Socio-Demographic and Preoperative Clinical Factors Associated With 5-Year Weight Trajectories After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy by Sahil Patel, MD, Chen Jiang, PhD, Brandon Cowan, MD, Jie Yin, MS, Catherine Schaefer, PhD, Sanjoy Dutta, MD, Rouzbeh Mostaedi, MD, Hélène Choquet, PhD

“…Trajectory analyses were conducted from 5-year follow-up data to assign patients to “low,” “average,” or “high” postoperative %TBWL groups. We then evaluated whether age, sex, race/ethnicity, neighborhood deprivation index and preoperative body mass index (BMI)/weight loss, diabetes, hypertension, and sleep apnea contributed to postoperative %TBWL using logistic regression models. …”
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Sildenafil (Viagra) Protective Effects on Neuroinflammation: The Role of iNOS/NO System in an Inflammatory Demyelination Model by Catarina Raposo, Ana Karolina de Santana Nunes, Rayana Leal de Almeida Luna, Shyrlene Meiry da Rocha Araújo, Maria Alice da Cruz-Höfling, Christina Alves Peixoto

“…We recently demonstrated that sildenafil reduces the expression of cytokines, COX-2, and GFAP in a demyelinating model induced in wild-type (WT) mice. …”
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Using Peer-Learning and Game-Based Instruction for Achieving Long-Lasting Knowledge of Cybersecurity in Primary Schools by Maja Videnovik, Vladimir Trajkovik, Tone Vold, Linda Vibeke Kionig, Ana Madevska Bogdanova, Sonja Filiposka

“…However, teaching cybersecurity to primary school students faces several challenges, including limited resources, lack of specialized teachers, and age-appropriate content. In this paper, we propose a new and innovative approach for teaching cybersecurity to primary school students, which addresses these challenges. …”
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The impact of gestational age limits on abortion-related outcomes: a synthesis of legal and health evidence by Fiona de Londras, Amanda Cleeve, Maria I. Rodriguez, Alana Farrell, Magdalena Furgalska, Antonella F. Lavelanet

“…A search strategy was drawn up to capture public health, international human rights law, and policy evidence related to the impacts of GLs. We limited our search to papers published in English since 2010, including quantitative studies (comparative and non-comparative), qualitative and mixed-methods studies, reports, PhD theses, and economic or legal analyses. …”
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Enhancing Medical Student Engagement Through Cinematic Clinical Narratives: Multimodal Generative AI–Based Mixed Methods Study by Tyler Bland

“…ObjectiveThis study aims to enhance the teaching of clinical pharmacology in medical school by using a multimodal generative artificial intelligence (genAI) approach to create compelling, cinematic clinical narratives (CCNs). MethodsWe transformed a standard clinical case into an engaging, interactive multimedia experience called “Shattered Slippers.” …”
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The Protective Effects of Annexin A1 in Acute Lung Injury Mediated by Nrf2 by Hui Huang, Yuqin Shi, Yuequan Zhou

“…Additionally, AnxA1 attenuated oxidative stress in lung tissues of ALI mice by restoring the activity of catalase (CAT), SOD, and glutathione (GSH) but reducing the levels of malondialdehyde (MDA). We also found that AnxA1 suppressed activation of the NLRP3 signaling pathway. …”
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Advanced statistical analysis of air quality and its health impacts in India: Quantifying significance by detangling weather-driven effects by Akshansha Chauhan, Guggilla Pavan Sai, Chin-Yu Hsu

“…This study conducted a long-term analysis of air quality in five major Indian cities—Delhi, Kolkata, Bengaluru, Hyderabad, and Visakhapatnam—by analysing variations in PM2.5, PM10, NOx, NH3, SO2, CO, and O3, incorporating a de-weathering strategy to isolate meteorological influences. In Delhi, we observed significant reductions in PM10 (92.50–136.70 μg/m³), NOx (62.13–151.91 ppb), and CO (0.53–0.88 mg/m³), which shifted health risks from the 'extreme' to 'low' category. …”
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Conversational Therapy through Semi-Immersive Virtual Reality Environments for Language Recovery and Psychological Well-Being in Post Stroke Aphasia by A. Giachero, M. Calati, L. Pia, L. La Vista, M. Molo, C. Rugiero, C. Fornaro, P. Marangolo

