Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis by Min Zhang, Wenting Su, Jiahui Deng, Bin Zhai, Gaizhi Zhu, Ran Gao, Qi Zeng, Jinming Qiu, Ziqing Bian, He Xiao, Guoming Luan, Renxi Wang

“…Results We identified 74 genome-wide significant loci for psoriasis. …”
Get full text

Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer by Luis Aparicio, Laura Crowley, John R. Christin, Caroline J. Laplaca, Hanina Hibshoosh, Raul Rabadan, Michael M. Shen

“…In the human prostate, we find substantial rewiring of transcriptional programs across epithelial cell types in benign prostate hyperplasia and treatment-naïve prostate cancer. …”
Get full text

Impaired cognitive function and decreased monoamine neurotransmitters in the DNAJC12 gene knockout mouse model by Shunan Wang, Ming Shen, Bo Pang, Bo Zhou, Yuan Yuan, Mei Lu, Xiangling Deng, Min Yang, Shufang Liu, Qiong Wang, Mei Xue, Qisheng Xia, Zhixin Zhang

“…Results We reported two patients with mutations in the DNAJC12 gene. …”
Get full text

Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery by Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa

“…Methods We build cell type-specific gene-drug perturbation networks from CMap data using a statistical procedure we call Quantile-based Instance Z-score Consensus (QUIZ-C). …”
Get full text

The Fate of the Interstellar Medium in Early-type Galaxies. V. Active Galactic Nucleus Feedback from Optical Spectral Classification by Oleh Ryzhov, Michał J. Michałowski, J. Nadolny, J. Hjorth, A. Leśniewska, M. Solar, P. Nowaczyk, C. Gall, T. T. Takeuchi

“…We find that strong AGNs can play a significant role in the ISM removal process only for galaxies with ages lower than 10 ^9.4 yr, but we cannot rule out the influence of weak AGNs at any age. …”
Get full text

Significance of supervision sampling in control of communicable respiratory disease simulated by a new model during different stages of the disease by Alphonse Houssou Hounye, Xiaogao Pan, Yuqi Zhao, Cong Cao, Jiaoju Wang, Abidi Mimi Venunye, Li Xiong, Xiangping Chai, Muzhou Hou

“…Furthermore, we calibrated the transmission and clearance rates by considering the impact of various control strategies on the epidemiological dynamics, which we used to project the future course of COVID-19. …”
Get full text

COSMIC’s Large-scale Search for Technosignatures during the VLA Sky Survey: Survey Description and First Results by C. D. Tremblay, J. Sofair, L. Steffes, T. Myburgh, D. Czech, P. B. Demorest, R. A. Donnachie, A. W. Pollak, M. Ruzindana, Siemion A. P. V., S. S. Varghese, S. Z. Sheikh

“…Developing algorithms to search through data efficiently is a challenging part of searching for signs of technology beyond our solar system. We have built a digital signal processing system and computer cluster on the backend of the Karl G. …”
Get full text

UltraTimTrack: a Kalman-filter-based algorithm to track muscle fascicles in ultrasound image sequences by Tim J. van der Zee, Paolo Tecchio, Daniel Hahn, Brent J. Raiteri

“…Methods We applied a Kalman filter to combine fascicle length and fascicle angle estimates from existing and openly-available UltraTrack and TimTrack algorithms into a hybrid algorithm called UltraTimTrack. …”
Get full text

The incidence of incomplete abortion and the prevalence of abortion-related morbidity in South African public hospitals, 2018 by D N Conco, J Levin, B Komane, K Blanchard, T Bessenaar, N G Nkosi, S Fonn

“…We wanted to compare our data with 2000 and 1994 survey results to assess change. …”
Get full text

Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis by Mariarita Spampinato, Cesarina Giallongo, Sebastiano Giallongo, Enrico La Spina, Andrea Duminuco, Lucia Longhitano, Rosario Caltabiano, Lucia Salvatorelli, Giuseppe Broggi, Elisabetta P. Pricoco, Vittorio Del Fabro, Ilaria Dulcamare, Antonio Massimo DI Mauro, Alessandra Romano, Francesco Di Raimondo, Giovanni Li Volti, Giuseppe A. Palumbo, Daniele Tibullo

