Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tu... by Joseph Donovan, Dong Huu Khanh Trinh, Ronald B. Geskus, Marcel Wolbers, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Le Thanh Hoang Nhat

“…The primary endpoint was all-cause death or new neurological event over the first 12 months after randomisation. We took a hybrid trial-design approach which aims to prove non-inferiority of placebo first but also allows claiming superiority of placebo in case dexamethasone causes substantial harm. …”
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Non-Anatomic Reconstruction in Multiligament Knee Injuries: A Functional Approach by Mihai Hurmuz, Cătălin-Adrian Miu, Daniel Ceachir, Romulus-Fabian Tatu, Mihai Andrei, Bogdan Andor, Alexandru Catalin Motofelea, Călin Tudor Hozan

“…<i>Material and methods</i>: In this study, we assessed the outcomes of a non-anatomic, hybrid surgical approach involving combined arthroscopic and open non-anatomic ligament reconstruction in 60 patients with multiligament knee injuries. …”
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Use of a synthetic form Avrodes for transfer of leaf rust resistance from Aegilops speltoides to common wheat by R. O. Davoyan, I. V. Bebyakina, E. R. Davoyan, D. S. Mikov, E. D. Badaeva, I. G. Adonina, E. A. Salina, A. N. Zinchenco, Y. S. Zubanova

“…The analysis of chromosome pairing in F1 hybrids showed that the transfer of a genetic material from Avrodes to common wheat basically occurs through translocations. …”
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Promoter Methylation Precedes Chromosomal Alterations in Colorectal Cancer Development by Sarah Derks, Cindy Postma, Peter T. M. Moerkerk, Sandra M. van den Bosch, Beatriz Carvalho, Mario A. J. A. Hermsen, Walter Giaretti, James G. Herman, Matty P. Weijenberg, Adriaan P. de Bruïne, Gerrit A. Meijer, Manon van Engeland

“…Chromosomal alterations were evaluated by comparative genomic hybridization. Results: Our data demonstrate that nonprogressed adenomas, progressed adenomas and carcinomas show similar frequencies of promoter methylation for the majority of the genes. …”
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Host protein PRPS2 interact with the non-structural protein p17 of Avian Reovirus and promote viral replication by Hu Xiaomiao, Zhao Ruihong, Li Wei, Pan Xiaocheng, Dai Yin, Wu Huimin, Wu Yantao, Zhang Chengcheng

“…To further elucidate the pathogenic mechanism basis of ARV p17 protein function, we employed a yeast two-hybrid system to identify Phosphoribosyl pyrophosphate synthetase 2 (PRPS2) as an interacting host protein with p17. …”
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Advanced Learning Technologies for Intelligent Transportation Systems: Prospects and Challenges by Ruhul Amin Khalil, Ziad Safelnasr, Naod Yemane, Mebruk Kedir, Atawulrahman Shafiqurrahman, NASIR SAEED

“…Besides, we identify several future challenges and research directions that can push the boundaries of ITS, including the critical aspects, including transfer learning, hybrid models, privacy and security, and ultra-reliable low-latency communication. …”
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How does community health feature in Global Financing Facility planning documents to support reproductive, maternal, newborn, child and adolescent health and nutrition (RMNAH-N)? i... by Joël Arthur Kiendrébéogo, Orokia Sory, Issa Kaboré, Yamba Kafando, Rosie Steege, Asha S. George, Meghan Bruce Kumar

“…We applied an iterative hybrid inductive-deductive approach to identify themes for data coding and extraction. …”
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TDCN: A novel temporal depthwise convolutional network for short-term load forecasting by Mingping Liu, Chenxu Xia, Yuxin Xia, Suhui Deng, Yuhao Wang

“…While numerous STLF models have been developed, many of these models are complex hybrid structures that struggle with issues such as overfitting, stacking errors, high computational costs, and suboptimal generalization. …”
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SEMI–DWARF PRODUCTIVE BARLEY LINES by B. A. Batasheva, V. I. Ibisheva, R. A. Abdullaev, O. N. Kovaleva, I. A. Zveinek, E. E. Radchenko

“…In the southern planar area of Dagestan, from 1993 till 2008, a research was conducted on the intraspecific diversity of cultivated barley (Hordeum vulgare L.) belonging to different ecogeographic groups, and growth types (2,021 accessions). The F1, F2 and F3 hybrids from crosses of the long-stemmed cultivar ‘Sonet’ with semi-dwarf forms were also studied. …”
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Charge-on-the-move solutions for future mobility: A review of current and future prospects by Mohd Aiman Khan, Wilco Burghout, Oded Cats, Erik Jenelius, Matej Cebecauer

“…The findings suggest that the future of EV charging will likely involve a hybrid approach, integrating both conventional and dynamic solutions. …”
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DNA Amplifications and Aneuploidy, High Proliferative Activity and Impaired Cell Cycle Control Characterize Breast Carcinomas with Poor Prognosis by Harald Blegen, John S. Will, B. Michael Ghadimi, Hesed‐Padilla Nash, Anders Zetterberg, Gert Auer, Thomas Ried

