Adaptive Neuro-Fuzzy Inference System guided objective function parameter optimization for inverse treatment planning by Eduardo Cisternas Jiménez, Fang-Fang Yin, Fang-Fang Yin, Fang-Fang Yin

“…This study presents a proof-of-concept artificial intelligence (AI) system based on an Adaptive Neuro-Fuzzy Inference System (ANFIS) to guide IMRT planning and achieve optimal, patient-specific prescriptions in aligned with a radiation oncologist's treatment objectives. We developed an in-house ANFIS-AI system utilizing Prescription Dose (PD) constraints to guide the optimization process toward achievable prescriptions. …”
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Pulmonary Bacterial Communities in Surgically Resected Noncystic Fibrosis Bronchiectasis Lungs Are Similar to Those in Cystic Fibrosis by Heather Maughan, Kristopher S. Cunningham, Pauline W. Wang, Yu Zhang, Marcelo Cypel, Cecilia Chaparro, D. Elizabeth Tullis, Thomas K. Waddell, Shaf Keshavjee, Mingyao Liu, David S. Guttman, David M. Hwang

“…Recurrent bacterial infections play a key role in the pathogenesis of bronchiectasis, but conventional microbiologic methods may fail to identify pathogens in many cases. We characterized and compared the pulmonary bacterial communities of cystic fibrosis (CF) and non-CF bronchiectasis patients using a culture-independent molecular approach. …”
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Indigenous and non-Indigenous people experiencing homelessness and mental illness in two Canadian cities: A retrospective analysis and implications for culturally informed action by Brittany Bingham, Akm Moniruzzaman, Michelle Patterson, Jino Distasio, Jitender Sareen, John O’Neil, Julian M Somers

“…This study investigated the history and current status of Indigenous and non-Indigenous people experiencing homelessness and mental illness. We hypothesised that compared with non-Indigenous people, those who are Indigenous would demonstrate histories of displacement earlier in life, higher rates of trauma and self-medication with alcohol and other substances.Design and setting Retrospective data were collected from a sample recruited through referral from diverse social and health agencies in Winnipeg and Vancouver.Participants Eligibility included being 19 years or older, current mental disorder and homelessness.Measures Data were collected via interviews, using questionnaires, on sociodemographics (eg, age, ethnicity, education), mental illness, substance use, physical health, service use and quality of life. …”
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Distribution of spinal damage in patients with axial spondyloarthritis as assessed by MRI: a prospective and blinded study by Andreas Haidmayer, Gabriel Adelsmayr, Christopher Spreizer, Eva Valentina Klocker, Franz Quehenberger, Michael Fuchsjaeger, Jens Thiel, Josef Hermann

“…Methods In this prospective and blinded investigation, we assessed the distribution of structural spinal lesions using magnetic resonance imaging (MRI) of the whole spine in 55 patients with axial SpA classified according to the Assessment in Spondyloarthritis International Society (ASAS) criteria. …”
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Comparative Analysis of Tenogenic Gene Expression in Tenocyte-Derived Induced Pluripotent Stem Cells and Bone Marrow-Derived Mesenchymal Stem Cells in Response to Biochemical and B... by Feikun Yang, Dean W. Richardson

“…Natural healing of injured tendon is poor, and cell-based therapeutic treatment is still a significant clinical challenge. In this study, we extensively investigated the expression of tenogenic genes in equine bone marrow mesenchymal stem cells (BMSCs) and tenocyte-derived induced pluripotent stem cells (teno-iPSCs) stimulated by growth factors (TGF-β3 and BMP12) combined with ectopic expression of tenogenic transcription factor MKX or cyclic uniaxial mechanical stretch. …”
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Elderly Patients with Nondistant Metastatic Pancreatic Head Adenocarcinoma Cannot Benefit from More Radical Surgery by Li Chen, Lanning Jia, Zhigang Tian, Yang Yang, Ke Zhao

