The Relationship between Perirenal Fat Thickness and Reduced Glomerular Filtration Rate in Patients with Type 2 Diabetes by Yuan Fang, Yuechao Xu, Yuxian Yang, Chang Liu, Dong Zhao, Jing Ke

“…Patients were divided into three groups according to PrFT, and we found patients with higher PrFT had lower eGFR. …”
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Adipose-Derived Mesenchymal Stem Cell Exosomes Suppress Hepatocellular Carcinoma Growth in a Rat Model: Apparent Diffusion Coefficient, Natural Killer T-Cell Responses, and Histopa... by Sheung-Fat Ko, Hon-Kan Yip, Yen-Yi Zhen, Chen-Chang Lee, Chia-Chang Lee, Chung-Cheng Huang, Shu-Hang Ng, Jui-Wei Lin

“…We sought to evaluate the effects of adipose-derived mesenchymal stem cells (ADMSCs) exosomes on hepatocellular carcinoma (HCC) in rats using apparent diffusion coefficient (ADC), natural killer T-cell (NKT-cell) responses, and histopathological features. …”
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Developing a youth-friendly internet-enabled HIV risk calculator: A collaborative approach with young key populations, living in Soweto, South Africa. by Mamakiri Mulaudzi, Gugulethu Tshabalala, Stefanie Hornschuh, Kofi Ebenezer Okyere-Dede, Minjue Wu, Oluwatobi Ifeloluwa Ariyo, Janan J Dietrich

“…Using qualitative research, we conducted an exploratory study with 40 young people including young key population (lesbian, gay, bisexual, transgender (LGBT) individuals, men who have sex with men (MSM), and female sex workers). …”
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A comparative analysis of COVID-19 seroprevalence rates, observed infection rates, and infection-related mortality by Eric W. Ford, Kunal N. Patel, Holly Ann Baus, Shannon Valenti, Jennifer A. Croker, Robert P. Kimberly, Steven E. Reis, Matthew J. Memoli

“…This study aims to extend previous research by incorporating infection-related mortality (IRM) to evaluate the discrepancies between seroprevalence data and infection rates reported to the Centers for Disease Control and Prevention (CDC), and to assess the implications for public health policy.Study designWe conducted a comparative analysis of seroprevalence data collected as part of an NIH study and CDC-reported infection rates across ten U.S. regions, focusing on their correlation with IRM calculations.MethodsThe analysis includes a revision of prior estimates of IRM using updated seroprevalence rates. …”
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Whole transcriptome analysis of unmutated sporadic ALS patients' peripheral blood reveals phenotype-specific gene expression signature by Francesca Dragoni, Maria Garofalo, Rosalinda Di Gerlando, Bartolo Rizzo, Matteo Bordoni, Eveljn Scarian, Camilla Viola, Veronica Bettoni, Giuseppe Fiamingo, Danilo Tornabene, Lucia Scanu, Orietta Pansarasa, Luca Diamanti, Stella Gagliardi

“…Our objective was to define a phenotype-specific transcriptomic signature of distinct ALS phenotypes, and lay the foundation for biomarkers development. We characterized 48 sALS patients by clinical and paraclinical parameters, and subdivided them in “Classic” (n = 12), “Bulbar” (n = 10), “Flail Arm” (n = 7), “Flail Leg” (n = 10) and “Pyramidal” (n = 9) phenotypes. …”
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Determination of the melanin and anthocyanin content in barley grains by digital image analysis using machine learning methods by E. G. Komyshev, M. A. Genaev, I. D. Busov, M. V. Kozhekin, N. V. Artemenko, A.  Y. Glagoleva, V. S. Koval, D. A. Afonnikov

“…Therefore, the development of a new method for quickly assessing the presence of pigments in the grain would help in investigating the mechanisms of genetic control of the pigment composition of barley grains. In this work, we developed a method for assessing the presence or absence of anthocyanins and melanin in the barley grain shell based on digital image analysis using computer vision and machine learning algo rithms. …”
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ERG mediates the differentiation of hepatic progenitor cells towards immunosuppressive PDGFRα+ cancer-associated fibroblasts during hepatocarcinogenesis by Haoran Bai, Xinyu Zhu, Lu Gao, Shiyao Feng, Hegen Li, Xiaoqiang Gu, Jiahua Xu, Chen Zong, Xiaojuan Hou, Xue Yang, Jinghua Jiang, Qiudong Zhao, Lixin Wei, Li Zhang, Zhipeng Han, Wenting Liu, Jianxin Qian

