Using verbal and social autopsy approaches to understand why neonates die in rural settings: a case study of a remote rural district in Uganda by Peter Waiswa, Rornald Muhumuza Kananura, Dinah Amongin, Joseph Akuze, Jacquellyn Nambi Ssanyu, Felix Kizito

“…This study employs a social and verbal autopsy approach to identify the causes, settings and health accessibility challenges surrounding neonatal deaths in the Luuka district from 1 January 2017 to 31 December 2019.Methods We analysed data from 172 neonatal verbal and social autopsies (VASA) conducted over 3 years, as part of a maternal and neonatal demand and supply health system strengthening intervention. …”
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Genomic Characterization and Functional Validation of Six <i>cis</i>-Regulatory Sequences in Medicinal Plant <i>Andrographis paniculata</i> by Xingbin Lv, Hua Yang, Yufang Hu, Qi Liang, Shuyun Tian, Lang Yang, Mingkun Huang, Ling Zhang, Yanqin Xu

“…With the rapid development of plant biotechnologies, such as transgenesis and gene editing tools, plant-derived CRSs have gradually replaced traditional CRSs, like the <i>35S</i> promoter, to avoid some negative effects caused by exogenous DNA sequences. In this study, we provided a comprehensive analysis of the published genomic data of <i>Andrographis paniculata</i> and identified six candidate <i>ApACRs</i>. …”
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Preoperative myosteatosis and perioperative serum chloride levels predict 180 day major complications after radical cystectomy by Wassapol Sornthai, Achiraya Teyateeti, Tawatchai Taweemonkongsap, Siros Jitpraphai, Varat Woranisarakul, Kantima Jongjitaree, Katunyou Mahamongkol, Nattaporn Wanvimolkul, Thitipat Hansomwong

“…Abstract This study aimed to investigate the role of myosteatosis, sarcopenia, and perioperative serum biomarkers as independent predictors of major complications within 180 days following radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). We retrospectively analyzed of 127 MIBC patients who underwent RC between 2013 and 2023 at a single institution. …”
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A Case of Nonfunctioning Pituitary Carcinoma That Responded to Temozolomide Treatment by Haruko Morokuma, Takao Ando, Takuya Hayashida, Ichiro Horie, Naoko Inoshita, Fumi Murata, Ikuko Ueki, Kan Nakamura, Misa Imaizumi, Toshiro Usa, Atsushi Kawakami

“…Only a few patients with a nonfunctioning pituitary carcinoma treated with TMZ have been reported. Here we describe our treatment of a patient with nonfunctioning pituitary carcinoma and a background of multiple endocrine neoplasia type 1. …”
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Relationship between Ca2+ and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells by Masahiko Kutsukake, Naoko Kuwabara, Yoshikazu Miyate, Kenzo Kudo, Shoko Goto, Eiichi Taira, Eiichi Tachikawa

“…However, whether their second messengers cooperatively or independently participate in steroid production remains unclear. We focused on the roles of Ca2+ and cAMP in cortisol production in bovine adrenal fasciculata cells stimulated by ACTH for a relatively short period (1 h). …”
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The Polymorphism −308G/A of Tumor Necrosis Factor-α Gene Modulates the Effect of Immunosuppressive Treatment in First Kidney Transplant Subjects Who Suffer an Acute Rejection by Ana Isabel Sánchez-Fructuoso, Isabel Pérez-Flores, Rosalia Valero, Maria Angeles Moreno, Miguel Fernandez-Arquero, Elena Urcelay, Cristina Fernández-Pérez, Jose Luis Santiago

“…As its impact on transplant outcome remains open to debate, we decided to genotype it in a cohort of transplant subjects. …”
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Prospective Longitudinal Characterization of the Relationship between Diabetes and Cardiac Structural and Functional Changes by Amrit Chowdhary, Nicholas Jex, Sharmaine Thirunavukarasu, Amanda MacCannell, Natalie Haywood, Altaf Almutairi, Lavanya Athithan, Manali Jain, Thomas Craven, Arka Das, Noor Sharrack, Christopher E. D. Saunderson, Anshuman Sengupta, Lee Roberts, Peter Swoboda, Richard Cubbon, Klaus Witte, John Greenwood, Sven Plein, Eylem Levelt

