Advancing cancer therapy with custom-built alternating electric field devices by Isobel Jobson, Nguyen T. N. Vo, Edward Kujawinski, Chris Denning, Snow Stolnik, Veeren M. Chauhan, Frankie Rawson

“…Conclusions The initial hypothesis for the lack of effect of electrical stimulation on the adherent cells was that, due to only a single pair of electrodes being used, the proportion of cells that were in the correct orientation for electric field effects was limited. …”
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The ground beneath our feet: A critical reflection on 135 years of landscape evolution models for southern Africa by Rivoningo Khosa, Vela Mbele, Kelly Kirsten, Robyn Pickering

“…Here, we present a review of this field, starting with the foundational studies from the late 1890s, which underpin Dart’s hypothesis. We examine the work of 20th-century researchers who developed models of landscape evolution; however, almost all of these models have been qualitative. …”
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The Use of Mebendazole in COVID-19 Patients: An Observational Retrospective Single Center Study by Mostafa W. Galal, Mahmoud Ahmed, Yanqiu Shao, Chao Xing, Wael Ali, Abd Elhamid Baly, Abdallah Elfiky, Khaled Amer, John Schoggins, Hesham A. Sadek, Zeinab N. Gobara

“…The findings from this small observational study are hypothesis-generating and preclude drawing conclusions about clinical efficacy. …”
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Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma by Lawrence G Lum, Parameswaran Hari, Aniko Szabo, Michele Donato, Jee Hyun Park, Daniel H Fowler, Binod Dhakal, Saurabh Chhabra, Deborah D Glass, David S Siegel, Tania C Felizardo

“…Only 4 of 14 patients (29%) had a serious adverse event (≥ grade 3) of any attribution.Conclusions Consistent with our hypothesis, ex vivo manufacturing using mTOR inhibition and IFN-α polarization consistently yielded a novel RAPA-201 DP that possessed a desirable phenotype relative to cytokine phenotype, memory status, and checkpoint expression. …”
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Inferior outcome of stand-alone short versus long tibial stem in revision total knee arthroplasty. A retrospective comparative study with minimum 2 year follow-up by Abdelatif Elsayed Ahmed, Abu Mukh Assala, Elsaid Ahmed Nady Saleh, Youssef Ahmed Omar, Foissey Constant, Servien Elvire, Lustig Sebastien

“…The current study aims to compare the performance of short tibial stems with long tibial stems, investigating their intermediate-term radiographic and survival outcomes in RTKA. The main hypothesis is that the two types of tibial stems would exhibit similar complication and revision rates in mid-term follow-up. …”
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Facial Anthropometry and Self-expressed Behaviours: A Systematic Review by Ankit Srivastava, Vilas Chimurkar, Nisha Mani Pandey, Anand Bihari

“…Conclusion: The data from various populations in present review support the hypothesis that facial structures are important biological markers for assessing behaviours or personality traits. …”
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Half-Elemental Diet Shifts the Human Intestinal Bacterial Compositions and Metabolites: A Pilot Study with Healthy Individuals by Jun Miyoshi, Daisuke Saito, Mio Nakamura, Miki Miura, Tatsuya Mitsui, Toru Kudo, Shinnosuke Murakami, Minoru Matsuura, Tadakazu Hisamatsu

“…Given that inflammation can be a confounding factor affecting the intestinal microbiota, we aimed to test our hypothesis among healthy individuals in this pilot study. …”
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Oxidative stress in critically ill neonatal foals by David Wong, Dipak Kumar Sahoo, Cosette Faivre, Jamie Kopper, Katie Dersh, Theresa Beachler, Melissa Esser

“…Abstract Background Oxidative injury occurs in septic people, but the role of oxidative stress and antioxidants has rarely been evaluated in foals. Objectives/Hypothesis To measure reactive oxygen species (ROS), biomarkers of oxidative injury, and antioxidants in neonatal foals. …”
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Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs by Jocelyn Mott, Arnon Gal, Antonio Maria Tardo, Alisa Berg, Riley Claude, Alexis Hoelmer, Mei Lun Mui, Avin Arjoonsingh, Chen Gilor

