Chest CT Scan Features to Predict COVID-19 Patients’ Outcome and Survival by Mohammad-Mehdi Mehrabi Nejad, Aminreza Abkhoo, Faeze Salahshour, Mohammadreza Salehi, Masoumeh Gity, Hamidreza Komaki, Shahriar Kolahi

“…Using a case-control design, we included all laboratory-confirmed COVID-19 patients who were deceased, from June to September 2020, in a tertiary-referral-collegiate hospital and had on-admission chest CT as the case group. …”
Get full text

Connections Across Open Water: A Bi‐Organelle, Genomics‐Scale Assessment of Atlantic‐Wide Population Dynamics in a Pelagic, Endangered Apex Predator Shark (Isurus oxyrinchus) by Andrea M. Bernard, Marissa R. Mehlrose, Kimberly A. Finnegan, Bradley M. Wetherbee, Mahmood S. Shivji

“…Genomic‐scale population assessments for this apex predator species have not been previously available to inform management planning; thus, we investigated the population genetics of mako sharks across the Atlantic using a bi‐organelle genomics approach. …”
Get full text

Sequencing Analysis of Invasive Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Isolates Secondary to Gastrointestinal Colonization by Gaetano Maugeri, Maddalena Calvo, Dafne Bongiorno, Dalida Bivona, Giuseppe Migliorisi, Grete Francesca Privitera, Guido Scalia, Stefania Stefani

“…Infection development often derives from gastrointestinal colonization; thus, it is fundamental to monitor asymptomatic <i>K. pneumoniae</i> colonization through surveillance protocols, especially for intensive care and immunocompromised patients. We described a six-month routine screening protocol from the Policlinico of Catania (Italy), while blood samples were collected from the same patients only in cases of a systemic infection suspicion. …”
Get full text

The Effects of Hyperacute Serum on the Elements of the Human Subchondral Bone Marrow Niche by Melinda Simon, Bálint Major, Gabriella Vácz, Olga Kuten, István Hornyák, Adél Hinsenkamp, Dorottya Kardos, Marcell Bagó, Domonkos Cseh, Adrienn Sárközi, Denes Horvathy, Stefan Nehrer, Zsombor Lacza

“…Hyperacute serum (HAS), a new serum derivative, has been designed to approximate the natural coagulation cascade with a single-step, additive-free preparation method. We investigated the effects of HAS on monolayer MSC cultures and in their natural niche, in 3D subchondral bone and marrow explants. …”
Get full text

Effect of PCSK9 Inhibitor on Blood Lipid Levels in Patients with High and Very-High CVD Risk: A Systematic Review and Meta-Analysis by Yue Zhang, Yanrong Suo, Lin Yang, Xiaolu Zhang, Qun Yu, Miao Zeng, Wenlan Zhang, Xijuan Jiang, Yijing Wang

“…Objectives. We aimed to investigate the effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor on blood lipid levels in patients with high and very-high cardiovascular risk. …”
Get full text

COVID-19 and pediatric out-of-hospital cardiac arrest using U.S. registry database by Christopher Schmitt, Gary Beasley, Karine Guerrier, Jennifer Kramer, Maryam Y. Naim, Heather Griffis, Bryan McNally, Paul S. Chan, Rabab Al-Araji, Joseph Rossano

“…Background: Out-of-hospital cardiac arrests (OHCA) increased in the adult population during the COVID pandemic.1,2,3,4,5,6,7,8 Objectives: We aimed to determine if OHCAs increased in the pediatric population during the COVID pandemic and whether the pandemic exacerbated pre-existing racial and socio-economic disparities.13,17,18,19,20 Methods: Utilizing data from 2015 to 2020 from the Cardiac Arrest Registry to Enhance Survival (CARES) database, 13,513 pediatric OHCAs were analyzed. …”
Get full text

Risk factors for pelvic lymph node metastasis in cervical cancer: a retrospective analysis of 186 patients by Xingyu Sun, Lijuan He, Shaohua Wang

“…This study aimed to identify significant clinical and pathological risk factors associated with pelvic lymph node metastasis in patients with cervical cancer.MethodsWe conducted a retrospective analysis of 186 cervical cancer patients treated at the Affiliated Hospital, Southwest Medical University from January 2010 to December 2020. …”
Get full text

