Target-specific peptides for BK virus agnoprotein identified through phage display screening: advancing antiviral therapeutics by Xiaofei Xing, Jingxian Han, Keke Wang, Fuyun Tian, CuiXia Jiang, Wei Liang, Lin Qi, Xin Yue, Yinhang Wen, Yuwei Hu, Hui Qiao

“…Utilizing phage display technology, we conducted screening to identify specific binding peptides against the agnoprotein. …”
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The Effect of Age on Clinical and Laboratory Parameters in Reproductive Age Women with Endometrial Polyps by Aytekin Tokmak, Ebru Ersoy, Ali Özgür Ersoy, Esra Yaşar Çelik, Ali İrfan Güzel, Mustafa Uğur

“… OBJECTIVE: To compare clinical and laboratory parameters in middle and advanced reproductive age women with endometrial polyps. STUDY DESIGN: We designed a retrospective study among reproductive age women who were managed at our clinic with the diagnosis of endometrial polyps. …”
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The MIR181A2HG/miR‐5680/VCAN‐CD44 Axis Regulates Gastric Cancer Lymph Node Metastasis by Promoting M2 Macrophage Polarization by Weijie Zang, Yongpu Yang, Junjie Chen, Qinsheng Mao, Wanjiang Xue, Yilin Hu

“…ABSTRACT Background Lymphatic metastasis in gastric cancer (GC) profoundly influences its prognosis, but the precise mechanism remains elusive. In this study, we identified the long noncoding RNA MIR181A2HG as being upregulated in GC and associated with LNs metastasis and prognosis. …”
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Stress and Strain: Differentiating the Responses to High and Moderate Heat Loads and Subsequent Recovery in Grain-Fed Feedlot Steers—Metabolic Hormones by Gene Wijffels, Megan L. Sullivan, Sally Stockwell, Suzie Briscoe, Roger Pearson, Stephen T. Anderson, Yutao Li, Cintia C. de Melo Costa, Russell McCulloch, John B. Gaughan

“…There were linear relationships between T3 concentration and THI, and T3 and T4 levels and DMI only. We highlight comparisons with previously reported metabolic hormone responses of grain-fed Black Angus steers to a moderate-heat-load challenge.…”
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Prehospital triage of patients with acute cardiac complaints: study protocol of HART-c, a multicentre prospective study by Jan Bosch, Charles JHJ Kirchhof, Mark J Boogers, Enrico de Koning, Tom E Biersteker, Saskia Beeres, Barbra E Backus, Reza Alizadeh Dehnavi, Helen AM Silvius, Martin Schalij

“…The main results of this trial will be disseminated in one paper.Discussion The HART-c study evaluates the efficacy and feasibility of a prehospital triage method that combines prehospital patient assessment and direct consultation of a cardiologist who has access to live-monitored data, hospital data and real-time hospital admission capacity. We expect this triage method to substantially reduce unnecessary ED visits.…”
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Targeting the Vasculature of Colorectal Carcinoma with a Fused Protein of (RGD)3-tTF by Zheng-jie Huang, Yilin Zhao, Wei-yuan Luo, Jun You, Shui-wen Li, Wen-cheng Yi, Sheng-yu Wang, Jiang-hua Yan, Qi Luo

“…Truncated tissue factor (tTF) fusion protein targeting tumor vasculature can induce tumor vascular thrombosis and necrosis. Here, we generated (RGD)3-tTF in which three arginine-glycine-aspartic (RGD) targeting integrin αvβ3 and tTF induce blood coagulation in tumor vessels. …”
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Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability by Lipeng Dong, Huimin Qiao, Xiangjian Zhang, Xiaolin Zhang, Chaohui Wang, Lina Wang, Lili Cui, Jingru Zhao, Yinxue Xing, Yanhua Li, Zongjie Liu, Chunhua Zhu

“…To decide whether this effect applies to ischemic injury in brain, we therefore investigate the potential neuroprotective role of PN and the underlying mechanisms. …”
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Incidence and risk factors for mortality of vertebral osteomyelitis: a retrospective analysis using the Japanese diagnosis procedure combination database by Hideo Yasunaga, Hirotaka Chikuda, Kiyohide Fushimi, Hiromasa Horiguchi, Toru Akiyama, Kazuo Saita

