Case report: Bevacizumab-induced cerebrovascular events: a case series report and literature review by Ke Chen, Boyang Jiang, Boyang Jiang, Huiping Yan, Huiping Yan, Liu Yang, Liu Yang, Zheling Chen, Zheling Chen

“…At the same time, this study reviewed the related studies of cardiovascular and cerebrovascular accidents caused by bevacizumab, and analyzed the management of such bevacizumab-related adverse events. We put forward our own views on the early identification and long-term management of adverse events, as well as the subsequent reuse of bevacizumab, hoping to provide more basis for the management of clinical bevacizumab application.…”
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Comparison of Endocrine Profile and In Vitro Fertilization Outcome in Patients with PCOS, Ovulatory PCO, or Normal Ovaries by Yi-Ping Zhong, Ying Ying, Hai-Tao Wu, Can-Quan Zhou, Yan-Wen Xu, Qiong Wang, Jie Li, Xiao-Ting Shen, Jin Li

“…Since the incidence of OHSS was much higher in the PCOS and ovulatory PCO patients, we should take more care of these patients and try to prevent severe OHSS.…”
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How does the medicines retail sector ensure continued access to medicines during public health emergencies? Lessons from the COVID-19 pandemic in Uganda by Eleanor Hutchinson, Sunday Mundua, Jessica Myers, Sian E. Clarke, Kristian Schultz Hansen, Chrispus Mayora, Freddie Ssengooba, Freddy Eric Kitutu

“…This paper analyses the role of the MRS in the response to COVID-19 in Uganda, the extent to which it was incorporated into national planning and in the continuity of essential services.Methods We conducted a cross-sectional study using sequential mixed methods in two purposively sampled rural districts in central Uganda. …”
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Anterior Cruciate Ligament Mechanical Response to Load in the Setting of Changes to the Medial Meniscus by Angela Hussain, Muffaddal Madraswala, Jason Koh, Farid Amirouche

“…<b>Hypothesis/Purpose</b>: This study aims to investigate how the ACL compensates for the change in knee joint stability and contact pressures due to partial horizontal cleavage tears (HCTs) in the meniscus, such as partial meniscectomy and partial transplantation on knee joint stability and contact pressures. We hypothesize that HCTs will increase contact pressures and decrease joint stability, thereby inducing compensatory stress on the anterior cruciate ligament (ACL). …”
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Knowledge and attitude among Egyptian medical students regarding the role of human papillomavirus vaccine in prevention of oropharyngeal cancer: a questionnaire-based observational... by Mohammed. N. Abdelaziz, Abdullah Hefnawy, Hajer Azzam, Omar Reisha, Omar Hamdy

“…The study was a cross-sectional questionnaire-based study consisting of 696 participants from the first to fifth-year students enrolled in any Egyptian medical school registered in the academic year 2023–2024, specifically from June to August 2024, except non-medical, graduate, and non-Egyptian students who met the exclusion criteria. We privately gathered answers via colleagues and electronically via online Google forms posted on social media groups. …”
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Is vaginal breech delivery associated with higher risk for perinatal death and cerebral palsy compared with vaginal cephalic birth? Registry-based cohort study in Norway by Guro L Andersen, Solveig Bjellmo, Sissel Hjelle, Pål Richard Romundstad, Torstein Vik, Marit Petra Martinussen, Dag Moster

“…However, the absolute risk for these outcomes was low, and taking into consideration potential long-term adverse consequences of CD for the child and later deliveries, we therefore conclude that vaginal breech delivery may be recommended, provided competent obstetric care and strict criteria for selection to vaginal delivery.…”
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An Experimental Investigation on the Relationship between MS Frequency Response and Coal and Gas Outburst by Quanjie Zhu, Qingsong Li, Yu Feng, Xianwei Heng, Shaoquan Li, Tao Yang

