Artificial intelligence driven clustering of blood pressure profiles reveals frailty in orthostatic hypertension by Claire M. Owen, Jaume Bacardit, Maw P. Tan, Nor I. Saedon, Choon‐Hian Goh, Julia L. Newton, James Frith

“…Applying machine learning to an existing dataset of community‐based adults undergoing postural assessment, we identified three distinct clusters (iOHYPO, OHYPO and OHYPER) akin to initial and classic orthostatic hypotension and orthostatic hypertension, respectively. …”
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Anatomy-Informed Multimodal Learning for Myocardial Infarction Prediction by Ivan-Daniel Sievering, Ortal Senouf, Thabo Mahendiran, David Nanchen, Stephane Fournier, Olivier Muller, Pascal Frossard, Emmanuel Abbe, Dorina Thanou

“…<italic>Goal:</italic> In patients with coronary artery disease, the prediction of future cardiac events such as myocardial infarction (MI) remains a major challenge. In this work, we propose a novel anatomy-informed multimodal deep learning framework to predict future MI from clinical data and Invasive Coronary Angiography (ICA) images. …”
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Diagnostic efficiency of exome-based sequencing in pediatric patients with epilepsy by Huafang Zou, Huafang Zou, Qian Zhang, Jianxiang Liao, Jianxiang Liao, Dongfang Zou, Zhanqi Hu, Bing Li, Li Chen, Jialun Wen, Xia Zhao, Victor Wei Zhang, Dezhi Cao, Dezhi Cao

“…Additionally, data concerning clinical symptoms, neuroimaging findings, treatment responses, and prognostic outcomes were collected and analyzed.ResultsThe overall diagnostic yield was 32.8% (85/259), with a diagnostic yield of 40.0% for exome-based epilepsy panels, 30.1% for CES, and 27.8% for WES. We identified 82 cases with pathogenic or likely pathogenic SNVs and 4 cases with pathogenic CNVs, of which one case with both SNV and CNV. …”
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Dual anti-CTLA-4 and anti-PD-1 blockade in metastatic basal cell carcinoma by Sandip P. Patel, Eleanor Cano-Linson, Young Kwang Chae, Shiruyeh Schokrpur, Christopher D. Lao, Benjamin C. Powers, Adrienne I. Victor, Adedayo A. Onitilo, Sarah Shin, Naoko Takebe, Sara Threlkel, Christine M. McLeod, Helen X. Chen, Elad Sharon, Megan Othus, Christopher W. Ryan, Charles D. Blanke, Razelle Kurzrock

“…Abstract We report the basal cell cancer (BCC) cohort of the SWOG/NCI 1609 Dual Anti-CTLA-4 & Anti-PD-1 blockade in Rare Tumors (DART), a phase II prospective, multicenter basket trial of nivolumab and ipilimumab. …”
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Evaluation of Tumor Viability for Primary and Bone Metastases in Metastatic Castration-Resistant Prostate Cancer Using Whole-Body Magnetic Resonance Imaging by Hiromichi Iwamura, Yasuhiro Kaiho, Jun Ito, Go Anan, Nozomi Satani, Tomonori Matsuura, Ryo Tamura, Kazuhiro Murakami, Kaneki Koyama, Makoto Sato

“…Based on these findings, we reasoned that viable tumor cells inducing disease progression may primarily exist in the primary lesions and not in the metastatic lesions, and combined prostate radiotherapy and systemic hormonal therapy resulted in successful clinical response and disease control. …”
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Prescription of Strong Opioids in Chronic Non-Cancer Pain in the Province of Valladolid (Spain) by Rodrigo Enríquez de Salamanca Gambara, Ana María Sierra Santos, Ana María Ruiz San Pedro, Federico Montero Cuadrado, Irene Muñoz León, Miguel Ángel Castro Villamor, Alicia Córdoba Romero, Ana María Del Olmo Tornero, Lucía Pérez Pérez, León Morales-Quezada

“…<b>Objectives:</b> Our objectives were to determine the prevalence and profile of patients using SOs for CNCP in PC consultations in Valladolid in 2022, and to describe the consumption of SO prescribed for CNCP from 2020 to 2023. <b>Methods:</b> We conducted a descriptive and retrospective study using data extracted from the Pharmaceutical Consumption Information System of Castilla y León. …”
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Developing a rapid screening tool for high-risk ICU patients of sepsis: integrating electronic medical records with machine learning methods for mortality prediction in hospitalize... by Songchang Shi, Lihui Zhang, Shujuan Zhang, Jinyang Shi, Donghuang Hong, Siqi Wu, Xiaobin Pan, Wei Lin

