Determinants of ICT Adoption and Performance in Healthcare: The Role of Individual Attributes and Organizational Contextual Factors by Abey Jose, Alejandro F. Mac Cawley, Luis Enberg Gaete, Guilherme Luz Tortorella, Roberto Vassolo, Manisha Kumar, Nick Rich, Maneesh Kumar

“…Implementing Information and Communication Technologies (ICTs) in the healthcare sector faces several barriers, and the pace of adoption may vary depending on several factors, including individual attributes such as competence and experience, along with contextual factors such as size, type, and location of the organization. We conducted a global survey involving healthcare professionals (n =204) to understand the role of various determinants in adopting ICTs and their implications for organizational performance. …”
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Synthesis, X-Ray Crystal Structures, and Preliminary Antiproliferative Activities of New s-Triazine-hydroxybenzylidene Hydrazone Derivatives by Assem Barakat, Fardous F. El-Senduny, Zainab Almarhoon, Hessa H. Al-Rasheed, Farid A. Badria, Abdullah Mohammed Al-Majid, Hazem A. Ghabbour, Ayman El-Faham

“…We herein report a new small library of Schiff-base compounds that encompasses s-triazine and (2 or 4)-hydroxylbenzylidene derivatives. …”
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The Link between Overweight/Obesity and Noncommunicable Diseases in Ethiopia: Evidences from Nationwide WHO STEPS Survey 2015 by Bedilu Alamirie Ejigu, Fentanesh Nibret Tiruneh

“…Therefore, the aim of this study is to examine the association between overweight/obesity and the common NCDs while adjusting for other important factors. Methods. We analysed data from the 2015 Ethiopia WHO STEPS survey, which was conducted in 2015. …”
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The Impact of COVID-19 on Clinical Outcomes in Patients With Traumatic Brain Injury by Farnaz Mahdavi, Sima Fallah-Arzpeima, Zoheir Reihanian, Khatereh Asadi, Nooshin Zaresharifi, Roghaye Zare, Mohammad Ali Yazdanipour, Masoud Shabani Chobe

“…Materials & Methods: In this study, we included TBI patients presenting to an academic trauma center in the North of Iran and categorized them into two groups: infected with COVID-19 and non-infected. …”
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Behavioral representations within the endogenous dual attentional pathways during audiovisual integration processing by Zhongtian Guan, Mingli Yan, Miao He, Yubo Liu, Zhixi Zhang, Chunlin Li

“…However, the cognitive strategies and neural mechanisms involved in audiovisual integration under endogenous attentional modulation are unclear, and in particular, the functional relationship between the dorsal and ventral pathways still needs to be thoroughly investigated.MethodsWe design only auditory (A), only visual (V), and audiovisual attention (VA) tasks based on the classical Posner paradigm with spatial, temporal and neutral cues for behavioral indicators, brain activation, and their correlations.ResultsOur results showed significant differences in behavioral performance between tasks, with weaker performance on the dual-channel task than on the single-channel task. …”
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Systolic blood pressure response during exercise testing in symptomatic severe aortic stenosis by Kristofer Hedman, Anna Carlén, Eva Nylander, Éva Tamás, Carl Bellander, Henric Nilsson

“…Aims Exercise testing remains underused in patients with aortic stenosis (AS), partly due to concerns about an exercise-induced drop in systolic blood pressure (SBP). We aimed to study the SBP response to exercise in patients with severe symptomatic AS prior to surgery and 1 year postoperatively.Methods Patients scheduled for aortic valve replacement due to severe symptomatic AS were enrolled at a single centre in a prospective observational cohort study. …”
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Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

“…Novel engineered IL-2 agonists strive to increase the therapeutic window of aldesleukin (human IL-2) by increasing selectivity toward effector over regulatory T cells and reducing dose-limiting toxicities. Here we describe ANV419, an IL-2/anti-IL2 antibody fusion protein designed for selective IL-2 receptor βγ (IL-2 Rβγ) activation by sterically hindering IL-2 from binding to IL-2 Rα. …”
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Demography and fitness of Sesamia inferens Walker (Lepidoptera: Noctuidae) on three important gramineous crops by Chen Li, Zhen Shen, Liang-De Tang, Xi-Ya Wang, Yuan-Qin Huang, Yu-Fei Zhang, Ming-Yue Mu, Guy Smagghe, Lian-Sheng Zang

“…Methods In this context, we assessed the adaptation of S. inferens to three gramineous crop host plants (maize, rice and sorghum) based on age-stage, two-sex life table theory. …”
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The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability by Emily Graham, Lucia Rampazzo, Chin Wei Brian Leung, Jacob Wall, Emőke Zsanett Gerőcz, Mikhail Liskovykh, Nikolay Goncharov, Xanita Saayman, Ramazan Gundogdu, Masato T. Kanemaki, Hiroshi Masumoto, Vladimir Larionov, Natalay Kouprina, Fumiko Esashi

“…This study investigates the role of the homologous recombination (HR) mediators BRCA2 and PALB2 in centromere stability. We find that BRCA2, but not PALB2, is essential for maintaining a human artificial chromosome. …”
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Refining δ15N isotopic fingerprints of local NOx for accurate source identification of nitrate in PM2.5 by Hao Xiao, Qinkai Li, Shiyuan Ding, Wenjing Dai, Gaoyang Cui, Xiaodong Li