“…In a cohort of type 2 diabetic (T2D) patients who underwent baseline cardiac magnetic resonance (CMR) and biomarker testing, during a median follow-up of 6 years, we aimed to determine longitudinal changes in the phenotypic expression of heart disease in diabetes, report clinical outcomes, and compare baseline clinical characteristics and CMR findings of patients who experienced major adverse cardiovascular events (MACE) to those remaining MACE free. …”
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A case of Saturday night retinopathy following postoperative orbital compression bandaging: Diagnosis and evaluation using multimodal imaging by Rong Luan, Jinzhi Zhao, Zeying Liu, Limin Zhu, Lingyao Kong, Xiaorong Li, Tingting Lin

“…We report a rare case of Saturday Night Retinopathy (SNR) following postoperative orbital compression bandaging, highlighting the value of multimodal imaging in diagnosis and management. …”
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Mapping provider and consumer voices using the AACTT framework: a focus group study of advance care planning by Lisa Guccione, Stephanie Best, Sonia Fullerton, Sanchia Aranda, Jill J. Francis

“…Aim Using advance care planning (ACP) as an exemplar complex healthcare process, we describe a method for using the AACTT framework to 1) map a complex model of care across a patient journey 2) capture the consumer perspective; and 3) operationalise these perspectives by comparing across groups and identifying alignments or misalignments. …”
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Colorectal cancer detection with enhanced precision using a hybrid supervised and unsupervised learning approach by Akella S. Narasimha Raju, K. Venkatesh, Ranjith Kumar Gatla, Eswara Prasad Konakalla, Marwa M. Eid, Nataliia Titova, Sherif S. M. Ghoneim, Ramy N. R. Ghaly

“…The hybrid schema of this work treats the deficiencies of the previous approaches, such as incorporating CNN-based effective feature extraction, Transformer networks for developing attention mechanisms, and finally the fine decision boundary of the support vector machine. Further, we refine this process via unsupervised clustering for the purpose of enhancing the visualisation of such a procedure. …”
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Provider Practices and Perceived Barriers and Facilitators in Improving Quality Practices in Radiation Oncology Peer Review by Leslie Chang, MD, Sara Alcorn, MD, PhD, Khinh Ranh Voong, MD, MPH, Todd R. McNutt, PhD, Ori Shokek, MD, Suzanne Evans, MD, MPH, Jean L. Wright, MD

“…Purpose: Radiation oncology peer review evaluates case-specific qualitative treatment planning decisions. We sought to understand interdisciplinary perspectives on peer review to identify factors affecting stakeholder engagement and implementation of recommendations. …”
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Exploring Mitochondrial Evolutionary Pathways: Insights into the Origin of the Endemic Ohrid Trout by Anila Hoda, Chiara Locci, Ilenia Azzena, Noemi Pascale, Ilaria Deplano, Roland Kristo, Arian Demiri, Fabio Scarpa, Marco Casu, Daria Sanna

“…This study aimed to investigate the genetic variability and population structure of <i>Salmo letnica</i> morphotypes using the mitochondrial Control Region as molecular marker. We obtained 127 sequences from <i>Salmo letnica</i> morphotypes and compared them with sequences from other species within the genus <i>Salmo</i>. …”
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Metal-organic cage crosslinked nanocomposites with enhanced high-temperature capacitive energy storage performance by Shuo Zhao, Weifeng Peng, Le Zhou, Shuqi Dai, Weibin Ren, Erxiang Xu, Yao Xiao, Mufeng Zhang, Mingjun Huang, Yang Shen, Ce-Wen Nan

“…However, the agglomeration of inorganic nanoparticles and the destabilization of the organic-inorganic interface at high temperatures have limited the development of nanocomposites toward large-scale industrial production. In this work, we synthesize metal-organic cage crosslinked nanocomposites by incorporating self-assembled metal-organic cages with amino reaction sites into the polyetherimide matrix. …”
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The assessment of change in human heat stress risk in Brazil projected by the CMIP6 models by Laila K Gohar, Dan Bernie, Damian Wilson, Kate Willett, Richard Betts

