Hindguts of Kyphosus sydneyanus harbor phylogenetically and genomically distinct Alistipes capable of degrading algal polysaccharides and diazotrophy by Cesar T. Facimoto, Kendall D. Clements, W. Lindsey White, Kim M. Handley

“…To further explore host-associated traits unique to K. sydneyanus-derived Alistipes, we compared 445 high-quality genomes of Alistipes available in public databases (e.g., human and ruminant associated) with 99 metagenome-assembled genomes (MAGs) from the K. sydneyanus gut. …”
Get full text

Comparison of mNGS with conventional methods for diagnosis of cryptococcal meningitis: a retrospective study by Zai-Jie Jiang, Jian-Chen Hong, Bi-Wei Lin, Wei-Qing Zhang, Qi-Chao Fan, Bi-Hui Yang, Xiang-Ping Yao

“…Abstract The application of metagenomic next-generation sequencing (mNGS) in the diagnosis of cryptococcal meningitis is relatively under characterized. Here, we retrospectively evaluated data from cryptococcal meningitis patients who were tested using mNGS and/or routine testing, including fungal culture, India ink staining, and cryptococcal antigen (CrAg) testing. …”
Get full text

ForestAlign: Automatic forest structure-based alignment for multi-view TLS and ALS point clouds by Juan Castorena, L. Turin Dickman, Adam J. Killebrew, James R. Gattiker, Rod Linn, E. Louise Loudermilk

“…., reflective or marked trees), which are impractical at scale. Here, we propose ForestAlign: an effective, target-less, and fully automatic co-registration method for aligning forest point clouds collected from multi-view, multi-scale LiDAR sources. …”
Get full text

NIH funding for the pediatric surgeon-scientist: An analysis of current trends by Colton D. Wayne, MD, Zachary Dumbauld, BS, Ethan Mills, BS, Diana L. Farmer, MD, Gail E. Besner, MD

“…Given increasing clinical demands, we sought to analyze the current state of NIH funding for pediatric surgeon-scientists. …”
Get full text

Impact of COVID-19 on the Air Quality over China and India Using Long-term (2009–2020) Multi-satellite Data by Manish Soni, Sunita Verma, Hiren Jethava, Swagata Payra, Lok Lamsal, Priyanshu Gupta, Janhavi Singh

“…Abstract We have examined the air quality over China, India and demonstrated marked differences in levels of air pollution resulted from the COVID-19 restrictions during December–April, 2019–20 to that of 11 years mean of 2009–19. …”
Get full text

Was It an Adrenocortical Adenoma or an Adrenocortical Carcinoma? Limitation of the Weiss Scoring System in Determining the Malignant Potential of Adrenocortical Tumor: Report on Tw... by Cheuk-Lik Wong, Chun-Kit Fok, Yuk-Kit Chan, Vicki Ho-Kee Tam, Lai-Ming Fung

“…The recommended classification system, namely, the Weiss scoring system, is not without flaws. We herein report two cases of ACC which were initially diagnosed as ACA according to the Weiss scoring system but developed distant metastases in subsequent years. …”
Get full text

CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemia by Tianhui Liu, Tanzhen Wang, Lijuan Qi, Yujie Liu, Meng Shan, Fuqiang Wang, Yanglan Fang, Sining Liu, Lijun Wen, Suning Chen, Depei Wu, Yang Xu

“…Here, using the most prevalent RARG fusion, CPSF6-RARG (CR), as a representative, we reveal that the CR fusion, enhances the expansion of myeloid progenitors, impairs their maturation and synergizes with RAS mutations to drive more aggressive myeloid malignancies. …”
Get full text

Institutional, neighborhood, and life stressors on loneliness among older adults by Kazumi Tsuchiya, Amy Danielle Thierry, Harry Owen Taylor

“…Our study assessed the relationship between these stressors and loneliness among specific racial/ethnic groups of older adults. Methods We used the Health and Retirement Study data (n = 9,904) to examine whether PID, SLE, and PNC were associated with loneliness. …”
Get full text

