Mechanism of Action of Icariin in Bone Marrow Mesenchymal Stem Cells by Aofei Yang, Chaochao Yu, Qilin Lu, Hao Li, Zhanghua Li, Chengjian He

“…Bone regenerative therapy primarily relies on the bone marrow mesenchymal stem cells (BMSCs) and their ability to differentiate osteogenically. Icariin (ICA) is the active ingredient of Herba epimedii, a common herb used in traditional Chinese medicine (TCM) formulations, and can effectively enhance BMSC proliferation and osteogenesis. …”
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Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer’s Disease by Denglei Ma, Lihong Zhao, Li Zhang, Yali Li, Lan Zhang, Lin Li

“…Neural stem cell (NSC) transplantation has emerged as a promising therapeutic approach for treating AD. Icariin (ICA) is the main active component in Epimedium, a traditional Chinese herb. …”
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Evaluating the antifibrotic potential of naringenin, asiatic acid, and icariin using murine and human precision‐cut liver slices by Ke Luo, Yana Geng, Dorenda Oosterhuis, Vincent E. deMeijer, Peter Olinga

“…This study investigated the antifibrotic potential of naringenin (NRG), asiatic acid (AA), and icariin (ICA) using murine and human precision‐cut liver slices (PCLS). …”
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A Natural Flavonoid Glucoside, Icariin, Regulates Th17 and Alleviates Rheumatoid Arthritis in a Murine Model by Liqun Chi, Wenyuan Gao, Xiangrong Shu, Xin Lu

“…A recent study showed that icariin suppressed cartilage and bone degradation in mice of collagen-induced arthritis. …”
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Retraction Note: Bone-targeting drug delivery system of biomineral-binding liposomes loaded with icariin enhances the treatment for osteoporosis by Xiaoduan Sun, Jun Wei, Jiayao Lyu, Tierong Bian, Zhongbing Liu, Juan Huang, Fengjuan Pi, Chunhong Li, Zhirong Zhong

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Slowly Delivered Icariin/Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells to Promote the Healing of Calvarial Critical-Size Bone Defects by Tianlin Liu, Xin Zhang, Yuan Luo, Yuanliang Huang, Gang Wu

“…Icariin that was adsorbed onto the SMC-PHBHHx scaffold showed a slow release profile within a 2-week monitoring span. …”
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Correction: Fahmy et al. Optimized Icariin Cubosomes Exhibit Augmented Cytotoxicity against SKOV-3 Ovarian Cancer Cells.... by Usama A. Fahmy, Omar Fahmy, Nabil A. Alhakamy

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Investigation of the osteogenic effects of ICA and ICSII on rat bone marrow mesenchymal stem cells by Zhangshun Yao, Weixiang Huang, Yan Yang, Leiyan Zou, Yunpeng Zhang, Jing Zhang, Guangming Luo

“…Abstract Icariin (ICA) serves as the primary biologically active compound in traditional Chinese medicine Epimedium, while Icariside II (ICSII) represents one of its gastrointestinal metabolites. …”
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Content Determination of Active Component in Huangqi Yinyanghuo Group and Its Effects on hTERT and Bcl-2 Protein in Osteosarcoma by Ying Tan, Lei Tan, Shuai Huang, Junfan Lu, Longtan Yu

“…To screen the optimal extraction process and content determination of active component of Huangqi Yinyanghuo group (HYG) and to study the effects of HYG on human telomerase reverse transcriptase (hTERT) and Bcl-2 protein in osteosarcoma (HOS) cells, providing the theoretical basis for clinical application of HYG in treatment of osteosarcoma, orthogonal design table L9(43) was used to design the extraction process of HYG, and icariin was taken as the investigation index to optimize the extraction process of HYG. 0.125, 0.25, 0.5, 1, 2, 4, and 8 μmol/L HYG were taken to act separately on logarithmic growth phase osteosarcoma HOS cells, CCK-8 assay was used to determine cell viability, and immunohistochemical SP assay was used to determine the expression of hTERT and Bcl-2 protein. …”
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Quality Evaluation of Traditional Chinese Medicine Prescription in Naolingsu Capsule Based on Combinative Method of Fingerprint, Quantitative Determination, and Chemometrics by Lili Xu, Yang Jiao, Weiliang Cui, Bing Wang, Dongxiao Guo, Fei Xue, Xiangrong Mu, Huifen Li, Yongqiang Lin, Huibin Lin

“…Rehmannioside D (RD), methylophiopogonanone A (MPA), 3,6′-disinapoyl sucrose (DS), schisandrin B (SSB), epimedin C (EC), icariin (ICA), and jujuboside B (JB) were considered as the potential chemical markers for NLSC quality control. …”
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