Immune checkpoint inhibitors in cancer patients with autoimmune disease: Safety and efficacy by Jiayuan Le, Yuming Sun, Guangtong Deng, Yating Dian, Yanli Xie, Furong Zeng

“…The utilization of immune-checkpoint inhibitors (ICIs) in cancer immunotherapy frequently leads to the occurrence of immune-related adverse events (irAEs), making it generally not recommended for patients with preexisting autoimmune diseases. Hence, we conducted a meta-analysis on safety and efficacy of ICIs in cancer patients with preexisting autoimmune diseases to provide further insights. …”
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Prenatal exposure to polycyclic aromatic hydrocarbons and blood pressure in the early life of children by Xiaodong Chen, Lingling Dong, Lina Yang, Yan Yang, Liyu Yang, Sijia Han

“…Multivariable regression models, adjusted for key confounders, were used to explore associations between PAH metabolites and blood pressure. Additionally, we applied quantile g-computation (g-comp) and Bayesian kernel machine regression (BKMR) to assess the combined and interaction effects of multiple PAH metabolites. …”
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Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury by Kim Joo-Il, Park Sang-Wook, Lim Jhong-Jae, Sohn Se-Il, Shin Ji-Su, Park Sang Cheol, Jang Young Pyo, Chung Eun Kyoung, Lee Hong-Woo, Lee Kyung-Tae

“…In this study, we investigated the gastroprotective effect of an isopropanol extract from the aerial parts of Artemisia princeps (IPAP) and developed a gastroretentive floating tablet of IPAP (IPAP-FR) for maximized local gastroprotective effects. …”
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Polymorphisms of Vitamin D Signaling Pathway Genes and Calcium-Sensing Receptor Gene in respect to Survival of Hemodialysis Patients: A Prospective Observational Study by Alicja E. Grzegorzewska, Monika K. Świderska, Adrianna Mostowska, Wojciech Warchoł, Paweł P. Jagodziński

“…We evaluated in the 7-year prospective study whether variants in vitamin D pathway genes and calcium-sensing receptor gene (CASR) are determinants of mortality in hemodialysis (HD) patients (n=532). …”
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Characteristics and Outcomes of Younger Adults with Embolic Stroke of Undetermined Source (ESUS): A Retrospective Study by Ali M. Al Khathaami, Bayan Al Bdah, Abdulmjeed Alnosair, Abdulkarim Alturki, Rayan Alrebdi, Shorug Alwayili, Sulaiman Alhamzah, Fahad A. M. AlKhathaami, Nasser Alotaibi

“…Embolic stroke of undetermined source (ESUS) in younger adults may have different risk factors compared with ESUS in elderly, and the approach to ESUS in young adults may require new therapies. We aimed to investigate the characteristics and outcomes in younger adults with ESUS at a single centre in Saudi Arabia. …”
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DETERMINE THE POLICY TARGET TO INCREASE INSTITUTIONAL DELIVERY AMONG INDONESIAN FEMALE WORKERS by Isyatun Mardhiyah Syahri, Agung Dwi Laksono, Maya Fitria, Nikmatur Rohmah, Dina Bisara Lolong, Abdulah Saleh Alruwaili

“…In addition to institutional delivery as the dependent variable, we examined eight independent variables: residence, age, education, marital status, wealth, insurance, antenatal care (ANC), and parity. …”
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Prevention and Reversal of Diabetes by All-Trans Retinoid Acid and Exendin-4 in NOD Mice by Jyuhn-Huarng Juang, Yang-Hau Van, Chien-Hung Kuo, Mei-Yin Lin, Ying-Hsiu Liu, Han-Ying Chang

“…Meanwhile, exendin-4 increases beta-cell function and mass. Thus, we hypothesized that ATRA and exendin-4 combination therapy would prevent and reverse autoimmune diabetes. …”
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An Exploration of the Cellular Microenvironment of the Female Pig Urethra: Translational Insights for Urological Research by Agustín Cartes, Caroll Stoore, María Soledad Baquedano, Christian Hidalgo, Felipe Lillo, Eduardo Landerer, Galia Ramírez-Toloza, Rodolfo Paredes

