Magnetic resonance imaging does not distinguish Kallmann syndrome from normosmic isolated hypogonadotropic hypogonadism by Małgorzata Kałużna, Katarzyna Katulska, Katarzyna Ziemnicka, Pola Kompf, Bartłomiej Budny, Paweł Komarnicki, Michał Rabijewski, Jerzy Moczko, Jarosław Kałużny, Marek Ruchała

“…Introduction and objectives: Isolated hypogonadotropic hypogonadism (IHH) may be associated with pituitary gland and olfactory system disorders. We aimed to correlate findings of magnetic resonance imaging (MRI) of the pituitary gland and olfactory system in IHH patients with the patients’ olfactory phenotype. …”
Get full text

Acute kidney injury in patients treated with immune checkpoint inhibitors: a single-center retrospective study by Ping Zhou, Bing Liu, Ning Shen, Xiaoting Fan, Shangwei Lu, Zhijuan Kong, Ying Gao, Zhimei Lv, Rong Wang

“…However, studies on this topic in Chinese cancer patients are very limited. Therefore, we conducted a retrospective study on the incidence, risk factors, clinical features and renal recovery of ICI-AKI in all patients with malignancies treated with ICIs in Shandong Provincial Hospital Affiliated to Shandong First Medical University.Methods In this single-center retrospective cohort study, the data of 904 patients who received immune checkpoint inhibitors (ICIs) treatment were retrospectively analyzed. …”
Get full text

Vitamin D Supplementation and Hemoglobin Levels in Hypertensive Patients: A Randomized Controlled Trial by Jana B. Ernst, Andreas Tomaschitz, Martin R. Grübler, Martin Gaksch, Katharina Kienreich, Nicolas Verheyen, Winfried März, Stefan Pilz, Armin Zittermann

“…Epidemiological evidence suggests that circulating 25-hydroxyvitamin D (25OHD) levels are inversely associated with hemoglobin (Hb) levels and anemia risk. We evaluated whether vitamin D supplementation improves Hb levels and reduces anemia risk in hypertensive patients. …”
Get full text

Psychological aspects of patients with breast cancer depending on the presence of visible postoperative defect by A. D. Zikiryakhodzhaev, M. V. Ermoschenkova, N. A. Sirota, B. A. Fetisov

“…The study of coping behavior of patients with breast cancer (I, II stages) in the postoperative period with «externally visible postoperative defect".Materials and methods. We studied the psychological characteristics of 35 patients with breast cancer (I, II stage), who underwent radical mastectomy, women were characterized in the postoperative period as "externally visible postoperative defect" ("e.v.p.d."), 35 patients with breast cancer (I, II stage) who underwent ablative and reconstructive plastic surgery, women were characterized in the postoperative period as "without an externally visible postoperative defect" ("without an e.v.p.d.").The results and conclusions. …”
Get full text

Immunogenicity of HIV-1 <i>Env</i> mRNA and <i>Env-Gag</i> VLP mRNA Vaccines in Mice by Qi Ma, Jing Yang, Xiaoguang Zhang, Hongxia Li, Yanzhe Hao, Xia Feng

“…Background: The development of a protective vaccine is critical for conclusively ending the human immunodeficiency virus (HIV) epidemic. Methods: We constructed nucleotide-modified mRNA vaccines expressing HIV-1 Env and Gag proteins. …”
Get full text

The impact of the international rice genebank’s (IRG) on rice farming in Bangladesh by Donald Villanueva, Yuji Enriquez, Grace Lee Capilit

“…Using data from the farm household survey conducted by the International Rice Research Institute (IRRI) in 2016 in five divisions in Bangladesh, a pedigree analysis was conducted that related the productivity changes in farmers’ fields explicitly to genebank accessions through varietal improvement. Afterward, we evaluated the economic benefit of IRG contribution in rice varietal improvement in Bangladesh using the computed marginal increases in productivity, average paddy price, and estimated total rice area. …”
Get full text

Comparison of IL-17 and FOXP3+ Levels in Maternal and Children Leprosy Patients in Endemic and Nonendemic Areas by Flora Ramona Sigit Prakoeswa, Faradiba Maharani, Munawaroh Fitriah, Jusak Nugraha, Hardyanto Soebono, Budi Prasetyo, Santi Martini, Dominicus Husada, Hari Basuki Notobroto, Muhammad Yulianto Listiawan, Anang Endaryanto, Cita Rosita Sigit Prakoeswa