Diabetes self-management education (DSME) for older persons in Western countries: A scoping review. by Pilar Camargo-Plazas, Madison Robertson, Beatriz Alvarado, Geneviève C Paré, Idevania G Costa, Lenora Duhn

“…In this scoping review, we considered all studies about DSME for older persons with T1D and T2D in Western countries where lifestyles, risks, prevention, treatment of diabetes, and approaches to self-management and DSME are similar (e.g., North America, Western and Northern Europe and Australasia). …”
Get full text

Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway by Mingming Xu, Jiyuan Chen, Lin Gao, Shaoxi Cai, Hangming Dong

“…The aim of this study is to explore the mechanism by which microplastics influence the secretion of HSP90α and the progression of asthma. Initially, we found that microplastics were destroyed airway epithelial barrier, resulting in inherent dysfunction in the secretion of HSP90α. …”
Get full text

Etiologies and Outcomes of Acute Liver Failure in a Spanish Community by Emilio Fábrega, Miguel Ángel Mieses, Alvaro Terán, Irene Moraleja, Fernando Casafont, Javier Crespo, Fernando Pons-Romero

“…In the last decade, there is no information about ALF in our country. For these reasons we analyze retrospectively, in a ten-year period (2000 to 2010), the presumed causes, clinical characteristics, course, and outcome of ALF in a Spanish community. …”
Get full text

Genome-based analysis of the genetic pattern of black sheep in Qira sheep by Wen Zhou, Xiaopeng Li, Xuechen Zhang, Lijun Zhu, Yuwei Peng, Cheng-long Zhang, Zhipeng Han, Ruizhi Yang, Xinyu Bai, Quanfeng Wang, Yuejun Zhao, Shudong Liu

“…In order to explore the candidate genes related to black wool formation in Qira sheep. Methods We selected 123 adult healthy ewes with different coat colors in Qira sheep groups (black (B), brown (Y) and grey (G)) and extracted DNA from their venous blood to obtain Illumina Ovine SNP 50K chip data. …”
Get full text

Under simulated microgravity and gravity, anthocyanin is regulated by DcaWRKY2 in Dendrobium catenatum leaves by Tianze Hou, Baoqiang Zheng, Fucheng Peng, Zehui Jiang, Wenbo Zhang, Yan Wang

“…Furthermore, based on the transcriptome sequencing, differentially expressed genes (DEGs), and weighted gene co-expression network analysis combined with RT-qPCR, we identified one WRKY gene, DcaWRKY2, from a Dendrobium catenatum under simulated microgravity conditions, which indicated that DcaWRKY2 may be involved in anthocyanin biosynthesis under simulated microgravity conditions. …”
Get full text

The role of TRECs/KRECs as immune indicators that reflect immunophenotypes and predict the risk of infection in systemic autoimmune diseases by Takuji Itakura, Hirokazu Sasaki, Tadashi Hosoya, Natsuka Umezawa, Tetsuya Saito, Hideyuki Iwai, Hisanori Hasegawa, Hiroyuki Sato, Akihiro Hirakawa, Kohsuke Imai, Tomohiro Morio, Naoki Kimura, Shinsuke Yasuda

“…To clarify the significance of TRECs and KRECs as immune indicators in patients with systemic autoimmune diseases, we prospectively evaluated TREC and KREC levels with qPCR, lymphocyte phenotypes with flow cytometry, along with lymphocyte counts and serum immunoglobulin levels in peripheral blood samples from newly diagnosed patients. …”
Get full text

Effects of Functional Oligosaccharides Extracted from Straw on the Growth, Feeding, Physiology, Histology, Muscle Texture, and Gut Microbiota of Micropterus salmoides by Benli Wu, Long Huang, Cangcang Wu, Jing Chen, Xiajun Chen, Xiang Wang, Kai Cui, Zhigang Liu, Jixiang He

