Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Tramadol Consumption After Arthroscopic Shoulder Surgery: A Prospective, Randomized, Double-blind Clinic... by Muhittin CALIM, Serdar YESILTAS, Mustafa GUNAY, Ismail SUMER, Sedat AKBAS

“…Methods: In this study, we enrolled sixty-four patients who were scheduled to undergo arthroscopic shoulder surgery and met the inclusion criteria of having American Society of Anesthesiologists scores between 1 and 3 and falling within the age range of 18 to 85 years. …”
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The SPICE Modeling of a Radiation Sensor Based on a MOSFET with a Dielectric HfO₂/SiO₂ Double-Layer by Miloš Marjanović, Stefan D. Ilić, Sandra Veljković, Nikola Mitrović, Umutcan Gurer, Ozan Yilmaz, Aysegul Kahraman, Aliekber Aktag, Huseyin Karacali, Erhan Budak, Danijel Danković, Goran Ristić, Ercan Yilmaz

“…We report on a procedure for extracting the SPICE model parameters of a RADFET sensor with a dielectric HfO₂/SiO₂ double-layer. …”
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Pilot study of extended-release lorcaserin for cocaine use disorder among men who have sex with men: A double-blind, placebo-controlled randomized trial. by Glenn-Milo Santos, Janet Ikeda, Phillip Coffin, John E Walker, Tim Matheson, Matthew McLaughlin, Jennifer Jain, Eric Vittinghoff, Steven L Batki

“…However, self-reported cocaine use in timeline follow-back declined more significantly in the lorcaserin group compared to placebo (IRR: 0.66; 95%CI = 0.49-0.88; P = 0.004).<h4>Conclusion</h4>We found that it is feasible, acceptable, and tolerable to conduct a placebo-controlled pharmacologic trial for MSM with CUD who are actively using cocaine. …”
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Development and application of reverse transcriptase droplet digital PCR technology for sensitive detection of BVDV-1 and BTV in bovine semen by Zhichao Yu, Linjun Chen, Qiang Cui, Han Yan, Junyan Li, Xiaoping Luo, Yingying Li, Xianghong Ju, Yanhong Yong, Namula Zhao, Zhiguo Zhao

“…Thus, establishing an early detection method for BVDV-1 and BTV infection is important for the trading of semen. In this study, we developed two RT‒ddPCR methods to detect BVDV-1 and BTV, and each method was evaluated for repeatability, limit of detection and specificity. …”
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Multiscale Adaptively Spatial Feature Fusion Network for Spacecraft Component Recognition by Wuxia Zhang, Xiaoxiao Shao, Chao Mei, Xiaoying Pan, Xiaoqiang Lu

“…In order to address these issues, we propose a multiscale adaptively spatial feature fusion network (MASFFN) for spacecraft component recognition. …”
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Delphi consensus survey: the opinions of patients living with refractory ulcerative proctitis and the health care professionals who care for them by Philip Smith, Stuart Bloom, Christian Selinger, Ailsa Hart, Christopher Lamb, Anjan Dhar, Helen Steed, Matthew Brookes, Jonathan Macdonald, Ian Arnott, Shellie Radford, Gordon W Moran, Susan Ritchie, Victoria Fletcher, Jonathan Segal, N Sharma, Shahida Din, Daniel Gaya, J Butterworth, S Andrews, P Adams, Deborah Morris, Pearl Avery, Philip Oppong, Mario Guslandi, Maro Kyriacou, Rachel Linger, Madhoor Ramdeen, John Appleton, John Anneh, B Kussel

“…Following completion of three Delphi survey rounds, all 14 statements reached consensus following appropriate revision.Conclusions We established consensus on the thoughts and opinions related to refractory proctitis from both the experts who manage this disease and the patients living with it. …”
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Safety Assessment of Glucose-Lowering Drugs and Importance of Structured Education during Ramadan: A Systematic Review and Meta-Analysis by Rashmi Shiju, Ayesha Akhil, Smitha Thankachan, Jaakko Tuomilehto, Monira Al Arouj, Abdullah Bennakhi

“…However, there is a lack of standard guidelines to be followed in association with structured education and administration of drugs and dosage. Therefore, we performed a systematic review and meta-analysis of the literature to determine the safety and efficacy of different classes of drugs and the importance of structured education during Ramadan. …”
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Impact of commercial gut health interventions on caecal metagenome and broiler performance by Gladys Maria Pangga, Banaz Star-Shirko, Androniki Psifidi, Dong Xia, Nicolae Corcionivoschi, Carmel Kelly, Callie Hughes, Ursula Lavery, Anne Richmond, Umer Zeeshan Ijaz, Ozan Gundogdu

“…In this study, across three broiler production cycles, we compared the metagenomes and performance of broilers provided with ionophores (as the control group) against birds subjected to five different GHI combinations involving vaccination, probiotics, prebiotics, essential oils, and reduction of ionophore use. …”
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Disparity of serum uric acid threshold for CKD among hypertensive and non-hypertensive individuals by Bowen Zhu, Fang Li, Weidong Zhang, Shuan Zhao, Nana Song, Shi Jin, Ziyan Shen, Yufei Lu, Yang Li, Hong Liu

“…The interaction effect analysis were used to assess the impact of sUA and hypertension on CKD. We also compared the distribution of sUA and the CKD risk in community populations, distinguishing between those with and without hypertension. …”
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Human Umbilical Cord Mesenchymal Stem Cells Attenuate Ocular Hypertension-Induced Retinal Neuroinflammation via Toll-Like Receptor 4 Pathway by Shangli Ji, Jie Xiao, Jian Liu, Shibo Tang