“…Thresholds in the environmental conditions leading to heat stress in humans are projected to be exceeded for long periods of the year across large parts of the country. We analyse future changes in the frequency of exceeding heat stress related thresholds during the hottest part of the day as measured by the Wet Bulb Globe Temperature (WBGT) and using the CMIP6 climate projections. …”
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Effects of laparoscopic sleeve gastrectomy on nonalcoholic fatty liver disease and TGF-β signaling pathway by Hideki Kumagai, Akira Sasaki, Akira Umemura, Keisuke Kakisaka, Takeshi Iwaya, Satoshi S Nishizuka

“…Proteomic analysis identified 1,912 proteins, many of which were related to the TGF-β signaling pathway. Among these proteins, we focused on five TGF-β-related proteins: asporin, EMILIN-1, platelet factor-4, serglycin, and thrombospondin-1. …”
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circSLC6A6 Sponges miR-497-5p to Promote Endometrial Cancer Progression via the PI4KB/Hedgehog Axis by Juan Hu, Xing Peng, Weina Du, Yichuan Huang, Chun Zhang, Xian Zhang

“…The in vivo assay was performed to reveal the function of circSLC6A6 in tumorigenesis. Results. We found that circSLC6A6 was highly expressed in both EC tissues and cells. …”
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Scoping review to identify strategies and interventions improving interprofessional collaboration and integration in primary care by Roy Remmen, Kris Van den Broeck, Peter Pype, Peter Van Bogaert, Muhammed Mustafa Sirimsi, Hans De Loof, Kristel De Vliegher

“…The identified strategies and interventions were inductively categorised under five main themes: (1) Acceptance and team readiness towards collaboration, (2) acting as a team and not as an individual; (3) communication strategies and shared decision making, (4) coordination in primary care and (5) integration of caregivers and their skills and competences.Conclusions We identified a mix of strategies and interventions that can function as ‘building blocks’, for the development of a generic intervention to improve collaboration in different types of primary care settings and organisations.…”
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Carbon injection potential of the mesopelagic-migrant pump in the Southern Ocean during summer by Katherine Baker, Katherine Baker, Svenja Halfter, Svenja Halfter, Ben Scoulding, Kerrie M. Swadling, Kerrie M. Swadling, Shane A. Richards, Matthieu Bressac, Matthieu Bressac, Caroline A. Sutton, Philip W. Boyd, Philip W. Boyd

“…This is known as the mesopelagic-migrant pump (MMP). We investigated the magnitude of the MMP at one subantarctic and two polar sites in summer by assessing particulate and dissolved carbon export below 200 m depth based on DVM and the composition of the mesopelagic community. …”
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Experimental Studies on Physicochemical Parameters of Water Samples before and after Treatment with a Cold Atmospheric Plasma Jet and its Optical Characterization by Hom Bahadur Baniya, Rajesh Prakash Guragain, Gobinda Prasad Panta, Santosh Dhungana, Ganesh Kuwar Chhetri, Ujjwal Man Joshi, Bishnu Prasad Pandey, Deepak Prasad Subedi

“…Nowadays, researches have been carried out on ozonation through plasma jet interaction with surface drinking water. In this paper, we compare the change in physical and chemical parameters of surface water used for drinking purposes. …”
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Impact of the Seeding Method on Physiological, Agronomic, and Biochemical Performance of Sesame (Sesamum indicum L.) Varieties Grown in Burkina Faso by Badiel Badoua, Kihindo Adama Pascal, Yao Koffi Bertin, Nana Rasmata, Ouedraogo Razacswendé Fanta, Dondasse Edmond, Tamini Zoumbiessé

“…This situation is very worrying and needs to be rectified. For this reason, we undertook this study to highlight the impact of the seeding method on the physiological, morphological, and agronomic performances of sesame (Sesamum indicum L.) varieties grown in Burkina Faso. …”
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