“…We conducted an 8-week feeding trial to investigate the effect of mixed functional oligosaccharides (chitosan oligosaccharide, fructooligosaccharide, and xylooligosaccharide) extracted from wheat straw on the growth, feeding, physiology, histology, muscle texture, and gut microbiota of Micropterus salmoides. …”
Get full text

Optogenetic Inhibition of Striatal Neuronal Activity Improves the Survival of Transplanted Neural Stem Cells and Neurological Outcomes after Ischemic Stroke in Mice by Yifan Lu, Lu Jiang, Wanlu Li, Meijie Qu, Yaying Song, Xiaosong He, Zhijun Zhang, Guo-Yuan Yang, Yongting Wang

“…However, how the survival, proliferation, migration, and differentiation of implanted NSC are influenced by endogenous neuronal activity remains unclear. In this work, we used optogenetic techniques to control the activity of striatal neurons and investigated how their activity affected the survival and migration of transplanted NSCs and overall neurological outcome after ischemic stroke. …”
Get full text

Pseudoaneurysm of the Anterior Tibial Artery following Ankle Arthroscopy in a Soccer Player by Ichiro Tonogai, Tetsuya Matsuura, Toshiyuki Iwame, Keizo Wada, Tomoya Takasago, Tomohiro Goto, Daisuke Hamada, Yohei Kawatani, Eiki Fujimoto, Tetsuya Kitagawa, Shyoichiro Takao, Seiji Iwamoto, Moriaki Yamanaka, Masafumi Harada, Koichi Sairyo

“…To our knowledge, only 11 cases of pseudoaneurysm involving the anterior tibial artery after ankle arthroscopy have been described in the literature. Here we reported a rare case of a 19-year-old soccer player who presented with pseudoaneurysm of the anterior tibial artery following ankle arthroscopy using an ankle distraction method and underwent anastomosis for the anterior tibial artery injury. …”
Get full text

Modeling compositional heterogeneity resolves deep phylogeny of flowering plants by Yongli Wang, Yan-Da Li, Shuo Wang, Erik Tihelka, Michael S. Engel, Chenyang Cai

“…However, owing to ancient rapid radiations, the interrelationships among the five lineages of Mesangiospermae, the vast majority of angiosperms, remain contentious. Here we show that, although plastid and mitochondrial genomes lack sufficient phylogenetic signal for resolving deeper phylogeny, the relationships among five mesangiosperm lineages can be confidently resolved under better-fitting models using genome-scale data. …”
Get full text

Elevated SAMD3 expression in T cells predicts improved survival in pancreatic ductal adenocarcinoma patients by Lingyi Fu, Enliang Zhou, Shuo Li, Ziteng Li, Liyan Wu, Xinxin Zhou, Lang Tian, Bokang Cui

“…This study aimed to demonstrate that elevated sterile alpha motif domain-containing protein 3 (SAMD3) expression in effector CD8+ T cells was associated with improved survival in PDAC patients. Design We investigated the heterogeneity and gene expression profiles of T cells using a single-cell RNA sequencing (sc-RNA-seq) dataset comprised of human PDAC samples. …”
Get full text

Interindividual Variability Response to Resistance and High-Intensity Interval Training on Blood Pressure Reduction in Hypertensive Older Adults by Johnattan Cano-Montoya, Nicolas Hurtado, Carolina Núñez Vergara, Sebastián Báez Vargas, Marcela Rojas-Vargas, Sergio Martínez-Huenchullán, Cristian Alvarez, Mikel Izquierdo

“…Background: This study evaluated the effects of resistance training (RT) and high-intensity interval training (HIIT) on systolic (SBP) and diastolic blood pressure (DBP) in hypertensive older adults undergoing pharmacological therapy over four and eight weeks. We compared the efficacy of RT and HIIT in reducing non-responders (NRs) between weeks 4 and 8 and analyzed time-course adaptations in NRs and responders (Rs). …”
Get full text