“…Pancreatic head cancer occurs mainly in people over the age of 60, and its morbidity and mortality increase with age. We investigated whether these elderly patients with nondistant metastases would benefit more from expanded pancreaticoduodenectomy (EPD) compared with standard pancreaticoduodenectomy (SPD). …”
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Investigation of the Feasibility and Safety of a Highly Intensive Penetration Technique for Recanalization in Severe Calcified Femoropopliteal Occlusive Lesions: A Retrospective Ob... by Shinsuke Mori, Keisuke Hirano, Yusuke Setonaga, Toshihiko Kishida, Tomoya Fukagawa, Kohei Yamaguchi, Masafumi Mizusawa, Masakazu Tsutsumi, Norihiro Kobayashi, Yoshiaki Ito

“…To address this issue, we employed a novel highly intensive penetration (HIP) technique. …”
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Geochemistry and Genesis of Oil and Gas Seeps in the Junggar Basin, NW China: Implications for Hybrid Petroleum Systems by Jingkun Zhang, Jian Cao, Yan Wang, Jun Li, Guang Hu, Ni Zhou, Tianming Shi

“…However, the genesis of these seeps remains poorly known, limiting the understanding of their implications for petroluem geology and hydrocarbon exploration. Here, we investigate 26 samples of oil and gas seeps from nine outcrops within five areas along the margins of the Junggar Basin to determine the geochemical characteristics of the hydrocarbons, constrain their genesis, and discuss future exploration strategies. …”
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Pinglu Canal Construction and Its Impact on Wildlife Habitat Connectivity: A Multi-Species Network Analysis and Ecological Restoration Strategy by Yuan Cao, Kai Su, Yongfa You, Xuebing Jiang, Chuang Li, Junjie Chen

“…Through complex network analysis, we assess habitat connectivity before and after the canal’s construction, as well as after implementing habitat optimization strategies. …”
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Population characteristics, prescription patterns and glycemic control of users of flash glucose monitoring systems in Brazil: a real-world evidence study by Karla Santo, Josué Nieri, Karine Risério, Karla F. S. Melo

“…Abstract Background To date, there is a lack of information on the use of flash glucose monitoring system (fCGM) in low-middle income countries, such as Brazil, as well as on digital health platforms most used to calculate the bolus insulin dose. In this study, we aimed to describe the population characteristics, prescription patterns and glycemic control of fCGM users compared to blood glucose monitoring (BGM) system in those who use Glic™, a digital health platform in Brazil, and to assess factors associated with better glycemic control in this population. …”
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Evaluation of the effects of short-term PM2.5 exposure on triglyceride-glucose metrics in a population in eastern China by Zhenpeng Guo, Chenchen Yang, Qiang Zhang, Xinling Shi, Xiaona Li, Qun Zhang, Jianming Wang

“…Objective This study endeavors to probe the association between PM2.5 and TyG within the population of eastern China and to determine whether there are disparities in this association among diverse subgroups. Methods We conducted an ecological study on a cohort comprising 39,011 individuals who had undergone at least two physical examinations between 2017 and 2019 at the First Affiliated Hospital of Nanjing Medical University, China. …”
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Experience of Kenyan researchers and policy-makers with knowledge translation during COVID-19: a qualitative interview study by Edwine Barasa, Benjamin Tsofa, Mike English, Sassy Molyneux, Dorcas Mwikali Kamuya, Fatuma Hassan Guleid, Alex Njeru, Joy Kiptim, Emelda Okiro, David Kariuki

“…Objectives Researchers at the KEMRI-Wellcome Trust Research Programme (KWTRP) carried out knowledge translation (KT) activities to support policy-makers as the Kenyan Government responded to the COVID-19 pandemic. We assessed the usefulness of these activities to identify the facilitators and barriers to KT and suggest actions that facilitate KT in similar settings.Design The study adopted a qualitative interview study design.Setting and participants Researchers at KWTRP in Kenya who were involved in KT activities during the COVID-19 pandemic (n=6) were selected to participate in key informant interviews to describe their experience. …”
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Effects of cardiovascular health, musculoskeletal health and physical fitness on occupational performance of firefighters: protocol for a systematic review and meta-analysis by Andre Pascal Kengne, Denise Smith, Jaron Ras, Elpidoforos Soterakis Soteriades, Lloyd Leach

