Healthy food prescription incentive programme for adults with type 2 diabetes who are experiencing food insecurity: protocol for a randomised controlled trial, modelling and implem... by Colleen Norris, Tyler Williamson, Richard Oster, Dana Lee Olstad, Laura White, David J T Campbell, Sharlette Dunn, Kim D Raine, Mary L'Abbé, Richard Lewanczuk, Lorraine L Lipscombe, Eldon Spackman, Reed Beall, Kienan Williams, Sara Scott, Gabrielle L Zimmermann, Kerry A McBrien, Kieran J D Steer, Catherine B Chan, Sheila Tyminski, Seth Berkowitz, Alun L Edwards, Terry Saunders-Smith, Saania Tariq, Naomi Popeski, Sara Nejatinamini, Aruba Naser, Carlota Basualdo-Hammond, Petra O’Connell, Judy Seidel, Jason Cabaj

“…We will use a type 2 hybrid-effectiveness design to examine the reach, effectiveness, adoption, implementation and maintenance (RE-AIM) of a healthy food prescription incentive programme for adults experiencing food insecurity and persistent hyperglycaemia. …”
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NEAT1 regulates BMSCs aging through disruption of FGF2 nuclear transport by Zifei Wang, Wenyu Zhen, Qing Wang, Yuqiang Sun, Siyu Jin, Sensen Yu, Xing Wu, Wenhao Zhang, Yulong Zhang, Fei Xu, Rui Wang, Yuxuan Xie, Wansu Sun, Jianguang Xu, Hengguo Zhang

“…NEAT1 expression and distribution changes during aging process were observed using fluorescence in situ hybridization (FISH) in young (3 months) and aged (18 months) mice or human BMSCs. …”
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Clinical and cost-effectiveness of Knee Arthroplasty versus Joint Distraction for Osteoarthritis (KARDS): protocol for a multicentre, phase III, randomised control trial by Deborah D Stocken, Dennis G McGonagle, David Murray, Catherine Reynolds, Catherine Fernandez, David R Ellard, Andrew Metcalfe, Hemant Sharma, Paul Harwood, Hamish Simpson, Hemant Pandit, Susanne Arnold, Cerys Joyce Tassinari, Ruchi Higham, Isabelle Louise Smith, Ruben Mujica-Mota, Thomas William Hamilton, Julie Croft

“…The KARDS trial will investigate whether KJD is non-inferior to KR in terms of patient-reported postoperative pain 12 months post-surgery.Methods and analysis KARDS is a phase III, multicentre, pragmatic, open-label, individually randomised controlled non-inferiority trial comparing KJD with KR in patients with severe knee OA, employing a hybrid-expertise design, with internal pilot phase and process evaluation. 344 participants will be randomised (1:1) to KJD or KR. …”
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Improving glycemic control by transitioning from the MiniMedTM 640G to 770G in Japanese adults with type 1 diabetes mellitus: a prospective, single-center, observational study by Satoshi Kubota, Ai Sato, Manami Hosokawa, Yosuke Okubo, Shohei Takayama, Atsuko Kaneko, Yasuho Shimada, Yuki Asano, Yoshihiko Sato, Masanori Yamazaki, Mitsuhisa Komatsu

“…The effectiveness of a hybrid closed-loop (HCL) system in improving glycemic control is unclear in Japanese individuals. …”
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CitySEIRCast: an agent-based city digital twin for pandemic analysis and simulation by Shakir Bilal, Wajdi Zaatour, Yilian Alonso Otano, Arindam Saha, Ken Newcomb, Soo Kim, Jun Kim, Raveena Ginjala, Derek Groen, Edwin Michael

“…Our data pipelines and workflows are designed purposefully to be flexible and scalable so that we can implement the system on hybrid cloud/cluster systems and be agile enough to address different population settings and indeed, diseases. …”
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Combining genotyping approaches improves resolution for association mapping: a case study in tropical maize under water stress conditions by Fernanda Carla Ferreira de Pontes, Ingrid Pinheiro Machado, Maria Valnice de Souza Silveira, Antônio Lucas Aguiar Lobo, Felipe Sabadin, Roberto Fritsche-Neto, Júlio César DoVale