The Importance of the Prenyl Group in the Activities of Osthole in Enhancing Bone Formation and Inhibiting Bone Resorption In Vitro by Yuan-Kun Zhai, Ya-Lei Pan, Yin-Bo Niu, Chen-Rui Li, Xiang-Long Wu, Wu-Tu Fan, Ting-Li Lu, Qi-Bing Mei, Cory J. Xian

“…Osthole has both the prenyl group and bone-protective activities, but the relationship is still unknown. In this study we found that osthole exerted a potent ability to promote proliferation and osteogenic function of rat bone marrow stromal cells and osteoblasts, including improved cell viability, alkaline phosphatase activity, enhanced secretion of collagen-I, bone morphogenetic protein-2, osteocalcin and osteopontin, stimulated mRNA expression of insulin-like growth factor-1, runt-related transcription factor-2, osterix, OPG (osteoprotegerin), RANKL (receptor activator for nuclear factor-κB ligand), and the ratio of OPG/RANKL, as well as increasing the formation of mineralized nodules. …”
Get full text

Effects of Seed Processing with Cold Plasma on Growth and Biochemical Traits of <i>Stevia rebaudiana</i> Bertoni Under Different Cultivation Conditions: In Soil Versus Aeroponics by Augustė Judickaitė, Emilija Jankaitytė, Evaldas Ramanciuškas, Laima Degutytė-Fomins, Zita Naučienė, Gediminas Kudirka, Takamasa Okumura, Kazunori Koga, Masaharu Shiratani, Vida Mildažienė, Rasa Žūkienė

“…This study compared the effects of seed treatment with low-pressure cold plasma (CP) and atmospheric dielectric barrier discharge (DBD) plasma on morpho-biochemical traits in <i>Stevia rabaudiana</i> Bertoni plants cultivated by two methods: in soil and aeroponics. We investigated the impact of the treatments on the germination, plant growth, and content of secondary metabolites, namely steviol glycosides (SGs), rebaudioside A (RebA), and stevioside (Stev), as well as phenolic compounds and flavonoids. …”
Get full text

Clinicopathological Features, Treatment Strategy, and Prognosis of Primary Non-Hodgkin’s Lymphoma of the Duodenum: A SEER Database Analysis by Guoliang Zheng, Yue Wang, Yan Zhao, Zhichao Zheng

“…Primary duodenum lymphoma (PDL) is extremely rare with limited data available in the literature. In this study, we sought to describe clinical features and identify factors affecting survival in patients with PDL using a large population cohort. …”
Get full text

Prognostic factors for head and neck cancer of unknown primary including the impact of human papilloma virus infection by Lars Axelsson, Jan Nyman, Hedda Haugen-Cange, Mogens Bove, Leif Johansson, Shahin De Lara, Anikó Kovács, Eva Hammerlid

“…Independent prognostic factors for survival were age over 70 years, HPV status and N3 stage. We recommend that HPV analysis should be performed routinely for HNCUP. …”
Get full text

Socioeconomic position across the life course and falls among middle- and older-aged adults: protocol for a systematic review by Stéphane Cullati, Anita van Zwieten, Catherine Sherrington, Fiona M Blyth, Saman Khalatbari-Soltani, Marcia R Franco, Frerik Smit

“…This study, therefore, aims to synthesise existing knowledge on the association between SEP across the life course and falls within middle- and older-aged adults.Methods and analysis We systematically searched for literature in three academic databases from database inception to 15 March 2024: MEDLINE (Ovid), Embase (Ovid) and PsycInfo (Ovid). …”
Get full text

The Association between Antihypertensive Medication Use and Blood Pressure Is Influenced by Obesity by Jash S. Parikh, Arshdeep K. Randhawa, Sean Wharton, Heather Edgell, Jennifer L. Kuk

“…Therefore, it is important to examine blood pressure (BP) differences in populations that are using these medications with differing obesity status. Aim. We examined whether BP attained when using various antihypertensive medications varies amongst different body mass index (BMI) categories and whether antihypertensive medication use is associated with differences in other metabolic risk factors, independent of BMI. …”
Get full text