“…The synthesis of quantitative data (using a meta-analysis methodology) will involve the integration of quantitative findings from multiple studies to achieve coherence.Ethics and dissemination This study obtained ethical clearance from the University of the Western Cape Biomedical Research Ethics Committee (BM21/10/9). We will disseminate the findings of in peer-reviewed journals and at national and international conferences. …”
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Graft-Versus-Host Disease Sustains Coagulation Activity for two Years After Pediatric Allogeneic Hematopoietic Stem Cell Transplantation by Satu Långström MD, PhD, Minna Koskenvuo MD, PhD, Pasi Huttunen MD, PhD, Riitta Lassila MD, PhD, Mervi Taskinen MD, PhD, Susanna Ranta MD, PhD, Markku Heikinheimo MD, PhD, Anne Mäkipernaa MD, PhD

“…In six patients with chronic graft-versus-host disease (cGVHD), specifically in those having gastrointestinal (GI) tract cGVHD, we observed continued longitudinal alterations in the coagulation system. …”
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Is There Any Point in a Corticosteroid Treatment of Intermittent Asthma? by Ivana Stankovic, Tatjana Pejcic, Branislava Milenkovic, Dragana Jovanovic, Milan Rancic

“…At the end of the study, in Group A, we found a statistically significant decrease of BHR (PD20 0.98 vs. 2.07) (p < 0.001), diurnal peak expiratory flow (PEF) variability (17.9 vs. 13.8) (p < 0.001), symptom scores (0.63 vs. 0.30) (p < 0.001), and used rescue medication (p < 0.001), while the parameters of lung function remained unchanged except for forced expiratory volume in 1 sec (FEV1), which had a statistically significant increase (3.58 vs. 3.66) (p < 0.001). …”
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Application of Image Denoising Method Based on Two-Way Coupling Diffusion Equation in Public Security Forensics by Yiqun Wang, Changpeng He, Zhenjiang Li

“…By improving the second-order partial differential equation, a new diffusion function with better diffusion effect than the original model is constructed. We combined the adaptive edge threshold and stop criterion to establish a new denoising algorithm model, which can get better denoising results. …”
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Second Trimester Umbilical Cord Coiling Index and Perinatal Outcomes by Yusuf Aytaç Tohma, Mehmet Metin Altay, Derya Turgut, Selcan Coşkun, Eylem Ünlübilgin, Sertaç Esin, Orhan Gelişen, Okyar Erol

“…According to aUCI there was a statistical difference in GDM, preeclampsia and IUGR and different from the literature, in our study, we found a statistically significant difference in hypercoiled umbilical cords in terms of preeclampsia. …”
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Two Cysteines in Raf Kinase Inhibitor Protein Make Differential Contributions to Structural Dynamics In Vitro by Hyun Sang Cho, Mohammad Faysal Al Mazid, Eun-Young Lee, Md Abu Rayhan, Hyoun Sook Kim, Byung Il Lee, Hye Jin You

“…It is still unclear how RKIP switches between monomeric and dimeric forms. Here, we identified the role of cysteine 133 in RKIP structural dynamics using recombinant human RKIP (rhRKIP) proteins purified from <i>Escherichia coli</i> BL21(DE3) cells. …”
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Guanxinning Tablet Attenuates Coronary Atherosclerosis via Regulating the Gut Microbiota and Their Metabolites in Tibetan Minipigs Induced by a High-Fat Diet by Qinqin Yang, Yanyun Xu, Liye Shen, Yongming Pan, Junjie Huang, Quanxin Ma, Chen Yu, Jiaojiao Chen, Yu Chen, Minli Chen

“…Following the establishment of a CA model in Tibetan minipigs, GXNT was orally administrated. We simultaneously detected blood lipid levels, observed ventricular function using ultrasound examination, measured platelet aggregation, and checked changes in inflammatory factors, oxidative stress factors, and vascular endothelial injury-related indexes applying ELISA assays. …”
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The association of activity patterns on female reproductive diseases: a prospective cohort study of UK biobank by Huanyu Guo, Yingzi Sun, Wei Gao, Yuqing Liu, Tianshu Han, Dandan Zhang

“…Conclusions Compared with midday-afternoon group, morning and mixed MVPA timing groups, but not evening group, were associated with decreased risks for female reproductive diseases and PCOS. In addition, we found that women with mixed MVPA timing exercise had a lower risk of HMB, compared with the reference group.…”
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