Sex-Specific Differences in the Pathophysiology of Hypertension by Hannah Zhang, Pawan K. Singal, Amir Ravandi, Inna Rabinovich-Nikitin

“…Sex hormones likely play a key role, as they modulate many factors related to hypertension development. In this review, we postulate the potential role for sexually dimorphic fat metabolism in the physiology of hypertension. …”
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Ultrahigh piezoelectric performances of (K,Na)NbO3 based ceramics enabled by structural flexibility and grain orientation by Li-Feng Zhu, Dong Liu, Xiaoming Shi, Shiqing Deng, Jiecheng Liu, Li-Yu Wei, Zi-Qi Yang, Qi Wang, Bo-Ping Zhang, Houbing Huang, Shujun Zhang, Jing-Feng Li

“…Abstract (K,Na)NbO3-based ceramics are deemed among the most promising lead-free piezoelectric materials, though their overall piezoelectric performance still lags behind the mainstream lead-containing counterparts. Here, we achieve an ultrahigh piezoelectric charge coefficient d33 ∼ 807 pC·N−1, along with a high longitudinal electromechanical coupling factor (k33 ∼ 88%) and Curie temperature (Tc ∼ 245 °C) in the (K,Na)(Nb1-x Sb x )O3-Bi0.5Na0.5ZrO3-BiFeO3 (KNN-xSb) system through structural flexibility and grain orientation strategies. …”
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A Machine Learning Approach Using Topic Modeling to Identify and Assess Experiences of Patients With Colorectal Cancer: Explorative Study by Kelly Voigt, Yingtao Sun, Ayush Patandin, Johanna Hendriks, Richard Hendrik Goossens, Cornelis Verhoef, Olga Husson, Dirk Grünhagen, Jiwon Jung

“…The more emotional content in home context discussions underscores the personal impact of CRC beyond clinical settings. Based on our study, we found that a machine learning-supported approach is a promising solution to analyze patients’ experiences. …”
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Perceptions, Uses, and Information Sources of Medical Cannabis Among Patients With Cancer by Vera Qu, BA, Caressa Hui, MD, Jennifer Hall, BA, Kekoa Taparra, MD, PhD, Tanaya Kollipara, BA, Sandy Trieu, MD, Beth Beadle, MD, PhD, Scott Soltys, MD, Erqi L. Pollom, MD

“…Purpose: Although medical cannabis (MC) has been shown to relieve cancer- and treatment-related symptoms, there is increasing misinformation regarding its antitumor efficacy. We aimed to identify opportunities for oncologists to communicate evidence-based guidance to patients regarding its use. …”
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Increasing Health Burdens Driven by Global Trade Induced Air Pollution by Ruifei Li, Yu Luo, Xu Zhu, Jin Zhang, Pei Hua, Zhenyu Wang, Wenyu Yang, Qiuwen Chen, Hui Li

“…Abstract Globalization has led to an increasing geographical separation of primary input, consumption and production, and consequently to a substantial transboundary transfer of air pollution and associated health burdens through international trade. Here, we develop an integrated framework to determine the consumption‐ and income‐based global atmospheric emissions, and quantify the drivers of associated health impacts from 2000 to 2015, and evaluate the impacts of international trade on PM2.5‐related deaths by hypothetical scenarios. …”
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Implications of cytokine genes polymorphisms in Jordanian patients with obsessive compulsive disorder by Ahmad M. Khalil, Manal W. Khrais, Khaled M. Al-Qaoud, Mohamad Y. Al Ta’any

“…Only a few studies have been encountered in the literature in this field. We aimed at providing experimental evidence for single nucleotide polymorphisms (SNPs) in candidate cytokine genes for the etiology of OCD. …”
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Hirsutism Caused by Pregnancy Luteoma in a Low-Resource Setting: A Case Report and Literature Review by David Hamisi Mvunta, Fatemazahra Amiji, Mubina Suleiman, Francisco Baraka, Ikrah Abdallah, Mabula Kazabula, Peter J. T. Wangwe, Furaha August

