Perioperative estimations of oxygen consumption from LiDCO™plus-derived cardiac output and Ca-cvO2 difference: Relationship with measurements by indirect calorimetry in elderly pat... by Julia Jakobsson, Carl Norén, Eva Hagel, Magnus Backheden, Sigridur Kalman, Erzsébet Bartha

“…In addition, reverse Fick calculations report generally lower values of oxygen consumption.<h4>Methods</h4>We investigated the relationship between perioperative estimations of VO2 (EVO2), from LiDCO™plus-derived (LiDCO Ltd, Cambridge, UK) cardiac output and arterial-central venous oxygen content difference (Ca-cvO2), with indirect calorimetry (GVO2) by QuarkRMR (COSMED srl. …”
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Investigating the Role of Osteopontin (OPN) in the Progression of Breast, Prostate, Renal and Skin Cancers by Gautam Kundu, Selvakumar Elangovan

“…<b>Methods</b>: In this study, we conducted a further examination of the transcriptomic expression profile of SPP1 (Osteopontin) during the progression of cancer in four human tissues, breast, prostate, renal and skin, in order to understand the circumstances conducive to its activation and dysregulation, the biological pathways and other mechanisms involved as well as differences in its splicing patterns influencing its expression and functionality. …”
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Neglecting the neglected: Tobacco cessation support is 'essential' for the management of asthma and COPD by Dilek Karadogan, İlknur Kaya, Merve Yumrukuz Şenel, Esin Bilgin Konyalıhatipoğlu, Tahsin Gökhan Telatar, Metin Akgün

“…Introduction Asthma and COPD management have a broad framework, and smoking cessation plays an essential role. We examine the management of asthma and COPD patients not only for inhaler treatment options but also for essential interventions, such as smoking cessation support. …”
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Population pharmacokinetics of iruplinalkib in healthy volunteers and patients with solid tumors by Guihong Yang, Yimei Wang, Huimin Zhao, Ziyi Jiang, Shansong Zheng, Mingjing Ge, Meimei Si, Xiaoyan Kang

“…Pharmacokinetics (PK) data of iruplinalkib have been collected in healthy subjects and patient populations in several studies. We developed a population PK (PopPK) model for describing iruplinalkib plasma concentrations and for evaluating whether dose adjustments are necessary based on demographic factors or disease characteristics. …”
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Analysis of application of heat loss recovery system using organic Rankine сycle for drive of process equipment by A. M. Kalashnikov, A. A. Kapelyukhovskaya, I. D. Obukhov

“…When modeling heat exchange processes, the following boundary conditions are adopted: the temperature of the heated surface; the coil heat exchanger is located at a distance from the heated surface of the process equipment. From these results, we can draw the following conclusions: the increase in the temperature of the heated surface leads to the increase of the heating zone of the refrigerant with high capacity and, hence, to increase heat capacity; increasing the refrigerant flow rate, the lower the temperature of the refrigerant at the exit, but increases the thermal capacity; increasing the pressure of the heated refrigerant increases the thermal; this design of the heat exchanger allows you to achieve the necessary power for the operation of the drive by: changing the flow rate of the refrigerant, the excess pressure of the refrigerant, the number of elbows, as well as by installing a heat-reflecting casing…”
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Ultra high density imaging arrays in diffuse optical tomography for human brain mapping improve image quality and decoding performance by Zachary E. Markow, Jason W. Trobaugh, Edward J. Richter, Kalyan Tripathy, Sean M. Rafferty, Alexandra M. Svoboda, Mariel L. Schroeder, Tracy M. Burns-Yocum, Karla M. Bergonzi, Mark A. Chevillet, Emily M. Mugler, Adam T. Eggebrecht, Joseph P. Culver

“…Herein, simulations indicated reducing inter-optode spacing to 6.5 mm, creating a higher-density grid with more source-detector distances, would further improve image quality and noise-resolution tradeoff, with diminishing returns below 6.5 mm. We then constructed an ultra-high-density DOT system (6.5-mm spacing) with 140 dB dynamic range that imaged stimulus-evoked activations with 30–50% higher spatial resolution and repeatable multi-focal activity with excellent agreement with participant-matched fMRI. …”
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The Role of Motivation to Promote Personal and Social Responsibility Through PE and Sport: A Comparative Exploratory Investigation of Prospective PE Teachers and Sports Leaders in... by Istvan Soos, Ian Whyte, Diana Szekeres, Karoly Ozsvath, Attila Szabo, Jonathan Ling, Jose Francisco Jiménez-Parra, Alfonso Valero-Valenzuela