“…Given the importance of these aspects for aphasia recovery, we believe that our results add to previous evidence which points to the ecological validity and feasibility of VR treatment for language recovery and psychosocial well-being.…”
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AN EXPERIMENTAL STUDY OF THE EFFECT OF RARE POLYMORPHISMS OF HUMAN HBB, HBD AND F9 PROMOTER TATA BOXES ON THE KINETICS OF INTERACTION WITH THE TATA-BINDING PROTEIN by E. B. Sharypova, I. A. Drachkova, E. V. Kashina, D. A. Rasskazov, P. M. Ponomarenko, M. P. Ponomarenko, N. А. Kolchanov, L. K. Savinkova

“…Previously, it was shown that a number of annotated single-nucleotide polymorphisms of TATA boxes of these genes associated with the occurrence of ß- and δ-thalassemia affect the interaction with the TATAbinding protein, the interaction changing proportionally with the change in the number of gene products. In the present work, we investigate the effect of rare not annotated single-nucleotide polymorphisms (SNPs) of TATA boxes of these genes with an unknown manifestation on the TATA-binding protein interaction. …”
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From Polydeoxyribonucleotides (PDRNs) to Polynucleotides (PNs): Bridging the Gap Between Scientific Definitions, Molecular Insights, and Clinical Applications of Multifunctional Bi... by Cíntia Marques, Alexandre Porcello, Marco Cerrano, Farid Hadjab, Michèle Chemali, Kelly Lourenço, Basste Hadjab, Wassim Raffoul, Lee Ann Applegate, Alexis E. Laurent

“…To specifically address this PDRN/PN ambiguity, this narrative review proposes a standardized structure-based nomenclature for these DNA-derived polymers, the “Marques Polynucleotide Cutoff”, set at 1500 kDa. Thus, we propose that the term “PDRN” should be exclusively reserved for small- and medium-chain polymers (MW < 1500 kDa), while the term “PN” should specifically be used to denote longer-chain polymers (MW ≥ 1500 kDa). …”
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USP20 mediates malignant phenotypic changes in bladder cancer through direct interactions with YAP1 by Wensun Chen, Siqi Wu, Yifan Chen, Weijian Li, Yiqing Cao, Yingchun Liang, Xiyu Dai, Xinan Chen, Yilin Chen, Tian Chen, Shenghua Liu, Chen Yang, Haowen Jiang

“…Hippo pathway activity is controlled by the phosphorylation cascade in the MST1/2-LATS1/2-YAP1 axis, in addition to other modifications such as ubiquitination of the Hippo pathway proteins through the co-regulation of E3 ligases and deubiquitinases. In this study, we identified USP20 as a Hippo/YAP1 pathway-related deubiquitinase using combined siRNA screening and a deubiquitinase overexpression assay. …”
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Current Updates on Molecular Diagnostic Assays Used for Detection of <i>Candida auris</i>: A Systematic Review by River Chun-Wai Wong, Alfred Lok-Hang Lee, Ingrid Yu-Ying Cheung, Viola Chi-Ying Chow, Margaret Ip, Christopher Koon-Chi Lai

“…<b>Conclusions</b>: Here, we describe a useful summary to enlighten readers from clinical microbiology laboratories on the nucleic acid extraction protocols and performance of various molecular diagnostic assays used for the detection of <i>C. auris</i>.…”
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Ultrafast laser welding of transparent materials: from principles to applications by Xianshi Jia, Jinlin Luo, Kai Li, Cong Wang, Zhou Li, Mengmeng Wang, Zhengyi Jiang, Vadim P Veiko, Ji’an Duan

