Regulation and Mechanism of miR-518d through the PPARα-Mediated NF-κB Pathway in the Development of Gestational Diabetes Mellitus by Hui Qiu, Xuemin Liu, Shenshen Yao, Jiaren Zhou, Xue Zhang, Juan Du

“…In this study, mouse GDM models were established to further prove the previous hypothesis with an in vivo experiment. A total of 40 C57BL/6J mice were randomly divided into the following groups: normal diet group (ControlMs), GDM group (GDMMs group), GDM+miR-518d antagomir group, and GDM+miR-518d antagomir+PPARα antagonist group. …”
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Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics by Grant McGee Talkington, Grant McGee Talkington, Paresh Kolluru, Timothy E. Gressett, Timothy E. Gressett, Saifudeen Ismael, Umar Meenakshi, Mariana Acquarone, Rebecca J. Solch-Ottaiano, Amanda White, Blake Ouvrier, Blake Ouvrier, Kristina Paré, Nicholas Parker, Amanda Watters, Nabeela Siddeeque, Brooke Sullivan, Nilesh Ganguli, Victor Calero-Hernandez, Gregory Hall, Michele Longo, Gregory J. Bix, Gregory J. Bix, Gregory J. Bix, Gregory J. Bix

“…In this review, we explore the mechanistic hypotheses of these neurological changes, which describe CNS invasion, neuroinflammation, blood-brain barrier disruption, and gut-brain axis dysregulation, along with the novel vascular disruption hypothesis that highlights endothelial dysfunction and hypoperfusion as a core underlying mechanism. …”
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Safety and efficacy of catheter ablation in atrial fibrillation patients with heart failure with preserved ejection fraction by Songbing Long, Yuanjun Sun, ShiYu Dai, Xianjie Xiao, Zhongzhen Wang, Wei Sun, Lianjun Gao, Yunlong Xia, Xiaomeng Yin

“…However, previous studies have been limited by a lack of control groups and significant heterogeneity in their methodologies. Hypothesis CA for AF in HFPEF patients may not increase the complications and had similarly the rate of freedom from AF vs. patients without HFPEF, and it may reduce hospitalizations and mortality and improve heart function VS medical treatment. …”
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How mechanochemistry affects the composition and properties of disordered fluorite BaSnF4? by Mercadier, Briséïs, Legein, Christophe, Duttine, Mathieu, Body, Monique, Gutierrez, Ana Gabriela Porras, Leclerc, Sandrine, Lebedev, Oleg,  Masquelier, Christian, Dambournet, Damien

“…We hypothesized that this new environment originates from the formation of an anion-excess fluorite-type phase $\mathrm{BaSn}_{1-x}^{(\mathrm{II})}\mathrm{Sn}_{x}^{(\mathrm{IV})}\mathrm{F}_{4}\mathrm{O}_{x}$ induced by prolonged milling. Such a hypothesis is supported by the occurrence of fluoride ions located within octahedral sites, which are likely to be bound to Sn(IV) resulting to their lower mobility as shown by 19F solid-state NMR. …”
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Les réseaux d’alimentation en eau des pentes de la Croix-Rousse et de la presqu’île de Lyon by Jules Ramona

“…In the absence of a pressurised water system, the hypothesis of a complementary water supply for this sector is seems plausible.…”
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Persistent organochlorine pesticides and cardiometabolic outcomes among middle-aged Latina women in a California agricultural community: The CHAMACOS Maternal Cognition Study by Marcella Warner, Stephen Rauch, Brenda Eskenazi, Lucia Calderon, Robert B. Gunier, Katherine Kogut, Nina Holland, Weihong Guo, Julianna Deardorff, Jacqueline M. Torres

“…In addition, we provide new evidence suggesting associations with biomarkers of blood pressure, insulin resistance, dyslipidemia and inflammation, supporting the hypothesis that exposure may have long-term influences on cardiovascular disease risk.…”
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Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study by J. Furuzawa-Carballeda, D. Aguilar-León, A. Gamboa-Domínguez, M. A. Valdovinos, C. Nuñez-Álvarez, L. A. Martín-del-Campo, A. B. Enríquez, E. Coss-Adame, A. E. Svarch, A. Flores-Nájera, A. Villa-Baños, J. C. Ceballos, G. Torres-Villalobos