“…Differences were found by country and by sex. Discussion: We suggest that a hybridised model incorporating Teaching Personal and Social Responsibility and the Sports Education Model is employed with sport and physical education students to optimise potential for transfer of values and behaviours.…”
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RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy by Ichiro Yajima, Mayuko Y. Kumasaka, Nguyen Dinh Thang, Yuji Goto, Kozue Takeda, Osamu Yamanoshita, Machiko Iida, Nobutaka Ohgami, Haruka Tamura, Yoshiyuki Kawamoto, Masashi Kato

“…To find better approaches to therapies for patients, understanding these MAPK and AKT signaling mechanisms of melanoma development and progression is important. Here, we review MAPK and AKT signaling networks associated with melanoma development and progression.…”
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Case Report: Dangerous liaisons between splenectomy and eltrombopag-induced chronic thromboembolic pulmonary hypertension in patients with immune thrombocytopenia: report of two ca... by Roberto Castelli, Enrico Atzori, Alessandro Palmerio Delitala, Salvatore Antonio Masala, Valentina Micheluzzi, Enrico Ponti, Enrico Ponti, Giuseppe Sanna, Dante Castro, Antonio Gidaro, Mattia Donadoni, Roberto Manetti, Pierluigi Merella, Nicia Isabella Profili, Andrea Maria D'Armini, Gavino Casu, Gavino Casu

“…Chronic thromboembolic pulmonary hypertension is a rare disease that results from a persistent, organized thromboembolic obstruction of the pulmonary arteries due to an incompletely resolved pulmonary embolism.Case presentationsWe report two cases of chronic thromboembolic pulmonary hypertension induced by a thrombotic mechanism after treatment with splenectomy and Eltrombopag, a thrombopoietin receptor agonist, for refractory primary immune thrombocytopenia. …”
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Antibiogram for Haemodialysis Catheter-Related Bloodstream Infections by Abdul Halim Abdul Gafor, Pau Cheong Ping, Anis Farahanum Zainal Abidin, Muhammad Zulhilmie Saruddin, Ng Kah Yan, Siti Qania’ah Adam, Ramliza Ramli, Anita Sulong, Petrick Periyasamy

“…Eight (44.4%) patients had gram-negative infections, 7 (38.9%) patients gram-positive infections, and 3 (16.7%) patients had polymicrobial infections. We noted that most of the gram-negative bacteria were sensitive to ceftazidime. …”
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Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy by Tarek Kamal Abouzed, Seiichi Munesue, Ai Harashima, Yusuke Masuo, Yukio Kato, Khaled Khailo, Hiroshi Yamamoto, Yasuhiko Yamamoto

“…Hemodynamic, inflammatory, and metabolic factors are considered as developmental factors for diabetic nephropathy. In this study, we evaluated whether pharmacological interventions with salicylate, compared to pyridoxamine, could prevent diabetic nephropathy in mice. …”
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Anatomic Variations Important for Dental Implantation in the Mandible—A Systematic Review by Zlata Rajkovic Pavlovic, Milos Stepovic, Marija Bubalo, Ivana Zivanovic Macuzic, Maja Vulovic, Nevena Folic, Jovana Milosavljevic, Valentina Opancina, Dobrivoje Stojadinovic

“…With this systematic review, we would like to summarize the results from different studies that are relevant to this subject and that are up to date, presenting their main findings, the measurements of mentioned landmarks, and giving clinical implications that will be helpful to practitioners in their better understanding of this topic. …”
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Smoking as a risk factor for lung cancer in women and men: a systematic review and meta-analysis by Sanne A E Peters, Mark Woodward, Paul Mitchell, Rachel R Huxley, Gemma Taylor, Linda M O’Keeffe

“…Objectives To investigate the sex-specific association between smoking and lung cancer.Design Systematic review and meta-analysis.Data sources We searched PubMed and EMBASE from 1 January 1999 to 15 April 2016 for cohort studies. …”
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Association of a Common Variant at 10q26 and Benign Prostatic Hyperplasia Aggressiveness in Han Chinese Descent by Xin Gu, Tao Huang, Ding Xu, Liujian Duan, Yang Jiao, Jian Kang, S. Lilly Zheng, Jianfeng Xu, Jielin Sun, Jun Qi

