Physically Meaningful Surrogate Data for COPD by Harry J. Davies, Ghena Hammour, Hongjian Xiao, Patrik Bachtiger, Alexander Larionov, Philip L. Molyneaux, Nicholas S. Peters, Danilo P. Mandic

“…Deep learning techniques are “data hungry” whilst patient-based data is invariably expensive and time consuming to record. To this end, we introduce a novel COPD-simulator, a physical apparatus with an easy to replicate design which enables rapid and effective generation of a wide range of COPD-like data from healthy subjects, for enhanced training of deep learning frameworks. …”
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Association of Matrix Metalloproteinase 9 (MMP-9) Polymorphisms with Asthma Risk: A Meta-Analysis by Fenfang Zou, Jianpeng Zhang, Guoan Xiang, Hongbin Jiao, Hongmei Gao

“…Seven studies with 1592 asthma patients and 1987 controls were finally identified. Overall, we found no significant association between −1562 C > T, rs3918242 polymorphism, and asthma susceptibility in any of the genetic model comparisons. …”
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ZenLDA: Large-Scale Topic Model Training on Distributed Data-Parallel Platform by Bo Zhao, Hucheng Zhou, Guoqiang Li, Yihua Huang

“…Many large-scale LDA training systems have been developed, which usually prefer a customized design from top to bottom with sophisticated synchronization support. We propose an LDA training system named ZenLDA, which follows a generalized design for the distributed data-parallel platform. …”
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Adolescent mice exposed to TBI developed PD-like pathology in middle age by Rong Sha, Mingzhe Wu, Pengfei Wang, Ziyuan Chen, Wei Lei, Shimiao Wang, Shun Gong, Guobiao Liang, Rui Zhao, Yingqun Tao

“…However, the precise mechanism by which chronic TBI initiates PD pathogenesis is not yet fully understood. In our present study, we assessed the chronic progression and pathogenesis of PD-like behavior at different intervals in TBI mice. …”
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Copy number amplification of FLAD1 promotes the progression of triple-negative breast cancer through lipid metabolism by Xiao-Qing Song, Tian-Jian Yu, Yang Ou-Yang, Jia-Han Ding, Yi-Zhou Jiang, Zhi-Ming Shao, Yi Xiao

“…Through an integrated analysis of our TNBC multiomic dataset (n = 465) and subsequent experimental validation, we identify copy number amplification of the metabolic gene flavin-adenine dinucleotide synthetase 1 (FLAD1) as a crucial genetic event that drives TNBC progression. …”
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Clinical analysis of pulmonary mucosa-associated lymphoid tissue lymphoma coexisting with lung cancer by Heng Yang, Man-Hui Li, Qiu-Hong Li, Ke-Bin Cheng, Wei-Jun Cao

“…The clinical characteristics and prognostic factors of this co-occurrence, however, remain poorly understood. Methods We retrospectively analyzed the clinical, imaging, genetic mutations and pathological data among adult patients with pulmonary MALT lymphoma coexisting with lung cancer who were confirmed by pathological examinations after operation at Shanghai Pulmonary Hospital between 1st January 2013 and 31st May 2024. …”
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Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, Brazil by Joao Leandro Paula Ferreira, Rosangela Rodrigues, Andre Minhoto Lança, Valeria Correia de Almeida, Simone Queiroz Rocha, Taisa Grotta Ragazzo, Denise Lotufo Estevam, Luis Fernando de Macedo Brigido

“…In Brazil, low to intermediate resistance levels have been described. We assessed 225 HIV-1 infected, antiretroviral naïve individuals, from HIV Reference Centers at two major metropolitan areas of Sao Paulo (Sao Paulo and Campinas), the state that concentrates most of the Brazilian Aids cases. …”
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Gender Differences in the Appetite Response to a Satiating Diet by Alexandra Bédard, Anne-Marie Hudon, Vicky Drapeau, Louise Corneau, Sylvie Dodin, Simone Lemieux

