Associations between inflammation and striatal dopamine D2-receptor availability in aging by Vanessa Crine, Goran Papenberg, Jarkko Johansson, Carl-Johan Boraxbekk, Anders Wåhlin, Ulman Lindenberger, Martin Lövdén, Katrine Riklund, Lars Bäckman, Lars Nyberg, Nina Karalija

“…Factors underlying individual differences in dopamine integrity at older ages remain, however, unclear. Here we aimed at investigating: (i) whether inflammation is associated with levels and 5-year changes of in vivo dopamine D2-receptor (DRD2) availability, (ii) if DRD2-inflammation associations differ between men and women, and (iii) whether inflammation and cerebral small-vessel disease (white-matter lesions) serve as two independent predictors of DRD2 availability. …”
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The Restoration Effect of Degraded Grassland Depends on the Response of Species Root Distribution to Resource Availability by Yiming Zhao, Hui Li, Fei Peng, Dabu Xilatu, Qing Chen, Shan Lin

“…In the recovery of degraded grassland by N fertilizer, we should not only consider the aboveground biomass but also pay special attention to the resource competition of individual plant species due to the possible discrepancy in rooting systems.…”
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Is the convergence insufficiency symptom survey applicable to elderly individuals? by Saeid Abdi, Haleh Kangari, Saeed Rahmani, Alireza Akbarzadeh Baghban, Zahra Kamary Rad

“…However, due to this survey’s multidimensionality, we recommend additional objective examinations in presbyopic adults with CI.…”
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Understanding cellular proliferation activity in breast cancer using multi-compartment model of transverse relaxation time mapping on 3T MRI by Kangwa Alex Nkonde, Kangwa Alex Nkonde, Sai Man Cheung, Nicholas Senn, Jiabao He

“…Multi-compartment model of transverse relaxation time has been proposed to differentiate intra- and extra-cellular space and biochemical environment but susceptible to noise, with recent development of Bayesian algorithm suggested to improve robustness. We hence hypothesise that intra- and extra-cellular transverse relaxation times using Bayesian algorithm might be sensitive to proliferative activity.Materials and methodsTwenty whole tumour specimens freshly excised from patients with invasive ductal carcinoma were scanned on a 3 T clinical scanner. …”
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Dietary Supplementation with Omega-3-PUFA-Rich Fish Oil Reduces Signs of Food Allergy in Ovalbumin-Sensitized Mice by Olívia Gonçalves de Matos, Sylvia Stella Amaral, Pedro Elias Marques Pereira da Silva, Denise Alves Perez, Débora Moreira Alvarenga, Adaliene Versiani Matos Ferreira, Jacqueline Alvarez-Leite, Gustavo Batista Menezes, Denise Carmona Cara

“…We investigated the effect of dietary supplementation with n-3 PUFA (fish oil source) in an experimental model of food allergy. …”
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Influence of age, sex, and presence of cleft lip and palate on the quantity and quality of saliva-derived DNA by Lina M. Escobar, Zita Bendahan, Deisy Abril, David Díaz-Baez, Adolfo Paternina, Farith González-Martinez, Ma Clara González-Carrera

“…Kruskal-Wallis test was used to compare frequencies between groups, and Spearman's rho for correlations.We obtained saliva DNA from 314 individuals: 107 with CL/P (mean age: 12.7 ± 6.5 years), 103 parents of children with CL/P (mean age: 41.1 ± 9.3 years), 52 individuals without CL/P under 18 years old (controls), and 52 individuals without CL/P over 18 years old (controls). …”
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Comprehensive multispectral and computational study of isoxazolidine derivative ‘ISoXD3’: Synthesis, spectral characteristics, DNA binding, and comparative effects of allyl and pro... by Ibrahim A. Alhagri, Siwar Ghannay, Norah A. Al-Suwailem, Rania Hussien Al-Ashwal, Sadeq M. AlHazmy, Sabri Messaoudi, Kaiss Aouadi

“…In this article, we have synthesized and examined the spectral properties of the isoxazolidine derivative ISoXD3, particularly its UV–Visible and fluorescence spectra. …”
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Inhibitory Effects of a Novel PPAR-γ Agonist MEKT1 on Pomc Expression/ACTH Secretion in AtT20 Cells by Rehana Parvin, Erika Noro, Akiko Saito-Hakoda, Hiroki Shimada, Susumu Suzuki, Kyoko Shimizu, Hiroyuki Miyachi, Atsushi Yokoyama, Akira Sugawara