“…Recent studies reported that rs2252004 at 10q26 was significantly associated with prostate cancer (PCa) risk in a Japanese population and was subsequently confirmed in a Chinese population. We aimed to assess the relationship between this locus and risk/aggressiveness of benign prostatic hyperplasia (BPH). …”
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Ex Vivo Restimulation of Human PBMC Expands a CD3+CD4-CD8-γδ+ T Cell Population That Can Confound the Evaluation of CD4 and CD8 T Cell Responses to Vaccination by B. J. Sedgmen, L. Papalia, L. Wang, A. R. Dyson, H. A. McCallum, C. M. Simson, M. J. Pearse, E. Maraskovsky, D. Hung, P. P. Eomois, G. Hartel, M. J. Barnden, S. P. Rockman

“…During the assessment of cell-mediated immunity (CMI) in subjects participating in a large-scale influenza vaccine trial, we identified the expansion of an IFN-γ-producing CD3+CD4-CD8-γδ+ T cell population in the peripheral blood of 90/610 (15%) healthy subjects. …”
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In Vivo Evaluation of the Combined Anticancer Effects of Cisplatin and SAHA in Nonsmall Cell Lung Carcinoma Using [18F]FAHA and [18F]FDG PET/CT Imaging by Skye Hsin-Hsien Yeh, Ming Hsien Lin, I. I. Leo Garcia Flores, Uday Mukhopadhyay, Danial Young, Kazuma Ogawa, Jeong-Hwan Jeong, William Tong, Juri G. Gelovani, Nobuyoshi Fukumitsu

“…Use of [18F] FAHA, a HDAC IIa-specific radionuclide, for molecular imaging may enable longitudinal, noninvasive assessment of HDAC activity/expression in metastatic cancer. We evaluated the synergistic anticancer effects of cisplatin and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) in xenograft models of nonsmall cell lung cancer (NSCLC) using [18F] FAHA and [18F] FDG PET/CT imaging. …”
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Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes by Amina Lazrek, Sebastiano Finocchi Ghersi, Adeline Petre, Sarah Houabes, Anne-Agathe Serre, Frederic Gassa, Magali Sandt, Cecile Laude, Camille Roukoz, Salvatore Cozzi

“…This article examines the critical role of a biodegradable hydrogel spacer, which creates a temporary interspace between the prostate and the rectum, thus reducing radiation exposure to healthy tissues.Case descriptionWe present a case of a man with a history of intermediate-risk prostate adenocarcinoma initially treated with external beam radiotherapy in 2015. …”
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Production of an Extract with β-1,4-Xylanase Activity by <i>Fusarium oxysporum</i> f. sp. <i>melonis</i> on a Sonicated Brewer’s Spent Grain Substrate by Irma A. Arreola-Cruz, Rosalba Troncoso-Rojas, Francisco Vásquez-Lara, Nina G. Heredia-Sandoval, Alma R. Islas-Rubio

“…<i>melonis</i> with β-1,4-xylanase activity after fermentation on a Brewers’ spent grain (BSG)-containing substrate. We prepared the BSG substrate, with or without sonication, for the submerged fermentation of <i>Fusarium oxysporum</i> previously isolated from local soil and preserved at 4 °C. …”
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Hypoxia signature derived from tumor-associated endothelial cells predict prognosis in gastric cancer by Ruiheng Wang, Ruiheng Wang, Guijun Liu, Guijun Liu, Ke Wang, Zhanglei Pan, Zhanglei Pan, Zhihua Pei, Xijiao Hu, Xijiao Hu

“…In gastric cancer, the mechanism of how hypoxia metabolism affects the tumor microenvironment and immunotherapy efficacy remains to be elucidated.MethodsWe used the bulk-mapping method to analyze the signatures correlated with the response of immunotherapy in the single-cell dataset. …”
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Protein-DNA interactions: statistical analysis of interatomic contacts in major and minor grooves by A. A. Anashkina, E. N. Kuznetsov, A. V.  Batianovskii, L. A. Uroshlev, V. G. Tumanyan, N. G. Esipova

“…Understanding the principles of specific recognition of DNA sites will open the way to understand how these processes are controlled and to interfere in their operation. In the paper we studied contacts between the protein and DNA at the atomic level in the structures of all the 3 518 protein­DNA complexes available in PDB by the Voronoi–Delaunay tessellation method. …”
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