“…In order to explore whether specific cytogenetic abnormalities can be used to stratify tumors with a distinctly different clinical course, we performed comparative genomic hybridization (CGH) of tumors from patients who were diagnosed with metastatic disease after an interval of less than 2 years or who remained free from distant metastases for more than 10 years. …”
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Extreme Heating of Minor Ions in Imbalanced Solar-wind Turbulence by Michael F. Zhang, Matthew W. Kunz, Jonathan Squire, Kristopher G. Klein

“…The recent discovery of the “helicity barrier” offers a mechanism in which imbalanced Alfvénic turbulence in low- β plasmas preferentially heats protons over electrons, generating high-frequency, proton-cyclotron-resonant fluctuations. We use the hybrid-kinetic particle-in-cell code Pegasus++ to drive imbalanced Alfvénic turbulence in a 3D low- β plasma with additional passive ion species, He ^2+ and O ^5+ . …”
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Risk of adverse cardiovascular events based on common genetic variants in 8-year follow-up of the LIPIDOGEN2015 population using the polygenic risk score (PRS): study design and me... by Maciej Banach, Martyna Fronczek, Tadeusz Osadnik, Agnieszka Gach, Dominik Strapagiel, Marcin Słomka, Mateusz Lejawa, Anna Goc, Ewa Boniewska-Bernacka, Anna Pańczyszyn, Gregory Y.H. Lip, Dimitri P. Mikhailidis, Peter P. Toth, Peter E. Penson, Jacek Jóźwiak

“…The samples were amplified, fragmented, and hybridized to BeadChips. The BeadChips were scanned using iScan and converted to genotypes using Genome Studio 2.0. …”
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Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tu... by Joseph Donovan, Dong Huu Khanh Trinh, Ronald B. Geskus, Marcel Wolbers, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Le Thanh Hoang Nhat

“…The primary endpoint was all-cause death or new neurological event over the first 12 months after randomisation. We took a hybrid trial-design approach which aims to prove non-inferiority of placebo first but also allows claiming superiority of placebo in case dexamethasone causes substantial harm. …”
Get full text

Integrated analysis of transcriptome, sRNAome, and degradome involved in the drought-response of maize Zhengdan958 by Yang Shuqiong, Liu Jiafei, Cao Lingling, Chen Jibao, Duan Pengfei

“…Further to help comprehending the molecular mechanisms underlying drought adaptability and tolerance of maize, an integrated multi-omics analysis of transcriptome, sRNAome, and degradome was performed on the seedling roots of an elite hybrid Zhengdan958 under drought stress. In this study, 2,911 genes, 32 conserved miRNAs, and 12 novel miRNAs showed a significantly differential expression under drought stress. …”
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TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis by Jing Li, Yosuke Nagasaka, Hongtao Shen, Xinyu Zhou, Jianjie Ma, Dilza Trevisan-Silva, Nicholas E. Sherman, Jayakrishna Ambati, Bradley D. Gelfand, Lian-Wang Guo

“…However, the role of partial EMT (pEMT), a hybrid state exhibiting both epithelial and mesenchymal markers, remains poorly understood in this context. …”
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Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing by Wei Duan, Yue Gao, Ruru Xu, Sheng Huang, Xueqian Xia, Jingwen Zhao, Longhuan Zeng, Qiaolin Wei, Jia-Wei Shen, Jianmin Wu, Yongke Zheng

“…In this study, a smart pro-angiogenic nanozyme is simply and efficiently synthesized by in situ reduction of Pt precursors on porous silicon (PSi) nanocarriers. Owing to the hybridization of Pt, the Pt-decorated PSi (Pt@PSi) nanocomposites exhibit excellent near-infrared (NIR) photothermal activity and peroxidase-like catalytic activity, which can be used for co-efficient antibacterial treatment. …”
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Advances in Hemodynamic Analysis in Cardiovascular Diseases Investigation of Energetic Characteristics of Adult and Pediatric Sputnik Left Ventricular Assist Devices during Mock Ci... by Alexander A. Pugovkin, Aleksandr G. Markov, Sergey V. Selishchev, Leonie Korn, Marian Walter, Steffen Leonhardt, Leo A. Bockeria, Olga L. Bockeria, Dmitry V. Telyshev

“…We investigate energetic characteristics of adult Sputnik 1 and Sputnik 2 LVADs connected to a hybrid adult mock circulation (HAMC) and also for the Sputnik pediatric rotary blood pump (PRBP) connected to a pediatric mock circulation (PMC). …”
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Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid—A Comprehensive Review of Formulation, Characterization, Applications, and Future Trends by Prateek Uttreja, Indrajeet Karnik, Ahmed Adel Ali Youssef, Nagarjuna Narala, Rasha M. Elkanayati, Srikanth Baisa, Nouf D. Alshammari, Srikanth Banda, Sateesh Kumar Vemula, Michael A. Repka

“…Additionally, emerging trends, including 3D printing, hybrid systems, and supersaturable SEDDS (Su-SEDDS), are explored. …”
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The Inheritance and Variation of Floral Scent Compounds in Parent–Progeny Relationships of <i>Malus</i> by Junjun Fan, Yu Zai, Ye Peng, Qin Peng, Meng Sun, Qingqing Xiong, Jingze Ma, Chenchen Zhou, Wangxiang Zhang

“…Most compounds in the progenies were inherited from their maternal parent (60.61–75.00%), and most of them were significantly downregulated by hybridization. However, the content of several compounds in the progenies appeared transgressive, even unique. …”
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