Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences by Gregory C. Antell, Will Dampier, Benjamas Aiamkitsumrit, Michael R. Nonnemacher, Vanessa Pirrone, Wen Zhong, Katherine Kercher, Shendra Passic, Jean Williams, Yucheng Liu, Tony James, Jeffrey M. Jacobson, Zsofia Szep, Brian Wigdahl, Fred C. Krebs

“…Vpr is an HIV-1 accessory protein that plays numerous roles during viral replication, and some of which are cell type dependent. To test the hypothesis that HIV-1 tropism extends beyond the envelope into the vpr gene, studies were performed to identify the associations between coreceptor usage and Vpr variation in HIV-1-infected patients. …”
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Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentr... by Patrizia Bruzzi, Maria Francesca Messina, Alessandra Bartoli, Barbara Predieri, Laura Lucaccioni, Simona Filomena Madeo, Alberto Verrotti, Filippo De Luca, Lorenzo Iughetti

“…CPP in CP seems to progress rapidly along time supporting the hypothesis of a more intense activation of hypothalamic-pituitary-gonadal-axis in these patients.…”
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The Battle of Žalgiris / Grunwald: Unanswered Questions by Alfredas Bumblauskas

“… The aim of the article is, on the basis of the hints found in the sources and Sven Ekdahl's hypothesis, to look at the battle of Žalgiris (Grunwald) as a typical fight of medieval knights, the conceptions of the nature of which in historiography, ignoring the issues of tactics, are obviously outdated. …”
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Examining the Effect of Prototypical Leadership Style on Leader Effectiveness: Mediating role of Perceived Integrity and Moderating Role of Leader-leader Exchange by Elham Ebrahimi, SHabnam Zarjou

“…Results Research hypotheses were confirmed except for the first hypothesis. The results of the research data analysis showed that prototypical leadership does not have a significant direct effect on the leader's effectiveness, but this relationship is established through the mediating role of the leader's perceived integrity. …”
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How does the first index mode of birth in public or private hospitals predict subsequent births? A 16-year Australian population-based linked data study by Soo Downe, Hannah G Dahlen, Ank de Jonge, Lilian Peters, Michiel de Boer

“…With our aim, we have an innovative approach, specifically the women’s life course approach, which is hypothesis-generating and can be assessed in future studies.Design, setting and participants New South Wales population-linked data of low-risk women were analysed (2001–2016). …”
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Towards quantitative reconstruction of past monsoon precipitation based on tetraether membrane lipids in Chinese loess by J. Guo, J. Guo, M. Ziegler, L. Fuchs, Y. Sun, F. Peterse

“…At the precession scale, the DC record is in phase with <span class="inline-formula"><i>δ</i>²</span>H<span class="inline-formula">_wax</span> from the same section and the speleothem <span class="inline-formula"><i>δ</i>¹⁸</span>O record, which supports the hypothesis that monsoon precipitation is driven by Northern Hemisphere summer insolation.…”
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Large-scale spatio-temporal variation in vital rates and population dynamics of an alpine bird by Nater, Chloé R., Frassinelli, Francesco, Martin, James A., Nilsen, Erlend B.

“…While there was variation in the magnitude of the effect small rodent occupancy had on recruitment, the relationships were predominantly positive and thus consistent with the alternative prey hypothesis. Notably, the accurate estimation of covariate effect was only made possible by integrating data from several monitoring areas for analysis. …”
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Comparison of brain activity metrics in Chinese and Russian students while perceiving information referencing self or others by Q. Si, J. Tian, V. A. Savostyanov, D. A. Lebedkin, A. V. Bocharov, A. N. Savostyanov

“…Using this module, brain electrical activity (EEG) indicators reflecting individual characteristics of recognition of information related to oneself and other people were compared between groups of 30 Chinese (14 men and 16 women, average age 23.2 ± 0.4 years) and 32 Russian (15 men, 17 women, average age 22.1 ± 0.4 years) participants. We tested the hypothesis that differences in brain activity in functional rest intervals between Chinese and Russian participants depend on their psychological differences in collectivism scores. …”
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Innate Immune Responses Associated with Resistance against Haemonchus contortus in Morada Nova Sheep by João Henrique Barbosa Toscano, Cintia Hiromi Okino, Isabella Barbosa dos Santos, Luciana Aparecida Giraldelo, Marei Borsch von Haehling, Sérgio Novita Esteves, Ana Carolina de Souza Chagas

“…The exacerbated proinflammatory response observed in susceptible animals, at both local and systemic levels, may be a consequence of high H. contortus parasitism. This hypothesis is corroborated by the higher blood levels of TNFα before the onset of infection, which probably remained elevated from the previous parasitic challenges. …”
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Association between neutrophil-to-eosinophil ratio and efficacy outcomes with avelumab plus axitinib or sunitinib in patients with advanced renal cell carcinoma: post hoc analyses... by Brian Rini, Mariangela Mariani, Alessandra di Pietro, Paul Nathan, Christian Kollmannsberger, Marc-Oliver Grimm, Martin H Voss, Bradley A McGregor, Mehmet A Bilen, Yoshihiko Tomita, Bo Huang, Robert Amezquita, Matthew Tucker, Yu-Wei Chen

