Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells by Carl D. Richards, Laura Izakelian, Anisha Dubey, Grace Zhang, Steven Wong, Karen Kwofie, Aatif Qureshi, Fernando Botelho

“…Although IL-33 expression can be altered upon NF-Kappa B activation, here we examine regulation by Oncostatin M, a gp130 cytokine family member, in mouse lung tissue. …”
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Effect of afzelin on inflammation and lipogenesis in particulate matter-stimulated C. acnes-treated SZ95 sebocytes by Ji Yeon Hong, Yong Hee Choi, Yoon Jin Roh, Mi-Kyung Lee, Christos C. Zouboulis, Kui Young Park

“…However, its effects on the molecular aspects of inflammation and lipogenesis in SZ95 sebocytes has not been investigated.ObjectiveThis study aimed to (i) investigate inflammatory and sebum secretion changes when a Cutibacterium acnes-treated immortalized human sebocyte cell line (SZ95) is exposed to particulate matter (PM) and (ii) examine the effects of afzelin on these.MethodsTo investigate the effect of afzelin on PM- and C. acnes-treated SZ95 sebocytes, we injected heat-killed C. acnes into SZ95 cells to induce acne-like status. …”
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Who freezes her eggs and why? psychological predictors, reasons, and outcomes of social egg freezing by Julia Jeannine Schmid, Seraina Weber, Ulrike Ehlert

“…Data on sociodemographic and psychological characteristics, attitudes towards motherhood, well-being, and reasons for SEF were assessed. We used multinomial logistic regression to identify predictors of SEF decision-making stages, principal components analysis to examine motives for SEF, and multiple linear regression to analyze associations between motives and psychological variables. …”
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Impact of fetal sex on neonatal outcomes in women with gestational diabetes mellitus: a systematic review and meta-analysis by Mahsa Maghalian, Zohreh Alizadeh-Dibazari, Mojgan Mirghafourvand

“…Therefore, the aim of our study was to investigate the impact of fetal sex on neonatal outcomes in mothers with GDM. Methods We conducted a systematic search of six database) PubMed, Cochrane Library, Scopus, Web of Science, SID (Persian database), and Embase (up to January 1, 2025. …”
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Educational Function of the State as an Object of Administrative and Legal Regulation by V. V. Abroskin

“…The education has been offered to be understood as a complex process regulated by the norms of national legislation, to ensure its quality we create relevant entities, entitled to provide educational services, which allows recipients of such services to realize personal potential based on their abilities, interests, needs, motivation, capabilities and experience. …”
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Monitoring of immune activation using biochemical changes in a porcine model of cardiac arrest by Anton Amann, Bernhard Widner, Josef Rieder, Herwig Antretter, Georg Hoffmann, Viktoria Mayr, Hans-Ulrich Strohmenger, Dietmar Fuchs

“…In a porcine model of cardiac arrest, we examined the potential use of neopterin measurements and determination of the tryptophan degradation rate as a means of estimating the extent of immune activation. …”
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Basal-Supported Oral Therapy with Sitagliptin Counteracts Rebound Hyperglycemia Caused by GLP-1 Tachyphylaxis by Shu Meguro, Toshihide Kawai, Tomohiro Matsuhashi, Motoaki Sano, Keiichi Fukuda, Hiroshi Itoh, Yoshihiko Suzuki

“…Treatment with a glucagon-like peptide 1 (GLP-1) analog fails in some patients due to rebound hyperglycemia caused by tachyphylaxis (GLP-1 tachyphylaxis). We investigated the efficacy of basal-supported oral therapy (BOT) with insulin glargine and sitagliptin for counteracting GLP-1 tachyphylaxis. …”
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Antimicrobial photodynamic inactivation of Pseudomonas aeruginosa persister cells and biofilms by Mona Mahmoud, Peter Richter, Philipp Arnold, Michael Lebert, Andreas Burkovski

“…Within the biofilm, persister cells, sub-populations of slow-growing or growth-arrested cells, are associated with recalcitrance of infections and antibiotic treatment failure. Here, we investigate the influence of the anionic photosensitiser chlorophyllin (CHL)11 Abbreviations: CHL: Chlorophyllin; BP: Butylparaben; SHX: Serine hydroxamate; TEM: Transmission electron microscope; AMR: Antimicrobial resistance; aPDI: Antimicrobial photodynamic inactivation; LED: Light-emitting diodes exposed to red light alone and in combination with an activator of the mechanosensitive channels butylparaben (BP) on P. aeruginosa growing cells, persister cells, and biofilms. …”
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Circulating Inflammatory Markers Are Inversely Associated with Heart Rate Variability Measures in Type 1 Diabetes by Anne-Marie L. Wegeberg, Tina Okdahl, Tina Fløyel, Christina Brock, Niels Ejskjaer, Sam Riahi, Flemming Pociot, Joachim Størling, Birgitte Brock

“…Materials and Methods. We included 104 adults with type 1 diabetes. Heart rate variability, time domain, and frequency domains were calculated from a 24-hour Holter electrocardiogram, while cardiac vagal tone was determined from a 5-minute electrocardiogram. …”
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Pre-service teachers' technology acceptance of artificial intelligence (AI) applications in education by Isidro Max V. Alejandro, Joje Mar P. Sanchez, Gino G. Sumalinog, Janet A. Mananay, Charess E. Goles, Chery B. Fernandez

“…We verified a pre-service teachers' Extended Technology Acceptance Model (ETAM) for AI application use in education. …”
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MicroRNA-28-5p Regulates Liver Cancer Stem Cell Expansion via IGF-1 Pathway by Qing Xia, Tao Han, Pinghua Yang, Ruoyu Wang, Hengyu Li, Jin Zhang, Xinfeng Zhou

