Investigating the dual causative pathways linking immune cells and venous thromboembolism via Mendelian randomization analysis by Ning Qi, Zhuochen Lyu, Lu Huang, Yun Zhao, Wan Zhang, Xinfeng Zhou, Yang Zhang, Jiasen Cui

“…While this study is exploratory and needs validation, the findings of this study are hypothesis-generating with resect to the mechanisms underlying VTE and encourage further investigation into the role of immune activity in VTE pathology. …”
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Entre espaces domestiques et « espaces domestiqués » : « L’autonomisation intime » des étudiantes en Turquie by Tuğba Gökduman

“…The article makes the hypothesis that this mobility into the city, which is considered at first sight as an escape from the dominant sexual norms and from parental control, does not however mean a linear journey towards sexual emancipation. …”
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The Interpretation is the Message. Komposition als angewandte Interpretation bei György Kurtág by Tom Rojo Poller

“…Taking its cue from Kurtág’s remark that his composing is essentially motivated by his notion of interpretation, the present text assumes that the category of interpretation could be a key to open up new analytical perspectives on Kurtág’s compositions. This hypothesis is pursued in two methodical steps. First, the category of interpretation is conceptually unfolded by dissecting prominent aspects of Kurtág’s work which can be associated with a broad understanding of interpretation. …”
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Smartphone-Based Intervention Targeting Norms and Risk Perception Among University Students with Unhealthy Alcohol Use: Secondary Mediation Analysis of a Randomized Controlled Tria... by Joseph Studer, John A Cunningham, Elodie Schmutz, Jacques Gaume, Angéline Adam, Jean-Bernard Daeppen, Nicolas Bertholet

“… BackgroundMany digital interventions for unhealthy alcohol use are based on personalized normative feedback (PNF) and personalized feedback on risks for health (PFR). The hypothesis is that PNF and PFR affect drinkers’ perceptions of drinking norms and risks, resulting in changes in drinking behaviors. …”
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Athletic Shoulder Test Differences Exist Bilaterally in Healthy Pitchers by Aaron Trunt, Brandon T. Fisher, Lisa N. MacFadden

“…The Athletic Shoulder (ASH) test has been proposed as a reliable measure of shoulder strength, but has not yet been studied in baseball pitchers. # Hypothesis/Purpose The purpose of this study was to establish values for healthy baseball pitchers performing the ASH test, compare those values with other common tests of shoulder strength and function, and compare ASH test performance bilaterally. …”
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Comparison of the Journey II bicruciate stabilised (JII-BCS) and GENESIS II total knee arthroplasty for functional ability and motor impairment: the CAPAbility, blinded, randomised... by Allan B Clark, Toby O Smith, J Wells, Iain McNamara, Juliet High, Ann Marie Swart, Valerie Pomeroy, Graham Creelman, Celia Whitehouse, B Harry, Celia Clarke

“…The OKS scores for the JII-BCS and Genesis II groups were mean (SD) 42.97 (5.21) and 43.13 (5.20) respectively, adjusted effect size 0.35 (-2.01,2.71) p=0.771In secondary outcome measures, the Genesis II group demonstrated a significantly greater walking range-of-movement (50.62 (7.33) vs 46.07 (7.71) degrees, adjusted effect size, 3.14 (0.61,5.68) p=0.02) and higher peak knee flexion angular velocity during walking (mean (SD) 307.69 (38.96) vs 330.38 (41.40) degrees/second, adjusted effect size was 21.75 (4.54,38.96), p=0.01) and better postural control (smaller resultant centre of path length) during quiet standing than the JII-BCS group (mean (SD) 158.14 (65.40) vs 235.48 (176.94) mm, adjusted effect size, 59.91 (–105.98, –13.85) p=0.01.).Conclusions In this study population, the findings do not support the hypothesis that the Journey II BCS produces a better outcome than the Genesis II for the primary outcome of the OKS at 6 months after surgery.Trial registration number ISRCTN32315753.…”
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Early Electroacupuncture Extends the rtPA Time Window to 6 h in a Male Rat Model of Embolic Stroke via the ERK1/2-MMP9 Pathway by Xin-chang Zhang, Ya-hui Gu, Wen-tao Xu, Yang-yang Song, Ao Zhang, Zhi-hui Zhang, Si-yuan Jiang, Si-qi Chang, Guang-xia Ni

“…The present study was conducted to test the hypothesis that EA extends the therapeutic time window of rtPA for ischemic stroke in a male rat model of embolic stroke. …”
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Engagement féminin en Kabylie et intersection des revendications (1980-2001). Dominations, expériences et négociations identitaires by Margherita Rasulo

“…Particular attention is given to the association Tiɣri n’Ttmeṭṭut, active from 1989 to 1995, and the Black Spring Women’s Collective, active since 2001.The hypothesis of the article is that women’s movements and identity movements are part of a relationship of both tension and complementarity, with each generating reciprocal consequences, the scope of which we try to measure in particular for women, who are minoritised among the minorities. …”
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Pseudovibriamides from Pseudovibrio marine sponge bacteria promote flagellar motility via transcriptional modulation by Yitao Dai, Vitor Lourenzon, Laura P. Ióca, Dua Al-Smadi, Lydia Arnold, Ian McIntire, Roberto G. S. Berlinck, Alessandra S. Eustáquio