“…Methods To test the involvement of lactate in MF milieu transformation, we measured its levels in MF patients’ sera, eventually finding a massive accumulation of this metabolite, which we showed to promote the expansion of immunosuppressive subsets. …”
Get full text

A Three-Stage-Concatenated Non-Linear MMSE Interference Rejection Combining Aided MIMO-OFDM Receiver and its EXIT-Chart Analysis by Jue Chen, Siyao Lu, Tsang-Yi Wang, Jwo-Yuh Wu, Chih-Peng Li, Soon Xin Ng, Robert G. Maunder, Lajos Hanzo

“…Based on this concept, we then design a novel NL equalizer relying on the Smart Ordering and Candidate Adding (SOCA) algorithm. …”
Get full text

Phytochemical analysis, antioxidant, anti-inflammatory and enzyme inhibitory activities of bean pear (Pyrus calleryana fruit) by Huan Zhao, Huan Zhao, Qinqin Wang, Lanlan Yang, Lanlan Yang, Yuanquan Ran, Qiong Hu, Yi Hong, Minyi Tian, Minyi Tian, Minyi Tian

“…The present study reported phytochemical constituents, antioxidant, anti-inflammatory, and enzyme inhibitory activities of P. calleryana fruit water extract (WE) and ethanol extract (EE). In the P. calleryana fruit WE and EE, 63 compounds were identified using UHPLC-Q-Orbitrap-MS analysis, including 23 phenols, 13 flavonoids, 14 terpenoids, and 13 other types of compounds. …”
Get full text

Promoting engagement in online learning beyond COVID‐19: Possible strategies and directions for future research by Khe Foon Hew, Weijiao Huang

“…For each of the three strategies, we provide a description with relevant empirical studies based on our own work as well as previous work in the literature and discuss possible directions for further research.…”
Get full text

Real Root Polynomials and Real Root Preserving Transformations by Suchada Pongprasert, Kanyarat Chaengsisai, Wuttichai Kaewleamthong, Puttarawadee Sriphrom

“…In this article, we give explicit forms of polynomials in Pn such that all of their roots are real. …”
Get full text

Melatonin Induces per1a Expression in Zebrafish Brain by Cher Ryn Lim, Zhen Xuen Brandon Low, Tomoko Sogo, Yatinesh Kumari

“…We have also demonstrated that an acute injection of melatonin in the middle of the subjective day induces per1a expression in zebrafish brain. …”
Get full text

Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma by Lawrence A. Shirley, Laura K. Aguilar, Estuardo Aguilar-Cordova, Mark Bloomston, Jon P. Walker

“…We detail the rationale behind this strategy and the many benefits it provides. …”
Get full text

Application of Evolutionary Algorithms and Statistical Analysis in the Numerical Optimization of an Axial Compressor by Alberto Clarich, Giovanni Mosetti, Valentino Pediroda, Carlo Poloni

“…For the simulation of the fluid flow through the machine, we have used a cluster of 12 processors.…”
Get full text

Dynamic Analysis of Beddington–DeAngelis Predator-Prey System with Nonlinear Impulse Feedback Control by Dezhao Li, Huidong Cheng, Yu Liu

“…Thirdly, we give the threshold conditions for the existence and stability of boundary periodic solutions and present the parameter analysis. …”
Get full text

A Total Variation Model Based on the Strictly Convex Modification for Image Denoising by Boying Wu, Elisha Achieng Ogada, Jiebao Sun, Zhichang Guo

“…We propose a strictly convex functional in which the regular term consists of the total variation term and an adaptive logarithm based convex modification term. …”
Get full text

Prosthetic Valve Candida Endocarditis: A Case Report with 18F-FDG-PET/CT as Part of the Diagnostic Workup by Soile Pauliina Salomäki, Antti Saraste, Päivi Jalava-Karvinen, Laura Pirilä, Ulla Hohenthal

“…We also refer to 5 other cases we found from the published literature. …”
Get full text