Zinc regulates microglial polarization and inflammation through IKBα after spinal cord injury and promotes neuronal repair and motor function recovery in mice by Daoyong Li, Daoyong Li, Mingyu Bai, Mingyu Bai, Zhanpeng Guo, Yang Cui, Yang Cui, Xifan Mei, Xifan Mei, He Tian, He Tian, Zhaoliang Shen

“…This study investigates the mechanisms of zinc ion treatment in SCI, focusing on its effects on inflammation.MethodsWe used transcriptomic analysis to identify key pathways and genes involved in the inflammatory response in a mouse model of SCI. …”
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A proposed methodology for the definition of background and reference values for trace elements in fluvial sediments by F. Barrio-Parra, R. Álvarez, H. Serrano-García, M. Izquierdo-Díaz, A. Ordóñez, C.C. García-Fernández, E. De Miguel

“…This study proposes defining the “background” value as the trace element concentration that is consistently present in the unaltered natural environment, and the “reference” value as an upper limit of variation of naturally occurring concentrations, suggestive of anthropogenic enrichment if exceeded. We argue that background and reference values can be computed as the upper limits of the one-sided 95 % confidence interval for the median and for the 90th percentile, respectively. …”
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Liver Transplant From a Deceased Donor With Cystinosis: A Case Report by Raeda Taj, Kim Ng, Sanmati R. Cuddapah, Elizabeth B. Rand, Melissa Bleicher, Sandra Amaral, Maarouf A. Hoteit, Rajendar K. Reddy, Eyob Feyssa, Emma E. Furth, Kim M. Olthoff, Samir Abu‐Gazala, Matthew H. Levine, Frederick Vyas, Peter L. Abt

“…Although utilization of deceased donors with history of IMD warrants caution, there may be circumstances under which such donors could be considered as suitable organ donor candidates. We present the first known report of liver transplantation from a deceased donor with cystinosis. …”
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Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Fac... by Qie Guo, Xiao Li, Meng-Na Cui, Yu Liang, Xiang-Peng Li, Jun Zhao, Li-Na Wei, Xiao-Lei Zhang, Xiang Hua Quan

“…In recent years, although MMC has proven useful for the treatment of pterygium, its application has been controversial because of its clear toxicity and the possibility of ocular complications. In the current study, we prospectively recruited patients to receive or not receive a local injection of MMC (0.4 mg/ml). …”
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A Transcriptomic Dataset of Liver Tissues from Global and Liver-Specific Bmal1 Knockout Mice by Guohao Han, Dan Li, Haisen Zhang, Chao Li, Luda Yang, Tiantian Ma, Xuerong Wang, Bairong Ma, Xiaodie Wu, Yang Tao, Ziang Wang, Aihua Wang, Hsu-Wen Chao, Yaping Jin, Huatao Chen

“…To explore the transcriptional changes associated with Bmal1 deletion in liver tissues, we collected liver tissues from global and liver-specific Bmal1 knockout mice, along with their respective control groups, at two circadian time points (CT2 and CT14) and used them for transcriptome sequencing analysis. …”
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Vesicoureteral Reflux in Children with Accidental Diagnosis of Unilateral Small Size Kidney by Mohsen Mohammadi, Khadijeh Ebrahimi, Soraya Khafri, Maryam Nikpour, Hadi Sorkhi

“…This suggests that VUR may constitute a significant etiological factor in the development of small-size kidneys. We recommend that these children must be evaluated for VUR.…”
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Innovation through Wearable Sensors to Collect Real-Life Data among Pediatric Patients with Cardiometabolic Risk Factors by Kestens Yan, Barnett Tracie, Mathieu Marie-Ève, Henderson Mélanie, Bigras Jean-Luc, Thierry Benoit, Maxime St-Onge, Lambert Marie

“…While increasing evidence links environments to health behavior, clinicians lack information about patients’ physical activity levels and lifestyle environments. We present mobile health tools to collect and use spatio-behavioural lifestyle data for personalized physical activity plans in clinical settings. …”
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Overview of female healthcare providers’ outlooks on cervical cancer screening: a narrative review by Wubishet Gezimu, Ababo Demeke, Firomsa Bekele, Solomon Seyife Alemu, Lema Fikadu, Addisalem Workie Demsash, Geleta Nenko Dube, Gemeda Wakgari Kitil, Elias Ezo

“…Given that healthcare providers are on the frontlines (act as role models) in increasing the community’s cervical cancer screening uptake, we suggest concerned bodies increase screening access and implement staff training programs. …”
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Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation by Iona Davies, Alice E. Adriaenssens, William R. Scott, David Carling, Kevin G. Murphy, James S. Minnion, Stephen R. Bloom, Ben Jones, Tricia M-M. Tan

“…G-protein coupled receptor desensitisation is suggested to reduce the long-term efficacy of glucagon-like-peptide 1 receptor (GLP-1R) agonists and may similarly affect the efficacy of GIPR agonists. We explored the extent of pancreatic GIPR functional desensitisation with sustained agonist exposure. …”
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Vegetation Change and Its Response to Climate Change in Yunnan Province, China by Huaizhang Sun, Jiyan Wang, Junnan Xiong, Jinhu Bian, Huaan Jin, Weiming Cheng, Ainong Li

