Dynamic changes in the skin transcriptome for the melanin pigmentation in embryonic chickens by Dong Leng, Maosen Yang, Xiaomeng Miao, Zhiying Huang, Mengmeng Li, Jia Liu, Tao Wang, Diyan Li, Chungang Feng

“…Historically, research has concentrated primarily on specific developmental points or stages, but fewer studies have examined the entire transcriptome across the timeline of the development of the embryo integument. In our investigation, we undertook the sequencing of chicken embryo skin samples from d 4 to d 13 of incubation. …”
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Risks of Autologous Abdominal Free Flap Breast Reconstruction in Patients With Elevated Body Mass Index by Nathaniel A. Teitler, MD, Courtney J. Doherty, BS, Madalyn R. Adams, MD, Anna A. Podber, MD, Peter M. Granger, MD, Kaeli K. Samson, MPH, MA, Sean C. Figy, MD, Shannon L. Wong, MD, Heidi H. Hon, MD

“…To provide a clearer understanding of the challenges faced by patients with obesity, we present a single-center outcome analysis of individuals who underwent DIEP flap reconstruction. …”
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Thyroid Hormone Changes in the Northern Area of Tianjin during the COVID-19 Pandemic by Dong Weiwei, Wu Bei, Wang Hong, Wu Cailan, Shao Hailin, Xu Donghong, Wang Xiaolai, Hao Zhaohu, Li Shijun, Tan Jian, Jia Qiang

“…People who were pregnant, were lactating, or had mental illness were excluded. We used propensity score matching to form a cohort in which patients had similar baseline characteristics, and their anxiety level was measured by the Hamilton Anxiety Rating Scale (HAMA). …”
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High Body Roundness Index Is Associated With Unhealthy Sleep Patterns: Insights From NHANES (2007–2014) by Pingchuan Liu, Yuding Luo, Xing He, Jiali Zhang, Fanzhou Ren, Bingyang Zhang, Bo Zheng, Jian Wang

“…However, research investigating sleep patterns in relation to novel anthropometric indices is limited. Therefore, we conducted a cross‐sectional analysis of data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2014 to examine the relationship between the body roundness index (BRI) and unhealthy sleep patterns. …”
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Treatment Efficacy and Compliance in Patients with Diabetic Macular Edema Treated with Ranibizumab in a Real-Life Setting by Anne-Laurence Best, Franck Fajnkuchen, Sylvia Nghiem-Buffet, Typhaine Grenet, Gabriel Quentel, Corinne Delahaye-Mazza, Salomon Y. Cohen, Audrey Giocanti-Aurégan

“…Our study confirms the real-life efficacy of ranibizumab in DME at M12 and the need for a large number of injections to achieve better visual outcomes. We also showed a trend to a lower compliance in diabetic versus nAMD patients.…”
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Limited Vitrectomy versus Complete Vitrectomy for Epiretinal Membranes: A Comparative Multicenter Trial by Matteo Forlini, Purva Date, Domenico D’Eliseo, Paolo Rossini, Adriana Bratu, Andrea Volinia, Giovanni Neri, Tommaso Verdina, Maria Rosaria Carbotti, Gian Maria Cavallini, Luigi Sborgia, Alessandra Galeone, Aurelio Imburgia, Alessandro Mularoni, Alessandro Meduri

“…Incidence of iatrogenic retinal breaks, retinal detachment, surgical time, and visual outcomes were compared between groups. Results. We included 139 eyes in the analysis with a mean age being 72.2 ± 6.9 years. …”
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Targeting Nrf2/KEAP1 signaling pathway using bioactive compounds to combat mastitis by Muhammad Zahoor Khan, Liangliang Li, Yandong Zhan, Huang Binjiang, Xiaotong Liu, Xiyan Kou, Adnan Khan, Abdul Qadeer, Qudrat Ullah, Khalid J. Alzahrani, Tongtong Wang, Changfa Wang, Muhammad Zahoor

