Long-Term Intracranial Progression-Free Survival in Lung Cancer Brain Metastases Extended Beyond 50 Months with Gubenxiaoyi Formula (GBXY): A Groundbreaking Case Study by Zhengzheng Yang, Haiming Li, Lei Chen, Shujiao Li, Dong Chen, Taicheng Lu, Tongjing Ding, Ruiyang Han, Peiyu Cheng, Xiaomin Wang

“…Case presentation Here, we present a case of a middle-aged female with lung cancer BM, whose condition was assessed as progressive post-standard treatment including two local surgeries (both involving resection of cerebellar space-occupying lesions), stereotactic radiotherapy, chemotherapy and EGFR-TKIs. …”
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Hepatitis due to Coxsackie A virus in an adult: a case report by Likith Surendra, Varun Sharma, Milan Sivakumar, Tara Lanzendorf, Thomas C. Varkey, Kaivan Salehpour

“…Coxsackie virus-induced hepatitis has also been established in children; however, it has been rarely reported in the adult population. We present a unique case of an adult male with acute hepatitis from Coxsackie A exposure. …”
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Concomitant Treatment with Etanercept and Tacrolimus Synergistically Attenuates Arthritis Progression via Inhibition of Matrix Metalloproteinase-3 Production and Osteoclastogenesis... by Iwao Seki, Miwa Takai-Imamura, Tomomi Kohara-Tanaka, Satoshi Shirae, Minoru Sasano, Hiroaki Matsuno, Hiroyuki Aono

“…In the present study, we investigated the effects and mechanisms of action of a combined treatment with etanercept, a soluble tumor necrosis factor receptor (p75) Fc fusion protein, and tacrolimus, a calcineurin inhibitor on the progression of arthritis in human tumor necrosis factor-α (TNF-α) transgenic (hTNF-Tg) mice. …”
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In Vitro Evaluation of Leakage at Implant-Abutment Connection of Three Implant Systems Having the Same Prosthetic Interface Using Rhodamine B by Antoine Berberi, Georges Tehini, Khaldoun Rifai, Farah Bou Nasser Eddine, Nabil El Zein, Bassam Badran, Haidar Akl

“…Using Rhodamine B, a sensitive fluorescent tracer dye, we aim in this study to investigate leakage at implant-abutment connection of three implant systems having the same prosthetic interface. …”
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The relationship of the carriership of allelic variations in rs2228145 (A > C) of the<i>IL6R</i> gene with the levels of <i>VCAM1</i> and <i>ICAM1</i> gene transcripts in patients... by L. V. Topchieva, V. A. Korneva, I. V. Kurbatova

“…The aim of our work was to study the relationship of the carriership of rs2228145 (A &gt; C) allelic variations with the development of EAH and the VCAM1 and ICAM1 transcript levels. We analyzed samples of DNA isolated from the whole blood of 148 healthy donors and 152 patients with EAH (stages I-II). …”
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Association of TCF7L2 genetic variants rs12255372 and rs7903146 with the polycystic ovary syndrome risk: systematic review and meta-analysis by Idrees A. Shah, Rabiya Rashid, Haroon Rashid, Abid Bhat, Mohd Ashraf Ganie

“…Studies have persistently associated TCF7L2 genetic variations with T2DM, however, its results on PCOS are sparse and inconsistent. Methods We performed a comprehensive literature review of the data published till June 2024, on rs7903146, rs12255372, and PCOS in PubMed, Medline, the Cochrane Library, Google Scholar, Science Direct, Scopus, and Web of Science, followed by a meta-analysis to evaluate the association between these genetic variations and the PCOS risk. …”
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Activin levels correlate with lymphocytic infiltration in epithelial ovarian cancer by Elizabeth T. Evans, Emily F. Page, Alex Seok Choi, Zainab Shonibare, Andrea G. Kahn, Rebecca C. Arend, Karthikeyan Mythreye

