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2501
Les effets paradoxaux du transfert des forces de sécurité en Tunisie (juin 1955-mars 1956)
Published 2024-07-01“…Although they held the reins of the Tunisian government, the Bourguibists depended on French tutelage and police resources to repress their rivals while negotiating with France the conditions for Tunisia's emancipation.To explain this paradox, this article puts forward the hypothesis that the Yussefist opposition to the internal autonomy treaty contributed not only to the transfer of the law enforcement apparatus but also to the acceleration of independence. …”
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2502
Elevation of ganglioside degradation pathway drives GM2 and GM3 within amyloid plaques in a transgenic mouse model of Alzheimer's disease
Published 2025-02-01“…In addition to the amyloid hypothesis, lipid dysregulation is now recognized as a core component of AD pathology. …”
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2503
Patellofemoral Joint Loading During the Performance of the Forward and Side Lunge with Step Height Variations
Published 2022-02-01“…# Background Forward and side lunge exercises strengthen hip and thigh musculature, enhance patellofemoral joint stability, and are commonly used during patellofemoral rehabilitation and training for sport. # Hypothesis/Purpose The purpose was to quantify, via calculated estimates, patellofemoral force and stress between two lunge type variations (forward lunge versus side lunge) and between two step height variations (ground level versus 10 cm platform). …”
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2504
Double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparo...
Published 2025-01-01“…Melatonin potentiates the action of oxytocin and may promote the spontaneous onset of labour; therefore, we will test the hypothesis that exogenous melatonin supplementation in late pregnancy will reduce the rate of labour induction by 30% or more.Methods and analyses This is a double-blind, randomised, placebo-controlled trial in nulliparous pregnant women to reduce IOL rates. …”
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2505
Effects of Renal Denervation via Renal Artery Adventitial Cryoablation on Atrial Fibrillation and Cardiac Neural Remodeling
Published 2018-01-01“…The aims of this study were to test the hypothesis that renal artery adventitial ablation (RAAA) definitely had the effects of RDN and to study the effects of RDN via renal artery adventitial cryoablation (RAAC) on AF and cardiac neural remodeling. …”
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2506
Different Activity of the Biological Axis VEGF-Flt-1 (fms-Like Tyrosine Kinase 1) and CXC Chemokines between Pulmonary Sarcoidosis and Idiopathic Pulmonary Fibrosis: A Bronchoalveo...
Published 2009-01-01“…Our data suggest that increased expression of Flt-1 and downregulation of CXCL12𝛼 in IPF may further support the hypothesis of a different angiogenetic profile between fibrotic and granulomatous diseases. …”
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2507
Consistent Estimators of the Population Covariance Matrix and Its Reparameterizations
Published 2025-01-01“…A high-dimensional statistical hypothesis testing problem is used to carry out statistical inference for high-dimensional principal component analysis-related problems without the sparsity assumption. …”
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2508
Coexistence of multiple leaf nutrient resorption strategies in urban forests
Published 2025-01-01“…Elemental variability declined as element concentrations rose in both peri-urban and urban forests, consistent with the relevance of the Stability of Limiting Elements Hypothesis in urban ecosystems. Overall, these data emphasize the fact that multiple nutrient resorption strategies coexist in urban ecosystems, while also supporting the nutrient-dependent nature of these strategies.…”
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2509
Tracing Aquatic Macrophyte Development in Nansi Lake, Northern China's Largest Freshwater Lake: Plant Macrofossils From 1855 to Present
Published 2025-01-01“…The results confirmed our hypothesis that climatically and anthropogenically induced hydrological alterations were likely the primary drivers influencing macrophyte composition alteration and succession dynamics in the lake. …”
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2510
Machine learning models reveal microbial signatures in healthy human tissues, challenging the sterility of human organs
Published 2025-01-01“…The discoveries presented here confront the enduring dogma positing the sterility of internal tissues, yet further validation through controlled laboratory experiments is imperative to substantiate this hypothesis. Exploring the microbiome of internal tissues holds promise for elucidating the pathophysiology underlying both health and a spectrum of diseases, including sepsis, inflammation, and cancer.…”
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2511
Mathematical modelling and phylodynamics for the study of dog rabies dynamics and control: A scoping review.