“…This reduces pathogen-induced oxidative stress and inflammation by inhibiting NF-kB signaling in the mammary glands, one of the prominent pro-inflammatory signaling pathway. Here, we summarize recent studies to highlight the therapeutic potential of Nrf2/KEAP1 pathway in the prevention and treatment of mastitis. …”
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Understanding factors influencing safety and team functionality at operative vaginal birth through multidisciplinary perspectives: a mixed methods study by Sasha M. Skinner, Eleanor Kippen, Daniel L. Rolnik, Peter Neil, Ryan J. Hodges, Nadine Murry, Ben W. Mol, Arunaz Kumar

“…Thematic analysis of free-text survey responses and interviews identified themes influencing safety and team functionality at OVB. Findings We received 100 survey responses from obstetric (n = 41), midwifery (n = 52) and paediatric (n = 7) staff, including senior (n = 49) and junior (n = 51) roles. …”
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Subtle changes in Purkinje cell firing in Purkinje cell-specific Dyt1 ΔGAG knock-in mice by Hong Xing, Pallavi Girdhar, Yuning Liu, Fumiaki Yokoi, David E. Vaillancourt, Yuqing Li

“…Whether Pcp2-KI mice show similar abnormal Purkinje cell firing as the global KI mice, suggesting a cell-autonomous effect causes the abnormal Purkinje cell firing in the global KI mice, is unknown. We used acute cerebellar slice recording in Pcp2-KI mice to address this issue. …”
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Navigating next-gen nutrition care using artificial intelligence-assisted dietary assessment tools—a scoping review of potential applications by Anuja Phalle, Devaki Gokhale

“…In the final phase of screening, 66 articles were reviewed that matched our inclusion criteria and the review followed PRISMA-ScR reporting guidelines.ResultsWe observed that existing AI-assisted dietary assessment tools are integrated with mobile/web-based applications to provide a user-friendly interface. …”
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Combined Kidney-Liver, Heart-Liver, and Kidney-Pancreas Transplantations from a Single Deceased Donor by Matteo Ravaioli, Matteo Serenari, Matteo Cescon, Sofia Martin Suarez, Alessandro Cucchetti, Giorgio Ercolani, Massimo Del Gaudio, Fausto Catena, Cristina Morelli, Giorgio Arpesella, Antonio Daniele Pinna

“…Splitting the liver for two adults to increase the donor pool is still a debated issue, especially for combined organ transplantation. We described a case of liver-splitting procedure for two adults, which was successful even in the presence of combined organ transplantation. …”
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Successful Diagnosis of Sengers Syndrome Using a Comprehensive Genomic Analysis by Kohta Nakamura, Yukiko Yatsuka, Sachie Naito, Akira Hasegawa, Takeya Kasukawa, Atsushi Kondo, Yoshihito Kishita, Yohei Sugiyama, Takanori Onuki, Tomohiro Ebihara, Tomoko Tsuruoka, Takuya Fushimi, Akira Ohtake, Kei Murayama, Atsuko Imai‐Okazaki, Yasushi Okazaki

“…Dysfunction of acylglycerol kinase (AGK) is responsible for the disease, and several AGK gene variants have been reported. Methods We employed a comprehensive genomic analysis approach, including whole‐genome sequencing and RNA sequencing, combined with various bioinformatics tools. …”
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Soundscape analysis reveals fine ecological differences among coral reef habitats by Juan Carlos Azofeifa-Solano, Miles J.G. Parsons, Rohan Brooker, Robert McCauley, Daniel Pygas, William Feeney, Steve Simpson, Sophie L. Nedelec, Eve M. Croxford, Mark Meekan, Christine Erbe

“…Using the Soundscape Code—a method that summarizes soundscape amplitude, impulsiveness, periodicity, and uniformity—we analyzed habitat differentiation across 25 simultaneous recordings from back, flat, and fore reef zones. …”
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Metabolomics Reveals Distinct Metabolites between Lonicera japonica and Lonicera macranthoides Based on GC-MS by Rui-ying Liu, Jing Deng, Xiu-Lian Lin, Ya-mei Li, Yan Lin, Bo-hou Xia, Li-mei Lin

