Radix Scutellariae Ameliorates Stress-Induced Depressive-Like Behaviors via Protecting Neurons through the TGFβ3-Smad2/3-Nedd9 Signaling Pathway by Fan Zhao, Chenyiyu Zhang, Dong Xiao, Weihua Zhang, Liping Zhou, Simeng Gu, Rong Qu

“…Our previous studies found that Radix Scutellariae (RS) can rescue the stress-induced neuronal injury, but the mechanism is not clear. Here, we continued to investigate the underlying antidepressant mechanisms of the RS extract. …”
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Chaperones Utilization in Clinical Practice: Intimate and Sensitive Physical Examination Best Practice Strategies and Concepts in Modern Urological Medicine by Tarini Mitra, Nicolas K. Koerber, Harini Shah, Austin C. Kassels, Danyon J. Anderson, Brennen J. Cooper, Meghan B. Schaefer, Alan D. Kaye, Harish B. Bangalore Siddaiah, Jibin S. Mathew, Jeffrey R. Sterritt, Zachary S. Lee, Ivan Urits

“…In the present investigation, we conducted a systematic review of prospective, case-control, and retrospective studies and followed the PRISMA 2020 guidelines for data reporting. …”
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HI-CMAIM: Hybrid Intelligence-Based Multi-Source Unstructured Chinese Map Annotation Interpretation Model by Jiaxin Ren, Wanzeng Liu, Jun Chen, Xiuli Zhu, Ran Li, Tingting Zhao, Jiadong Zhang, Yuan Tao, Shunxi Yin, Xi Zhai, Yunlu Peng, Xinpeng Wang

“…Firstly, leveraging expert knowledge in an innovative way, we constructed a high-quality expert knowledge-based map annotation dataset (EKMAD), which significantly enhanced data diversity and accuracy. …”
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Sustained Interleukin-1β Exposure Modulates Multiple Steps in Glucocorticoid Receptor Signaling, Promoting Split-Resistance to the Transactivation of Prominent Anti-Inflammatory Ge... by Pedro Escoll, Ismael Ranz, Norman Muñoz-Antón, Ana van-den-Rym, Melchor Alvarez-Mon, Carlos Martínez-Alonso, Eva Sanz, Antonio de-la-Hera

“…As sustained IL-1β exposure is key in the pathogenesis of several major diseases with prevalent GCR, we examined GR signaling and the mRNA expression of six GR-driven genes in cells cultured in IL-1β and afterwards challenged with GC. …”
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Analysis of pulmonary sequestration cases, based on the 11-year birth defects surveillance data of Changsha hospitals by Ruobin Xie, Tao-Sha Wang, Yanling Wang, Wei-Dong Wang

“…Given the scarcity of related literature on PS, this present study aimed to investigate its prevalence, factors affecting survival, and strategies to avoid misdiagnosis and inappropriate treatment in adulthood. Based on our results, we proposed three levels of preventive care for prenatal and postnatal diagnoses and childhood prevention of the complications of PS. …”
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Stentless Strategy by Drug-Coated Balloon Angioplasty following Directional Coronary Atherectomy for Left Main Bifurcation Lesion by Norihiro Kobayashi, Masahiro Yamawaki, Shinsuke Mori, Masakazu Tsutsumi, Yohsuke Honda, Kenji Makino, Shigemitsu Shirai, Masafumi Mizusawa, Yoshiaki Ito

“…Aims. We aimed to evaluate the efficacy of stentless strategy by drug-coated balloon (DCB) angioplasty following directional coronary atherectomy (DCA) for left main (LM) bifurcation lesions. …”
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Exosomes and Their Therapeutic Potentials of Stem Cells by Chao Han, Xuan Sun, Ling Liu, Haiyang Jiang, Yan Shen, Xiaoyun Xu, Jie Li, Guoxin Zhang, Jinsha Huang, Zhicheng Lin, Nian Xiong, Tao Wang