“…Abstract Background The advantages of insulin degludec 100 U/mL (IDeg100) in the treatment of diabetes mellitus (DM) include consistent release, predictable glucose‐lowering effect, and minimal day‐to‐day variability. Hypothesis/Objectives To describe the use of IDeg100 in dogs with DM, level of diabetic control and adverse effects. …”
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Macro-environment oscillation notably up risk of water quality degradation: A case study in Shanxi Reservoir, China by Wangwei Cai, Jihong Xia, Zewen Liu, Jiayi Zu, Shuyi Ji, Yue Wang, Qihua Wang

“…Shanxi Reservoir in Zhejiang, China, a large reservoir with a total storage capacity of 1.82 billion m3 was used as the study area to test this hypothesis. Monthly macro-environment data from 2014 to 2022 (sample size = 108), including 10 factors of meteorology, hydrology, and pollution, was used to create a Macro-Environment Index (MEI) by Principal Component Analysis. …”
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Recognition of HER2 expression in hepatocellular carcinoma and its significance in postoperative tumor recurrence by Ji‐Hua Shi, Wen‐Zhi Guo, Yang Jin, Hua-Peng Zhang, Chun Pang, Jie Li, Pål‐Dag Line, Shui‐Jun Zhang

“…Abstract Background The ERBB2 oncogene hypothesis is challenged in hepatocellular carcinoma (HCC) with the conflicting evidences of human epidermal growth factor receptor 2 (HER2) overexpression. …”
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Gut microbiota and kidney function in autosomal dominant polycystic kidney disease participants in Cameroon: a cross-sectional study by Inès Obolo Nwaga, Victorine Bandolo Nzana, Rhoda Nsen Bughe, Isaac Dah, Cheboh Cho-Fon, Maimouna Mahamat, Emmanuelle Ndjong, Aristide Nono, Jean Claude Mballa, Fon Abongwa Acho, Vicky Ama Moor, Wilfred Fon Mbacham, François Folefack Kaze

“…Abstract Background and hypothesis Gut dysbiosis characterized by an imbalance in pathobionts (Enterobacter, Escherichia and Salmonella) and symbionts (Bifidobacterium, Lactobacillus and Prevotella) can occur during chronic kidney disease (CKD) progression. …”
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Potentiality of algorithms and artificial intelligence adoption to improve medication management in primary care: a systematic review by Gianfranco Damiani, Antonio Oliva, Gerardo Altamura, Massimo Zedda, Mario Cesare Nurchis, Giovanni Aulino, Aurora Heidar Alizadeh, Francesca Cazzato, Gabriele Della Morte, Matteo Caputo, Simone Grassi, Maria Teresa Riccardi, Martina Sapienza, Giorgio Sessa

“…Ten out of 14 included studies, corresponding to 71% of articles, reported a reduction of medication errors, supporting the hypothesis that AI is an important tool for patient safety.Conclusion This study highlights how a proper application of AI in primary care is possible, since it provides an important tool to support the physician with drug management in non-hospital environments.…”
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GRB 241107A: A Giant Flare from a Close-by Extragalactic Magnetar? by James Craig Rodi, Dominik Patryk Pacholski, Sandro Mereghetti, Edoardo Arrigoni, Angela Bazzano, Lorenzo Natalucci, Ruben Salvaterra, Pietro Ubertini

“…For the 4.1 Mpc distance of PGC 86046, the isotropic energy of 1.6 × 10 ^45 erg is in agreement with this hypothesis, which is also supported by the time-resolved spectral properties similar to those of the few other extragalactic magnetars giant flares detected so far.…”
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Impacts of Legacy and Contemporary Nitrogen Inputs on N2O and CO2 Emissions in Miscanthus and Maize Cultivated Soils by Jaejin Lee, Paul Villanueva, Kate Glanville, Andy Vanloocke, Wendy H. Yang, Angela Kent, Marshall McDaniel, Steven J. Hall, Adina Howe