“…The loss of myenteric plexus associated with inflammatory infiltrates and autoantibodies support the hypothesis of an autoimmune mechanism. Thirty-two patients diagnosed by high-resolution manometry with achalasia were included. …”
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Harnessing new mHealth technologies to Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam (V-SMART trial): a protocol for a randomised controlled trial by Ben J Marais, Joel Negin, James Johnston, Virginia Wiseman, Greg J Fox, Thu Anh Nguyen, Binh Hoa Nguyen, Viet Nhung Nguyen, Justin Beardsley, Guy Barrington Marks, Kavindhran Velen, Tho Dang, Hoang Anh Nguyen, Dinh Hoa Vu, Thu Thuong Do, Cuong Pham Duc, Huu Lan Nguyen, Huu Thuong Pham, Warwick Britton

“…This trial will test the hypothesis that an mHealth intervention can improve treatment success among patients with MDR-TB and is cost-effective compared with standard practice.Methods and analysis A community-based, open-label, parallel-group randomised controlled trial will be conducted among patients treated for MDR-TB in seven provinces of Vietnam. …”
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Microbiota, parasitic infections and their relationship with nutritional status and neurocognitive functioning in children from Ecuador—Proyecto Guagua: research protocol for a cro... by Sandra Victoria Abril-Ulloa, Tannia Valeria Carpio-Arias, Renata Alejandra Alvarado-Barba, Cristina Gabriela Ríos-Romero, Pamela Vinueza-Veloz, Sueny Paloma Lima-dos-Santos, Sueny Paloma Lima-dos-Santos, Igor Eduardo Astudillo-Skliarova, Igor Eduardo Astudillo-Skliarova, Ruth Irene Arias-Gutiérrez, Manuel Pérez-Quintana, Henk-Jan Boele, Henk-Jan Boele, Henk-Jan Boele, María Fernanda Vinueza-Veloz

“…We also plan to test the hypothesis that an altered microbiota mediates the influence of malnutrition on neurocognitive functioning and parasitosis.Ethics and disseminationProyecto Guagua received ethical approval from the Ethics Committee of Universidad de Cuenca in July 2022. …”
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Assessing the feasibility of measuring residents’ quality of life in English care homes and the construct validity and internal consistency of measures completed by staff proxy: a... by Claire Goodman, Julienne Meyer, Karen Spilsbury, Barbara Hanratty, Rachael Carroll, Adam L Gordon, Gizdem Akdur, Anne Killett, Jennifer Burton, Ann-Marie Towers, Stacey Rand, Nick Smith, Sinead Palmer, Stephen Allan, Lucy Anne Webster

“…Objectives To assess the feasibility of capturing older care home residents’ quality of life (QoL) in digital social care records and the construct validity (hypothesis testing) and internal consistency (Cronbach’s alpha) of four QoL measures.Design Cross-sectional data collected in wave 1 of the DACHA (Developing resources And minimum dataset for Care Homes’ Adoption) study, a mixed-methods pilot of a prototype minimum dataset (MDS).Setting Care homes (with or without nursing) registered to provide care for older adults (>65 years) and/or those living with dementia. …”
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Les techniques de construction du second forum de Bavay (Nord) : utilisation, origine et datation des matériaux en terre cuite by Xavier Deru, Christine Louvion

“…Apart from the souterrain parts of the cryptoporticus, the conservation status of the elevations is poor; they only reach heights of 1 to 2 m in certain sectors. However, a hypothesis of reconstruction with a model of architectural information was initiated during a mediation project (Cyberforum) and updated in the scope of this article.The forum underwent two main phases, which extended over the same surface, but present several differences; the detailed layout of the areas, elevations, and especially construction techniques; the second phase introduced the use of levelling courses of bricks in low walls. …”
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Biochar effects on durum wheat (Triticum durum) under ambient and elevated atmospheric CO2 by Lorenzo Brilli, Franz-Werner Badeck, Lorenzo Genesio, Silvia Baronti, Fulvia Rizza, Clara Fares, Luigi Cattivelli, Franco Miglietta, Anita Maienza, Alessandro Zaldei, Federica Camin, Rosella Motzo, Piero Toscano

“…The use of biochar as amendment, thanks to its well-known ability to improve soil fertility and crop production and quality, could be a suitable solution to cope with the negative effect of e[CO2] on qualitative traits. To test this hypothesis, we present the results of an open field experiment investigating the combined effects of biochar application and e[CO2] on quantitative and qualitative performance of two commercial durum wheat (Triticum durum) cultivars (Aureo and Claudio). …”
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Biological embodiment of educational attainment and future risk of breast cancer: findings from a French prospective cohort by Cyrille Delpierre, Raphaële Castagné, Eloïse Berger, Gianluca Severi, Marie-Christine Boutron-Ruault, Laura Baglietto, Laure Dossus, Amandine Gelot, Richard Dudouet