“…Methods This multicenter retrospective cohort study analyzed electronic medical records of sepsis patients using machine learning methods. We evaluated model performance in predicting sepsis outcomes within the first 24 h of ICU admission across US and Chinese healthcare settings. …”
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A Case of Violent Suicide Attempt in a Context of Myxedema Psychosis following Radioiodine Treatment in a Patient with Graves’ Disease by Louise Todorov, Amel Ait Boudaoud, Rachel Pascal de Raykeer, Alina Radu, Khadija Lahlou-Laforêt, Frédéric Limosin, Cédric Lemogne, Sébastien Czernichow

“…However, less attention has been paid to suicidal behavior in these patients. Case Report. We report a case of suicide attempt by self-stabbing in a 43-year-old woman without past psychiatric history, four months after radioiodine therapy for Graves’ disease. …”
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Synthesis and kinetic evaluation of analogs of (E)-4-amino-3-methylbut-2-en-1-yl diphosphate, a potent inhibitor of the IspH metalloenzyme by Petit, Benoît Eric, Jobelius, Hannah, Bianchino, Gabriella Ines, Guérin, Mélina, Borel, Franck, Chaignon, Philippe, Seemann, Myriam

“…AMBPP has substantial limitations for drug development due to its poor metabolic stability. Here, we investigate the replacement of the diphosphate moiety of AMBPP by more stable mimics: sulfonate, phosphonate or phosphinophosphonate. …”
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Fluoroscopic Stenting as a Bridge to Surgery versus Emergency Management for Malignant Obstruction of the Colon by Fan Xue, Feng Lin, Jun Zhou, Ning Feng, You-Gang Cui, Xu Zhang, Yu-Peng Yi, Wen-Zhi Liu

“…To investigate the feasibility of a SEMS (self-expandable metallic stent) as a bridge to surgery for malignant colonic obstruction. Methods. We retrospectively reviewed 83 patients that were in accordance with inclusion criteria; of these, 33 patients that underwent fluoroscopy-guided SEMS placement followed by elective curative resection were classified as a SEMS group and 50 patients, who received emergency surgery (ES), were classified as an ES group. …”
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Chronic Gastroesophageal Reflux Dysregulates Proteostasis in Esophageal Epithelial CellsSummary by Kodisundaram Paulrasu, Ravindran Caspa Gokulan, Wael El-Rifai, Zhibin Chen, Jianwen Que, Timothy C. Wang, Olivier G. Boutaud, Karoline Briegel, Sergey I. Dikalov, Monica T. Garcia-Buitrago, Alexander I. Zaika

“…These products of lipid peroxidation rapidly interact with cellular proteins forming protein adducts. Here, we investigated the interrelationship between isoLG adduction and aggregation of cellular proteins. …”
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Long-term risk factors for developing Barrett’s oesophagus in patients with gastro-oesophageal reflux disease: a longitudinal cohort study by John F Dillon, Paul Brennan, James Cotton, James Carberry, Christopher J Byrne

“…Background and aims Several characteristics are known to affect the risk of Barrett’s oesophagus (BO) in the general population, with symptomatic gastro-oesophageal reflux disease (GORD) being a critical risk factor. In this study, we examined factors that influence BO development in people living with GORD.Design People living with GORD were recruited from an endoscopy unit with lifestyle, medical and prescribing history collected. …”
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Constraints of S–Pb–Sr Isotope Compositions and Rb–Sr Isotopic Age on the Origin of the Laoyingqing Noncarbonate-Hosted Pb–Zn Deposit in the Kunyang Group, SW China by Hongsheng Gong, Runsheng Han, Peng Wu, Gang Chen, Lingjie Li

“…This can be interpreted as a result of mixing with reduced S that was mainly derived from the thermochemically reduced S in the overlying strata and a small amount of reduced S produced by the pyrolysis of S-containing organic matter. We conclude that the Laoyingqing deposit and most of the Pb–Zn deposits in the SYGT are Mississippi Valley-type deposits, thereby providing new ideas for investigating the deep and peripheral areas of Pb–Zn deposits.…”
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Synovial biomarkers in the diagnosis of post-traumatic osteoarthritis following anterior cruciate ligament and meniscus injuries: protocol for a systematic review by Helena Donato, Fernando Fonseca, João Pedro Oliveira, João Castro Mendes, José Casanova, Alexandrina Ferreira Mendes

