University proceedings. Volga region. Natural sciences by I.S. Makeev, T.A. Konchina, M.S. Lyubov, O.I. Nedoseko

“…Background.We suppose a comprehensive description of macrophyte communities using both the traditional allocation of dominant and subdominant species and an integral assessment of species diversity using the natural logarithmic Shannon index, the Pielou evenness index, and the Simpson diversity index. …”

Comparison of Inhibitor and Substrate Selectivity between Rodent and Human Vascular Adhesion Protein-1 by Ryo Kubota, Michael J. Reid, Kuo Lee Lieu, Mark Orme, Christine Diamond, Niklas Tulberg, Susan H. Henry

“…Although the sensitivity of these two inhibitors was the lowest in the mouse enzyme, we found no significant differences between mouse, rat, and human VAP-1. …”
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AOZORA: long-term safety and joint health in paediatric persons with haemophilia A without factor VIII inhibitors receiving emicizumab – protocol for a multicentre, open-label, pha... by Seitaro Yoshida, Masashi Taki, Hideyuki Takedani, Midori Shima, Keiji Nogami, Azusa Nagao, Haruko Yamaguchi-Suita, Yui Kyogoku, Akira Ishiguro, Kaoru Kitsukawa

“…The AOZORA study will evaluate the long-term safety and joint health of paediatric PwHA without factor (F)VIII inhibitors taking emicizumab; here, we report the details of the study protocol and baseline data.Methods and analysis AOZORA is a multicentre, open-label, phase IV clinical study in Japan that aims to enrol approximately 30 PwHA aged <12 years without FVIII inhibitors. …”
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Diagnostic and Management Pathways for Pulmonary Carcinoid Tumours in the United Kingdom: Results from the National Lung Neuroendocrine Tumour Pathway Project by Wasat Mansoor, Stuart Ferguson, Victoria Ross, Denis Talbot

“…There is inconsistency among published guidelines for the optimal diagnostic and management pathways for patients with typical (TC) or atypical (AC) pulmonary carcinoid tumours. We conducted a UK-wide clinician survey to assess current practice for the diagnosis, management, and follow-up of patients with TC/AC and descriptively compared management between European Neuroendocrine Tumor Society (ENETS) accredited centres of excellence (CoE) and nonaccredited centres (non-CoE). …”
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Exploring <i>RNF213</i> in Ischemic Stroke and Moyamoya Disease: From Cellular Models to Clinical Insights by Benjamin Y. Q. Tan, Charlene H. P. Kok, Megan B. J. Ng, Shaun Loong, Eric Jou, Leonard L. L. Yeo, Weiping Han, Christopher D. Anderson, Chiea Chuen Khor, Poh San Lai

“…Key mechanisms by which <i>RNF213</i> variants contribute to disease pathogenesis are explored, alongside discussions on their clinical utility as biomarkers and therapeutic targets. Additionally, we address the gene’s implications for disease prediction, risk assessment, and cascade screening. …”
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New Insight on the Sublethal Effect of Bt-Cry1Ab in <i>Spodoptera litura</i> (Fabricius): Tissular Distribution of Cry1Ab, Ultrastructural Alterations and the Lysosomal Response by Yan-Jue Wang, Ya-Qin Shen, Ying-Dan Xiao, Xue Yang, Shao-Peng Hao, Jian-Qiu Liu, Xiao-Xue Yang, Kazuei Mita, Ya-Jing Xu

“…Bt has been applied as a gene source for insect-resistant transgenic crops, which represents efficient control of insect pests. In this study, we evaluated the pesticidal specificity of one Bt maize strain, DBN9936, that expresses Cry1Ab protein in <i>Spodoptera litura</i> larvae. …”
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Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report by Zewei Chen, Shangxi Fu, Jun Wu, Xiaoling Luo, Zhiguo Mao, Dechao Xu, Xiang Gao