“…We examined gender differences in appetite sensations when exposed to Mediterranean diet (MedDiet) meals and determined whether there are gender differences in the change in the satiating properties of the MedDiet over time. …”
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Pain Measurement through Temperature Changes in Children Undergoing Dental Extractions by Eleazar S. Kolosovas-Machuca, Mario A. Martínez-Jiménez, José L. Ramírez-GarcíaLuna, Francisco J. González, Amaury J. Pozos-Guillen, Nadia P. Campos-Lara, Mauricio Pierdant-Perez

“…Afterwards, correlation between temperature and heart rate was assessed. Results. We found significant differences in temperature and heart rate before the procedure and during the dental extraction (mean difference 4.07°C, p<0.001, and 18.11 beats per minute, p<0.001) and no evidence of correlation between both measurements. …”
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Encapsulation of Hydrogen Peroxide in PVA/PVP Hydrogels for Medical Applications by Natalie Mounayer, Sivan Shoshani, Elena Afrimzon, Taly Iline-Vul, Moris Topaz, Ehud Banin, Shlomo Margel

“…The antibacterial activity of the hydrogel films was examined on four medically relevant bacteria: <i>Staphylococcus aureus</i>, <i>Enterococcus faecalis</i>, <i>Escherichia coli</i>, and <i>Pseudomonas aeruginosa</i>, with an adapted disk diffusion assay. Using this assay, we also evaluated the antibacterial effect of the hydrogel films over the course of days, demonstrating the HP controlled release from these hydrogels. …”
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Langerhans cell histiocytosis in children: the value of ultrasound in diagnosis and follow-up by Jinjin Yang, Xiaohua Huang, Zhongtao Bao, Jing Xu, Huimei Huang, Hongjie Huang, Ling Chen

“…Thirty-one had single-system involvement (SS-LCH), and 13 had multisystem involvement (MS-LCH) among the 44 children. We analyzed the clinical characteristics, ultrasound (US) images, and images from other modalities, including X-ray, computed tomography (CT), and magnetic resonance imaging (MRI). …”
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IMRAS-Immunization with radiation-attenuated Plasmodium falciparum sporozoites by mosquito bite: Cellular immunity to sporozoites, CSP, AMA1, TRAP and CelTOS. by Martha Sedegah, Michael R Hollingdale, Harini Ganeshan, Maria Belmonte, Jun Huang, Arnel Belmonte, Sandra Inoue, Rachel Velasco, Bradley Hickey, Nimfa Teneza-Mora, Joanne Lumsden, Sharina Reyes, Jo Glenna Banania, Anatalio Reyes, Ivelese Guzman, Thomas L Richie, Judith E Epstein, Eileen Villasante

“…<h4>Background</h4>Immunization with radiation-attenuated sporozoites (RAS) by mosquito bites provides >90% sterile protection against Plasmodium falciparum malaria in humans. We conducted a clinical trial based on data from previous RAS clinical trials that suggested that 800-1200 infected bites should induce ~50% protective vaccine efficacy (VE) against controlled human malaria infection (CHMI) administered three weeks after the final immunization. …”
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The Carcinoma–Stromal Ratio of Colon Carcinoma Is an Independent Factor for Survival Compared to Lymph Node Status and Tumor Stage by Wilma E. Mesker, Jan M. C. Junggeburt, Karoly Szuhai, Pieter de Heer, Hans Morreau, Hans J. Tanke, Rob A. E. M. Tollenaar

“…Background: Tumor staging insufficiently discriminates between colon cancer patients with poor and better prognosis. We have evaluated, for the primary tumor, if the carcinoma-percentage (CP), as a derivative from the carcinoma-stromal ratio, can be applied as a candidate marker to identify patients for adjuvant therapy. …”
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Detailed Fluid Inclusion and Stable Isotope Analysis on Deep Carbonates from the North Alpine Foreland Basin to Constrain Paleofluid Evolution by Elena Mraz, Markus Wolfgramm, Inga Moeck, Kurosch Thuro

