A real-world Pharmacovigilance study of brodalumab based on the FDA adverse event reporting system by Ke He, Kaidi Zhao, Tingyi Yin, Meng Liu, Jiashu Liu, Wenqian Du, Xinyi Liu, Baochen Cheng, Dewu Zhang, Yan Zheng

“…The study identified several adverse reactions already listed on the drug’s label that showed positive signals, including arthralgia, headache, myalgia, suicidal ideation, oropharyngeal pain, injection site mass, and infections. Additionally, we found potential adverse reactions not noted on the drug’s label that exhibited positive signals, including depression, increased blood pressure, peripheral swelling, gait disturbance, inability to walk, stress, myocardial infarction, sepsis, uveitis, nephrolithiasis, and interstitial lung disease. …”
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Effect of a nutritional immunomodulator in dry cows heat stressed with an electric blanket model by L.T. Casarotto, L. Cattaneo, K.M. Glosson, B.D. Humphrey, J.D. Chapman, G.E. Dahl

“…The objectives of this study were to explore efficacy of the EB on cows during the dry period, as well as to examine the effect of feeding OMN to heat-stressed cows. We hypothesized that EB would increase body temperature in dry cows and OMN would ameliorate the effects of heat stress. …”
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Unlocking the Potential of RNA Sequencing in COVID-19: Toward Accurate Diagnosis and Personalized Medicine by Heba M. Saad Eldien, Abdulrahman H. Almaeen, Ahmed Abo El Fath, Ahmed E. Taha, Rehab Ahmed, Hassabelrasoul Elfadil, Helal F. Hetta

“…A comprehensive literature review was conducted using PubMed, Scopus, Web of Science, and Google Scholar. We employed Medical Subject Headings (MeSH) terms and relevant keywords to identify studies that explored the role of RNAseq in COVID-19 diagnostics, prognostics, and therapeutics. …”
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Design and Characterization of Line-Waves Waveguides for Microwave Applications by Alessio Monti, Stefano Vellucci, Mirko Barbuto, Valentina Verri, Francesco Verni, Claudio Massagrande, Davide Ramaccia, Michela Longhi, Zahra Hamzavi-Zarghani, Luca Stefanini, Alessandro Toscano, Filiberto Bilotti

“…To fill this gap, here we report a simple and straightforward workflow for designing waveguides supporting 1D modes propagation. …”
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Adipocyte DIO2 Expression Increases in Human Obesity but Is Not Related to Systemic Insulin Sensitivity by David Bradley, Joey Liu, Alecia Blaszczak, Valerie Wright, Anahita Jalilvand, Bradley Needleman, Sabrena Noria, David Renton, Willa Hsueh

“…Although higher DIO2 was strongly related to reduced fatty acid synthesis/oxidation and mitochondrial function, we found no relationship to proinflammatory cytokines or insulin resistance and no difference based on diabetic status. …”
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Morphology and Immunoexpression of Selenoproteins in Term Placenta of Alpaca (<i>Vicugna pacos</i>) from the Peruvian Andes by Miluska Beatriz Navarrete Zamora, Francisco Acuña, Mônica Duarte da Silva, Thamires Santos-Silva, Matheus Henrique Herminio Garcia, Rodrigo da Silva Nunes Barreto, Alberto Sato Sato, Claudio Gustavo Barbeito, Maria Angelica Miglino

“…This study examined the term placenta morphology of alpacas (<i>Vicugna pacos</i>, N = 12) and the immunoexpression of antioxidant selenoproteins (SP). We hypothesize that the placenta of alpacas, adapted to high altitudes, has characteristics with other species also adapted to altitude. …”
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Genetic markers of children asthma: predisposition to disease course variants by M. V. Smolnikova, Ed. W. Kasparov, M. A. Malinchik, K. V. Kopylova