“…Recent studies show SNP-Array, GBS, and Mock yield similar results for population structure, heterotic groups definition, tester selection, and genomic hybrid prediction. However, no studies have examined the results generated by these different genotyping approaches for GWAS. …”
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Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD by Pritha Majumder, Biswanath Chatterjee, Khadiza Akter, Asmar Ahsan, Su Jie Tan, Chi-Chen Huang, Jen-Fei Chu, Che-Kun James Shen

“…., immunoprecipitation (IP), RNA-IP, Immunofluorescence (IF)/fluorescence in situ hybridization (FISH), live cell imaging, live cell tracking of RNA using beacon, and mouse model study are used to elucidate a novel mechanism regulating dendritic spine transport of mRNAs in mammalian neurons. …”
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Educating the digital generation: the role of virtual communities by E. M. Kharlanova, N. V. Sivrikova, S. V. Roslyakova, E. G. Chernikova

“…Adolescent self-realisation takes place in this mixed, or hybrid, space employing its means. One of them is virtual communities, i.e. communities existing on the platforms of digital resources, using digital devices, information and communication technologies. …”
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Relationship between stress hyperglycemia ratio and progression of non target coronary lesions: a retrospective cohort study by Shiqi Liu, Ziyang Wu, Gaoliang Yan, Yong Qiao, Yuhan Qin, Dong Wang, Chengchun Tang

“…With the increase of SHR, the risk of non target lesions progression continued to increase, and the risk was significant when the SHR was greater than 0.96, but tended to be stable when the SHR was greater than 1.36 (p = 0.0047). A hybrid model combining logistic regression and XGBoost yielded the best predictive performance, with an AUC of 0.78 (95% CI: 0.72–0.85), incorporating SHR, number and stenosis severity of non target lesions (NTLs), hypertension and high-density lipoprotein cholesterol (HDL-c). …”
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Designing a Policy-Making Model for Biomass Energy Development Training in the Agricultural Supply Chain Sector by Tahereh Pourelmi, Seyed Mohammad Shobeiri, Enayatollah Yazdanpanah, Gholam Reza Bakhshi Khaniki, Mahdieh Rezaei

“…This basic-applied and hybrid survey aimed to design and validate a policy-making model for biomass energy development training in the agricultural supply chain sector. …”
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Response surface methodology and adaptive neuro-fuzzy inference system for adsorption of reactive orange 16 by hydrochar by J. Oliver Paul Nayagam, K. Prasanna

“…Experimental data was evaluated using a hybrid least square and gradient technique. Statistical and residual errors assessed experimental and mathematical model correctness. …”
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Mapping and Summarizing the Research on AI Systems for Automating Medical History Taking and Triage: Scoping Review by Elin Siira, Hanna Johansson, Jens Nygren

“…The predominant type of AI system identified was the hybrid model (n=68, 79%), with forecasting (n=40, 47%) and recognition (n=36, 42%) being the most common tasks performed. …”
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Genomic analysis of the SMN1 gene region in patients with clinically diagnosed spinal muscular atrophy: a retrospective observational study by Tamaki Kato, Mamoru Yokomura, Yutaka Osawa, Kensuke Matsuo, Yuji Kubo, Taihei Homma, Kayoko Saito

“…Three SNVs in intron 6, c.834+1506A>G (n = 9), c.834+1751G>A (n = 2), and c.835-367C>A (n = 5) were identified; all were numerically, and c.834+1506A>G and c.835-367C>A were significantly, more frequent in patients with 0 copies versus those with ≥ 1 copy of exon 7 in SMN1. We confirmed 3 hybrid SMN gene types in 5 patients that contained SMN2 gene sequence (aaTgg) flanked by upstream “t” and downstream “G” SMN1 sequence. …”
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Standalone and Minigrid-Connected Solar Energy Systems for Rural Application in Rwanda: An In Situ Study by Kuo-Chi Chang, Noel Hagumimana, Jishi Zheng, Godwin Norense Osarumwense Asemota, Jean De Dieu Niyonteze, Walter Nsengiyumva, Aphrodis Nduwamungu, Samuel Bimenyimana