“…Consequently, the Upper Jurassic seawater has been diluted by a meteoric fluid to a low saline fluid (<1 g/L), especially in areas with high permeability. Here, we show how a better understanding of cementation trajectory at depth can help to generate a better understanding of geothermal usability in deep carbonate reservoirs.…”
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Effectiveness of chain of survival for out-of-hospital-cardiac-arrest (OHCA) in resource limited countries: A systematic review by Mirza Noor Ali Baig, Zafar Fatmi, Nadeem Ullah Khan, Uzma Rahim Khan, Ahmed Raheem, Junaid Abdul Razzak

“…Aim: Given the critical disparities in survival for out-of-hospital-cardiac-arrest (OHCA) in resource limited countries and the lack of context-specific evidence to guide resuscitation practices, we aimed to systematically evaluate the effectiveness of the chain of survival components including bystander response, emergency medical services (EMS) response, advanced life support, and post-resuscitation care on outcomes such as return of spontaneous circulation, survival to admission, survival to hospital discharge, and neurological outcomes in these settings. …”
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Prevalence of Dental Caries in 5- and 6-Year-Old Myanmar Children by Yoshiaki Nomura, Khin Maung, Eint Min Kay Khine, Khin Myo Sint, May Phyo Lin, Min Khaing Win Myint, Thu Aung, Kaoru Sogabe, Ryoko Otsuka, Ayako Okada, Erika Kakuta, Wit Yee Wint, Masahide Uraguchi, Ryo Hasegawa, Nobuhiro Hanada

“…There are no national data available of the oral health in Myanmar. In this study, we examined dental caries status of 187 school children located in the suburban area of Naypyidaw, capital of Myanmar, at the age of five and six and analyzed by the individual level and tooth level. …”
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Dexmedetomidine Attenuates Myocardial Ischemia-Reperfusion Injury in Diabetes Mellitus by Inhibiting Endoplasmic Reticulum Stress by Jinjie Li, Ying Zhao, Nan Zhou, Longyun Li, Kai Li

“…With the increasing incidence of diabetes mellitus (DM) combined with myocardial ischemia, how to reduce myocardial ischemia-reperfusion injury in DM patients has become a major problem faced by clinicians. We investigated the therapeutic effects of dexmedetomidine (DEX) on myocardial ischemia-reperfusion injury in DM rats and its effect on endoplasmic reticulum stress. …”
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Manifestation of agronomically valuable traits in the progeny of a sorghum mutant carrying the genetic construct for RNA silencing of the γ-kafirin gene by L. A. Elkonin, N. V. Borisenko, T. E. Pylaev, O. A. Kenzhegulov, S. Kh. Sarsenova, N. Yu. Selivanov, V. M. Panin

“…Using Agrobacterium-mediated genetic transformation of immature embryos of the grain sorghum cv. Avans we have obtained a mutant with improved digestibility of endosperm proteins (up to 92 %) carrying a genetic construct for RNA silencing of the gKAF1 gene. …”
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The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis by Umar Akram, Obaid Ur Rehman, Eeshal Fatima, Zain Ali Nadeem, Omer Usman, Waqas Rasheed, Ramsha Ali, Khawaja Abdul Rehman, Abdulqadir J. Nashwan

“…Several new clinical trials have emerged since the previous meta‐analysis conducted in 2020. We conducted this updated meta‐analysis to assess clinical efficacy of lubiprostone in these patients. …”
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Impact of diet on vitamin D status in a Sri Lanka-based sample of pregnant women by Kaneshapillai Anusha, Liyanage Guwani, Hettiaratchi Usha, Gunasekera Dulanie

“…There was a significant positive correlation between dietary vitamin D and serum 25-hydroxyvitamin D (25(OH)D) (r = 0.355, P < 0.01). 12.4%, 50.6% and 37% of the mothers were vitamin D deficient, insufficient and sufficient, respectively. We showed a significant difference in levels of dietary vitamin D intake between serum 25(OH)D deficient/insufficient (dietary vitamin D: 1,083.6 ± 1,026.4 IU/day) and 25(OH)D sufficient (dietary vitamin D: 1,638.5 ± 1,456.1 IU/day) groups. …”
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