“…The features of each stage, including the time-frequency domain, were extracted and quantitatively expressed. We finally arrive at the following conclusions: (1) CGOB exhibits significantly periodic characteristics, and each CGOB stage corresponds to the significant response characteristics of MS. …”
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Assembly of soil multitrophic community regulates multifunctionality via multifaceted biotic factors in subtropical ecosystems by Chao Chang, En Hu, Xiaofeng Tang, Sisi Ye, Dan Zhao, Zhi Qu, Ming Li

“…However, there remains limited systematic research on how the assembly processes of multiple organismal groups affect soil ecosystem functions through their influence on biodiversity and species interactions. Here, we analyzed 331 soil samples from different land-use types (cropland, forest, and grassland) in the Qinling-Daba Mountains to investigate the drivers, assembly processes, and network stability of multitrophic organisms. …”
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CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers by Chiara Tuccilli, Enke Baldini, Salvatore Sorrenti, Antonio Catania, Alessandro Antonelli, Poupak Fallahi, Francesco Tartaglia, Susi Barollo, Caterina Mian, Andrea Palmieri, Giovanni Carbotta, Stefano Arcieri, Daniele Pironi, Massimo Vergine, Massimo Monti, Salvatore Ulisse

“…The latter was also associated with the CD80 downregulation, which was also related to the absence of lymph node metastasis. In conclusion, we documented the overall dysregulation of PD-1 and CTLA-4 ligands in PTC and ATC tissues and a possible prognostic value for CD80 gene expression in PTC.…”
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Irinotecan Plus S-1 Followed by Hepatectomy for a Patient with Initially Unresectable Colorectal Liver Metastases, Who Showed Severe Drug Rash with Oxaliplatin Plus 5-FU and Leucov... by Hiroyuki Komori, Toru Beppu, Yasuo Sakamoto, Yuji Miyamoto, Hiromitsu Hayashi, Katsunori Imai, Hidetoshi Nitta, Masayuki Watanabe, Hideo Baba

“…Although she reported no prior history of adverse reactions to tegafur-uracil, a drug lymphocyte stimulation test showed an allergic response to 5-FU. We subsequently replaced with Irinotecan plus S-1 (IRIS) chemotherapy which was well tolerated and resulted in a partial response after 3 cycles. …”
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Hyperadaptor; Temperature-insensitive tensile properties of Ni-based high-entropy alloy a wide temperature range by Hyojin Park, Sujung Son, Soung Yeoul Ahn, Hyojeong Ha, Rae Eon Kim, Jae Heung Lee, Hyo Moon Joo, Jung Gi Kim, Hyoung Seop Kim

“…This study introduces the concept of ‘Hyperadaptor’ alloys, materials engineered to maintain consistent performance across a wide range of environmental conditions. We present a Ni-based high-entropy alloy (HEA) that exhibits minimal sensitivity to temperature variations from 77 K to 873 K, maintaining both strength and ductility due to nano-sized L12 precipitates, coarse grain, and high stacking fault energy. …”
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Occurrence and Multi-Locus Genotyping of <i>Giardia duodenalis</i> in Black Goats from Fujian Province, China by Shou-Xiao Huang, Kai Hu, Peng-Fei Fu, Si-Ang Li, Yang Liu, Zhipeng Niu, Dong-Hui Zhou

“…To evaluate the prevalence and genetic diversity of <i>G. duodenalis</i> in black goats, we collected 539 fecal samples from nine districts in Fujian Province, China. …”
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Interaction between arbuscular mycorrhizal fungi and dark septate endophytes in the root systems of Populus euphratica and Haloxylon ammodendron under different drought conditions... by Huimei Wang, Huimei Wang, Hengfang Wang, Hengfang Wang, Shengtao Wei, Shengtao Wei, Li Sun, Li Sun, Li Sun, Linlin Cheng, Linlin Cheng

