Pediatric Interstitial Lung Disease Masquerading as Difficult Asthma: Management Dilemmas for Rare Lung Disease in Children by EY Chan, Sharon D Dell

“…She did not have sustained improvement with systemic corticosteroids, hydroxychloroquine or clarithromycin. Cardiac catheterization confirmed the presence of secondary pulmonary hypertension. …”
Get full text

Hyper IgG4-Related Disease Presenting with Orbital Tumor and Immune Deficiency by Caroline G. Olson, Nancy Y. Olson

“…The patient was started on prednisone and tried several immunosuppressive medications including mycophenolate mofetil, methotrexate, hydroxychloroquine, and azathioprine with decrease in size of the orbital pseudotumor. …”
Get full text

Comparative-effectiveness research of COVID-19 treatment: a rapid scoping review by Sharon E Straus, Jesmin Antony, Andrea C Tricco, Rachel Warren, Erin Macdonald, Ba Pham, Milan Patel, Fatemeh Yazdi, Amruta Radhakrishnan, Marco Ghassemi, Patricia Rios, Chantal Williams, Naveeta Ramkissoon, Matthew P Muller, Nazia Darvesh, Gordon V Cormack, Maura R Grossman, Melissa Kampman, Reid Robson

“…The most common treatments were tocilizumab (11%), hydroxychloroquine (9%) and convalescent plasma (7%). The most common therapeutic categories were non-steroidal immunosuppressants (18%), steroids (15%) and antivirals (14%). …”
Get full text

A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…FindingsIn this series of observational, retrospective, case-control, pharmacovigilance analyses of the FDA Adverse Event Reporting System, the odds of reporting the adverse event pemphigus were significantly elevated among individuals exposed to 11/36 previously reported trigger drugs namely, gold sodium thiomalate, penicillamine, piroxicam, rifampin, hydroxychloroquine, imiquimod, hydrochlorothiazide, irbesartan, lisinopril, nivolumab, and nifedipine.MeaningEnvironmental exposures such as drugs are relevant players in the pathogenesis of autoimmune diseases and clinicians who treat patients with autoimmune blistering diseases such as pemphigus should consider performing a detailed medication history leveraging this information regarding deleterious drug-disease interactions at initial evaluation as well as longitudinal monitoring of patients to better inform clinical care decisions.ImportancePemphigus vulgaris (PV) is a rare, potentially fatal autoimmune disease with pathogenic contributions from both genetic as well as environmental factors, notably drug exposures. …”
Get full text

Herpes Simplex Virus-2 Hepatitis: A Case Report and Review of the Literature by Amna Ahmed, Alejandro Granillo, Ethan Burns, Kerri Glassner, Nishath Naseem, Christopher Force, Suzanne M. Crumley, Ashley Drews

“…We present a case of a young female on chronic prednisone and hydroxychloroquine for systemic lupus erythematosus (SLE) who was diagnosed with HSV-2 hepatitis after presenting with right-sided chest and abdominal discomfort. …”
Get full text

A Rare Case of a Pregnant Woman with Severe Thrombocytopenia Associated with Systemic Lupus Erythematosus by Gitanshi Arora, Gauri Abhishek Prabhu

“…Treatment included methylprednisolone pulse therapy, hydroxychloroquine, and intravenous immunoglobulin (IVIG). …”
Get full text

Maternal and Fetal Outcomes in Critically Ill Patients Infected with COVID‐19: A Case Series by Zenab Yusuf Tambawala, Fatima Cherifi, Wafa Mohsen, Tazeen Makhdoom, Lama Khaled Hamza

“…Results: Despite trying all available known therapies for COVID-19 at the time they presented, such as remdesivir, favipravir, steroid, hydroxychloroquine, pegylated interferon, N-acetyl cysteine, anticoagulants, prone positioning, mechanical ventilation, extracorporeal membrane oxygenation, and early delivery by cesarean, these young women in the reproductive age group could not be saved. …”
Get full text

Porphyria Cutanea Tarda in a Patient with End-Stage Renal Disease: A Case of Successful Treatment with Deferoxamine and Ferric Carboxymaltose by Natacha Rodrigues, Fernando Caeiro, Alice Santana, Teresa Mendes, Leonor Lopes

“…Also, conventional treatment of PCT is compromised in these patients as hydroxychloroquine is contraindicated, phlebotomies with the stipulated frequency are poorly tolerated in already anaemia-prone patients, and iron-chelating agents are less efficient in removing iron and contribute to worsening anaemia. …”
Get full text

Systemic lupus erythematosus in a patient with 22q11.2 deletion syndrome: A case report and review of the literature by Chen Sun, Pingyang Han, Juzhen Yan

“…Treatment with prednisone, hydroxychloroquine and azathioprine resulted in improvement. …”
Get full text

Behçet’s disease in pregnancy: a case report and literature review by Xiangyue Li, Xuemei Huang, Xiaolan Yu

“…The final treatment regimen included azithromycin, hydroxychloroquine, prednisone, and low-molecular-weight heparin calcium. …”
Get full text

Anti-SARS-CoV-2 Biotherapeutics and Chemotherapeutics: An Insight into Product Specifications and Marketing Dynamics by Vijay Kotra, Dinakar Mallem, Anil Kumar Kanuri, Mahesh Reddy Burra, Shaik Nyamathullah, Looi Shu Ying, Khairul Anwar Husain, Ravi Varala, Madhadevi Sudhakar, Khang Wen Goh, Toong Hai Sam, Long Chiau Ming