“…Abstract Objective The TGF‐β superfamily member activin, a dimer of the gene products of INHBA and/or INHBB, has been implicated in immune cell maturation and recruitment, but its immune impact within epithelial ovarian cancer (EOC) is not well characterized. We sought to explore differences in activin (INHBA/ Inhibin‐βA and INHBB/ Inhibin‐βB) between malignant and ovarian tissues at the RNA and protein level and assess the relationship between activin and immune cells in EOC. …”
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A novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative inhibits cell proliferation by suppressing the MEK/ERK signaling pathway in colorectal cancer by Li Weiwei, Yang Zhifu, Ding Likun, Wang Ying, Zhao Xian, Chu Jian Jie, Ji Qing, Yao Minna, Wang Jingwen

“…Therefore, in the present study, we synthesized a novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative (compound 4) using fragment- and structure-based techniques and then investigated the anticancer effect and underlying mechanism of anti-CRC. …”
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cfDNA as a surrogate marker for COVID-19 severity in patients with influenza-like symptoms with and without SARS-CoV-2 infections in general practice: a study protocol for a prospe... by Dorothea Dehnen, Elmo Neuberger, Jürgen in der Schmitten, Ekaterini Giagkou, Perikles Simon, Suzan Botzenhardt

“…To identify a possible predictive marker for the differentiation and prognosis of illness with influenza-like symptoms with and without SARS-CoV-2 infections in general practice, we will analyse the concentrations of cell-free DNA (cfDNA) levels, laboratory and clinical parameters, temperature, oxygen saturation, breathing rate and concomitant symptoms in patients with flu-like symptoms with and without a SARS-CoV-2 infection.Methods and analysis This is a single-centre, two-arm, parallel longitudinal cohort study with a total of 44 patients. 22 patients with flu-like symptoms without a SARS-CoV-2 infection and 22 patients with flu-like symptoms with a SARS-CoV-2 infection will be recruited. …”
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Individual patterns of anadromy determine the cost of salmon lice exposure in brown trout by K. L. Hawley, H. A. Urke, T. Kristensen, T. O. Haugen

“…This flexibility in migratory behavior also creates analytical challenges in estimating lice infestation levels and the consequences of exposure. We utilized simulated individual migration trajectories of facultatively anadromous brown trout (Salmo trutta) (N = 8049), generated from spatial‐temporal fjord‐use models fitted to empirical tracking data (N = 517). …”
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Spina Bifida Occulta with Bilateral Spondylolysis at the Thoracolumbar Junction Presenting Cauda Equina Syndrome by Kentaro Mataki, Masao Koda, Yosuke Shibao, Hiroshi Kumagai, Katsuya Nagashima, Kousei Miura, Hiroshi Noguchi, Toru Funayama, Tetsuya Abe, Masashi Yamazaki

“…No report has described the coexistence of SBO and spondylolysis at the thoracolumbar junction. We report a case of SBO with spondylolysis at L1, presenting cauda equine syndrome. …”
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Beyond motor learning: Insights from infant magnetic resonance imaging on the critical role of the cerebellum in behavioral development by Lauren Wagner, Melis E Cakar, Megan Banchik, Emily Chiem, Siobhan Sive Glynn, Amy H Than, Shulamite A Green, Mirella Dapretto

“…Our focus centered on both term and preterm infants, excluding studies of perinatal injury and cerebellar pathology. We conclude that the cerebellum is implicated in many non-motor behaviors and implicit learning mechanisms in infancy. …”
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Estimating the impact of the Mongol expansion upon the gene pool of Tuvans by L. D. Damba, Е. V. Balanovskaya, M. K. Zhabagin, Y. М. Yusupov, Y. V. Bogunov, Z. M. Sabitov, A. T. Agdzhoyan, N. A. Korotkova, M. B. Lavryashina, B. B. Mongush, U. N. Kavai-ool, O. P. Balanovsky