“…Background and AimsArbuscular mycorrhizal fungi (AMF) and dark septate endophytes (DSE) are known to enhance the tolerance of host plants to biotic and abiotic stresses, but the mechanism of their interaction under natural conditions has not been extensively studied.MethodsWe analyzed the endophytic fungal diversity and colonization characteristics in the typical desert plants Populus euphratica and Haloxylon ammodendron and the relationship between them and environmental factors.ResultsExcept for DSE in the roots of H. ammodendron, the colonization rates of AMF and DSE were significantly positively correlated with drought severity. …”
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Metabolic Syndrome May Not be a Good Predictor of Coronary Artery Disease in the Iranian Population: Population-Specific Definitions are Required by Mahmoud Ebrahimi, Seyyed Mohammad Reza Kazemi-Bajestani, Majid Ghayour-Mobarhan, Mohsen Moohebati, Roghaye Paydar, Mohsen Azimi-Nezhad, Habib Ollah Esmaily, Gordon A. A. Ferns

“…Metabolic syndrome (MS) is associated with an increased risk of coronary artery disease (CAD) in Western populations. We have investigated the relationship between the presence of MS and other conventional risk factors, and angiographically defined CAD, in a Middle Eastern population. …”
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H3K4 methylation regulates development, DNA repair, and virulence in Mucorales by Macario Osorio-Concepción, Carlos Lax, Damaris Lorenzo-Gutiérrez, José Tomás Cánovas-Márquez, Ghizlane Tahiri, Eusebio Navarro, Ulrike Binder, Francisco Esteban Nicolás, Victoriano Garre

“…However, the role of epigenetic changes at the histone level never has been studied in Mucorales. Here, we dissected the functional role of Set1, a histone methyltransferase that catalyzes the methylation of H3K4, which is associated with the activation of gene transcription and virulence. …”
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Perspectives of health workers on the facilitators and barriers to antiretroviral therapy adherence following intensive adherence counseling in Northern Uganda by Humphrey Beja, Daisy Nakayiwa, Innocent Ocitti Owachgiu, Micheal Tonny Edek, Veronic Kobusinge, Oscar Akaki, Samson Udho

“…There is limited literature on the facilitators and barriers to ART adherence following IAC.ObjectiveThis study aimed to explore the perspectives of healthcare workers (HCWs) on the facilitators and barriers to ART adherence following IAC among PLWH in Northern Uganda.MethodsThis was a descriptive qualitative study conducted among HCWs at the ART clinics of the two highest-volume public health facilities in Lira District. We purposively sampled 15 study participants and conducted face-to-face in-depth interviews using an interview guide formulated based on the components of the Capability, Opportunity, and Motivation framework for Behavior change (COM-B framework). …”
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Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice by Satoshi Okano, Akira Yasui, Shin-ichiro Kanno, Kennichi Satoh, Masahiko Igarashi, Osamu Nakajima

“…To assess the feature of the expression of KPNA2 in the development of the ductal atypia and islet architectures, we scrutinized the pancreas of Tg mice histopathologically. …”
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Identification and Expression Analysis of Sugar Transporter Gene Family in Aspergillus oryzae by Gongbo Lv, Chunmiao Jiang, Tiantian Liang, Yayi Tu, Xiaojie Cheng, Bin Zeng, Bin He

“…To investigate the potential roles of SUTs in A. oryzae, we performed an integrative analysis of the SUT gene family in this study. …”
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Artificial intelligence methods applied to longitudinal data from electronic health records for prediction of cancer: a scoping review by Victoria Moglia, Owen Johnson, Gordon Cook, Marc de Kamps, Lesley Smith

“…Conclusion This review highlights the breadth of approaches to cancer prediction from longitudinal data. We identify areas where reporting of methods could be improved, particularly regarding where in a patients’ trajectory the model is applied. …”
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Explainable Self-Supervised Dynamic Neuroimaging Using Time Reversal by Zafar Iqbal, Md. Mahfuzur Rahman, Usman Mahmood, Qasim Zia, Zening Fu, Vince D. Calhoun, Sergey Plis

“…TR aims to learn temporal dependencies in data, leveraging large datasets for pretraining and applying this knowledge to improve schizophrenia classification on smaller datasets. Methods: We pretrained an LSTM-based model with attention using the TR approach, focusing on learning the direction of time in fMRI data, achieving over 98 % accuracy on HCP and UK Biobank datasets. …”
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