“…Objective To examine the incidence of vertebral osteomyelitis (VO) and the clinical features of VO focusing on risk factors for death using a Japanese nationwide administrative database.Design Retrospective observational study.Setting Hospitals adopting the Diagnosis Procedure Combination system during 2007–2010.Participants We identified 7118 patients who were diagnosed with VO (International Classification of Diseases, 10th Revision codes: A18.0, M46.4, M46.5, M46.8, M46.9, M48.9 and M49.3, checked with the detailed diagnoses in each case and all other codes indicating the presence of a specific infection) and hospitalised between July and December, 2007–2010, using the Japanese Diagnosis Procedure Combination database.Main outcome measures The annual incidence of VO was estimated. …”
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Transferability of bioprocessing modes for recombinant protease production: from fed-batch to continuous cultivation with Bacillus licheniformis by Stefan Kittler, Fabian Müller, Mohamed Elshazly, Georg Benjamin Wandrey, Tobias Klein, Andreas Daub, Oliver Spadiut, Julian Kopp

“…Yet, research focusing on Bacillus strains is limited, therefore we aimed to establish a continuous cultivation as a competitive alternative to fed-batch. …”
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Identification of Microbial and Proteomic Biomarkers in Early Childhood Caries by Thomas C. Hart, Patricia M. Corby, Milos Hauskrecht, Ok Hee Ryu, Richard Pelikan, Michal Valko, Maria B. Oliveira, Gerald T. Hoehn, Walter A. Bretz

“…In order to determine potential useful biomarkers for dental caries, a multivariate classification analysis was employed to build predictive models capable of classifying microbial and salivary sample profiles with generalization performance. We used high-throughput methodologies including multiplexed microbial arrays and SELDI-TOF-MS profiling to characterize the oral flora and salivary proteome in 204 children aged 1–8 years (n=118 caries-free, n=86 caries-active). …”
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Design and Dynamic Analysis of Ideological and Political Education Platform Based on Network Multimedia Technology by Xiaowen Chen

“…Because of the thought-political education platform design and ideological dynamic analysis of network multimedia technology, this study analyzes the construction and teaching circumstances of the platform, and then uses principal component analysis to analyze students’ political theory, political attitude, civilized etiquette, observance of thought, collective thought, public welfare thought, analysis of learning ideas, get the eigenvalues and variance %, of which the proportion of variance of the first four principal components exceeds 90%; public welfare activities and the idea of abiding by laws and regulations have a better influence on the first main component; collective thinking has a comparison on the impact of the second principal component, the correlation between the indicators of thought-political education and the concept of students’ quality is greater than 0.75; it shows that each index has a large degree of correlation with the concept of students’ quality, among which Political attitudes have the greatest impact on students’ quality outlook, with a correlation coefficient of 0.911; secondly, using a nonhomogeneous hidden Markov model to analyze ideological dynamics, we can get the learning situation in different ideological states; finally, the hot spots during the epidemic are related to ideological dynamics Sexual analysis showed that the p values were all less than 0.05, and the correlation analysis between hotspots and ideological dynamics during the epidemic was significant, namely “national sentiments”, “social responsibility”, “angels in white”, “Chinese power”, and “the benevolence of doctors”. …”
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Healthcare utilisation by pregnant patients with asthma in South Korea: a cohort study using nationwide claims data by Deog Kyeom Kim, Chang-Hoon Lee, Ho Il Yoon, Jae-Joon Yim, Eun Jin Jang, Jimin Kim, Yun Jung Kim, Seongmi Choi, Joon-Ho Lee

“…Objectives Few nationwide population-based studies have examined the burden of asthma during pregnancy. Here, we investigated the burden and medical treatment of asthma during pregnancy requiring healthcare utilisation in South Korea.Design Cohort study.Setting Nationwide insurance claims database.Participants A total of 1 306 281 pregnant women who delivered in South Korea in 2009–2011.Outcomes The prevalence and exacerbation rates of asthma requiring healthcare utilisation, and the prescription of antiasthmatic drugs during pregnancy.Results The prevalence of asthma requiring healthcare utilisation was 0.43% among pregnant women. …”
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Cold temperature-related attributable risk for emergency circulatory hospitalizations, length of stay, and healthcare costs in Hong Kong by Eliza Lai-Yi Wong, Hong Qiu

