Polymer-metal powders melt extrusion printing to produce high-density, high-conductivity pure copper components by Xiuhu Guo, Junnan Liu, Lu Li, Xiaoying Cui, Muhammad Dilawer Hayat, Peng Cao, Zhentao Yuan, Xiao Wang, Xiulin Chen

“…In this study, we utilized material extrusion (MEX) molding additive manufacturing and debinding sintering technology to create pure copper parts with high density and exceptional conductivity. …”
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Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD by Katarzyna Neubauer, Malgorzata Matusiewicz, Iwona Bednarz-Misa, Sabina Gorska, Andrzej Gamian, Malgorzata Krzystek-Korpacka

“…Despite the acknowledged contribution of eosinophils to the disease pathogenesis, available data on cytokines closely related to the peripheral eosinophils in inflammatory bowel disease (IBD) are scattered. We assessed the concentrations of eosinophil-associated cytokines and growth factors in the group of 277 individuals (101 patients with Crohn’s disease (CD), 77 with ulcerative colitis (UC), 16 with irritable bowel syndrome (IBS), and 83 healthy controls) and referred to IBD activity and the levels of hsCRP. …”
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Increased Phenotype Severity Associated with Splice-Site Variants in a Hungarian Pediatric Neurofibromatosis 1 Cohort: A Retrospective Study by Klára Veres, Benedek Nagy, Zsófia Ember, Judit Bene, Kinga Hadzsiev, Márta Medvecz, László Szabó, Zsuzsanna Zsófia Szalai

“…Although genotype–phenotype correlation studies are increasing, robust clinically relevant correlations have remained limited. <b>Methods:</b> We conducted a retrospective analysis of data obtained from a cohort of 204 Hungarian individuals, with a mean age of 16 years (age range: 1–33 years). …”
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Risk of aortic aneurysm and dissection following exposure to fluoroquinolones, common antibiotics, and febrile illness using a self-controlled case series study design: Retrospecti... by Ajit A Londhe, Chantal E Holy, James Weaver, Sergio Fonseca, Angelina Villasis, Daniel Fife

“…<h4>Outcome</h4>AAD.<h4>Methods</h4>We studied patients with exposures and AAD between 2012 and 2017 in 3 databases. …”
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A forestry investigation: Exploring factors behind improved tree species classification using bark images by Gokul Kottilapurath Surendran, Deekshitha, Martin Lukac, Martin Lukac, Jozef Vybostok, Martin Mokros

“…Convolutional Neural Networks (CNNs) consistently deliver the highest accuracy, even with diverse datasets, but fine-tuning these algorithms poses significant challenges for interdisciplinary researchers. To address this, we developed Windows-based research software, CNN Parameter Tuner 1.0, which allows the import of various data formats (jpg and png) and efficiently conducts parameter tuning by selecting parameters and values from the menu options.…”
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The potential for gene-editing to increase muscle growth in pigs: experiences with editing myostatin by A. C. Dilger, X. Chen, L. T. Honegger, B. M. Marron, J. E. Beever

“…The use of both microinjection and somatic cell nuclear transfer appear to be susceptible to these viability issues. Herein, we report a successful editing of myostatin in pigs using a zinc-finger nuclease targeted at exon 3 of myostatin. …”
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Relevance of tumor boards for the inclusion of patients in oncological clinical trials by Hendrik Dapper, Maurice Dantes, Peter Herschbach, Hana Algül, Volker Heinemann

“…At cancer centers, the recommendation about the appropriate therapy for the individual tumor patient is usually made in interdisciplinary case discussions in multidisciplinary tumor boards (MDT). In this study, we examined the impact of MDTs for the inclusion of patients in therapy trials. …”
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Exploring the effects of Tianma Gouteng granules on L-NAME-induced hypertensive rats based on 16S rDNA gene sequencing and metabolomics by Li Cheng, Zhenyang Huang, Jiawei He, Xinyi Zhang, Jiangxue Di, Hanmei Jiang, Yi Liu