“…In addition, via in vitro experiments, we found that the increased expression of the TLR4 signaling pathway induced by lipopolysaccharide (LPS) was markedly decreased after hUC-MSCs were cocultured with rMC-1 and BV2 cells. …”
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GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway by Yajing Wang, Ping Lu, Weifeng Zhang, Qianming Du, Jingjing Tang, Hong Wang, Jinrong Lu, Rong Hu

“…Nonresolving inflammation is one of the consistent features of the tumor microenvironment in the intestine and plays a critical role in the initiation and development of colon cancer. Here we reported the inhibitory effects of GEN-27, a new derivative of genistein, on the inflammation-related colon cancer cell proliferation and delineated the mechanism of its action. …”
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Mitochondrial DNA from endothelial cells activated the cGAS-STING pathway and regulated pyroptosis in lung ischaemia reperfusion injury after lung transplantation by Ying-nan Ju, Hu Li, Zi-peng Zhuo, Qing Yang, Wei Gao

“…Moreover, after the administration of deoxyribonuclease (DNase) I, the reoxygenated endothelial cells were also examined for cellular function and inflammatory factor expression. Finally, we administered an agonist of STING and an inhibitor of cathepsin B to the normal endothelium and investigated pyroptosis and pyroptotic proteins. …”
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THE DEVELOPMENT OF SCIENCE AND THE FATE OF A SCIENTIST (FOLLOWING GENETICS) by Jonas Rubikas

“…One can notice that a change of levels occurs at almost every 30-year period. We are now in the last third of the fourth level of investigation. …”
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Streptococcus suis-associated neonatal meningitis and sepsis: characterization, antimicrobial resistance, and public health implications by Giovanna Fusco, Rubina Paradiso, Lorena Cardillo, Maria Antonia Salvia, Saveria Dodaro, Veronica Del Monaco, Gianfranco Scarpelli, Francesca Greco, Antonio Rinaldi, Lorella Barca, Stefania Ambrogio, Antonio Limone, Esterina De Carlo, Giorgia Borriello

“…S. suis meningitis and sepsis are mainly reported in adults, related to direct contact with pigs or contaminated pork meat consumption, while it is rarely reported in children. Herein, we describe the first case of S. suis in a newborn associated with meningitis and antimicrobial resistance. …”
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Randomised trials in maternal and perinatal health in low and middle-income countries from 2010 to 2019: a systematic scoping review by Joshua P Vogel, Jack Williams, Tari Turner, Steve McDonald, Alexander John Eggleston, Annabel Richards, Elise Farrington, Wai Chung Tse, Ayeshini Sella Hewage

“…Objectives To identify and map all trials in maternal health conducted in low and middle-income countries (LMIC) over the 10-year period from 2010 to 2019, to identify geographical and thematic trends, as well as comparing to global causes of maternal death and preidentified priority areas.Design Systematic scoping review.Primary and secondary outcome measures Extracted data included location, study characteristics and whether trials corresponded to causes of mortality and identified research priority topics.Results We searched the Cochrane Central Register of Controlled Trials database, a combined registry of trials from multiple sources. …”
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Burden assessment of podoconiosis in Wayu Tuka woreda, east Wollega zone, western Ethiopia: a community-based cross-sectional study by Kebede Deribe, Gail Davey, Kenate Bekele, Tsige Amberbir, Geleta Tadele, Abdi Samuel

“…Footwear use and daily foot hygiene were associated with decreased odds of ALA. We recommend prevention and morbidity management interventions to address this developmental challenge.…”
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Surgical treatment of obesity and excess risk of developing heart failure in a controlled cohort study by Christina E. Lundberg, Shabbar Jamaly, Martin Adiels, Jesper Lagergren, Carl Johan Svensson, Lena Björck, Annika Rosengren

“…Abstract Aim We aim to assess the risk of heart failure in patients with obesity with and without gastric bypass surgery compared with population controls. …”
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Rare <i>Wolbachia</i> genotypes in laboratory <i>Drosophila melanogaster</i> strains by A. S. Ryabinin, O. D. Shishkina, Yu. Yu. Ilinsky, R. A. Bykov

“…The same genotype also increases the intensity of dopamine metabolism in Drosophila compared to the MEL-group genotypes. In the present study, we searched for the rare Wolbachia wMelCS and wMelCS2 genotypes, as well as for new genotypes in wild-type D. melanogaster strains and in several mutant laboratory strains. …”
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Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc by Michael Mimouni, Hadas Stiebel-Kalish, Irena Serov, Gabriel Chodick, Mohammad Zbedat, Dan D. Gaton

“…In this retrospective cross-sectional study, we collected data from the eyes of 25 patients with suprasellar craniopharyngioma or pituitary macroadenomas (group 1) and 35 patients with primary open-angle glaucoma (POAG) (group 2), seen between 2001 and 2015, all with a visual acuity of ≥20/40, for whom Stratus Time-Domain (TD) optic nerve OCT scans were available. …”
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The double-edged sword of statins in intracerebral hemorrhage patients: a systematic review and meta-analysis by Zheng Li, Wen-qi Xu, Jiao-qi Wang, Jia-hui Yang, Xiao-hua Shi, Cheng-bing Wang, Zhong-xin Xu, Jin-lan Jiang

“…BackgroundThis meta-analysis aimed to investigate the effect of statins on the prognosis of patients with intracerebral hemorrhage (ICH).MethodsWe conducted a systematic search using the keywords “statin” and “intracerebral hemorrhage” across four electronic databases (PubMed, Cochrane Library, Web of Science, and Embase) from their inception to October 31, 2023, to identify studies comparing the effects of statins on the prognosis of patients with ICH. …”
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