“…These searches will use combinations of predefined keywords, such as “knee”, “synovial fluid”, “post-traumatic osteoarthritis”, “anterior cruciate ligament”, “meniscus”, “trauma”, “inflammation” and “biomarker”. We will include randomised clinical trials, non-randomised prospective or retrospective clinical studies, case controls, cohort studies and case series, ranging from database inception to 30 June 2024 and published in English. …”
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The Impact of Infectious Diseases on Clinical Characteristics and Immunological Correlations in Pediatric Henoch–Schönlein Purpura: A Five-Year Retrospective Study by Sînziana Oprițescu, Gabriela Viorela Nițescu, Mihaela Golumbeanu, Dora Boghițoiu, Elena Iuliana Ioniță, Diana-Andreea Ușurelu, Cristian Lucaci, Adriana Negoiță, Elena Moroșan

“…<b>Methods:</b> To answer this question, we conducted a five-year hospital-based retrospective study that included 144 hospitalized children who were diagnosed with HSP during hospitalization. …”
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Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice by David W. Hawman, Thomas Tipih, Eddie Hodge, E. Taylor Stone, Nikole Warner, Natalie McCarthy, Brian Granger, Kimberly Meade-White, Shanna Leventhal, Kiara Hatzakis, Stephanie Park, Karen Gaffney, Kyle Rosenke, Jesse H. Erasmus, Heinz Feldmann

“…It is unclear if these stockpiled vaccines will need to be updated to match the contemporary H5N1 strains. Here we show that a replicating RNA vaccine expressing the HA of an H5N1 isolated from a US dairy cow confers complete protection against homologous lethal challenge in mice. …”
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Diabetes control in public assistance recipients and free/low-cost medical care program beneficiaries in Japan: a retrospective cross-sectional study by Daisuke Nishioka, Mitsuhiko Funakoshi, Seiji Haruguchi, Sakae Yonemura, Takashi Takebe, Misato Nonaka, Sanae Iwashita

“…This study aimed to elucidate the blood glucose control status among individuals with low income (ie, recipients of public assistance (PARs) and free/low-cost medical care (FLCMC) programme beneficiaries) and to investigate the effects of public subsidies for medical expenses on treatment adherence among low-income patients with diabetes.Methods We conducted a secondary analysis of medical records from 910 outpatients with diabetes who underwent pharmacological treatment for &gt;90 days. …”
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The Impact of Onchocerciasis Elimination Measures in Africa: A Systematic Review by Policarpo Ncogo, Christine Giesen, María Jesús Perteguer, Maria P. Rebollo, Rufino Nguema, Agustín Benito, Zaida Herrador

“…Methodology: A systematic peer review of the existing literature following the PRISMA guidelines was performed between November 2021 and April 2022. We selected studies on onchocerciasis control measures in Africa since the implementation of the first Onchocerciasis Control Programme (OCP) measures in 1974. …”
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Videofluoroscopic swallowing study predicts clinical outcomes in critically Ill children with dysphagia: a retrospective observational study by Yoonju Na, Jaeyoung Choi, Jihong Choi, Su Mi Oh, Hyuna Jang, Suein Choi, Joongbum Cho, Jeong-Yi Kwon

“…Data were collected from the pediatric intensive care unit (PICU) of a single tertiary medical center in South Korea between March 2019 and December 2022. We reviewed VFSS conducted on patients in the PICU who were referred by clinicians suspecting dysphagia.ResultsA total of 36 children were included in the study; 52.8% exhibited aspiration on VFSS. …”
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Asymptomatic malaria parasitaemia and seizure control in children with nodding syndrome; a cross-sectional study by Charles R J C Newton, Albert Ningwa, Kevin Marsh, Richard Idro, Rodney Ogwang, Ronald Anguzu, Pamela Akun, Edward Kayongo

“…This study examined the relationship between P. falciparum infection and seizure control in children with a unique epilepsy type, the nodding syndrome.Design This cross-sectional study was nested in an ongoing trial ‘Doxycycline for the treatment of nodding syndrome (NCT02850913)’. We hypothesised that, in patients with epilepsy, infection by P. falciparum, including asymptomatic infections, increases the risk of seizures and impairs seizure control.Setting and participants Participants were Ugandan children with nodding syndrome, age ≥8 years, receiving sodium valproate. …”
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