“…The principles of ultrafast laser welding, bottleneck problems in the welding, novel welding methods, advances in welding performance, in-situ monitoring and diagnosis, and various applications are reviewed. Finally, we offer a forward-looking perspective on the fundamental challenges within the field of ultrafast laser welding and identify key areas for future research, underscoring the imperative need for ongoing innovation and exploration.…”
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Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D by Yang Qin, Li Liu, Yanwen Zhang, Xiaowei Chen, Jiani Zhang, Sunwang Ling, Jianguang Wang, Xinyu Yang

“…However, there remains limited understanding regarding specific citrullinated proteins and their implications in the progression of RA. In this study, we screen and verify insulin-like growth factor-2 mRNA binding protein 1 (IGF2BP1) as a novel citrullinated protein with significantly elevated citrullinated level in RA. …”
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Brief intervention to reduce fatigue impact in patients with inflammatory arthritis: design and outcomes of a single-arm feasibility study by Paul Ewings, Emma Dures, Sarah Hewlett, Joanna Thorn, Mwidimi Ndosi, Siobhan Creanor, Jo Adams, Lance M McCracken, Joe Lomax, Susan Bridgewater, Bryan Abbott, Alice Berry, Marie Urban

“…Objectives Patients with inflammatory arthritis report that fatigue is challenging to manage. We developed a manualised, one-to-one, cognitive–behavioural intervention, delivered by rheumatology health professionals (RHPs). …”
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Transcriptomic and physiological analyses reveal that cytokinin is involved in the compound leaf development of alfalfa by Hongyao Mei, Jiajun Yan, Xuexin Jia, Weilin Wang, Shuangshuang Li, Ruiqi Sun, Hongjiao Jiang, Lijun Xie, Chuanen Zhou, Shiqie Bai, Lu Han

“…In this study, to elucidate the mechanism of compound leaf development, we isolated and examined the alfalfa phenotype Chuancao No.7, exhibiting five leaflets. …”
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Model for predicting metabolic activity in athletes based on biochemical blood test analysis by Victoria A. Zaborova, Evgenii I. Balakin, Ksenia A. Yurku, Olga E. Aprishko, Vasiliy I. Pustovoyt

“…The nature of adaptation to physical stress is associated with the specificity, focus, and degree of biochemical and functional changes that occur during muscular work. In this study, we aimed to develop a diagnostic model for predicting metabolic processes in athletes based on standard biochemical blood analysis indicators. …”
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Continuous-wave Laser on Er,Yb-Codoped Pentaborate Crystal by K. N. Gorbachenya, V. E. Kisel, R. V. Deineka, A. S. Yasukevich, N. V. Kuleshov, V. V. Maltsev, D. D. Mitina, E. A. Volkova, N. I. Leonyuk

“…We report, for the first time to our knowledge, a diode-pumped continuous-wave microchip Er,Yb:YMgB5O10 laser. …”
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The Impact of Heating Methods on Respiratory and Allergic Diseases in Preschool Children: A Repeated Cross-Sectional Survey Across Northern and Southern China by Chenyang Wang, Shaohua Li, Yan Zhang, Haixia Zhou, Peiwen Zhang, Wei Yu

“…Using Pearson’s chi-squared tests, we analyzed the associations between four indoor heating methods—convective heating (CH), convective and radiant heating (CH&RH), radiant heating (RH), and polluting heating (PH)—and nine respiratory and allergic diseases. …”
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Company's diversification strategy and crash risk stock prices emphasizing operational slack and management ability by Majid Moradi, Roqaye Talebi, Hamid Reza Pakdaman

“…And according to the third hypothesis, management ability strengthens the negative relationship between diversification strategy and the risk of falling stock prices, not confirmed.Originality/Value: From the aspect of research innovation, we can mention the following: first, it showed that the diverse operations of companies act as a factor in reducing the risk of their collapse, thereby clarifying a new reason for companies to expand their operational scope. …”
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