“…Ascending evidence indicated that exosomes might be the main components of paracrine factors; thus, understanding the role of exosomes in each subtype of stem cells is far-reaching. In this review, we discuss the functions of exosomes from different types of stem cells and emphasize the therapeutic potentials of exosomes, providing an alternative way of developing strategies to cure diseases.…”
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Phase angle in bioelectrical impedance analysis for assessing congestion in acute heart failure. by Sangho Sohn, Jinsung Jeon, Ji Eun Lee, Soo Hyung Park, Dong Oh Kang, Eun Jin Park, Dae-In Lee, Jah Yeon Choi, Seung Young Roh, Jin Oh Na, Cheol Ung Choi, Jin Won Kim, Seung Woon Rha, Chang Gyu Park, Sunki Lee, Eung Ju Kim

“…<h4>Background</h4>The phase angle (PhA) in bioelectrical impedance analysis (BIA) reflects the cell membrane integrity or body fluid equilibrium. We examined how the PhA aligns with previously known markers of acute heart failure (HF) and assessed its value as a screening tool.…”
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EZH2 inhibition induces pyroptosis via RHA-mediated S100A9 overexpression in myelodysplastic syndromes by Qi Zhang, Yingwan Luo, Li Ye, Yuxia Wang, Lu Wang, Wenli Yang, Wei Lang, Shuanghong Zhu, Lingxu Jiang, Weimei Jin, Chen Mei, Xinping Zhou, Yanling Ren, Liya Ma, Gaixiang Xu, Bowatte Gedara Lakmal Vimukthi Bandara Bowattage, Hongyan Tong, Jie Sun

“…Enhancer of zeste homolog 2 (EZH2) is an important regulator in gene expression through methyltransferase-dependent or methyltransferase-independent mechanisms. Herein, we found EZH2 inhibition led to MDS cell pyroptosis through RNA Helicase A (RHA) down-regulation induced overexpression of S100A9, a key regulator of inflammasome activation and pyroptosis. …”
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Metacavities by harnessing the linear-crossing metamaterials by Wu Jiaju, Guo Zhiwei, Qi Xin, Wei Qian, He Li, Fang Kai, Sun Yong, Li Yunhui, Chen Yuguang, Jiang Haitao, Chen Hong

“…When the defect or impurity exists inside the cavity, the formed cavity mode will be destroyed. Here, we propose a metacavity consisting of arrays of linear-crossing metamaterials (LCMMs) with abnormal dispersion, where each LCMM offers both the directional propagation channel for all incident angles and the negative refraction across its neighboring LCMMs. …”
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Pathogen delivery route impacts disease severity in experimental Mycoplasma ovipneumoniae infection of domestic lambs by Bryan Tegner Jacobson, Jessica DeWit-Dibbert, LaShae Zanca, Sobha Sonar, Carol Hardy, Michael Throolin, Patricia C. Brewster, Kaitlyn Andujo, Kerri Jones, Jonathon Sago, Stephen Smith, Lizabeth Bowen, Diane Bimczok

“…However, studies on both natural and experimental M. ovipneumoniae infection have reported highly variable clinical signs and pathology. Here, we assessed the impact of administering M. ovipneumoniae to the upper respiratory tract (URT) or to the lower respiratory tract (LRT) of two-month-old specific pathogen-free lambs. …”
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Pharmacological Mechanism of Zuojin Pill for Gastroesophageal Reflux Disease: A Network Pharmacology Study by Mi Lv, Jinke Huang, Jiayan Hu, Wenxi Yu, Ping Liu, Kunli Zhang, Fengyun Wang

“…Although Zuojin Pill (ZJP) is widely used in China as a traditional prescription to treat gastroesophageal reflux disease (GERD), its exact mechanism of action is still unknown. Therefore, we employed network pharmacology (NP), molecular docking (MD), and molecular dynamics simulation (MDS) to investigate the pharmacological mechanisms of ZJP against GERD. …”
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Changes in Methylation Patterns of Tumor Suppressor Genes during Extended Human Embryonic Stem Cell Cultures by Kyung Min Kang, Jeoung Eun Lee, Ji Eun Park, Hyunjin Kim, Hee Yeon Jang, Minyeon Go, Dong Ryul Lee, Sung Han Shim

“…While studies on embryonic stem cells have been actively conducted, little is known about the epigenetic mechanisms in human embryonic stem cells (hESCs) in extended culture systems. Here, we investigated whether CpG island (CGI) methylation patterns of 24 tumor suppressor genes could be maintained during extended hESC cultures. …”
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Hemodynamic disturbance and mTORC1 activation: Unveiling the biomechanical pathogenesis of thoracic aortic aneurysms in Marfan syndrome by Ming-Yuan Liu, Meili Wang, Junjun Liu, An-Qiang Sun, Chang-Shun He, Xin Cong, Wei Kong, Wei Li