“…Genotyping was carried out using real-time PCR. We identified markers predisposing to the development of different variants of the course of childhood asthma: the CT genotype and T allele of IL4 rs2243250 are associated with asthma (p &lt; 0.05), especially in mild asthma and in controlled asthma. …”
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Three-Dimensional Reconstruction and Numerical Simulation Analysis of Acid-Corroded Sandstone Based on CT by Zizhen Miao, Shuguang Li, Jiangsheng Xie, Runke Huo, Fan Ding, Hongtao Zhu, Xingzhi Yang, Xiaoke Li

“…Comparing the numerical simulation results with the physical experiment results, we found that the three-dimensional finite element model based on CT scanning technology can genuinely reflect sandstone’s corrosion characteristic. …”
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Optimization of In Vivo Studies by Combining Planar Dynamic and Tomographic Imaging: Workflow Evaluation on a Superparamagnetic Nanoparticles System by Maritina Rouchota, Alessio Adamiano, Michele Iafisco, Eirini Fragogeorgi, Irineos Pilatis, Gilles Doumont, Sébastien Boutry, Daniele Catalucci, Argyro Zacharioudaki, George C. Kagadis

“…Molecular imaging holds great promise in the noninvasive monitoring of several diseases with nanoparticles (NPs) being considered an efficient imaging tool for cancer, central nervous system, and heart- or bone-related diseases and for disorders of the mononuclear phagocytic system (MPS). In the present study, we used an iron-based nanoformulation, already established as an MRI/SPECT probe, as well as to load different biomolecules, to investigate its potential for nuclear planar and tomographic imaging of several target tissues following its distribution via different administration routes. …”
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Independent Heath Facility Meets Cancer Care Ontario and Canadian Association of Gastroenterology Guidelines for Endoscopic Procedure Wait Times While Meeting Quality Indicators: A... by Fraser Kegel, Niv Sne, Timothy Rice, Eric Joy, Shayan Shahsavar, Celeste A. Collins, Maria Gagarine, Alexandra Allard-Coutu, Lisa Klotz, Angela Coates, Kamyar Kahnamoui, Marko Simunovic

“…Canadian independent health facilities (IHFs) have been implemented to reduce hospital endoscopy volume and expedite endoscopic evaluations for patients suspected to have underlying colorectal cancer. Methods. We conducted a retrospective review of a prospective database at a large-volume urban IHF. …”
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Effects of Soil-Transmitted Helminths and Intestinal Protozoan Infections on Haemoglobin Levels among School-Aged Children in Belo and Bui, North West Cameroon: A Cross-Sectional S... by Frederick Nchang Cho, Humphrey Ngala Ngala, Ranibell Tung Bongazi, Rogers Sanga Kinsam, Beltha Tahnteng Tata, Desmond Aji, Paulette Ngum Fru, Patrick Kofon Jokwi

“…Soil-transmitted helminths are known to affect both growth and haemoglobin levels. In this study, we determine the prevalence of intestinal parasites and explored its association with anaemia in school-aged children (SAC). …”
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The Relevance of the Virchow Node and Virchow Triad in Renal Cancer Diagnosis by Luiza-Roxana Dorobantu-Lungu, Viviana Dinca, Andrei Gegiu, Dan Spataru, Andreea Toma, Luminita Welt, Mihaela Florentina Badea, Constantin Caruntu, Cristian Scheau, Ilinca Savulescu-Fiedler

“…The prognosis for these kidney cancers is poorer compared to other types. <b>Methods:</b> We present a case of a 66-year-old man with Virchow–Troisier adenopathy during physical examination, which raises the suspicion of infra-diaphragmatic tumor. …”
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Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Apical Membrane Antigen 1 (AMA1) by Umashankar Vetrivel, Shalini Muralikumar, B Mahalakshmi, K Lily Therese, HN Madhavan, Mohamed Alameen, Indhuja Thirumudi