“…Thus, the management of pregnancy luteomas depends on the clinical situation. Case. We report a case of 28-year-old gravida 2, para 1 who presented at 39+1 weeks of gestation with prolonged labor and delivered by emergency cesarean. …”
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Subtalar arthroereisis for simultaneous treatment of flexible pes planus during surgical correction of hallux valgus by Fan Yang, Chenglin Wu, Jiazheng Wang, Guohua Mei, Jian Zou, Jianfeng Xue, Yan Su, Xin Ma, Jieyuan Zhang, Zhongmin Shi

“…Subtalar arthroereisis using a HyProCure implant (SOH) was performed to correct hindfoot valgus based on shared decision-making. We collected and compared pre- and at least 2 year postoperative clinical outcomes (American Orthopaedic Foot & Ankle Society (AOFAS) forefoot, hindfoot score, Visual Analog Scale (VAS) pain intensity) and radiographic outcomes (hallux valgus angle (HVA), intermetatarsal angle (IMA), Meary’s angle, talonavicular coverage angle (TNCA), and calcaneal pitch (CP) angle in both groups. …”
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Nest site selection during the second breeding attempt in Japanese tits (Parus minor): effects of nest site characteristics by Xudong Li, Jiangping Yu, Li Zhang, Dake Yin, Keqin Zhang, Mingju E, Haitao Wang

“…This research aimed to determine whether Japanese tits (Parus minor), who are facultatively double-brooded, alter the features of their nest sites due to changes in the surrounding environment during their second breeding attempt. We compared nest site features of the Japanese tit’s nest boxes used for the first brood, those used for the second brood, and control nest boxes (which were unoccupied and located in the same forest patch as the nest boxes for the second brood during the corresponding year). …”
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Activity Concentrations of Sr-90 and Cs-137 in Seawater and Sediment in the Gulf of Tonkin, Vietnam by Trong-Ngo Nguyen, Quang-Thien Tran, Van-Phuc Nguyen, Nhu-Sieu Le, Son-Hai Phan, Xuan-Thang Le, Thi-Thu-Hang Vuong, Van-Phu Nguyen, Đinh-Tung Nguyen, Đinh-Khoa Tran, Minh-Đao Nguyen, Quang-Trung Phan, Thi-Mong-Tham Vo, Van-Thang Duong, Ngoc-Chung Le

“…In this study, we measured the activity concentrations of Cs-137 and Sr-90 in surface seawater and surface sediments at the Tra Co, Bach Long Vi, and Ky Anh locations in the Gulf of Tonkin, Vietnam, from December 2018 to October 2019. …”
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Pretransplant Immune- and Apoptosis-Related Gene Expression Is Associated with Kidney Allograft Function by Dorota Kamińska, Katarzyna Kościelska-Kasprzak, Paweł Chudoba, Oktawia Mazanowska, Mirosław Banasik, Marcelina Żabinska, Maria Boratyńska, Agnieszka Lepiesza, Agnieszka Gomółkiewicz, Piotr Dzięgiel, Marian Klinger

“…In a prospective study, we analyzed pretransplant peripheral blood gene expression in87 renal transplant candidates with real-time PCR on custom-designed low density arrays (TaqMan). …”
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Long-term mortality in patients with end-stage renal disease undergoing hemodialysis and peritoneal dialysis: a propensity score matching retrospective study by Pengjie Zhang, Liru Xun, Nan Bao, Ding Tong, Bin Duan, Du Peng

“…This study aimed to investigate the differences in survival and the factors that influence it in patients with end-stage renal disease treated with HD or PD.Methods We retrospectively analyzed factors related to all-cause death with renal replacement therapy and compared the long-term mortality between HD and PD strategies in patients with ESRD who started HD or PD treatment in our renal HD center between January 1, 2008, and December 1, 2021.Results Overall, 1,319 patients were included, comprising 690 and 629 patients in the HD and PD groups, respectively, according to the inclusion criteria. …”
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Case report: Unraveling a unique case of male occult breast cancer with axillary intricacies and a comprehensive literature dive by Xintong Xie, Xiangyi Kong, Xiangyi Kong, Hongnan Jiang, Jidong Gao, Jidong Gao

“…An exceedingly rare variant is male occult breast cancer, which is primarily characterized by axillary lymph node enlargement without an identifiable primary breast tumor. We report an intriguing case of a septuagenarian patient diagnosed with male occult breast cancer. …”
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Inactivation of Escherichia coli O157:H7 in Dairy Manure Compost with Alkaline Walnut Hull Biochar by Joshua B. Gurtler, Charles A. Mullen