“…Many studies support the hypothesis that education has a distinctive effect on physiological processes associated with health, independently of known risk factors.Objectives In this study, we aimed to determine whether the biological embodiment of education could be part of the observed social inequalities in BC risk. …”
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L’ensemble monumental du Pâtis à Vieillevigne (Loire-Atlantique) : un nouvel exemple de complexe sur cour laténien en Gaule by Yann Dufay-Garel, Marie Grall, Sandrine Paradis-Grenouillet, Rémy Wassong

“…We therefore advance the hypothesis that the foundation dates from before this period, probably sometime in the 3rd century BC. …”
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Lipoleiomyoma of the uterus in a woman of reproductive age (clinical case) by V.V. Talash, Ya.V. Palyokha, A.M. Gromova, V.V. Talash, V.B. Martynenko, N.O. Prylutska, N.I. Mityunina

“…Im­munohistochemically, a positive reaction for caldesmon, desmin, smooth muscle actin alpha of tumor cells and for S.100 (DAKO, polyclonal) fatty cells was detected, which confirmed the hypothesis of direct transformation of smooth muscle cells existing in the leiomyoma of the uterus into fatty cells. …”
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Phenotypic and Complete Reference Whole Genome Sequence Analyses of Two <i>Paenibacillus</i> spp. Isolates from a Gray Wolf (<i>Canis lupus</i>) Gastrointestinal Tract by Jessika L. Bryant, Jennifer McCabe, C. Cristoph Klews, MiCayla Johnson, Ariel N. Atchley, Thomas W. Cousins, Maya Barnard-Davidson, Kristina M. Smith, Mark R. Ackermann, Michael Netherland, Nur A. Hasan, Peter A. Jordan, Evan S. Forsythe, Patrick N. Ball, Bruce S. Seal

“…WGS analyses and phenotypic assays supported the hypothesis that the isolates described constitute two novel candidate probiotic bacteria for potential use in dogs.…”
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Pengaruh Kebisingan Lalulintas terhadap Konsentrasi Belajar Siswa SMP N 1 Padang by Amwal Halil, Amel Yanis, Mustafa Noer

“…Learning concentration level of student was measured by using digit symbol test and digit span test. Hypothesis analysis was done by chi square test with 95% of confidence level (p = 0.05). …”
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Behaviour of the Foramen Ovale Flow in Fetuses with Intrauterine Growth Restriction by Ângela R. L. Nader, Paulo Zielinsky, Alexandre Antonio Naujorks, Luiz Henrique S. Nicoloso, Antonio Luiz Piccoli Junior, Natássia Miranda Sulis, Luiza Ferreira van der Sand, Victoria de Bittencourt Antunes, Gabriela dos Santos Marinho, Fernanda Greinert dos Santos, Natan Pereira Gosmann, Eduardo Becker Júnior, Renato Frajndlich, Tamara Beherens, Marcelo Brandão da Silva, Caroline Barbisan, Stefano Busato, Mauro Lopes, Caroline Klein

“…This study was designed to test this hypothesis. Methods. Forty pregnant women (24–38 weeks) were divided into 3 groups: group I (IUGR), group II (adequate growth and maternal hypertension), and group III (normal controls). …”
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Effectiveness of Massive Open Online Course on Risk Communication Knowledge in Global Health Emergencies Among Nurses by Khin Thandar Aung, Rafiza Abdul Razak, Muhammad Fadli Zulkafley

“…Consequently, the alternate hypothesis (HA) is accepted, signifying a substantial improvement in nurses' knowledge of risk communication in global health emergencies. …”
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Prognostic utility of neutrophil gelatinase-associated lipocalin (NGAL) levels for cardiovascular events in patients with stable coronary artery disease treated with percutaneous c... by Ting-Yu Lin, Hsin-Bang Leu, Yen-Wen Wu, Wei-Kung Tseng, Tsung-Hsien Lin, Hung-I Yeh, Kuan-Cheng Chang, Ji-Hung Wang, Wei-Hsian Yin, Chau-Chung Wu, Chun-Yao Huang, Shing-Jong Lin, Chien-Yi Hsu, Jaw-Wen Chen

“…Furthermore, no significant prognostic predictive value between NGAL levels and stable CAD has been established. Hypothesis We aimed to investigate the prognostic role of NGAL levels in a prospective cohort study of patients with stable CAD treated with percutaneous coronary intervention (PCI). …”
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