“…Tianma Gouteng Granules (TG), a traditional Chinese medicine compound, has been proven to be an effective compound for the treatment of hypertension by traditional Chinese medicine diagnosis, but the target and therapeutic mechanism of TG on hypertension are still unclear. Aim of the study: We explored the mechanism of action of TG on hypertension by 16S rDNA gene sequencing and non-targeted metabolomics, verified the correlation between hypertension and intestinal flora, searched for potential markers of intestinal flora, and screened for the correlation between different flora and different metabolites, which facilitates a more scientific and reasonable guidance for the administration of TG. …”
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Six new species of zombie-ant fungi from Yunnan in China by Dexiang Tang, Ou Huang, Weiqiu Zou, Yuanbing Wang, Yao Wang, Quanying Dong, Tao Sun, Gang Yang, Hong Yu

“…This study contributes towards a better understanding of the evolutionary relationship between hosts and fungi, and provides novel insights into the morphology, distribution, parasitism, and ecology of Ophiocordyceps unilateralis sensu lato. We have provided a method for obtaining living cultures of Ophiocordyceps unilateralis complex species and their asexual morphs based on the living cultures, which is of significant value for further studies of Ophiocordyceps unilateralis complex species in the future.…”
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Is Weight Loss the Main Driver for A1C Improvement by Glucagon‐Like Peptide 1 (GLP‐1) Receptor Agonists? A 2.5‐Year Analysis in Real‐World Clinical Practice by Marwa Al‐Badri, Shilton Dhaver, Osama Hamdy

“…However, it remains unclear whether weight reduction is the primary driver of glycemic improvement. Methods We retrospectively evaluated 256 patients with T2D who were treated with exenatide (n = 84), dulaglutide (n = 99), or semaglutide (n = 73) for 2.5 years without interruption in real‐world clinical practice. …”
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Statistical analysis plan for a pragmatic randomised controlled trial comparing enhanced acceptance and commitment therapy plus ( +) added to usual aftercare versus usual aftercare... by Clare Robinson, Trudie Chalder, Paul McCrone, Olivier Quintin, Evdoxia Gkaintatzi, Imran Khan, Stephanie J. C. Taylor, on behalf of the SURECAN GROUP

“…Abstract Background The aim of the SURECAN trial is to evaluate a person-centred intervention, based on Acceptance and Commitment Therapy (ACT Plus ( +)), for people who have completed treatment for cancer with curative intent, but are experiencing poor quality of life. We present the statistical analysis plan for assessing the effectiveness and cost-effectiveness of the intervention in improving quality of life 1 year post randomisation. …”
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Slight Pro-Inflammatory Immunomodulation Properties of Dendritic Cells by Gardnerella vaginalis: The “Invisible Man” of Bacterial Vaginosis? by Thomas Bertran, Patrick Brachet, Marjolaine Vareille-Delarbre, Julie Falenta, Annie Dosgilbert, Marie-Paule Vasson, Christiane Forestier, Arlette Tridon, Bertrand Evrard

“…In the genital mucosa, dendritic cells (DCs) sense bacteria of the microenvironment via receptors and then orchestrate the immune response by induction of different T cell subtypes. We investigated the interactions between G. vaginalis and human monocyte-derived DCs using a wide range of bacterial concentrations (multiplicity of infection from 0.01 to 100), and the effects of this pathogen on PHA-induced lymphocyte proliferation. …”
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Cancer incidence and the influence of immunosuppressive agents in Korean patients with systemic lupus erythematosus: a retrospective cohort study by Soo-Kyung Cho, Jung-Yong Han, Yena Jeon, Seung-Hun You, Sun-Young Jung, Eun Jin Jang, Yoon-Kyoung Sung

“…Abstract Background To investigate cancer incidence and the potential influence of immunosuppressive agents in Korean systemic lupus erythematosus (SLE) patients. Methods We conducted a retrospective analysis utilizing data from the Korea Healthcare Bigdata Linked Platform, which integrated the National Central Cancer Registry and National Health Insurance Service databases covering the period 2008–2017. …”
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Organic Light-Emitting Diode with Color Tunable between Bluish-White Daylight and Orange-White Dusk Hue by Shih-Yun Liao, Sudhir Kumar, Hui-Huan Yu, Chih-Chia An, Ya-Chi Wang, Jhong-Wei Lin, Yung-Lee Wang, Yung-Chun Liu, Chun-Long Wu, Jwo-Huei Jou