“…Background: The association of ambient temperature with the length of hospital stays and healthcare costs has not been well-explored. We aimed to examine the association of temperature with emergency hospital admission (EHA) count and length of stay (LOS) for total and cause-specific circulatory diseases and evaluate the temperature-related attributable risk and healthcare costs. …”
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Optimizing Cucumber (<i>Cucumis sativus</i> L.) Fruit Metabolomics Under Elevated CO₂ and High-Temperature Stress in the Greenhouse by Xian Du, Yang Song, Lu Pan, Shimao Cui

“…., ’Jinyou 35’) were grown under soil conditions in the greenhouse. We used untargeted metabolomics methods to analyze the effects of varying temperatures (normal temperatures of 25 to 35 °C and high temperatures of 35 to 45 °C) and CO₂ concentrations (400 ± 20 µmol/mol and 1200 ± 20 µmol/mol) on the morpho-physiological traits, yield-associated traits, and metabolomic profiles of cucumber fruits. …”
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A novel high-resolution eco-functional vegetation mapping of coastal dunes by Michele Innangi, Mirko Di Febbraro, Marco Balsi, Ginevra Colonna, Michele Finizio, Federica Pontieri, Maria Laura Carranza

“…Using synchronized vegetation sampling and UAV surveys along the central Adriatic coast, we identified and mapped distinct eco-functional types within the dune landscape. …”
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Assessment of Traffic-Related Ambient Air Particulate Matter (PM) Levels in Douala, Cameroon by Yannick Cédric Ngangmo, Cyrille Adiang Mezoue, Cyrille Meukaleuni, Brice B. S. Wandjie, David Monkam

“…The problem of poor air quality in many SSA countries is due to lack of information about the hazards of poor air quality, lack of monitoring equipment, and lack of measuring stations: this is the case in Cameroon. We are avoiding these problems by using portable, low-cost, low-maintenance air quality monitoring equipment, including the OC 300 dust particle laser, to observe pollution levels of particle matter levels in the PK17 Douala-Cameroon, a locality in the Central African region where no air quality data previously existed. …”
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Investigating the Agreement of Hypomagnesemia Diagnosis in Three Perimeter of Serum, Urine, and Red Blood Cell in Intensive Care Unit: Pilot Study by Nastaran Nazarzade, Mojtaba Mojtahedzadeh, Farshid Gholami, Amirmahdi Mojtahedzadeh, Maryam Shiehmorteza, Amirhossein Ghanbarzamani

“…Methods: Diagnosis of hypomagnesemia is done by measuring serum magnesium, urine magnesium, and magnesium in RBCs. We conducted a prospective study on 30 critically ill patients (14 male, and 16 female) who were admitted to the ICU to examine the prevalence of magnesium deficiency. …”
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Sigmoid Volvulus in Pregnancy Assessed by Contrast-Enhanced Computed Tomography Scanning by Toshiaki Watanabe, Tadatsugu Kinjo, Yoshino Kinjyo, Hayase Nitta, Hitoshi Masamoto, Keiko Mekaru, Yoichi Aoki

“…She was suspected of having a sigmoid volvulus at 33 weeks and 3 days of gestation. We decided to perform a cesarean section to secure the operative field for an intestinal resection following delivery. …”
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Efficacy and Safety of Different Acupuncture Treatments for Cancer-Related Pain: A Systematic Review and Network Meta-Analysis by Tianle Xie MD, Can Liu MD, Yudi Wu MD, Xiuxiu Li MD, Qianyun Yang PhD, Jing Tan PhD

“…Publication bias and quality of randomized controlled trials were assessed using the Cochrane Risk of Bias tool and the Jadad scale, and network meta-analyses were performed using Stata 15 and R 4.3.2. Results: We incorporated 111 studies encompassing 9549 individuals diagnosed with cancer, examining 29 distinct therapies. …”
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Prevalence of neonatal sepsis and associated factors among neonates admitted in the neonatal intensive care unit at Lira Regional Referral Hospital, Northern Uganda. by Brendah Katugume, JohnBaptist Muzungu, Nelson Okello, Eustes Kigongo, Deborah Andrinar Namutebi

“…Early risk factor identification and improved obstetric care are proven to reduce deaths due to NS, yet there is scanty literature on the LRRH. We, therefore, determined the prevalence of NS and identified its associated factors within the LRRH of northern Uganda.…”
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