“…Our investigation delves into the pivotal role of hemodynamic disturbance in the pathogenesis of TAA, with a particular emphasis on the mechanistic contributions of the mammalian target of rapamycin (mTOR) signaling cascade. We uncovered that activation of the mTOR complex 1 (mTORC1) within smooth muscle cells, instigated by the oscillatory wall shear stress (OSS) that stems from disturbed flow (DF), is a catalyst for TAA progression. …”
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Enhancing mechanical properties of (HfMoNbZrTa)1-xNx films through multi-phase structures in substoichiometric compositions by Yiming Ruan, Jigang Xie, Lin He, Fugui Zhang, Jie Shi, Hengning Hu, Yun Chen, Rui Shu, Liuquan Yang, Hao Du

“…The evolution of film structure is highly dependent on both selection and concentration of cation and anion elements. In this work, we utilized strong nitride-forming elements (Hf, Nb, Zr, and Ta) and the weak nitride-forming element Mo as the metallic cations in a multi-principal element nitride system. …”
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Molybdate delays sulphide formation in the sediment and transfer to the bulk liquid in a model shrimp pond by Torun, Funda, Hostins, Barbara, De Schryver, Peter, Boon, Nico, De Vrieze, Jo

“…Molybdate treatment is a promising strategy to inhibit sulphate reduction, thus, preventing sulphide accumulation. We used an experimental shrimp pond model to simulate the organic waste accumulation and sulphide formation during the final 61 days of a full shrimp growth cycle. …”
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Clinically oriented automatic three-dimensional enamel segmentation via deep learning by Wenting Yu, Xinwen Wang, Huifang Yang

“…This study aims to develop a deep learning work, 2.5D Attention U-Net, trained on small sample datasets, for the automatical, efficient, and accurate segmentation of enamel across all teeth in clinical settings. Methods We propose a fully automated computer-aided enamel segmentation model based on an instance segmentation network, 2.5D Attention U-Net. …”
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Physical Fruit Traits, Proximate Composition, Antioxidant Activity, and Profiling of Fatty Acids and Minerals of Wild Jujube (Ziziphus lotus L. (Desf.)) Fruits from Eleven Moroccan... by Hasna Ait Bouzid, El Hassan Sakar, Laila Bijla, Mohamed Ibourki, Ahmed Zeroual, Jamila Gagour, Jamal Koubachi, Khalid Majourhat, Saïd Gharby

“…TPC and TFC as well as antioxidant activity (ABTS, DPPH, and FRAP) were determined on four different extracts, namely, ethanol extract (EE), methanol extract (ME), acetone extract (AE), and water extract (WE). Our outcomes revealed significant differences (p<0.05) among different origins for the measured fruit traits including ash (1.69–2.31%), moisture (2.56–5.69%), proteins (2.63–4.64%), oil (1.59–2.91%) and carbohydrates (86.82–89.20%). …”
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Associations between Autoimmunity and Depression: Serum IL-6 and IL-17 Have Directly Impact on the HAMD Scores in Patients with First-Episode Depressive Disorder by Lijuan Mao, Xiajin Ren, Xin Wang, Feng Tian

“…The study is aimed at evaluating the immune-activation state before and after treatment in patients with first-episode depressive disorder (FDD) with evaluating the ILs and CRP levels and further clarifying the association between autoimmunity and the etiology and pathogenesis of FDD. Methods. We designed a case-control study. FDD patients and healthy subjects were enrolled in the FDD group and control group. …”
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Variations in the physicochemical properties of soil, enzyme activities, and the characteristics of bacterial communities within algal biocrusts and subsoils across different plant... by Haonian Li, Zhongju Meng, Xiaomen Ren, Yanlong Han

“…., Salix psammophila and Hedysarum scoparium), in the Hobq Desert, as well as from mobile sandy lands. We collected soil from the 0–2 cm (including the crust layer), 2–5 cm, and 5–10 cm soil layers, and measured and analyzed the soil physicochemical properties, enzyme activity and soil bacterial community characteristics. …”
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