“…Interaction tests that assessed the association between treatment and NER yielded conflicting results when NER was assessed as a dichotomised variable (median cut-off) or continuous variable.Conclusion Hypothesis-generating analyses suggest that baseline NER may be prognostic for longer OS irrespective of treatment. …”
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Heavy metal contamination in freshwater habitats impairs the growth and reproductive health of wild spotted snakehead Channa punctata (Channidae) in Bangladesh by Imran Parvez, Sharmin Ahmed, Nazifa Tasnim, Rubaiya Pervin, Md Ashraful Alam, Md Nasir Khan, Yeasmin Ara, Harunur Rashid, Siriporn Pradit

“…This study evaluated the hypothesis of whether heavy metal contamination in aquatic habitats impacts fish growth and reproduction using wild Channa punctata as an experimental animal. …”
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Risk Factors for Fracture in Patients with Coexisting Chronic Kidney Disease and Type 2 Diabetes: An Observational Analysis from the CREDENCE Trial by Tamara K. Young, Nigel D. Toussaint, Gian Luca Di Tanna, Clare Arnott, Carinna Hockham, Amy Kang, Aletta E. Schutte, Vlado Perkovic, Kenneth W. Mahaffey, Rajiv Agarwal, George L. Bakris, David M. Charytan, Hiddo J. L. Heerspink, Adeera Levin, Carol Pollock, David C. Wheeler, Hong Zhang, Meg J. Jardine

“…The goodness of fit of the various hypothesis sets was similar (AIC range 1870.92–1849.51, SBC range 1875.60–1948.04). …”
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Plasma prolactin axis shift from placental to pituitary origin in late prepartum mice by Taku James Sairenji, Shinnosuke Masuda, Yuya Higuchi, Mitsue Miyazaki, Hiroyuki Yajima, Oh Kwan Ee, Yuki Fujiwara, Takuya Araki, Noriaki Shimokawa, Noriyuki Koibuchi

“…To investigate this hypothesis and to seek proteomic changes, we performed a shotgun proteome analysis of the placental tissue using data-independent acquisition mass spectrometry (DIA-MS). …”
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Can enhanced CSR quality reduce the cost of debt capital? An empirical analysis of CEO expertise and non-financial reporting practices in China by Oleh Pasko, Yang Zhang, Nelia Proskurina, Vadym Sapych, Yelyzaveta Mykhailova

“…The results obtained indicate that higher CSR quality significantly correlates with a lower cost of debt capital, supporting the hypothesis that improved CSR disclosure reduces perceived credit risk. …”
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The mediating effect of the budget process on the performance of small- and medium-sized enterprises in Ho Chi Minh City, Vietnam by Vuong Khanh Tuan, Premkumar Rajagopal

“…Structural equation modelling (SEM) was used to test both the conceptual framework and the hypothesis of the real study. This study was conducted from October 2016 to June 2020. …”
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A Novel, Patient-Specific Mathematical Pathology Approach for Assessment of Surgical Volume: Application to Ductal Carcinoma in situ of The Breast by Mary E. Edgerton, Yao-Li Chuang, Paul Macklin, Wei Yang, Elaine L. Bearer, Vittorio Cristini

“…We then corroborated our hypothesis by comparing the predicted size of each tumor based on our model with the actual size of the pathological specimen after tumor excision (R2 = 0.74—0.88). …”
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Model Evaluasi Usability Menggunakan Confirmatory Factor Analysis pada KRS Online by Endah Ratna Arumi, Pristi Sukmasetya, Agus Setiawan

“…The results of the model test the hypothesis that there is one there is no positive influence between the variables easily receive detailed and specific information about KRS online, with respondents able to understand the contents and the contents of the information displayed on KRS online with ease. …”
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Knowledge, Attitude, and Associated Factors towards Physical Assessment among Nurses Working in Intensive Care Units: A Multicenter Cross-Sectional Study by Bikis Liyew, Ambaye Dejen Tilahun, Tilahun Kassew

“…To assess knowledge, attitude, and associated factors towards physical assessment on critically ill patients among nurses working in the intensive care unit at Amhara regional state referral hospitals, Northwest Ethiopia, 2019. The research hypothesis: there is poor physical assessment knowledge, poor physical assessment attitude, and there are factors that are likely to affect nurses’ knowledge and attitude towards physical assessment providing this care to critically ill patients at Amhara regional state referral hospitals, Northwest Ethiopia, 2019. …”
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The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy by Zhaocheng Dong, Zhiyuan Liu, Haoran Dai, Wenbin Liu, Zhendong Feng, Qihan Zhao, Yu Gao, Fei Liu, Na Zhang, Xuan Dong, Xiaoshan Zhou, Jieli Du, Guangrui Huang, Xuefei Tian, Baoli Liu

“…In this review, we provide a brief overview of the types and functions of Breg found in human body, as well as the abnormal pathological and immunological phenomena in IMN, and propose the hypothesis that Breg is activated in IMN patients and the proportion of Br1 can be increased. …”
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Nature and Origin of Mineralizing Fluids in Hyperextensional Systems: The Case of Cretaceous Mg Metasomatism in the Pyrenees by Benoît Quesnel, Marie-Christine Boiron, Michel Cathelineau, Laurent Truche, Thomas Rigaudier, Gérard Bardoux, Pierre Agrinier, Michel de Saint Blanquat, Emmanuel Masini, Eric C. Gaucher

“…The geochemical proxies used in this study provide equivocal results. The first hypothesis is by far the most realistic one considering the numerous occurrences of Trias formations nearby, their deformation during the extension, and the drainage of the expulsed brines as evidenced by the high-salinity fluid inclusions found all around the deposit. …”
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