“…This could cause the increased number of children leprosy patients. We investigated the dysregulation of immune system by comparing IL-17 and FOXP3+ levels occurring in maternal and child leprosy patients in endemic and nonendemic areas. …”
Get full text

Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial by Masafumi Maruyama, Naoki Tanaka, Daisuke Kubota, Masayuki Miyajima, Takefumi Kimura, Koujiro Tokutake, Ryujiro Imai, Toru Fujisawa, Hiromitsu Mori, Yoshiaki Matsuda, Shuichi Wada, Akira Horiuchi, Kendo Kiyosawa

“…A new agent, potassium-competitive acid blocker vonoprazan (VPZ) has potent acid-inhibitory effects and may offer advantages over conventional H. pylori eradication therapies. We aimed to compare the eradication rate between VPZ-based treatment and PPI-based one. …”
Get full text

Efficacy of Physiologically Active nutrients in the Treatment of Asthenic Disorders in Patients with Chronic Diffuse Liver Diseases by M. V. Mayevskaya, M. A. Morozova, A. G. Beniashvili, V. D. Lunkov, V. T. Ivashkin

“…To objectify common symptoms, we used a D-FIS questionnaire (Daily Fatigue Impact Scale), a 4DSQ Four-Dimensional Symptom Questionnaire for assessing distress, depression, anxiety and somatization, and a SF-36 questionnaire for assessing the quality of life.Results. …”
Get full text

Effect of folic acid supplementation on diminished ovarian reserve: study protocol of a single-centre, open-label, randomised, placebo-controlled clinical trial by Yan Wang, Ling Zheng, Kaijun Liao, Dongli Lu, Jiaxin Wu, Binjin Wu, Zhaochun Wu, Zhenghua Jiang

“…It is therefore hypothesised that folic acid may improve DOR.Methods and analysis A single-centre, open-label, randomised, placebo-controlled clinical trial is designed. We plan to recruit 140 women with DOR at ages of 30–35 years. …”
Get full text

Transcriptomics-based analysis of neurotoxic and reproductive effects in turbot (Scophthalmus maximus) after exposure to tris (2-chloroethyl) phosphate (TCEP) by Xiaoqian Zhou, Weifeng Liu, Bailin Cong, Aifang Deng, Jing Lin, Linlin Zhao, Shenghao Liu

“…Firstly, the hormone levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), and 11-ketotestosterone (11-KT) were significantly decreased under prolonged TCEP stress, which may have a negative impact on normal reproductive function. We identified and summarized representative differentially expressed genes (DEGs) and their functions, such as endocrine system and oxidative stress. …”
Get full text

High-efficiency borohydride oxidation and oxygen reduction on titanium-supported Au(NiMo) catalysts for Alkaline fuel cells by Sukomol Barua, Aldona Balčiūnaitė, Jūratė Vaičiūnienė, Loreta Tamašauskaitė-Tamašiūnaitė, Eugenijus Norkus

“…In this research, we used a straightforward and cost-effective methodology to fabricate a three-dimensional nickel-molybdenum (NiMo) thin-layer coating, sparsely decorated with gold crystallites, on a titanium substrate (denoted as Au(NiMo)/Ti). …”
Get full text

Multisession Anodal tDCS Protocol Improves Motor System Function in an Aging Population by G. Dumel, M.-E. Bourassa, M. Desjardins, N. Voarino, C. Charlebois-Plante, J. Doyon, Louis De Beaumont

“…A total of 23 participants (51 to 69 years old) performed five consecutive, daily 20-minute sessions of a serial reaction time task (SRT task) concomitant with either anodal (n=12) or sham (n=11) M1 a-tDCS. Results. We found a significant group × training sessions interaction, indicating that whereas aging adults in the sham group exhibited little-to-no sequence-specific learning improvements beyond the first day of training, reproducible improvements in the ability to learn new motor sequences over 5 consecutive sessions were the net result in age-equivalent participants from the M1 a-tDCS group. …”
Get full text

Effects of Flash Glucose Monitoring on Dietary Variety, Physical Activity, and Self-Care Behaviors in Patients with Diabetes by Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, Kaoru Okubo, Yoshitaka Shirakura, Kentaro Azuma, Ryoko Hujiwara, Hiroka Takahashi, Kazuya Murata