“…In recent years, the arid climate and fragile ecosystem have led to great changes in vegetation in Yunnan Province, so it is very important to further study the relationship between vegetation and climate. In this study, we explored the temporal changes of normalized difference vegetation index (NDVI) in different seasons based on MOD13Q1 NDVI by the maximum value composite and then analyzed spatial distribution characteristics of vegetation using Sen’s tendency estimation, Mann–Kendall significance test, and coefficient of variation model (CV) combined with terrain factors. …”
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« Mon seul Shakespeare » by Jacques Nichet

“…I hope these few pages will reflect the real pleasure we all took in staging Shakespeare’s play whose text so generously rewards those who approach it with a form of innocence!…”
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Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults by Leticia Elizondo-Montemayor, Elena C. Castillo, Carlos Rodríguez-López, José R. Villarreal-Calderón, Merit Gómez-Carmona, Sofia Tenorio-Martínez, Bianca Nieblas, Gerardo García-Rivas

“…Ageing decreases pre-vitamin D production in the skin and is associated with altered cytokine profile. We performed a multivariate analysis considering lifestyle factors, anthropometric, and inflammatory markers according to seasonal variation in Mexican healthy older adults. …”
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MT-100, a human Tie2-agonistic antibody, improves penile neurovasculature in diabetic mice via the novel target Srpx2 by Fang-Yuan Liu, Young-Lai Cho, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Yan Huang, Anita Limanjaya, Mi-Hye Kwon, Jiyeon Ock, Seon-Jin Lee, Guo Nan Yin, Nam-Kyung Lee, Ji-Kan Ryu

“…Therefore, strategies for activating the Tie2 signaling pathway have been developed as potential therapies for neurovascular diseases. Here, we developed a human Tie2-agonistic antibody (MT-100) that not only resists Ang-2 antagonism and activates Tie2 signaling but also regulates a novel target, sushi repeat-containing protein X-linked 2 (Srpx2). …”
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The association between health literacy, private health insurance, and medical expenditure in South Korea by Jeehye Lee, Hye Sook Min, Dong-Hee Ryu

“…Methods Using data from the 2021 Korea Health Panel Study, we analyzed 5,469 participants aged 19–65. Logistic and multinomial logistic regression models were employed to assess factors influencing PHI enrollment. …”
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Optimization of Cannula Visibility during Ultrasound-Guided Subclavian Vein Catheterization, via a Longitudinal Approach, by Implementing Echogenic Technology by Konstantinos Stefanidis, Mariantina Fragou, Nicos Pentilas, Gregorios Kouraklis, Serafim Nanas, Richard H. Savel, Ariel L. Shiloh, Michel Slama, Dimitrios Karakitsos

“…One limitation of ultrasound-guided vascular access is the technical challenge of visualizing the cannula during insertion into the vessel. We hypothesized that the use of an echogenic vascular cannula (EC) would improve visualization when compared with a nonechogenic vascular cannula (NEC) during real-time ultrasound-guided subclavian vein (SCV) cannulation in the ICU. …”
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Physical, Textural, Rheological, and Sensory Characteristics of Amaranth-Based Wheat Flour Bread by Sahreen Nasir, Farhana Mehraj Allai, Murtaza Gani, Shaiq Ganaie, Khalid Gul, Aabida Jabeen, Darakshan Majeed

“…In this study, the chemical composition, colour analysis, and antioxidant properties of flour and bread were analysed. We also examined the rheological properties of dough and proximate, colour, textural, and organoleptic properties of amaranth wheat bread. …”
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Advances in the detection of virulence genes of Staphylococcus aureus originate from food by Yingying Zhao, Dandan Xia, Panpan Ma, Xiaofeng Gao, Wenyi Kang, Jinfeng Wei

“…It can cause food poisoning when we are infected, therefore, it is necessary to detect pathogenic bacteria. …”
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Asthma-associated prostate enlargement and bladder smooth muscle hypercontractility: unveiling a potential link to LUTS by Peibin Cen, Ming Chen, Xin Qiu, Wenbin Guo, Hongyu Lan, Xingyu Zhou, Ming Lei, Guohua Zeng, Qingfeng Yu

“…However, the potential link and mechanism remain unclear. In this study, we investigated the structural and molecular characteristics of the prostate, and the structural and functional characteristics of the bladder in an asthma rat model. …”
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Prevalence of malaria and associated factors among febrile children under 15 years at Bududa General Hospital, Eastern Uganda by Benson Okongo, Daisy Asiimwe, Clinton Olong, Enoch Muwanguzi, Robert Wagubi

“…Logistic regression models were used to determine the factors associated with malaria, and we considered ≤ 0.05 as the level of significance. …”
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Humanized Mouse Models for Immuno-Oncology Research: A Review and Implications in Lung Cancer Research by Cheol-Kyu Park, MD, PhD, Maryam Khalil, BSc, Nhu-An Pham, PhD, Stephanie Wong, BSc, Dalam Ly, PhD, Adrian Sacher, MD, FRCPC, Ming-Sound Tsao, MD, FRCPC

“…This review summarizes key concepts related to humanized mouse models. We highlight the various approaches to generate them, factors that are critical to successfully establishing such models, their respective limitations, and considerations in model selection for preclinical lung cancer immuno-oncology research and therapeutic studies.…”
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