“…There are several chemotherapeutics that have been studied for the treatment of COVID-19, including Paxlovid (Nirmatrelvir & Ritonavir) fixed dose combination, nirmatrelvir and ritonavir fixed dose combination, Remdesivir (Vekulary/Covifor) fixed dose combination, chloroquine and hydroxychloroquine, molnupiravir, favipiravir, Infliximab (Remsima®) fixed dose combination tocilizumab (Actimera), casirivimab+imdevimab (Ronapreve) fixed dose combination, ivermectin, methylprednisole. …”
Get full text

Coronavirus disease 2019 in kidney transplant recipients: a systematic review and meta-analysis by Quan Yao Ho, Rehena Sultana, Tung Lin Lee, Sobhana Thangaraju, Terence Kee, Htay Htay

“…It is uncertain whether high-dose corticosteroid or hydroxychloroquine reduces the risks of mortality in KTRs with COVID-19.…”
Get full text

Spontaneous Loculated Pneumomediastinum in a COVID-19-Infected Patient by Sirous Jafari, Zahra Jahani, Reihane Alikhani, SeyedAhmad SeyedAlinaghi, Malihe Hasannezhad, Faeze Salahshour, Ali Asadollahi-Amin

“…The combination of a chest tube, antibiotics (vancomycin 1 gr/bid and meropenem 1 g/bid), and antiviral (hydroxychloroquine 200 mg/bid and atazanavir 300 mg/daily) was prescribed, and continued treatment with antiviral and appropriate care for pneumomediastinum was successful. …”
Get full text

Antiviral Drugs Used to Treat COVID-19 are not Liver Safe: A Comparative Experimental Study by Asiye Aslı Emniyet Sert, Cemile Merve Seymen, Gülnur Take Kaplanoğlu

“…Methods: Thirty-three 8-10 week old Wistar albino male rats were separated into seven groups: the sham control groups for intravenous, subcutaneous, and gavage stress; the acyclovir, hydroxychloroquine, anakinra, and favipiravir groups. At the end of the experimental period, hematoxylin-eosin and silver impregnation histochemical, tumour necrosis factor-alpha (TNF-α)/interleukin-1 beta (IL-1β)/IL-6 immunohistochemical stainings were performed on liver tissue. …”
Get full text

Tjalma syndrome: A rare manifestation of systemic lupus erythematosus by Ashwaq Alhmoudi, Ahlam Almarzooqi, Maryam Alahmad, Amna Al Muhairi, Sehriban Diab, Raven Haan, Khalid Elsayed

“…She was subsequently treated with corticosteroids and hydroxychloroquine, resulting in the rapid resolution of the patient's nausea and emesis, and discharge from the hospital. …”
Get full text

Central nervous system involvement in Whipple's disease: Report of a rare pathological entity and comparative review of treatment strategies and outcomes by Moustafa A. Mansour, MD, MSc, MPhil, Reem W. Malaeb, BS, Islam E. Elnemr, MD, Mohamed Abdel-Fattah El-Salamoni, MD, Hamdi Nabawi Mostafa, MD, Zarina Ahmadi, MD

“…The patient was successfully treated with a combination of intravenous ceftriaxone followed by oral doxycycline and hydroxychloroquine, resulting in significant symptom improvement and full recovery of neurological function. …”
Get full text

Common variable immunodeficiency: An uncommon cause of bronchiectasis, granulomatous disease, chronic liver disease, and enteropathy – Case report and review of literature by Veena Shamsudeen, Arun Hegde, Uday Bhanu Kovilapu, Nisha Verma, Anurag Jain

“…She was managed with immunoglobulin replacement therapy, along with hydroxychloroquine and steroids with good response.…”
Get full text

Chronic Q Fever with Vascular Involvement: Progressive Abdominal Pain in a Patient with Aortic Aneurysm Repair in the United States by Zanthia Wiley, Sujan Reddy, Kara M. Jacobs Slifka, David C. Brandon, John Jernigan, Gilbert J. Kersh, Paige A. Armstrong

“…Treatment of chronic Q fever with vascular involvement includes a prolonged course of doxycycline and hydroxychloroquine (≥18 months) as well as early surgical intervention, which has been shown to improve survival. …”
Get full text

Management of a Novel Autoimmune Disease, COPA Syndrome, in Pregnancy by Archana Ayyar, Rachel D. Seaman, Kalpalatha Guntupalli, Mary C. Tolcher

“…On her first antepartum admission, rheumatology recommended management with hydroxychloroquine, inhaled corticosteroids (budesonide), and bronchodilators (albuterol inhaler) as needed. …”
Get full text

Clinical Outcomes in Patients with Cardiac Lupus: A Retrospective Study by K Maria Koshy, Tarun George, Sohini Das, J V Punitha, Sudha Jasmine Rajan, Bijesh Yadav, Thambu David Sudarsanam, Vijay Prakash Turaka

“…An elevated serum creatinine, elevated creatine Kinase–muscle/brain, neutrophilic leukocytosis, left ventricular systolic dysfunction, noninitiation of hydroxychloroquine, and the presence of neuropsychiatric lupus predicted mortality. …”
Get full text