“…To date, rare data on the application of daratumumab in patients with PGNMID after kidney transplantation have been reported. Herein, we first described a unique patient with recurrent PGNMID in kidney allograft who was treated with daratumumab after not responding to bortezomib-based regimens. …”
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Quantity and quality of napping to mitigate fatigue and sleepiness among nurses working long night shifts: a prospective observational study by Kazuhiro Watanabe, Inaho Shishido, Yoichi M. Ito, Rika Yano

“…Conclusions Nurses working long night shifts should consider both sufficient napping quantity and good napping quality. We suggest aiming for a TIB of at least 120 min and a SE of at least 70% to mitigate fatigue and sleepiness at the end of a night shift. …”
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Neuropsychological morbidity in the First Seizure Clinic: Prominent mood symptoms and memory issues in epilepsy by Remy Pugh, David N. Vaughan, Graeme D. Jackson, Jennie Ponsford, Chris Tailby

“…Plain Language Summary This study explored cognitive and psychological differences between various patient groups attending an Australian First Seizure Clinic. We found that learning and memory abilities were poorer in people with epilepsy than other patient groups including those with non‐epileptic seizures, and seizure‐mimics (fainting episodes). …”
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Assessing Methods to Measure Stem Diameter at Breast Height with High Pulse Density Helicopter Laser Scanning by Matthew J. Sumnall, Ivan Raigosa-Garcia, David R. Carter, Timothy J. Albaugh, Otávio C. Campoe, Rafael A. Rubilar, Bart Alexander, Christopher W. Cohrs, Rachel L. Cook

“…Technological developments have allowed helicopter airborne laser scanning (HALS) to produce high-density point clouds below the forest canopy. We present a tree stem classification method that combines linear shape detection and model-based clustering, using four discrete methods to estimate stem diameter. …”
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Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors by Alessandro Papale, Ilaria Maria Morella, Marzia Tina Indrigo, Rick Eugene Bernardi, Livia Marrone, Francesca Marchisella, Andrea Brancale, Rainer Spanagel, Riccardo Brambilla, Stefania Fasano

“…However, to date, no clinically relevant inhibitor of this cascade has been tested in experimental models of addiction, a necessary step toward clinical trials. We designed two new cell-penetrating peptides - RB1 and RB3 - that penetrate the brain and, in the micromolar range, inhibit phosphorylation of ERK, histone H3 and S6 ribosomal protein in striatal slices. …”
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Thermographic Scan of the Thoracolumbar Area in Dogs with Acute Intervertebral Disc Extrusion (IVDE): A Retrospective Study by Cristian Zaha, Liliana Cărpinișan, Larisa Schuszler, Nistor Paula, Tudor Căsălean, Tiana Florea, Văduva Cristina, Bogdan Sicoe, Ciprian Rujescu, Roxana Dascălu

“…Results: the thermal pattern and the local temperature of the thoracolumbar area present differences between healthy dogs and those with IVDE. Conclusions: we recommend thermographic scanning of the thoracolumbar area to find differences in local temperature between healthy dogs and those with intervertebral disc extrusion. …”
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Global leukemia burden and trends: a comprehensive analysis of temporal and spatial variations from 1990—2021 using GBD (Global Burden of Disease) data by Pengyu Huang, Jie Zhang

“…Methods Data were sourced from the GBD study, utilizing the Global Health Data Exchange (GHDx) query tool. We employed descriptive, trend, cluster, and forecasting analyses using age-standardized rates (ASRs) and the Estimated Annual Percentage Change (EAPC) to quantify changes over time. …”
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Coherent harmonic generation of magnons in spin textures by Guibin Lan, Kang-Yuan Liu, Zhenyu Wang, Fan Xia, Hongjun Xu, Tengyu Guo, Yu Zhang, Bin He, Jiahui Li, Caihua Wan, Gerrit E. W. Bauer, Peng Yan, Gang-Qin Liu, Xin-Yu Pan, Xiufeng Han, Guoqiang Yu

“…Here, using in-situ diamond sensors, we study the coherent harmonic generation of spin waves in a soft ferromagnet. …”
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Metabolic Syndrome in People Living with Human Immunodeficiency Virus: An Assessment of the Prevalence and the Agreement between Diagnostic Criteria by Kim Anh Nguyen, Nasheeta Peer, Anniza de Villiers, Barbara Mukasa, Tandi E. Matsha, Edward J. Mills, Andre Pascal Kengne