Published 2021-05-01“…Finally, interdisciplinary studies were determined to provide the most comprehensive assessments through hypothesis generation and testing. They also represent new avenues, especially concerning the reconstruction of local transmission chains or clusters through data integration.…”
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2512
Early selective attention to the articulating mouth as a potential female-specific marker of better language development in autism: a review
Published 2025-02-01“…Female infants look at the mouth of a talking face more than males without penalizing looking to the eyes, and reduced mouth-looking in early infancy relates to better vocabulary in toddlerhood only in females. In this hypothesis and theory article, we propose that unique female gaze patterns to the mouth may constitute an early female-specific candidate marker that acts as a protective marker for language development also in autism. …”
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2513
Neurodevelopmental Disorders and Connective Tissue-Related Symptoms: An Exploratory Case-Control Study in Children
Published 2024-12-01“…The familial prevalence of these symptoms suggests a potential genetic underpinning, further supporting the hypothesis of shared aetiological pathways. These insights underscore the need for interdisciplinary research to explore the mechanisms linking neurodevelopmental and connective tissue disorders, aiming to improve diagnosis and management strategies.…”
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2514
Mendelian Randomization Reveals Potential Causal Relationships Between DNA Damage Repair-Related Genes and Inflammatory Bowel Disease
Published 2025-01-01“…Colocalization analysis was employed to evaluate whether a single genetic variant simultaneously influences two traits, thereby validating the pleiotropy hypothesis. <b>Results:</b> We identified seven DDR-related genes (<i>Arid5b</i>, <i>Cox5a</i>, <i>Erbb2</i>, <i>Ube2l3</i>, <i>Gpx1</i>, <i>H2bcl2</i>, and <i>Mapk3</i>), 33 DNA methylation genes, and two DDR-related proteins (CD274 and FCGR2A) which were all causally associated with IBD and its subtypes. …”
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2515
IMPACT OF ENERGY PRICES ON PRICES OF BASIC TOURISM SERVICES IN THE EURO AREA
Published 2024-12-01“…The study reveals the existence of a specific functional relationship. The null hypothesis, which states that there is no causal link between energy product prices and the prices of services provided by hotels and restaurants, is also rejected. …”
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2516
Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampus
Published 2025-02-01“…Pleiotrophin (PTN) is a cytokine that regulates energy metabolism and high-fat diet (HFD)-induced neuroinflammation, suggesting that PTN could play an important role in the connection between obesity and brain alterations, including cognitive decline. To test this hypothesis, we used an HFD-induced obesity model in Ptn genetically deficient mice (Ptn−/−). …”
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2517
Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens
Published 2025-02-01“…Here, we tested this hypothesis by characterizing the effects of NRTIs on the innate immune response to bacteria. …”
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2518
Genetic Analysis of Undiagnosed Juvenile GM1-Gangliosidosis by Microarray and Exome Sequencing
Published 2018-01-01“…Recently, whole exome sequencing (WES) has become increasingly used when a strong hypothesis cannot be formulated based on the clinical phenotype. …”
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2519
Contract Management and Health Service Delivery in Uganda: A Case Study of Kabale Regional Referral Hospital, Kabale Municipality.
Published 2023“…It was concluded that there is a positive significant relationship between contract supervision and the delivery of healthcare services at Kabale Regional Referral Hospital in Kabale Municipality, rejecting null hypothesis one, which held that there is no significant relationship between contract supervision and the delivery of healthcare services in Kabale Municipality, there was a positive significant relationship between contract planning and the provision of health services in Kabale Municipality, and there was a positive significant relationship between contract risk management and health service delivery in Kabale Municipality. …”
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2520
Contract Management and Health Service Delivery in Uganda: A Case Study of Kabale Regional Referral Hospital, Kabale Municipality.
Published 2023“…It was concluded that there is a positive significant relationship between contract supervision and the delivery of healthcare services at Kabale Regional Referral Hospital in Kabale Municipality, rejecting null hypothesis one, which held that there is no significant relationship between contract supervision and the delivery of healthcare services in Kabale Municipality, there was a positive significant relationship between contract planning and the provision of health services in Kabale Municipality, and there was a positive significant relationship between contract risk management and health service delivery in Kabale Municipality. …”
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Thesis