“…However, the origin of CAFs has not been fully elucidated. We employed single-cell sequencing technology to identify the dynamic changes in different subsets of fibroblasts at different time points in rat primary HCC model. …”
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Elevated Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 Level in Patients with Acute Coronary Syndrome (ACS): A Biomarker of Disease Severity and Outcome by Shachaf Shiber, Vitaly Kliminski, Katia Orvin, Iftach Sagy, Mordehay Vaturi, Ran Kornowski, Michael Drescher, Yair Molad

“…Plasma levels of soluble triggering receptor expressed on myeloid cells (sTREM-1) reflect innate immune cell activation. We sought to evaluate sTREM-1 levels in patients with acute coronary syndrome (ACS) and their predictive value for disease severity and outcome. …”
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Prevalence of Fabry Disease among Patients with Parkinson’s Disease by Alexandra Lackova, Christian Beetz, Sebastian Oppermann, Peter Bauer, Petra Pavelekova, Tatiana Lorincova, Miriam Ostrozovicova, Kristina Kulcsarova, Jana Cobejova, Martin Cobej, Petra Levicka, Simona Liesenerova, Daniela Sendekova, Viktoria Sukovska, Zuzana Gdovinova, Vladimir Han, Mie Rizig, Henry Houlden, Matej Skorvanek

“…The aim of our study was to determine the prevalence of FD among patients with PD. Methods. We recruited 236 consecutive patients with PD from February 2018 to December 2020. …”
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The enriched gut commensal Faeciroseburia intestinalis contributes to the anti-metabolic disorders effects of the Ganoderma meroterpene derivative by Shanshan Qiao, Kai Wang, Chang Liu, Nan Zhou, Li Bao, Jun Wang, Shuangjiang Liu, Hongwei Liu

“…To specify the key commensal bacteria associating with the beneficial effects, we tried to isolate and compare the microbiota from the cecal samples of GMD- and vehicle-treated ob/ob mice, and further identified butyrate-producing bacterial strains. …”
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Continuous-flow columns packed with zero-valent iron and iron sulfide as a feasible strategy to remediate the persistent contaminant nitroguanidine by Youngjae Yu, Erika E. Rios-Valenciana, Robert A. Root, Reyes Sierra-Alvarez, Jon Chorover, Jim A. Field

“…However, NQ also represents an emerging contaminant whose environmental emissions can cause toxicity toward aquatic organisms, indicating the need for effective remediation strategies. Thus, we investigated the feasibility of treating water contaminated with NQ in continuous-flow columns packed with zero-valent iron (ZVI) or iron sulfide (FeS). …”
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Association between individual occupational noise exposure and overweight/obesity among automotive manufacturing workers in South China by Jiaheng Yu, Jiaxin CUI, Haijuan Huang, Jingwen Zhang, Xin Li, Yanmei Ruan, Zejin Ou, Zhi Wang

“…However, limited evidence exists regarding its association with obesity. We aim to investigate the effect of occupational noise exposure on the risk of overweight/obesity among workers, providing scientific evidence for the prevention and management of overweight/obesity in the occupational population. …”
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Surgical planning of small intestine neuroendocrine tumors: the concept of mesenteric tumor deposits by Romain L’Huillier, Gilles Poncet, Arnaud Pasquer, Thomas Walter, Catherine Lombard-Bohas, Valérie Hervieu, Bénédicte Cayot, Pierre-Jean Valette, Helen Cheung, Laurent Milot

“…Diagnostic accuracy and interobserver reliability analysis were performed. We included 45 patients (mean age: 61 years (28–84 years); 23 men). …”
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Identification of Cytosolic DNA Sensor cGAS-STING as Immune-Related Risk Factor in Renal Carcinoma following Pan-Cancer Analysis by Zheng Wu, Ying Lin, Li-Min Liu, Yan-Li Hou, Wei-Ting Qin, Lei Zhang, Shu-Heng Jiang, Qin Yang, Yong-Rui Bai

