Biomimetic bioreactor for potentiated uricase replacement therapy in hyperuricemia and gout by Bin Yang, Bin Yang, Guihu Luo, Tailei Nie, Zhenglan Ban, Quanxin Ning, Jialin Zhang, Xiangru Liu, Yanhua Lin, Xiaochun Xie, Qianyun Chen, Han Zhong, Ying Huang, Pan Liao, Yan Liu, Chenyang Guo, Chuanxu Cheng, Erwei Sun, Erwei Sun

“…IntroductionUricase replacement therapy is a promising approach for managing hyperuricemia and gout but is hindered by challenges such as short blood circulation time, reduced catalytic activity, and excessive hydrogen peroxide (H2O2) production. These limitations necessitate innovative strategies to enhance therapeutic efficacy and safety.MethodsWe designed and synthesized RBC@SeMSN@Uri, a red blood cell-coated biomimetic self-cascade bioreactor, which encapsulates uricase (Uri) and a selenium-based nano-scavenger (SeMSN) within RBC membranes. …”
Get full text

Surface functionalization of titanium implants with controlled-release glutathione conjugate for antioxidant and osteogenesis by Huichuan Xu, Kosuke Nozaki, Ziniu Yu, Nobuyuki Kawashima, Takeshi Ueno, Huaze Wu, Hao Wu, Noriyuki Wakabayashi

“…The oxidative stress microenvironment simulated using hydrogen peroxide (H2O2) showed that Ti substrates immobilizing VPA-GSH conjugates efficiently scavenged H2O2 and rescued cell viability owing to the controlled release of GSH. …”
Get full text

Overexpression of the <i>GmPM35</i> Gene Significantly Enhances Drought Tolerance in Transgenic Arabidopsis and Soybean by Xinyu Wang, Yao Sun, Rui Wang, Xinyang Li, Yongyi Li, Tianyu Wang, Zhaohao Guo, Yan Li, Wenxi Qiu, Shuyan Guan, Qi Zhang, Piwu Wang, Mingze Li, Siyan Liu, Xuhong Fan

“…Germination rate, root length, chlorophyll (CHL) content, Proline (Pro) content, malondialdehyde (MDA) content, superoxide anion (O₂^•−) content, hydrogen peroxide (H₂O₂) content, (NBT, DAB) staining, and activities of antioxidant enzymes (CAT, SOD, POD), and photosynthetic physiological indexes of the three different types of strains were measured and analyzed before and after drought stress. …”
Get full text

Improving Growth Performance and Reducing Mortality by Supplementing the Ethanolic Extract of Grape Leaves (Vinifera Vitis) in Broilers under Induced Ascites by Mokhtar Fathi, Taimour Tanha, Reza Taherkhani, Vahid Rezaee

“…Effective factors in the occurrence of ascites syndrome, can mention free radicals in the body such as superoxide, hydroxide and hydrogen peroxide. By reducing the capacity of the body's antioxidant systems, free radicals make the bird susceptible to various diseases. …”
Get full text

A Cardiac‐Targeting and Anchoring Bimetallic Cluster Nanozyme Alleviates Chemotherapy‐Induced Cardiac Ferroptosis and PANoptosis by Junyue Xing, Xiaohan Ma, Yanan Yu, Yangfan Xiao, Lu Chen, Weining Yuan, Yingying Wang, Keyu Liu, Zhiping Guo, Hao Tang, Kelong Fan, Wei Jiang

“…Theoretical calculations reveal the surface interactions of the prepared nanozymes that simulate the hydrogen peroxide decomposition process, showing that these bimetallic nanozymes readily undergo OH⁻ adsorption and O₂ desorption. …”
Get full text

The Role of Potassium Phosphite in Enhancing the Activity of Defense Enzymes in Rice Infected by Sheath Blight by Milad Habibi Daronkolaei, Mohammad Ali Tajick Ghanbary, Valiollah Babaeizad, Heshmatollah Rahimian, Ali Dehestani

“…Conclusion: CAT catalyzes the conversion of hydrogen peroxide into water and oxygen, protecting the plant against oxidative damage caused by pathogens. …”
Get full text

Improving Growth Performance, Biochemical Parameters and Reducing Mortality due to Ascites in Broilers by Propranolol Inclusion by Shahriar Saidian, Somaya Farahmand, Mokhtar Fathi, Salar Saifi

“…Effective factors in the occurrence of ascites syndrome included free radicals in the body such as superoxide, hydroxide, and hydrogen peroxide. By reducing the capacity of the body's antioxidant systems, free radicals make the bird susceptible to various diseases. …”
Get full text

Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice by Wen Yin, Heng Xu, Zhonghao Bai, Yue Wu, Yan Zhang, Rui Liu, Zhangzhao Wang, Bei Zhang, Jing Shen, Hao Zhang, Xin Chen, Danting Ma, Xiaofeng Shi, Lihui Yan, Chang Zhang, Hualiang Jiang, Kaixian Chen, Dean Guo, Wenyan Niu, Huiyong Yin, Weiping J. Zhang, Cheng Luo, Xiangyang Xie

“…Mechanistically, PRDX1 suppresses STAT signaling and protects mitochondrial function by scavenging hydrogen peroxide, and mitigating the oxidation of protein tyrosine phosphatases and lipid peroxidation. …”
Get full text

Multimodal lung cancer theranostics via manganese phosphate/quercetin particle by Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang, Yinan Liu, Hongda Liu, Chen Wang, HaiLu Yao, Linying Zhong, Yuanfeng Fu, Pengbo Guo, Weiqi Chen, Xinyu Zhou, Li Zou, Licheng Gan, Jiawei Yan, Yichong Hou, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Guang Han, Xijun Wang, Jigang Wang

“…Mechanistic studies indicated that QCT and Mn2+ exhibited excellent peroxidase-like (POD-like) activity, catalysing the conversion of endogenous hydrogen peroxide into highly toxic hydroxyl radicals through a Fenton-like reaction, depleting glutathione (GSH), promoting reactive oxygen species (ROS) generation in mitochondria and endoplasmic reticulum, and inducing ferroptosis. …”
Get full text

The Effect of Corona Dormancy on the Physiological Stress and Main Nutritional Components in the Transport of Trachinotus ovatus During Survival by Siwei LIU, Jiamei ZHONG, Xiuping FAN, Xiaoming QIN, Jian SHEN, Wenqi XU

“…The content of heat shock protein 70 (Hsp70), glutathione S-transferase (GST-S) activity, and catalase (CAT) activity in liver and brain tissues significantly increased (P < 0.05), while the content of malondialdehyde (MDA) in brain tissues was significantly decreased compared with that in the control group within 4–72 hours (P < 0.05), indicating that the technology can improve the tolerance of fish to environmental stress and reduce the degree of brain damage, reduce the lipid peroxidation in the brain and the accumulation of hydrogen peroxide in the liver, so as to reduce the damage cause by environmental stress and short-term damage to tissues. …”
Get full text