“…Although therapeutic effects of the peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists rosiglitazone and pioglitazone against Cushing’s disease have been reported, their effects are still controversial and inconsistent. We therefore examined the effects of a novel PPAR-γ agonist, MEKT1, on Pomc expression/ACTH secretion using murine corticotroph-derived AtT20 cells and compared its effects with those of rosiglitazone and pioglitazone. …”
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Suppressive Effect of Insulin on the Gene Expression and Plasma Concentrations of Mediators of Asthmatic Inflammation by Husam Ghanim, Kelly Green, Sanaa Abuaysheh, Manav Batra, Nitesh D. Kuhadiya, Reema Patel, Antoine Makdissi, Sandeep Dhindsa, Ajay Chaudhuri, Paresh Dandona

“…Following our recent demonstration that the chronic inflammatory and insulin resistant state of obesity is associated with an increase in the expression of mediators known to contribute to the pathogenesis of asthma and that weight loss after gastric bypass surgery results in the reduction of these genes, we have now hypothesized that insulin suppresses the cellular expression and plasma concentrations of these mediators. …”
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Clinical characteristics and management outcomes of pediatric patients with Coats disease complicated with retinoschisis (retinal cyst) by Tingyi Liang, Shaochi Zhang, Xiang Zhang, Xiaohan Wang, Xunda Ji, Peiquan Zhao

“…In total, 30.8% of the eyes had a final vision ≥20/200.ConclusionThe presence of retinoschisis (retinal cyst) in Coats disease is strongly associated with retinal telangiectasia and exudation and is indicative of active vascular disease requiring effective ablative treatment. We propose a novel approach, endolaser photocoagulation combined with external drainage of cystic fluid and intravitreal ranibizumab injection, which was effective in achieving final anatomic improvement with retinal cyst resolution.…”
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Advanced Machine Learning Ensembles for Improved Precipitation Forecasting: The Modified Stacking Ensemble Strategy in China by Tiantian Tang, Yifan Wu, Yujie Li, Lexi Xu, Xinyi Shi, Haitao Zhao, Guan Gui

“…This study proposes an advanced methodology for medium- and long-term hydrological forecasting by integrating multiple machine learning models through a modified stacking ensemble strategy (MSES). We developed and compared five deterministic precipitation forecasting models, including elastic net regression (ENR), support vector regression, random forest, extreme gradient boosting, and light gradient boosting to provide forecasts with lead times ranging from 0 to 5 months at a spatial resolution of 0.5<inline-formula><tex-math notation="LaTeX">$^\circ$</tex-math></inline-formula>. …”
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CAR-T therapy for endocrine neoplasms: novel targets and combination of therapies by Fang Wang, Ruiqi Zhang, Zhaokai Zhou, Run Shi, Fu Peng, Yudi Xu, Shuai Yang, Zhan Wang, Pengpeng Zhang, Rui Tu, Chun Zhang, Xingchen Liu, Jun Cai

“…Various therapies under investigation offer potential enhancements to CAR T cell efficacy through diverse mechanisms. Herein, we summarize recent advances in identifying targets of endocrine cancer for CAR therapy and provide an overview of combinatorial approaches.…”
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Silver Ecotoxicity Estimation by the Soil State Biological Indicators by S. I. Kolesnikov, N. I. Tsepina, L.V. Sudina, T. V. Minnikova, K. Sh. Kazeev, Yu. V. Akimenko

“…The aim of this study is to estimate silver ecotoxicity using the soil state biological indicators. We studied soils that are significantly different in resistance to heavy metal pollution: ordinary chernozem (Haplic Chernozems, Loamic), sierosands (Haplic Arenosols, Eutric), and brown forest acidic soil (Haplic Cambisols, Eutric). …”
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Effects of Elemental Mercury Vapor Inhalation on Arterial Blood Gases, Lung Histology, and Interleukin-1 Expression in Pulmonary Tissues of Rats by Liqaa A. Raffee, Khaled Z. Alawneh, Ruba A. Alassaf, Abdallah Alzoubi, Musa A. Alshehabat, Nadeem Alabdallah, Abdel-Hameed Al-Mistarehi