“…Considering its rhizomatous roots and perennial growth, we hypothesized that Miscanthus × giganteus (M×g) would be more sensitive to legacy N fertilization and the historical context of its environment than an annual crop like maize. To test this hypothesis, we examined the effects of legacy and contemporary N inputs on nitrous oxide (N2O) and carbon dioxide (CO2) emissions, as well as key N cycling genes in soils where M×g and maize were grown. …”
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Cell Morphology on Poly(methyl methacrylate) Microstructures as Function of Surface Energy by Matthias Katschnig, Boris Maroh, Natascha Andraschek, Sandra Schlögl, Ulrike Zefferer, Elisabeth Bock, Gerd Leitinger, Christa Trattnig, Maria Kaufmann, Werner Balika, Clemens Holzer, Ute Schäfer, Silke Patz

“…Here we evaluate the hypothesis that surface energy plays a decisive role in substrate-mediated modulation of cell phenotype by evaluation of cell behaviour on synthetic microstructures exhibiting pronounced differences in surface energy. …”
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Snow as an indicator of atmospheric transport of anthropogenic particles (microplastics and microfibers) from urban to Arctic regions by Jasmine T. Yu, Miriam L. Diamond, Eric Ward, Jennifer K. Adams, Amaya Cherian-Hall, Mary Gamberg, Tyler Obediah, Michael Palmer, Andrew Platt, Cassandra Worthy, Sarah A. Finkelstein, Liisa M. Jantunen

“…Our findings of APs in snow from uninhabited areas support the hypothesis that APs, especially microfibers, undergo long-range atmospheric transport whereby snow can scavenge and deposit APs in remote northern regions.…”
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Empirical evidence for a process-based model of health-related quality of life using network analysis by Nicolette Stogios, Nicolette Stogios, Troy Francis, Troy Francis, Rachel G. Peiris, Aleksandra Stanimirovic, Aleksandra Stanimirovic, Valeria Rac, Valeria Rac, Robert P. Nolan, Robert P. Nolan

“…In support of this approach, we developed a novel HRQL assessment tool called the EUROIA: EvalUation of goal-diRected activities to prOmote wellbeIng and heAlth, which uses self-report data to assess the frequency with which individuals engage in a sample of goal-directed activities in pursuit of living well.MethodsWe conducted a network analysis to evaluate the hypothesis that the EUROIA subscales would demonstrate a meaningful pattern of associations with an established HRQL measure and associated indices of psychosocial functioning and efficacy in self-managing a chronic medical condition.ResultsThe EUROIA is associated with established indices of HRQL in a manner that is theoretically consistent with our process-based model. …”
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Role of IPF genetic risk loci in post-COVID-19 lung abnormalities: a cohort study by James Johnston, Christopher Carlsten, Christopher J Ryerson, Alyson W Wong, Cameron J Hague, Julia Yang, Janice Leung, Daniel-Costin Marinescu, Aditi Shah, Darra Murphy

“…None of the risk alleles were significantly associated with reticulation at 3 months.Conclusion In an adjusted analysis controlling for severity of infection, MUC5B was associated with reduced ground glass and a trend towards concordant higher DLCO at 3 months after severe COVID-19 illness. This hypothesis-generating result suggests a possible protective effect of MUC5B in postinfectious lung abnormalities as compared with fibrosis in IPF, highlighting a plausible trade-off between its role in immune defence and epithelial cell function.…”
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The effects of age and sex on reference intervals for cobalamin, homocysteine, and serum and urinary methylmalonic acid in healthy adult dogs by Anna‐Lena Proksch, Sophia Schaefer, Vanessa Dreller, Judith Langenstein, Ralph Fingerhut, Natali Bauer, Andreas Moritz

“…Abstract Background In dogs, data on reference intervals (RIs) for cobalamin, markers of metabolism (markersB12met), age and sex effects are limited. Hypothesis/Objectives Establish RI for serum cobalamin, homocysteine, and methylmalonic acid (sMMA) concentrations, urinary methylmalonic acid‐to‐creatinine ratio (uMMA:crea), and determine effects of sex and age. …”
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