“…However, the antimicrobial inactivation of foodborne pathogens in compost, by amending with biochar without increased heating profiles, has not been evaluated. In this study, we examined the ability of biochar to inactivate E. coli O157:H7 (EC) in fresh dairy manure compost by amending with one of four types of biochar. …”
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Health utility value of overactive bladder in Japanese older adults by Takashi Yoshioka, Kenji Omae, Satoshi Funada, Tetsuji Minami, Rei Goto

“…Multivariable linear regression models were fitted to estimate the covariate‐adjusted disutilities of OAB. We selected eight covariates (age, sex, body mass index, education, income, smoking, alcohol use, and comorbidities) as potential confounders based on previous studies. …”
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Mechanical Ventilation and the Titer of Antibodies as Risk Factors for the Development of Transfusion-Related Lung Injury by A. P. J. Vlaar, M. T. Kuipers, J. J. Hofstra, E. K. Wolthuis, C. W. Wieland, J. J. T. H. Roelofs, L. Boon, M. J. Schultz, R. Lutter, N. P. Juffermans

“…Data is lacking on the relation between titer of antibodies infused and onset of TRALI. We determined whether onset of TRALI is dependent on the titer of MHC-I antibodies infused in a combined model of ventilator-induced lung injury and antibody-induced TRALl. …”
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Demographic Associations of Diabetes Status by Both Fasting Plasma Glucose Concentration and Glycated Hemoglobin in a Community Survey in Galle District, Sri Lanka by Keddagoda Gamage Piyumi Wasana, Anoja Priyadarshani Attanayake, Thilak Priyantha Weerarathna, Kamani Ayoma Perera Wijewardana Jayatilaka

“…Significance of odds of having diabetes by both tests with rising BMI (OR = 1.97, CI 1.15–3.36, p=0.013) and DM among FDR (OR = 7.95, CI 3.54–17.88, p=0.000) was seen. We conclude rising BMI and having DM among FDR are strongly associated with diabetes status diagnosed by both tests of FPG and HbA1C in community screening.…”
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Strategies to Improve the Quality and Freshness of Human Bone Marrow-Derived Mesenchymal Stem Cells for Neurological Diseases by Da Yeon Lee, Sung Eun Lee, Do Hyeon Kwon, Saraswathy Nithiyanandam, Mi Ha Lee, Ji Su Hwang, Shaherin Basith, Jung Hwan Ahn, Tae Hwan Shin, Gwang Lee

“…As studies on the traditional characteristics of hBM-MSCs before transplantation into the brain are very limited, omics and machine learning approaches are needed to evaluate cell conditions with indepth and comprehensive analyses. Here, we provide an overview of hBM-MSCs, the application of these cells to various neurological diseases, and improvements in their quality and freshness based on integrated omics after detachment from the culture dish for successful cell therapy.…”
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Long non-coding RNA NEAT1 promotes ovarian granulosa cell proliferation and cell cycle progression via the miR-29a-3p/IGF1 axis by Lina He, Jie Lin, Zhengwen Qin, Qing Xu, Li Hao, Yanhong Fu, Xu Ran, Wei Chen

“…Nuclear paraspeckle assembly transcript 1 (NEAT1) has been implicated in various cellular processes, but its role in granulosa cell function remains unclear. Methods We investigated the function of lncRNA NEAT1 in human ovarian granulosa-like tumor cells (KGN). …”
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Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses by Valentina Stock, Rebecca Hofer, Franziska Lochmann, Vera Spanke, Klaus R. Liedl, Jakob Troppmair, Thierry Langer, Hubert Gstach, Christian Dank, Chris A. Mayhew, Sarah Kammerer, Veronika Ruzsanyi

“…Its activity could be determined by non-invasive and cost-effective assays, such as breath analysis, for the personalised monitoring of drug response. For the first time, we identify an isotopically unlabelled CYP3A4 substrate, tolterodine that leads to the formation of a non-toxic volatile metabolite, acetone, which could potentially be applied to monitor CYP3A4 activity in humans. …”
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