“…Here, we define the borders of the pseudovibriamides gene cluster, assign function to biosynthetic genes using reverse genetics, and test the hypothesis that pseudovibriamides impact motility by modulating gene transcription. …”
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Genetic background and microbiome drive susceptibility to epicutaneous sensitization and food allergy in adjuvant-free mouse model by Tereza Hornikova, Anna Jelinkova, Zuzana Jiraskova Zakostelska, Tomas Thon, Stepan Coufal, Andrea Polouckova, Eliska Kopelentova, Miloslav Kverka, Peter Makovicky, Helena Tlaskalova-Hogenova, Anna Sediva, Martin Schwarzer, Dagmar Srutkova

“…BackgroundThe dual allergen exposure hypothesis states that sensitization to food antigens occurs through a damaged skin barrier in individuals with no previous oral tolerance to certain foods. …”
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Psychological peculiarities of professional development in late adulthood by E. F. Zeer, E. E. Symanyuk, A. A. Ryabukhina, G. I. Borisov

“…Correlation analysis confirmed the research hypothesis about the correlation between the quality of life and work motivation with the characteristics of professional development. …”
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Reims/Durocortorum, ville gauloise ? Hypothèses pour une nouvelle problématique des origines de l’agglomération by Robert Neiss

“…This in turn explains why the hypothesis of an ancient sanctuary previously occupying the same site as the impressive Roman one, allows us to decipher a reality that is otherwise difficult to understand. …”
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Comparative cardiometabolic safety and effectiveness of aripiprazole in people with severe mental illness: A target trial emulation. by Alvin Richards-Belle, Alvin Richards-Belle, Naomi Launders, Sarah Hardoon, Al Richards, Kenneth K C Man, Neil M Davies, Elvira Bramon, Joseph F Hayes, David P J Osborn

“…We investigated the hypothesis that aripiprazole has a favourable cardiometabolic profile, but similar effectiveness when compared to olanzapine, quetiapine, and risperidone.…”
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The effect of single and dual task training on the intracortical inhibition in young and old adults by Michael Wälchli, Craig Tokuno, Benedikt Lauber, Wolfgang Taube

“…More interestingly, intracortical inhibition was upregulated in young and downregulated in old, indicating age-specific adaptations in SICI following a comparable training protocol. Based on the hypothesis that intracortical inhibition decreases during initial motor learning and increases in later stages, we hypothesize that a training duration of 3 weeks is sufficient to induce positive cortical modulation in young adults but not in older adults. …”
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Les zones de production du fer en Bourgogne-Franche-Comté : une approche sur la longue durée par le radiocarbone by Marion Berranger, Marc Leroy, Hervé Laurent

“…Grouping of production for the Roman period is revealed to have been vastly different from the long-envisaged hypothesis of an activity dispersed over a large north-eastern quarter of France. …”
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Inducible engineering precursor metabolic flux for synthesizing hyaluronic acid of customized molecular weight in Streptococcus zooepidemicus by Rui Zhao, Jun Li, Yingtian Li, Xujuan Pei, Jingyi Di, Zhoujie Xie, Hao Liu, Weixia Gao

“…In contrast, SE2, utilizing the weaker promoter PR22, synthesized shorter HA with a MW of 1.63 MDa, thereby verifying the hypothesis. Finally, to precisely regulate HA MW according to specific demands, an efficient sucrose-induced expression system was screened and employed to control the transcription level of hasE, obtaining recombinant strain SE3. …”
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Mortality Prediction Using SaO2/FiO2 Ratio Based on eICU Database Analysis by Sharad Patel, Gurkeerat Singh, Samson Zarbiv, Kia Ghiassi, Jean-Sebastien Rachoin

“…S/F was a stronger predictor of mortality than P/F based upon feature importance evaluation of our data. Our study is hypothesis-generating and a prospective evaluation is warranted. …”
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Presenting the professional thinking model of employees based on the dimensions of ambivalence and psychological empowermen by Abdolmajid Kord, Mansur Garkaz, Alireza Maetoofi, Ali khuzin, Alireza Hasan Maleki

“…The research method is applicable in terms of its purpose, hypothesis-deductive in terms of the approach, and descriptive-exploratory in terms of the research implementation method. …”
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Hepatitis B Virus in Polish Blood Donors in the Period 2005–2019—Significant Changes in Epidemiology and Demographic Characteristics of Infected Donors by Aneta Kopacz, Dorota Kubicka-Russel, Grzegorz Liszewski, Ewa Sulkowska, Anna Chrzanowska, Paulina Zwolińska, Ewa Noceń, Anna Potępa, Magdalena Łętowska, Piotr Grabarczyk, the Group of Polish Blood Transfusion Centers for Blood Borne Pathogens

“…Confirmation of this hypothesis by the analysis of residual risk should be a subject of further studies.…”
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Association of pituitary neuroendocrine tumors and neurofibromatosis type 1: assessing causation versus coincidence. Case report by Mercedes Aguilar-Soto, Julia M. Zuarth-Vázquez, Laura Leyva-Figueroa, Karla Zarco-Ávila, Armando Gamboa-Domínguez, Aldo Eguiluz-Melendez, Laura C. Hernández-Ramírez

“…NF1 could drive pituitary tumorigenesis via haploinsufficiency, but this hypothesis requires further research. Additional clinical and molecular data from large cohorts of affected individuals should help clarify this question.…”
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