Effects of soil management strategies based on different principles on soil microbial communities and the outcomes for plant health by Xing Zhou, Qian Zhang, Yuanyuan Yan, Jisong Qu, Jun Zhou, Jun Zhao, Jinbo Zhang, Zucong Cai, Chuanchao Dai, Xinqi Huang

“…However, how the microbial communities that are altered by these strategies respond to pathogen invasion and contribute to plant health remains poorly understood. Here, we investigated the effects of representative chemical, physical, and biological strategies, namely, chemical fumigation (CF), heat disinfestation (HE), and reductive soil disinfestation (RSD), on soil microbial communities, pathogen invasion, and plant performance. …”
Get full text

Feature selection enhances peptide binding predictions for TCR-specific interactions by Hamid Teimouri, Hamid Teimouri, Zahra S. Ghoreyshi, Zahra S. Ghoreyshi, Anatoly B. Kolomeisky, Anatoly B. Kolomeisky, Anatoly B. Kolomeisky, Jason T. George, Jason T. George, Jason T. George, Jason T. George

“…To evaluate our approach across different TCR systems, we utilized a dataset that includes peptide libraries tested against three distinct murine TCRs. …”
Get full text

ESPGHAN and NASPGHAN 2024 protocol for paediatric functional constipation treatment guidelines (standard operating procedure) by Marc A Benninga, Morris Gordon, Nikhil Thapar, Osvaldo Borrelli, Vassiliki Sinopoulou, Merit Tabbers, Anil Darbari, Julie Khlevner, Anna de Geus, Marcin Banasiuk, Mary Boruta, Dawn Dore-Stites, Michelle Gould, Juliette Hawa, Kirsten Brooke Jones, Alexandra Kilgore, Hayat Mousa, Samuel Nurko

“…There is a need for an update to the joint European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) guidelines last released in 2014. We present the prospectively agreed operating procedure and technical review protocol in this manuscript.Methods ‘Grading of Recommendations Assessment, Development and Evaluation’ (GRADE) will be used for all phases of this guideline development. …”
Get full text

A meta-analysis of whole blood transcriptome reveals genes associated with increased neutrophil activity and T cell suppression in sepsis by T. N. Shruthi, Anbazhagan Kolandaswamy, Prabakara Somanna

“…Hence our study was limited to transcriptome data derived solely from whole blood to understand the pathogenesis and immune regulation in sepsis. Methods We considered six publically available whole blood transcriptome gene expression omnibus (GEO) datasets and analyzed them using GEO2R. …”
Get full text

Working memory and the need for explainable AI – Scenarios from healthcare, social media and insurance by M. Liebherr, E. Gößwein, C. Kannen, A. Babiker, S. Al-Shakhsi, V. Staab, B.J. Li, R. Ali, C. Montag

“…Further, all participants were presented three AI systems scenarios of relatively different degrees of (personal) relevance and, hence, personal investment: skin cancer detection (i), the personalization of social media feeds (ii), and the amount to pay for a car insurance (iii). We observed that people reported a higher need for XAI in scenarios where they were more personally invested (health, payment for insurance > social media); for signficant differences between these scenarios see the result section. …”
Get full text

Molecular characterization of a rare TP63 variant associated with split-hand/split-foot malformation 4 and incomplete penetrance: disruption of the p63-Dlx signaling pathway by Jianlong Zhuang, Yanqing Li, Yu’e Chen, Hegan Zhang, Shufen Liu, Manman Hu, Chunnuan Chen

“…Conclusion This study identifies, for the first time, the TP63 gene variant c.956G > A (p.Arg319His) as a causative factor for SHFM4 in Chinese individuals with incomplete penetrance. In addition, we hypothesize that the p.Arg319His variant functions as a gain-of-function variant, leading to the upregulation of cell adhesion target genes. …”
Get full text

Identification of Potential Biomarkers and Immune Features of Sepsis Using Bioinformatics Analysis by Fang-Chen Gong, Ran Ji, Yu-Ming Wang, Zhi-Tao Yang, Ying Chen, En-Qiang Mao, Er-Zhen Chen

“…Markers currently in use have shortcomings such as a lack of specificity and failures in the early detection of sepsis. In this study, we aimed to identify key genes involved in the molecular mechanisms of sepsis and search for potential new biomarkers and treatment targets for sepsis using bioinformatics analyses. …”
Get full text