“…The battery model for these two systems is 1.6 kWh daily load with 0.30 kW peak load for a single household and 193.05 kWh/day with 20.64 kW peak load for an off-grid PV microgrid. The hybrid optimization model for electric renewable (HOMER) software is used to determine the system size and its life cycle cost including the levelized cost of energy (LCOE) and net present cost (NPC) for each of these power generation models. …”
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Assessment of Convergence Angle of Tooth Preparations for Complete Crowns Among Dental Students: Typodont vs Simulator by Meriem Amine, Hafsa Oumayma Wahid, Saliha Fahi, Safaa Lehmouddi, Mouna Hamza, Samira Elarabi

“…A total of 140 dental preparations for cast crowns and metal-ceramics made by thirty-five 3rd year FDMC students were scanned by using the IDENTICA HYBRID optical scanner. The STL files were read by the 3D-TOOL-FREE software, two images were extracted for each preparation using the screen capture tool, and the two mediodistal (MD) and buccolingual angles (BL) were measured by the MB-RULER software. …”
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Trends and Gaps in Digital Precision Hypertension Management: Scoping Review by Namuun Clifford, Rachel Tunis, Adetimilehin Ariyo, Haoxiang Yu, Hyekyun Rhee, Kavita Radhakrishnan

“…Personalization characteristics of studies varied, with 43% (13/30) of studies using fully automated personalization approaches, 33% (10/30) using human-driven personalization, and 23% (7/30) using a hybrid approach. ConclusionsThis scoping review provides a comprehensive mapping of the literature on the current trends and gaps in digital precision health research for the management of HTN in adults. …”
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Molecular Patterns of MEFV Gene Mutations in Egyptian Patients with Familial Mediterranean Fever: A Retrospective Cohort Study by Amal R. Mansour, Ayman El-Shayeb, Nihal El Habachi, Mohamad A. Khodair, Doaa Elwazzan, Nermeen Abdeen, Marwa Said, Riham Ebaid, Noha ElShahawy, Amr Seif, Nadia Zaki

“…This test is based on reverse hybridization of biotinylated PCR products on immobilized oligonucleotides for mutations and controls in a parallel array of allele-specific oligonucleotides. …”
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Testing the Feasibility, Acceptability, and Potential Efficacy of an Innovative Digital Mental Health Care Delivery Model Designed to Increase Access to Care: Open Trial of the Dig... by Natalia Macrynikola, Kelly Chen, Erlend Lane, Nic Nguyen, Jennifer Pinto, Shirley Yen, John Torous

“…There is now a growing interest in hybrid, or blended, care approaches that use apps as tools to augment, rather than to entirely guide, care. …”
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Genome drafting of nosocomial infection CRE Klebsiella pneumoniae confirming resistance to colistin and eravacycline, carrying blaNDM-1, mcr-1, and blaKPC-2, in neonatology from No... by Xinlong Zhou, Kailash Wagh, Guizhen Lv, Devender Sharma, Wei Lei

“…For genetic analysis, both Illumina short-read and Nanopore long-read sequencing were used, followed by hybrid assembly for enhanced genome resolution. Plasmid and resistance gene profiles were determined using AMRFinder and PlasmidFinder databases.ResultsA total of three CRKP isolates (designated Kp1, Kp2, and Kp3) were identified. …”
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New approach to generating of human monoclonal antibodies specific to the proteolytic domain of botulinum neurotoxin A by Marina Vladimirovna Silkina, Alena Sergeevna Kartseva, Alena Konstantinovna Riabko, Mariia Aleksandrovna Makarova, Metkhun Madibronovich Rogozin, Yana Olegovna Romanenko, Igor Georgievich Shemyakin, Ivan Alekseevich Dyatlov, Victoria Valerievna Firstova

“…Conclusion: The use activated plasmablasts and memory B-cells isolated at the peak of the immune response (at day 7 of immunogenesis) that have not yet completed the terminal stage of differentiation but have undergone somatic hypermutation for hybridization allows us to obtain specific huMAbs even when the immune response of the donor is weak (with low levels of specific antibodies and specific B-cells in blood). …”
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