“…This complex formation is initiated by intermolecular interactions between the two secretory parasitic proteins—namely, apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2) and is critically essential for the host invasion process. By this study, we propose two potential leads, NSC95522 and NSC179676 that can efficiently target the AMA1 hydrophobic cleft, which is a hotspot for targeting MJ complex formation. …”
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Biomarker microRNA-371a-3p - expression in malignancies other than germ-cell tumours by Gazanfer Belge, Markus Klemke, Bendix Hansen, Cansu Dumlupinar, Aylin Igde, Dirk Arnold, Hans Salwender, Christian Wülfing, Armin Soave, Klaus-Peter Dieckmann

“…As knowledge about the expression of the marker in other malignancies is a prerequisite for the clinical application of the test we aimed to explore the M371 expression in other cancers. …”
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Evaluation of Psychological Distress in Infertile Women who Underwent ART Cycle During the COVID-19 Pandemic by Ebru Cogendez, Pinar Kumru, Sunullah Soysal, Enis Ozkaya, Belgin Devranoglu, Elif Tozkir, Ilhan Sanverdi

“… OBJECTIVE: We aimed to determine the frequency of psychological distress and related factors in infertile women who underwent assisted reproductive technologies during the COVID-19 pandemic and to develop health policies accordingly. …”
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DNA Amplifications and Aneuploidy, High Proliferative Activity and Impaired Cell Cycle Control Characterize Breast Carcinomas with Poor Prognosis by Harald Blegen, John S. Will, B. Michael Ghadimi, Hesed‐Padilla Nash, Anders Zetterberg, Gert Auer, Thomas Ried

“…In order to explore whether specific cytogenetic abnormalities can be used to stratify tumors with a distinctly different clinical course, we performed comparative genomic hybridization (CGH) of tumors from patients who were diagnosed with metastatic disease after an interval of less than 2 years or who remained free from distant metastases for more than 10 years. …”
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Changing Characteristics of Sandstone Pore Size under Cyclic Loading by Jiaguang Kan, Guichen Li, Nong Zhang, Peng Wang, Changliang Han, Shun Wang

“…These characteristics were studied under different pressures, pore diameters, and pore throat size distribution laws using a UTM5540 electronic universal testing machine, magnetic resonance imaging scanning, and low field nuclear magnetic resonance spectroscopy with cyclic loading on yellow sandstone. We found the following. (1) Under 0–10 MPa load, the peaks of the sandstone T2 spectrum move left as load increases, and the porosity of the sandstone decreases. …”
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Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs by Khushboo Agrawal, Viswanath Das, Natálie Táborská, Ján Gurský, Petr Džubák, Marián Hajdúch

“…While the effects of these epi-drugs alone or in combination with other anticancer therapies are well described, the influence of stromal cells and their secretome on cancer cell response to these agents remain elusive. In this study, we determined the effect of normal and senescent colon-unassociated fibroblasts and their conditioned medium on colorectal cancer (CRC) cell response to AZA and DAC using a cell-based DNA demethylation reporter system. …”
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Pirfenidone Alleviates Choroidal Neovascular Fibrosis through TGF-β/Smad Signaling Pathway by Chuang Gao, Xin Cao, Lili Huang, Yueqi Bao, Tao Li, Yue Di, Liucheng Wu, Yu Song

“…Our data showed PFD inhibited areas of fibrosis during day 21 to day 28. We also found that the levels of TGF-β2 protein expressions increasingly reached the peak till the 3rd week during the CNV development. …”
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Social issues in general practice – a survey assessing the interprofessional perspective of general practitioners and social workers regarding frequency, challenges, and needs by Tonia Gerber, Laura Diaz Hernandez, René Rüegg, Dunja Vetter, Andreas Zeller

“…The study aimed to analyse the occurrence of social problems as well as the strengths and weaknesses of existing working agreements between social services and GPs in primary care. Methods We carried out a cross-sectional online survey between December 2022 and January 2023 among a sample of Swiss GPs from the Sentinella-Network, the uniham-bb-Network and social workers from the SAGES-Network. …”
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