“…Consistently, miR-28-5p overexpression inhibited liver CSC’s self-renewal and tumorigenesis. Mechanistically, we found that insulin-like growth factor-1 (IGF-1) was a direct target of miR-28-5p in liver CSCs, and the effects of miR-28-5p on liver CSC’s self-renewal and tumorigenesis were dependent on IGF-1. …”
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A new scheme for boosting in situ Fenton-like reaction in plant pathogenic tissues for selective structural degradation of capsid proteins by Jun Ma, Ming Chen, Yujie Wang, Jiaying Li, Jian Tang, Shengjun Wu, Chi He, J. Paul Chen

“…Inducing viral capsid protein (CP) degradation via hydroxyl radicals (∙OH) generated by an in situ Fenton-like reaction within plant pathogenic tissues is proposed for combating plant viruses in this study. We designed a new Fenton-like reaction inducer, tCuinter-bCDs, which utilizes an internal doping strategy that reduces copper content by 89.89% compared to conventional doping methods, while still achieving a high coexistence of multivalent copper ions. …”
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The association of systemic immune-inflammation index with incident breast cancer and all-cause mortality: evidence from a large population-based study by Yu Li, Yu Li, Meng Yu, Ming Yang, Jingqi Yang

“…SII was calculated from complete blood count parameters. We used multifactor regression models to examine the associations between SII and the outcomes of interest.ResultsA total of 21,058 female participants were included in the study, of which 557 (2.7%) were identified as having breast cancer. …”
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Influence of mechanical stress on biomass allocation in three species (Pachira aquatica Aubl., Sextonia rubra (Mez) van der Werff and Simarouba amara Aubl.) with contrasting postur... by Barbara Ghislain, Sabrina Coste, Grégory Faure, Jocelyn Cazal, Jonathan Prunier, Bruno Clair

“…In angiosperms, depending on the species, tensile stress is generated either in wood (tension wood), in bark or in both. Aims Here, we investigated how gravitropic stimuli (tilted stems without any movement) may affect growth and biomass allocation and whether this process depends on the posture control mechanism of the species. …”
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Roman gems and finger-rings made of gold and glass from Nicea in Bithynia (south-eastern Marmara) by Fatih Hakan Kaya, Ergün Laflı, Martin Henig, Musa Albayrak

“…Na końcu artykułu zostały opisane złote i szklane pierścionki znajdujące się we wspomnianym muzeum. (Nikaia ve Bithynia’dan Roma Dönemi’ne Ait Bazı Gliptik Buluntular ile Altın ve Cam Yüzükler): Bu kısa yazıda İznik Arkeoloji Müzesi’nde saklanmakta olan Roma Dönemi’ne ait 22 adet gliptik örneği ile altın ve cam yüzükler tanıtılmaktadır. …”
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Neurocognitive Functioning among Children with Sickle Cell Anemia Attending SCA Clinic at MNH, Dar es Salaam, Tanzania by Limi O. Matondo, Edward Kija, Karim P. Manji

“…Children with SCA had more impairment in terms of copying and IQ. We recommend assessment at the younger age group, increased sample size in future studies, and long-term cohort follow-up.…”
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Future-proofing quality education using integrated assessment systems by Lucy Tambudzai Chamba, Namatirai Chikusvura

“…This gap between assessment and the needs of SDG4 presents a conundrum for educators: How can we develop assessment strategies that encompass multiple intelligences and prepare learners for the future while ensuring the delivery of quality education as outlined by SDG4? …”
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SECONDARY PROPHYLAXIS OF VENOUS THROMBOEMBOLISM (VTE) WITH LOW DOSE APIXABAN OR RIVAROXABAN: RESULTS FROM A PATIENT POPULATION WITH MORE THAN 2 YEARS OF MEDIAN FOLLOW-UP by Alessandro Laganà, Giovanni Manfredi Assanto, Chiara Masucci, Mauro Passucci, Livia Donzelli, Alessandra Serrao, Erminia Baldacci, Cristina Santoro, Antonio Chistolini

“…Objectives: The aim of our study was to evaluate the efficacy and safety of low-dose DOACs for VTE secondary prophylaxis, in patients at high risk of VTE recurrence. Methods: We retrospectively evaluated patients who required long-term anticoagulant secondary prophylaxis to prevent recurrent VTE, treated with apixaban 2.5 mg BID or rivaroxaban 10 mg daily with a follow-up ≥ 12 months. …”
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Comprehensive multi-omics, behavioral and morphological analysis of the hazards of nano-plastics in mice with internal carotid artery occlusion by Lu Wang, Jia-Qi Ma, Li-Jia Song, Xiao-Peng Qu, Yue Zhang, Hai-Ming Fan, Chao Wang, Long-Long Zheng, Guo-Dong Gao, Yan Qu, Liang-Liang Shen, Bei Liu

“…Mice with chronic internal carotid artery occlusion exposed to NPs showed behavioral abnormalities, such as depression and anxiety, thus indicating detrimental effects of NPs on the brain. Subsequently, we used proteomics and metabolomics to analyze the specific mechanisms underlying the damaging effects of NP deposition in the brain. …”
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Characteristics of the IBEX Ribbon and Their Implications for a Source Region Outside the Heliopause by Sung Jun Noh, Daniel B. Reisenfeld, Lauren J. Beesley, Yue Chen, Fan Guo, Herbert O. Funsten, Paul H. Janzen, Thomas K. Kim, Asher Merrill, Dave Osthus, Nehpreet K. Walia, Eric J. Zirnstein

“…By applying these metrics, we reveal new complexity to the evolution of the ribbon over time, highlighting the nuanced relationship between it and the solar wind. …”
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