“…With a view to trace the Mongol expansion in Tuvinian gene pool we studied two largest Tuvinian clans – those in which, according to data of humanities, one could expect the highest Central Asian ancestry, connected with the Mongol expansion. …”
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Locally Different Endothelial Nitric Oxide Synthase Protein Levels in Ascending Aortic Aneurysms of Bicuspid and Tricuspid Aortic Valve by Salah A. Mohamed, Arlo Radtke, Roza Saraei, Joern Bullerdiek, Hajar Sorani, Rolf Nimzyk, Antje Karluss, Hans H. Sievers, Gazanfer Belge

“…Dysregulated expression of the endothelial nitric oxide synthase (eNOS) is observed in aortic aneurysms associated with bicuspid aortic valve (BAV). We determined eNOS protein levels in various areas in ascending aortic aneurysms. …”
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Resilience throughout COVID-19: Unmasking the realities of COVID-19 and vaccination facilitators, barriers, and attitudes among Black Canadians. by Obidimma Ezezika, Toluwalope Adedugbe, Isaac Jonas, Meron Mengistu, Tatyana Graham, Bethelehem Girmay, Yanaminah Thullah, Chris Thompson

“…The present study investigated 1) experiences with COVID-19, 2) COVID-19's impact, and 3) factors that have influenced COVID-19 vaccine acceptance and uptake among stakeholders and partners from the Federation of Black Canadians' (FBC). We conducted semi-structured interviews with 130 individuals and four focus groups with FBC, including stakeholders and partners, between November 2021 and June 2022. …”
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Exploring Machine Learning Classification of Movement Phases in Hemiparetic Stroke Patients: A Controlled EEG-tDCS Study by Rishishankar E. Suresh, M S Zobaer, Matthew J. Triano, Brian F. Saway, Parneet Grewal, Nathan C. Rowland

“…This study assessed the effectiveness of various machine learning models in identifying movement phases in hemiparetic individuals undergoing simultaneous NIBS and EEG recordings. We hypothesized that transcranial direct current stimulation (tDCS), a form of NIBS, would enhance EEG signals related to movement phases and improve classification accuracy compared to sham stimulation. …”
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Intravitreal dexamethasone implant (Ozurdex®) findings over time: ultrasound and ultra-widefield fundus photography by Gabriela Assumpção Brito Pereira Pellegrini, Arnaldo Furman Bordon, Norma Allemann

“…Methods In this study, we included patients aged ≥ 18 years with one or two eyes who had an indication for Ozurdex® implants. …”
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Artificial intelligence‐based body composition analysis using computed tomography images predicts both prevalence and incidence of diabetes mellitus by Yoo Hyung Kim, Ji Won Yoon, Bon Hyang Lee, Jeong Hee Yoon, Hun Jee Choe, Tae Jung Oh, Jeong Min Lee, Young Min Cho

“…ABSTRACT Aim/Introduction We assess the efficacy of artificial intelligence (AI)‐based, fully automated, volumetric body composition metrics in predicting the risk of diabetes. …”
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Risk factors analysis and prediction model establishment of acute kidney injury after heart valve replacement in patients with normal renal function by Xiaofan Huang, Xiaofan Huang, Xiangyu Sun, Jiangang Song, Yongqiang Wang, Jindong Liu, Jindong Liu, Yu Zhang, Yu Zhang

“…The calibration curve slope was close to 1, and the DCA showed that the model produced better clinical benefits when the probability threshold was set at 10%–82%.ConclusionsWe developed a preoperative risk prediction model for AKI after heart valve replacement in patients with normal renal function, which demonstrated satisfactory discrimination and calibration.…”
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Leadership and management skills for student nurses: a scoping review by Hadi Zulhiqman Abdul-Rahim, Shahrimawati H. Sharbini, Mursidi Ali, Sarena Haji Hashim, Khadizah H. Abdul-Mumin

“…After conducting a one-month literature review using the selected keywords in PubMed, ScienceDirect, Scopus, and Google Scholar, we identified 394 citations. From these, fifteen articles were chosen for inclusion in the review. …”
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