“…The aim of this study was to explore the largely uncharted muscular structure of the female pig urethra, linking urethral muscle dysfunction to incontinence. We examined histological sections from the urethras of six sows using Hematoxylin-Eosin and Masson’s trichrome staining for morphometric analysis. …”
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Chlamydia cases in women of reproductive age, 2006–2020: an analysis of surveillance data from Southern China by Peizhen Zhao, Peng Liang, Jinshen Wang, Wenqian Xu, Shujie Huang, Cheng Wang

“…This study aimed to examine the trends and factors linked to newly diagnosed and reported chlamydia cases in women aged 15–49 in Guangdong Province from 2006 to 2020. Methods We included all newly diagnosed and reported chlamydia cases from January 1, 2006, to December 31, 2020. …”
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Management of rare and undiagnosed diseases: insights from researchers and healthcare professionals in Türkiye by Sinem Durmus, Emrah Yucesan, Sinem Aktug, Begum Utz, Ahmet Okay Caglayan, Ahmet Okay Caglayan, Pinar Gencpinar, Cagatay Günay, Yavuz Oktay, Ravza Nur Yildirim, Ayca Yigit, Ugur Ozbek

“…This study provides a detailed survey analysis that sheds light on the challenges that researchers and healthcare professionals face in diagnosing, treating, managing and conducting research on RD.MethodsWe developed a national online survey with three RD stakeholder groups (Researchers, Healthcare professionals and researcher-healthcare professionals) to identify the main challenges and needs in Türkiye for the diagnosis, treatment and follow-up processes of rare and undiagnosed diseases.ResultsThe survey was completed by 363 participants, revealing that participants face key challenges such as the need to refer patients to specialized centers, financial burdens, limited access to necessary tests, inadequate support for rare disease research and a lack of interdisciplinary collaboration. …”
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Static and dynamic assessments of park accessibility and equity across different living circles in shenzhen’s core area by Zhongshan Huang, Qiyue Jia, Shixian Luo, Zhigang Tu, Lei Zhao, Siyuan Li, Zhengyan Lu

“…By combining static and dynamic population data and employing the improved dynamic two-step floating catchment area (D2SFCA) and the traditional two-step floating catchment area (2SFCA) methods, we systematically evaluate the walkability and equity of parks within different living circles (5-, 15-, and 30 min). …”
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In vitro assessment of the nematicidal potential of Streptomyces violascens strain AS2 against root-knot nematodes (Meloidogyne sp.) by Azlay Latifa, Oubassou Ez-Zahra, Berr Alexandre, Mayad El Hassan, Barakate Mustapha

“…The detrimental environmental impacts and increasing resistance associated with synthetic nematicides have increased the need for biocontrol alternatives. Here, we report for the first time the nematicidal properties of Streptomyces violascens and its viability as a safe and effective solution against nematode infestation. …”
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A Novel Dry Model for Practicable Sphincterotomy and Precut Needle Knife Sphincterotomy by Akio Katanuma, Takao Itoi, Junko Umeda, Ryosuke Tonozuka, Shuntaro Mukai, Kei Yane, Toshifumi Kin, Kazuaki Matsumoto, Tomoaki Matsumori, Katsushige Gon, Ryo Takaki, Akiko Tomonari

“…Aim. We aimed to develop a simulation dry model for endoscopic sphincterotomy (ES) and needle knife precut sphincterotomy (NKP) and to evaluate its usefulness as a training simulator. …”
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Prospective de novo drug design with deep interactome learning by Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F. Nippa, Michael Iff, Jann Ledergerber, Carl C. G. Schiebroek, Valentina Romeo, Jan A. Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider

“…Abstract De novo drug design aims to generate molecules from scratch that possess specific chemical and pharmacological properties. We present a computational approach utilizing interactome-based deep learning for ligand- and structure-based generation of drug-like molecules. …”
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Chromatin environment-dependent effects of DOT1L on gene expression in male germ cells by Manon Coulée, Alberto de la Iglesia, Mélina Blanco, Clara Gobé, Clémentine Lapoujade, Côme Ialy-Radio, Lucia Alvarez-Gonzalez, Guillaume Meurice, Aurora Ruiz-Herrera, Pierre Fouchet, Julie Cocquet, Laïla El Khattabi

“…Here, by producing and integrating epigenomic and spike-in RNA-seq data, we decipher the molecular role of DOT1L during mouse spermatogenesis and show that it has opposite effects on gene expression depending on chromatin environment. …”
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Impact of a Novel Oblique-Tip Papillotome for Biliary Cannulation during ERCP: A Nonrandomized Coarsened Exact Matching Study by Hiroo Imazu, Shiaw-Hooi Ho, Shoryoku Hino, Khean-Lee Goh, Mitsuhiko Moriyama, Kazuki Sumiyama, Hisao Tajiri

“…Background. We developed a novel oblique-tip papillotome (OT-papillotome) to facilitate biliary cannulation during endoscopic retrograde cholangiopancreatography (ERCP). …”
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A Secure and Robust Machine Learning Model for Intrusion Detection in Internet of Vehicles by Pradeep Kumar Tiwari, Shiv Prakash, Animesh Tripathi, Tiansheng Yang, Rajkumar Singh Rathore, Manish Aggarwal, Narendra Kumar Shukla

“…This paper presents a robust machine learning (ML) technique to enhance the security of IoV networks by developing an efficient intrusion detection system (IDS). In this paper, we proposed a fine tree-based model to study the complex behavior of network traffic inside the IoV to detect and classify anomalies for securing the IoV. …”
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Brain neurons internalise polymeric micron-sized capsules: Insights from in vitro and in vivo studies by Olga Kopach, Olga A. Sindeeva, Kaiyu Zheng, Eleanor McGowan, Gleb B. Sukhorukov, Dmitri A. Rusakov

“…While polyelectrolyte-based biodegradable microcapsules can achieve highly localised drug release in tissues and cell cultures, delivering drugs to intracellular sites in the brain remains a significant challenge. In this study, we utilized advanced imaging techniques, both in vitro and in vivo, to investigate whether brain neurons can internalise polyelectrolyte-based microcapsules designed for drug delivery. …”
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Secular trends of epidemiologic patterns of chronic kidney disease over three decades: an updated analysis of the Global Burden of Disease Study 2019 by Jing Liu, Xue Li, Yongping Liu, Xiaodong Sun, Xiaojin Feng, Ningning Hou, Zhenna Chen

“…Objectives To assess the characteristics of the global death burden imposed by chronic kidney disease (CKD) and the attributable risk factors from 1990 to 2019 to help inform a framework for policy discussions, resource allocation and research priorities.Design A population-based observational study.Setting The death data and relative risk factors were obtained from the Global Burden of Disease (GBD) Study 2019 database.Main outcome measures Based on the GBD database, we estimated the death burden attributable to CKD stratified by sociodemographic index (SDI), geographic location, sex, age group, time period and risk factors from 1990 to 2019.Results Over three decade study period, the global number of CKD-related deaths increased from 0.60 million (95% uncertainty interval (UI): 0.57–0.63 million) in 1990 to 1.43 million (95% UI: 1.31–1.52 million) in 2019. …”
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Novel source/drain contact structure for a-IGZO devices: Oxygen-scavenger-layer metal-interlayer-semiconductor (OSL MIS) approach by Sungjoo Song, Jong-Hyun Kim, Jongyoun Park, Seung-Hwan Kim, Dongjin Ko, Hyejung Choi, Seiyon Kim, Hyun-Yong Yu

“…Despite various attempts to address the high contact resistance issue, including the metal-interlayer-semiconductor (MIS) contact structure, a novel approach is needed. Here, we propose an oxygen-scavenger-layer MIS (OSL MIS) contact structure which employs oxygen areal density (OAD) modulated OSL as the interlayer. …”
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