“…Metabolic pathway analysis showed that the galactose metabolism and starch and sucrose metabolism gathered as potential pathways caused these extraordinary differences of primary metabolites between LJ and LM. Further, we found that the differences of main medicinal ingredients between LJ and LM could be interpreted from these metabolites according to the analysis of mainly related pathways. …”
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Interferon-γ production in response to the cytotoxic T lymphocyte epitope within an antigen incorporated in simian virus 40 virus-like particles by Takeharu Watanabe, Masayuki Hayashi, Masaaki Arai, Sho Matsushita, Hiroshi Handa, Masaaki Kawano

“…In a previous study, we showed that administration of antigen-incorporated virus-like particles (VLPs) derived from simian virus 40 (SV40) induces production of cytotoxic T lymphocytes (CTL), as well as antibodies against the incorporated antigen(s), without the need for an adjuvant; however, it remains unclear how immune cells recognize and respond to the SV40 capsid because SV40 VLPs did not upregulate expression of maturation markers on dendritic cells. …”
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The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death by Margarida T. Grilo Ruivo, Ji-hun Shin, Todd Lenz, Stephanie Y. Matsuno, Katherine Olivia Yanes, Arnault Graindorge, Maguy Hamie, Laurence Berry-Sterkers, Mathieu Gissot, Hiba El Hajj, Karine G. Le Roch, Melissa B. Lodoen, Maryse Lebrun, Diana Marcela Penarete-Vargas

“…Toxoplasma counteracts host immune defenses by secreting effector proteins into host cells; however, how the parasite evades lytic cell death and the effectors involved remain poorly characterized. We identified ROP55, a rhoptry protein that promotes parasite survival by preventing lytic cell death in absence of IFN-γ stimulation. …”
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ClimaWATCH: A new interactive tool for community heat-health vulnerability assessments by Aparna Keshaviah, Dheeya Rizmie, Huihua Lu, Mike Rudacille, Eric Morris, Colleen Psomas, Farid Qamar, Xindi C. Hu

“…To boost heat preparedness and response, officials need information on where heat-related health issues concentrate and how risks vary by demographic, social, environmental, and infrastructural factors. We present a tool for heat-health vulnerability assessments, called ClimaWATCH, which links large, diverse data to summarize county, state, and national exposure to heatwaves; susceptibility based on various factors; and heat-related health burdens. …”
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Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study by Yarui Wei, Ziyu Wang, Kangkang Xue, Xiaoyu Niu, Longyao Ma, Shaoqiang Han, Baohong Wen, Yong Zhang, Huafu Chen, Jingliang Cheng

“…However, these individual studies vary greatly in their methods and findings, and important areas within CTCC and related genetic mechanism are unclear. We searched for consistent regions of circuit dysfunction using a functional magnetic resonance imaging (fMRI) meta-analysis, followed by meta-regression and functional annotation analysis. …”
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“Lung-on-a-chip” as an instrument for studying the pathophysiology of human respiration by Oksana A. Zhukova, Iuliia V. Ozerskaya, Dmitry V. Basmanov, Vsevolod Yu. Stolyarov, Vladimir G. Bogush, Vladimir V. Kolesov, Kirill A. Zykov, Gaukhar M. Yusubalieva, Vladimir P. Baklaushev

“…In the present review, we have analyzed the existing types of LoC, the biomaterials used, the methods of detecting molecular processes within the microfluidic devices and the main directions of research to be conducted using the “lung-on-a-chip”.…”
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Healthcare Costs and Resource Use Associated With Cervical Intraepithelial Neoplasia and Cervical Conization: A Retrospective Study of German Statutory Health Insurance Claims Data by Anna-Janina Stephan, Miriam Reuschenbach, Kunal Saxena, Vimalanand S. Prabhu, Christian Jacob, Kim M. Schneider, Wolfgang Greiner, Regine Wölle, Monika Hampl

“…**Objectives:** The aim of this study was to explore the health economic burden in women with CIN diagnoses who either underwent cervical conization or were managed conservatively. **Methods:** We conducted a retrospective claims data analysis using the InGef Research Database from 2013 to 2018. …”
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