of potentially inappropriate prescribing and related adverse events in older people: a cost-utility analysis using Markov models by Kathleen Bennett, Frank Moriarty, Tom Fahey, Caitriona Cahir

“…Objectives To determine the economic impact of three drugs commonly involved in potentially inappropriate prescribing (PIP) in adults aged ≥65 years, including their adverse effects (AEs): long-term use of non-steroidal anti-inflammatory drugs (NSAIDs), benzodiazepines and proton pump inhibitors (PPIs) at maximal dose; to assess cost-effectiveness of potential interventions to reduce PIP of each drug.Design Cost-utility analysis. We developed Markov models incorporating the AEs of each PIP, populated with published estimates of probabilities, health system costs (in 2014 euro) and utilities.Participants A hypothetical cohort of 65 year olds analysed over 35 1-year cycles with discounting at 5% per year.Outcome measures Incremental cost, quality-adjusted life years (QALYs) and incremental cost-effectiveness ratios with 95% credible intervals (CIs, generated in probabilistic sensitivity analysis) between each PIP and an appropriate alternative strategy. …”
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COVID-19 vaccine uptake in Zimbabwe and Sierra Leone: an application of Health Belief Model constructs by Simon Ssentongo, Alex Muhereza, Morie Mustapha, Ruth Gemi, Dennis Cherian, Rebecca Waugh, Benjamin Crookston, Cougar Hall, Mary Linehan, Hayden Borg, Joshua West

“…The survey assessed respondents' views in line with core HBM and TPB constructs, in addition to their levels of vaccine acceptance. We then employed adjusted logistic regression models to investigate the correlation between health behavior change theory constructs and vaccine uptake, taking into account variables like gender, age, education, and country of residence. …”
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Provider Adherence to the 2020 US Multi-Society Task Force Guidelines for Surveillance After Colonoscopy With Polypectomy by Benjamin E. Cassell, Katherine Scholand, Wyatt Tarter, Camille J. Hochheimer, Colleen Long, Gregory L. Austin

“…Background and Aims: The 2020 United States Multi-Society Task Force on Colorectal Cancer guidelines for surveillance after colonoscopy with polypectomy introduced significant changes in surveillance intervals. We sought to identify rates of adherence to these new guidelines at an academic medical center. …”
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High Dimensionality Reduction and Immune Phenotyping of Natural Killer and Invariant Natural Killer Cells in Latent Tuberculosis-Diabetes Comorbidity by Gokul Raj Kathamuthu, Nathella Pavan Kumar, Kadar Moideen, Pradeep A. Menon, Subash Babu

“…However, the role of NK and iNKT cells expressing cytokines, cytotoxic, and immune markers in latent tuberculosis (LTB), diabetes mellitus (DM), or preDM (PDM) and nonDM (NDM) comorbidities is not known. Thus, we have studied the unstimulated (UNS), Mycobacterium tuberculosis (Mtb [PPD, WCL]), and mitogen (P/I)-stimulated NK and iNKT cells expressing Type 1 (IFNγ, TNFα, and IL-2), Type 17 (IL-17A, IL-17F, and IL-22) cytokines, cytotoxic (perforin, granzyme B, and granulysin) and immune (GMCSF, PD-1, and CD69) markers in LTB comorbidities by dimensionality reduction and flow cytometry. …”
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Assessment of Strategy Disclosure Drivers in Annual Company Report: A Meta-Synthesis Analysis by Akram Taftiyan, Mohammad Salari Abarghuoi

“…Due to the absence of specific requirements and standards for preparing strategy disclosure reports in Iran, it appears that individuals working in this field may lack adequate theoretical knowledge on the subject. Therefore, we tried to use the opinions of experts who are theoretically familiar with the subject. …”
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Machine Knowledge and Human Cognition by Fashen Li, Lian Li, Jianping Yin, Liang Huang, Qingguo Zhou, Ning An, Yong Zhang, Li Liu, Jialin Zhang, Kun Kuang, Lei Yang, Zhixi Wu, Lianchun Yu

“…Intelligent machines are knowledge systems with unique knowledge structure and function. In this paper, we discuss issues including the characteristics and forms of machine knowledge, the relationship between knowledge and human cognition, and the approach to acquire machine knowledge. …”
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