“…Before initiating flash glucose monitoring and 12 weeks after its initiation, blood glucose-related parameters were assessed and self-administered questionnaires were completed (Dietary Variety Score (DVS), the International Physical Activity Questionnaire (IPAQ), the Summary of Diabetes Self-Care Activities Measure (SDSCA), and the Diabetes Treatment Satisfaction Questionnaire (DTSQ)) and compared between the two time points. We analyzed 42 patients with type 1 diabetes mellitus and 48 patients with type 2 diabetes mellitus. …”
Get full text

Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats by Jianmin Ran, Gang Xu, Huixuan Ma, Hailing Xu, Yan Liu, Rongshao Tan, Ping Zhu, Jun Song, Gancheng Lao

“…Aim. In this study, we aimed to investigate the effects of febuxostat, a novel inhibitor of xanthine oxidase (XO), on renal damage in streptozotocin- (STZ-) induced diabetic rats. …”
Get full text

Gross soil N transformations and microbial communities in Luxembourg beech forest (Fagus sylvatica L.) soils along a pH gradient by Mengru Jia, Annemieke Kooijman, Roland Bol, Wim W. Wessel, Kathrin Hassler, Albert Tietema

“…Acidic and calcareous soils differ in nitrogen (N) cycling, yet the underlying gross N transformations remain unclear in temperate forests. To address this gap, we quantified gross N transformations and microbial abundances in the organic layer and mineral topsoil (0–5 cm) of four closely situated beech forests along a natural pH gradient. …”
Get full text

Non-steroidal anti-inflammatory drugs and oxidative stress biomarkers in fish: a meta-analytic review by Luiz Henrique Zaniolo Justi, Juliana Ferreira Silva, Manuela Santos Santana, Henrique Aparecido Laureano, Meire Ellen Pereira, Cláudia Sirlene Oliveira, Izonete Cristina Guiloski

“…Through a meta-analytic review, we evaluated the effects of NSAIDs on oxidative stress biomarkers in fish. …”
Get full text

Evaluation of the immunological functions of placental alkaline phosphatase in vivo using ALPP transgenic mice by Tse-Ching Chen, Kwai-Fong Ng, Ning Chen, Yi-Ling Pan, Chun-An Cheng, Hsiao-Chun Wu, Yi-Jen Hsueh, Nien-Yi Chiang, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin

“…Nevertheless, little is known of its immune modulatory role in vivo. In this study, we generated ALPP transgenic mice and tested these mice in the LPS-induced sepsis and male-to-female skin graft rejection models. …”
Get full text

Monitoring of the Gasoline Oxygenate MTBE and BTEX Compounds in Groundwater in Catalonia (Northeast Spain) by J. Fraile, J.M. Niaerola, L. Olivella, M. Figueras, A. Ginebreda, M. Vilanova, D. Barcela

“…Headspace (HS) gas chromatography with flame ionisation detection (HS-GC-FID) and purge and trap (P) gas chromatography-mass spectrometry (P) were used for the determination of methyl-tert-butyl ether (MTBE) and benzene, toluene, and xylenes (BTEX) in groundwater. In this work, we present the first data on the levels of MTBE and BTEX in different groundwater wells in the area of Catalonia (northeast Spain). …”
Get full text

The relationship between perceptions toward advertising and consumption of energy-dense nutrient-poor foods among adults in the United States: results from a national survey by Chan L. Thai, Jacqui Villarreal, Jacqueline A. Thai

“…The purpose of this study is to explore (1) the differences in perceptions toward and trust in food advertisements between racial/ethnic population subgroups; and (2) the associations between perceptions toward food advertising and the consumption of energy-dense, nutrient poor (EDNP) foods among adults using data from a national data set (n = 1,535).MethodsData from the National Cancer Institute’s Family Life, Activity, Sun, Health, and Eating (FLASHE) survey were utilized in this secondary data analysis study. We conducted one-way ANOVAs to evaluate demographic subgroup differences within advertising trust and perceptions, and utilized bivariate and multivariable linear regression models to examine associations between (1) the perceptions toward and trust in food advertisements between racial/ethnic population subgroups; and (2) the associations between perceptions toward food advertising and the consumption of EDNP foods, while controlling for sociodemographic factors.ResultsResults show significant differences between racial/ethnic groups on advertising perceptions (F = 8.59, p &lt; 0.0001). …”
Get full text