“…We investigated the effects of elemental mercury vapor inhalation on arterial blood gases (ABGs), lung histology, and interleukin-1 (IL-1) expression in pulmonary tissues in rats. …”
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Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy by Katsuya Endo, Takehito Ito, Jun Nomura, Keigo Murakami, Shiho Kondo, Tomonori Satoh, Daisuke Fukushi, Yuki Yoshino, Yoshiteru Sasaki, Atsuko Takasu, Takayuki Kogure, Morihisa Hirota, Takayoshi Meguro, Kazuhiro Murakami, Junichi Kameoka, Kennichi Satoh

“…Multiple myeloma diagnosed from the gastrointestinal symptoms is rare. We report a case of an 80-year-old man with multiple myeloma accompanied by gastrointestinal AL amyloidosis and secondary protein-losing enteropathy. …”
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Characterization and DNA barcoding of Zambian plant species used as inoculum in the traditional fermentation of Munkoyo; a cereal-based beverage by Mubonda Kalumbilo, David Chuba, Agripina Banda, Eddy J. Smid, Sijmen E. Schoustra, Gerlinde B. De Deyn

“…To validate their identification, we evaluated three DNA barcoding markers (matK, rbcL, and ITS2) for species discrimination. …”
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Local anesthesia with and without conscious sedation versus general anesthesia for oral surgical procedures in pediatric patients: a retrospective cross-sectional study by Ana López-Velasco, Francisco Javier Carrera-Hueso, Miguel Puche-Torres, Francisco Javier Silvestre, Pedro Vázquez-Ferreiro

“…Objectives: To compare the effectiveness of general anesthesia versus local anesthesia with or without conscious sedation for minor oral surgery procedures in pediatric patients. Methods: We performed a retrospective chart review of 192 pediatric patients who underwent 227 minor oral surgery procedures between 2017 and 2019 at the Oral and Maxillofacial Surgery Department at Hospital Clínico Universitario in Valencia, Spain. …”
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Effect of Artificial Intelligence Helpfulness and Uncertainty on Cognitive Interactions with Pharmacists: Randomized Controlled Trial by Chuan-Ching Tsai, Jin Yong Kim, Qiyuan Chen, Brigid Rowell, X Jessie Yang, Raed Kontar, Megan Whitaker, Corey Lester

“…ObjectiveThis study aimed to evaluate the cognitive interaction patterns of pharmacists during medication product verification when using an AI prototype. Moreover, we examine the impact of AI’s assistance, both helpful and unhelpful, and the communication of uncertainty of AI-generated results on pharmacists’ cognitive interaction with the prototype. …”
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Patient Surgical Outcomes When Surgery Residents Are the Primary Surgeon by Intensity of Surgical Attending Supervision in Veterans Affairs Medical Centers by T. Michael Kashner, PhD, JD, MPH, Paul B. Greenberg, MD, MPH, Andrea D. Birnbaum, MD, PhD, John M. Byrne, DO, Karen M. Sanders, MD, Mark A. Wilson, MD, PhD, Marjorie A. Bowman, MD, MPA

“…Using health records from the Department of Veterans Affairs (VA), the largest healthcare training platform in the United States, we estimated independent associations between the intensity of attending supervision of surgical residents and 30-day postoperation patient outcomes. …”
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Visual Imagery in Modern Mind-Body Practices: Biophotonic Information Transfer through Water-Mediated Neural Resonance by Valeriy Babelyuk, Igor Popovych, Olga Smoleńska, Anna Michalska, Radosław Muszkieta, Magdalena Hagner-Derengowska, Yuriy Dobrovolsky, Galyna Dubkova, Tetyana Korolyshyn, Walery Zukow

“…To analyze and synthesize current evidence regarding the mechanisms of information transfer between practitioners of Kyokushin Karate and water, focusing on biophotonic emissions, neurophysiological changes, and subsequent effects on recipients of treated water. Methods. We reviewed primary research focusing on: (1) biophotonic emissions during martial arts practice, (2) water structure modifications through mental practices, and (3) neurophysiological effects of treated water. …”
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