“…The bluish-white daylight that is suitable for work shows a color temperature as high as 9,000 K, while the homey orange-white dusk hue is as low as 2,000 K. We demonstrate in this report the feasibility of using organic light-emitting diode (OLED) technology to fabricate sunlight-style illumination with a very wide color temperature range. …”
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Causal association of sex hormone-related traits with Alzheimer’s disease: a multivariable and network Mendelian randomization analysis by Yan Zhang, Zhen-dong Sun, Yu-shen Yang, Wei-dong Fu

“…Univariate and multivariate Mendelian randomization (MR) analyses were conducted to explore the possible causal relationship between these traits and AD. We used inverse variance weighted (IVW) MR as the main analysis.ResultsThe use of univariate MR-IVW revealed a possible causal relationship between SHBG [ORs (95% CI), 1.005 (1.001–1.009), p = 0.006], testosterone [ORs (95% CI), 0.994 (0.989–0.999), p = 0.013] and AD in female. …”
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Laser-based 3D printing and optical characterization of optical micro-nanostructures inspired by nocturnal insects compound eyes by Bogdan Stefanita Calin, Roxana Cristina Popescu, Eugenia Tanasa, Irina Alexandra Paun

“…For example, the development of 3D micro-nanostructures that mimic nocturnal insect eyes (optimized for night vision), emerges as promising technology for detection in IR spectral region. Here, we report a proof of principle concerning the design and laser 3D printing of all ultrastructural details of nocturnal moth Grapholita Funebrana eyes, for potential use as microlens arrays for IR detection systems. …”
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Constant Dizziness Versus Episodic Vertigo in Ménière’s Disease: Health-Related Quality of Life, Cognitive Dissonance, and Postural Problems by Ilmari Pyykkö, Jing Zou, Vinaya Manchaiah

“…In the self-administered rehabilitative training, there were no differences between any of the vertigo or dizziness groups although disease profile of MD differed significantly. Conclusion: We emphasize that constant dizziness in MD constitutes a long-term maladaptation to a vestibular and visual cognitive function causing cognitive dissonance. …”
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Wearable microfluidic biosensors with haptic feedback for continuous monitoring of hydration biomarkers in workers by Julia C. Spinelli, Brandon J. Suleski, Donald E. Wright, Joseph L. Grow, Gabriel R. Fagans, Maura J. Buckley, Da Som Yang, Kaitao Yang, Steven M. Beil, Jessica C. Wallace, Thomas S. DiZoglio, Jeffrey B. Model, Shirley Love, David E. Macintosh, Alan P. Scarth, Matthew T. Marrapode, Corinna Serviente, Raudel Avila, Barrak K. Alahmad, Michael A. Busa, John A. Wright, Weihua Li, Douglas J. Casa, John A. Rogers, Stephen P. Lee, Roozbeh Ghaffari, Alexander J. Aranyosi

“…These metrics have been challenging to achieve with wearable sensors. Here we present a closed-loop electrochemical/biophysical wearable sensing device and algorithms that directly measure whole-body sweat loss, sweating rate, sodium concentration, and sodium loss with electrode arrays embedded in a microfluidic channel. …”
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Low Circulating TRAIL Levels Are Associated with Increase of Resistin and Lipocalin-2/ngal Adipokines in Postmenopausal Women by Veronica Tisato, Paola Secchiero, Gloria Bonaccorsi, Carlo Bergamini, Pantaleo Greco, Giorgio Zauli, Carlo Cervellati

“…Evidence suggests that it might protect against metabolic abnormalities driven by obesity-induced dysregulated secretion of adipokines, but this role of TRAIL has not yet been fully established. On this basis, we aimed to investigate the potential association between TRAIL and adipokine levels in a cohort of subjects in which age/gender/hormonal interferences were excluded. …”
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Changes in grocery shopping behaviour among low-income households during the COVID-19 pandemic by Angela CB Trude, Caitlin M Lowery, Gabriela M Vedovato, Shahmir H Ali, Josephine M Dudzik

“… Abstract Objective: The Supplemental Nutrition Assistance Program (SNAP) Online Purchasing Pilot (OPP) authorised the use of SNAP benefits online in Maryland in May 2020. We assessed shopping behaviour and intentions associated with uptake and intended future use of online grocery shopping during and after COVID-19 among SNAP-eligible households. …”
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