“…Objectives. We determined metabolic syndrome (MetS) prevalence and assessed the agreement between different diagnostic criteria in HIV-infected South Africans. …”
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Apolipoproteins A and B and PCSK9: Nontraditional Cardiovascular Risk Factors in Chronic Kidney Disease and in End-Stage Renal Disease by Cristiana-Elena Vlad, Liliana Foia, Roxana Popescu, Iuliu Ivanov, Mihaela Catalina Luca, Carmen Delianu, Vasilica Toma, Cristian Statescu, Ciprian Rezus, Laura Florea

“…This review is aimed at establishing the biomarker (ApoA, ApoB, and PCSK9) level variations in uremic patients, to identify the studies showing the association between these biomarkers and the development of cardiovascular events and to depict the therapeutic options to reduce cardiovascular risk in CKD and ESRD patients. Methods. We searched the electronic database of PubMed, Scopus, EBSCO, and Cochrane CENTRAL for studies evaluating apolipoproteins and PCSK9 in CKD and ESRD. …”
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Evaluation of the Capability of Horizontal ATR-FTMIR and UV-Visible Spectroscopy in the Discrimination of Virgin Olive Oils from the Moroccan Region of Beni Mellal-Khenifra by Aimen El Orche, Mustapha Bouatia, Siham Yanisse, Houda Labjar, Mouad Mouhsin, Mohamed Bouha, Mustapha Oubenali, Mohamed Mbarki

“…One of the most important challenges in the authentication of olive oil is the determination of the geographical origin of virgin olive oil. In this work, we evaluated the capacity of two spectroscopic techniques, UV-Visible and ATR-FTMIR, coupled with chemometric tools to determine the geographical origin of olive oils. …”
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Disrupted Regional Spontaneous Neural Activity in Mild Cognitive Impairment Patients with Depressive Symptoms: A Resting-State fMRI Study by Xiaozheng Liu, Yunhai Tu, Yirou Zang, Aiqin Wu, Zhongwei Guo, Jiawei He

“…The current study sought to investigate the features of spontaneous brain activity in MCI patients with depressive symptoms (D-MCI) using coherence regional homogeneity (CReHo) analysis with resting-state functional magnetic resonance imaging (rsfMRI). We obtained rsfMRI data in 16 MCI patients with depressive symptoms and 18 nondepressed MCI patients (nD-MCI) using a 3 T scanner. …”
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Case report: an unusual long-term evolution of a diffuse midline glioma, H3K27 altered by Michael Griessmair, Michael Griessmair, Claire Delbridge, Claus Zimmer, Eva Mayr, Arthur Wagner, Julian Canisius, Marie-Christin Metz, Benedikt Wiestler, Benedikt Wiestler

“…BackgroundAs diffuse midline glioma, H3K27 altered, is a rare tumor entity with poor prognosis and few therapeutic options, only little is known so far about the genetic factors that influence tumorigenesis and the course of tumor development.PresentationWe present the case of a 38-year-old female patient who suffered from nausea, fatigue, and intermittent walking impairment, which developed over the course of four weeks. …”
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Endoscopic ultrasound-guided hepaticogastrostomy and endoscopic retrograde cholangiopancreatography-guided biliary drainage for distal malignant biliary obstruction due to pancreat... by Naminatsu Takahara, Yousuke Nakai, Kensaku Noguchi, Tatsunori Suzuki, Tatsuya Sato, Ryunosuke Hakuta, Kazunaga Ishigaki, Tomotaka Saito, Tsuyoshi Hamada, Mitsuhiro Fujishiro

“…Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) may reduce early RBO in cases of asymptomatic DI, even when ERCP is possible. Methods We enrolled 56 patients with pancreatic cancer and asymptomatic DI who underwent EUS-HGS (n=25) or ERCP-BD (n=31). …”
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