“…Finally, the cGAS-STING score was revealed to be an independent prognostic factor for KIRC patients and possessed a strong predictive power for the prognostic evaluation of KIRC and KIRP patients. Conclusions. We constructed a cGAS-STING gene signature to predict survival and tumor immunity across human cancers, which can serve as a novel prognostic indicator and therapeutic target, especially in KIRC and KIRP.…”
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Incomplete recovery in patients with minor head injury directly discharged home from the emergency department: a prospective cohort follow-up study by Bram Jacobs, Joukje van der Naalt, Jan Cornelis ter Maaten, Sophie Maria Coffeng, Laura Jane Kim

“…Objectives To determine the frequency of post-traumatic complaints and recovery rate of non-hospitalised patients with minor head injury (MHI) and their relationship with demographic and injury characteristics. We also evaluated the differences between patient groups in this least severe category of brain and head injury.Design Prospective cohort follow-up study.Setting Patients admitted to the emergency department (ED) of a tertiary hospital in the Netherlands.Participants 242 patients with MHI (n=100 with head injury only and n=142 with mild traumatic brain injury (mTBI)) discharged home directly after evaluation at the ED.Outcome measures The primary outcome measure was incomplete recovery at 3 months measured by the Glasgow Outcome Scale-Extended score <8. …”
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Diagnostic efficacy and necessity of 18F-FDG PET/CT in fever of unknown origin: insights from a retrospective cohort study by Xiaoman Yu, Shuang Wang, Na Du, Hongguang Zhao, Haiying Chen

“…BackgroundDespite advancements in medical examination equipment and techniques, fever of unknown origin (FUO) remains challenging in internal medicine.PurposeThis study evaluates the diagnostic efficacy and necessity of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with FUO.MethodsWe retrospectively analyzed the results of 18F-FDG PET/CT in a cohort of 284 patients with FUO admitted to the Department of Infection at the First Hospital of Jilin University between January 2018 and March 2024. …”
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Association of plasma biomarkers of Alzheimer’s pathology and neurodegeneration with gait performance in older adults by Farwa Ali, Jeremy A. Syrjanen, Dan J. Figdore, Walter K. Kremers, Michelle M. Mielke, Clifford R. Jack, David S. Knopman, Prashanthi Vemuri, Jonathan Graff-Radford, B. Gwen Windham, Leland R. Barnard, Ronald C. Petersen, Alicia Algeciras-Schimnich

“…Methods In a population-based cohort of older adults, we evaluate the hypothesis that plasma biomarkers of neurodegeneration and Alzheimer’s Disease pathology are associated with worse gait performance. …”
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Elevated concentrations of quaternary ammonium compounds in childcare centers: A pilot study by Yao Cheng, Zhong Lv, Erika Schreder, Min Hu, Abby Mutic, Guomao Zheng, Amina Salamova

“…High levels of QACs have been found in indoor dust in residential homes; however, there is limited information on QAC exposure in non-residential environments serving sensitive populations, such as childcare centers. In this study, we investigated the occurrence of QACs, including benzylalkyldimethyl ammonium compounds (BACs), dialkyldimethylammonium compounds (DADMACs), and alkyltrimethylammonium compounds (ATMACs), in dust from childcare centers and estimated daily intake of QACs by toddlers in chidlcare via dust ingestion. …”
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Whole slide image based deep learning refines prognosis and therapeutic response evaluation in lung adenocarcinoma by Tao Chen, Jialiang Wen, Xinchen Shen, Jiaqi Shen, Jiajun Deng, Mengmeng Zhao, Long Xu, Chunyan Wu, Bentong Yu, Minglei Yang, Minjie Ma, Junqi Wu, Yunlang She, Yifan Zhong, Likun Hou, Yanrui Jin, Chang Chen

“…Abstract Existing prognostic models are useful for estimating the prognosis of lung adenocarcinoma patients, but there remains room for improvement. In the current study, we developed a deep learning model based on histopathological images to predict the recurrence risk of lung adenocarcinoma patients. …”
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Multiple hosts, multiple impacts: the role of vertebrate host diversity in shaping mosquito life history and pathogen transmission by Vantaux, Amélie, Moiroux, Nicolas, Dabiré, Kounbobr Roch, Cohuet, Anna, Lefèvre, Thierry

“…Combining our results in a theoretical model, we show a decrease in the vectorial capacity of mosquitoes fed chicken or cow blood and an increase in the capacity of those fed sheep blood compared to those fed human blood. …”
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