“…However, the absence of a systematic study on the δ15N values of domestic NOx sources hinders accurate identification of NO3– sources in China. Here, we systematically determined and refined δ15N values for six categories of NOx sources in Tianjin using an active sampling method. …”
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Tackling ALT-positive neuroblastoma: is it time to redefine risk classification systems? A systematic review with IPD meta-analysis by Marta Avinent-Pérez, Frank Westermann, Samuel Navarro, Amparo López-Carrasco, Rosa Noguera

“…Methods: Following PRISMA-IPD guidelines, we conducted a comprehensive review of neuroblastoma patients retrieved from PubMed, Scopus, and Embase databases until March-2024. …”
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A network medicine approach to investigating ME/CFS pathogenesis in severely ill patients: a pilot study by Li-Yuan Hung, Chan-Shuo Wu, Chia-Jung Chang, Peng Li, Kimberly Hicks, Joshua J. Dibble, Braxton Morrison, Chimere L. Smith, Ronald W. Davis, Wenzhong Xiao

“…By utilizing a network analysis on whole genome sequencing (WGS) data from the Severely Ill Patient Study (SIPS), we identified ME/CFS-associated proteins and delineated the corresponding network-level module, termed the SIPS disease module, together with its relevant pathways. …”
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RETRACTED ARTICLE: LRPPRC regulates malignant behaviors, protects mitochondrial homeostasis, mitochondrial function in osteosarcoma and derived cancer stem-like cells by Ziyi Zhao, Yingwei Sun, Jing Tang, Yuting Yang, Xiaochao Xu

“…Effects of LRPPRC on CSCs were accessed after LRPPRC knockdown by introducing lentivirus containing shRNA targeting to LRPPRC mRNA. Results we found that LRPPRC was highly expressed in several osteosarcoma cell lines and that LRPPRC knockdown inhibited malignant behaviors, including proliferation, invasion, colony formation and tumor formation, in MG63 and U2OS cells. …”
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Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting by Erik Olsson, Henrik Lindman, Evangelos Digkas, Viktoria Thurfjell, Haidar Mir Ali, Ute Krüger, Anna-Karin Wennstig, Marie Sundqvist, Antonios Valachis

“…Purpose: We aimed to characterize genomic alterations with potential prognostic or predictive significance in patients with metastatic triple-negative breast cancer (mTNBC) treated with chemotherapy in a real-world setting. …”
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Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis by Noritaka Sawada, Kei Adachi, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Shuichiro Kobayashi, Shin-ichi Miyajima, Yuki Suzuki, Takeshi Kikuchi, Makoto Mizutani, Taku Toriumi, Masaki Honda, Akio Mitani, Tatsuaki Matsubara, Keiko Naruse

“…The prevention of periodontitis is especially important in diabetic patients because the relationship between diabetes and periodontitis is bidirectional. Here, we evaluated the impacts of glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide on the amelioration of periodontitis. …”
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Clinicopathological characteristics and outcomes of PLA2R related idiopathic membranous nephropathy in patients with seronegative PLA2R antibodies by Xue Li, Yang Shen, Yanchun Li, Lijie Ma, Qianmei Sun

“…However, little is known about the clinicopathological characteristics and prognosis of this subtype.Methods A total of 74 IMN patients with GAg + identified by kidney biopsy were enrolled in this study. We categorized patients into two groups based on the presence or absence of serum PLA2R antibody. …”
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Effect and factors associated with reactivation after intravitreal conbercept or aflibercept in retinopathy of prematurity by Chunling Huang, Weikang Zou, Wenbei Ma, Jiali Li, Yichen Bai, Rong Wu, Qiqi Li, Qi Fang, Wenna Chen, Xiaohe Lu, Songfu Feng

“…Abstract Background To evaluate the effect and factors associated with the reactivation of retinopathy of prematurity (ROP) after intravitreal conbercept or aflibercept. Methods We retrospectively reviewed the medical records of 176 eyes diagnosed with ROP and treated with anti-VEGF therapy between January 2018 and September 2022. …”
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Liver GlucokinaseA456V Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase by Anna Vidal-Alabró, Alícia G. Gómez-Valadés, Andrés Méndez-Lucas, Jordi Llorens, Ramon Bartrons, Jordi Bermúdez, Jose C. Perales

“…Several GK mutations affect GKRP binding, resulting in permanent activation of the enzyme. We hypothesize that hepatic overexpression of a mutated form of GK, GKA456V, described in a patient with persistent hyperinsulinemic hypoglycemia of infancy (PHHI) and could provide a model to study the consequences of GK-GKRP deregulation in vivo. …”
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Proton motive force generated by microbial rhodopsin promotes extracellular electron transfer by Wenqi Ding, Tong Lin, Yun Yang, Wen-Wei Li, Shaoan Cheng, Hao Song

“…Nevertheless, the impact of PMF on the EET efficiency remains ambiguous, while the microbial rhodopsin offers a simple and efficient avenue for non-photosynthetic cells to harness PMF. Here, we studied the function of three microbial rhodopsins (Arch, Mac, and cR-1) in facilitating EET via their heterologous expression in S. oneidensis, a model electroactive microorganism. …”
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Glycogen Storage Disease Type Ia: A Retrospective Claims Analysis of Complications, Resource Utilization, and Cost of Care by Eliza Kruger, Justin Nedzesky, Nina Thomas, Jeffrey D. Dunn, Andrew A. Grimm

“…**Objective:** This retrospective database analysis assessed the complications, resource utilization, and costs in a large cohort of patients with GSDIa. **Methods:** We conducted a retrospective cohort study of GSDIa patients and matched non-GSDIa comparators utilizing the PharMetrics® Plus database. …”
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