Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans by Hugues Allard-Chamard, Kirsty Hillier, Michelle L. Ramseier, Alice Bertocchi, Naoki Kaneko, Katherine Premo, Grace Yuen, Marshall Karpel, Vinay S. Mahajan, Christina Tsekeri, Joseph S. Hong, Jean Vencic, Rory Crotty, Anish V. Sharda, Sara Barmettler, Emma Westermann-Clark, Jolan E. Walter, Musie Ghebremichael, Alex K. Shalek, Jocelyn R. Farmer, Shiv Pillai

“…Abstract: Patients with cytotoxic T-lymphocyte–associated protein 4 (CTLA4) deficiency exhibit profound humoral immune dysfunction, yet the basis for the B-cell defect is not known. …”
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Sex hormones and allergies: exploring the gender differences in immune responses by Jesús Alberto Gutiérrez-Brito, José Álvaro Lomelí-Nieto, José Francisco Muñoz-Valle, Edith Oregon-Romero, Jazz Alan Corona-Angeles, Jorge Hernández-Bello

“…The evidence suggests that estrogens enhance immune humoral responses, autoimmunity, mast cell reactivity, and delayed IV allergic reactions, while androgens, progesterone, and glucocorticoids suppress them. …”
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Diagnosis and treatment of nervous system diseases at the beginning of the 19th century in Vilnius university clinics by E. Sakalauskaitė-Juodeikienė, G. Motiejūnas, D. Jatužis

“…In Vilnius, as in other European clinics, the causes of the diseases were sought in the internal organs (the influence of the solidism theory), but autopsy findings usually revealed the brain and spinal cord congestion with blood, confirming the inflammation of the nervous system (or humoralism) theory. The level of diagnostics and treatment of nervous system diseases in Vilnius corresponded to the level of Western Europe in the first half of the 19th century. …”
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Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus by Utpal Kumar Adhikari, Mourad Tayebi, M. Mizanur Rahman

“…In this report, we identified both T-cell and B-cell epitopes of the most antigenic OROV polyprotein with the potential to induce both humoral and cell-mediated immunity. Eighteen highly antigenic and immunogenic CD8+ T-cell epitopes were identified, including three 100% conserved epitopes (TSSWGCEEY, CSMCGLIHY, and LAIDTGCLY) as the potential vaccine candidates. …”
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Immune correlates of early clearance of Mycobacterium tuberculosis among tuberculosis household contacts in Indonesia by Todia P. Setiabudiawan, Lika Apriani, Ayesha J. Verrall, Fitria Utami, Marion Schneider, Agnes R. Indrati, Pauline P. Halim, Paulina Kaplonek, Hadar Malca, Jessica Shih-Lu Lee, Simone J. C. F. M. Moorlag, L. Charlotte J. de Bree, Vera P. Mourits, Leo A. B. Joosten, Mihai G. Netea, Bachti Alisjahbana, Ryan P. McNamara, Galit Alter, Arjan van Laarhoven, James E. Ussher, Katrina Sharples, Valerie A. C. M. Koeken, Philip C. Hill, Reinout van Crevel

“…Our findings suggest that a more efficient host innate immune response, rather than a humoral response, mediates early clearance of Mtb. …”
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Specific Antibody Production by Blood B Cells is Retained in Late Stage Drug-naïve HIV-infected Africans by Lydie Béniguel, Evelyne Bégaud, Fabrice Cognasse, Philippe Gabrié, Christophe D. Mbolidi, Mary A. Marovich, Céline Cazorla, Frédéric Lucht, Christian Genin, Olivier Garraud

“…As in vitro produced Abs retained the capacity of binding antigen and forming complexes, this study provides pre-clinical support for functional humoral responses despite major HIV- and other tropical pathogen-induced B cell perturbations.…”
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Allogeneic Mesenchymal Stem Cell Treatment Induces Specific Alloantibodies in Horses by Sean D. Owens, Amir Kol, Naomi J. Walker, Dori L. Borjesson

“…It is unknown whether horses that receive allogeneic mesenchymal stem cells (MSCs) injections develop specific humoral immune response. Our goal was to develop and validate a flow cytometric MSC crossmatch procedure and to determine if horses that received allogeneic MSCs in a clinical setting developed measurable antibodies following MSC administration. …”
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Systemic and immunotoxicity induced by topical application of perfluoroheptane sulfonic acid (PFHpS) or perfluorooctane sulfonic acid (PFOS) in a murine model by Lisa M. Weatherly, Hillary L. Shane, Laurel G. Jackson, Ewa Lukomska, Rachel Baur, Madison P. Cooper, Stacey E. Anderson

“…Additionally, PFHpS significantly reduced the humoral immune response and altered immune subsets in the spleen, suggesting immunosuppression. …”
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Identification of early prediction biomarkers of severity in patients with severe fever with thrombocytopenia syndrome based on plasma proteomics by Qian Zhang, Qian Zhang, Zhengyi Jiang, Nan Jiang, Luchen Shi, Jiaying Zhao, Jie Zhao, Jie Zhao, Ke Ouyang, Ke Ouyang, Huaying Huang, Huaying Huang, Yaqin Zhang, Yan Dai, Nannan Hu, Ping Shi, Yaping Han, Ke Jin, Jun Li

“…A cohort consisting of 190 patients with SFTS was used to develop the predictive model for severe illness and subsequently validate it in a new cohort consisting of 93 patients with SFTS.ResultsA significant increase in plasma proteins associated with various functional clusters, such as the proteasomal protein catabolic process, phagocytosis, and humoral immune response, was observed in severe SFTS patients. …”
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Effectiveness of rehabilitation interventions in patients with colorectal cancer: an overview of systematic reviews by Mengzhe Yang, Bhasker Amatya, Sana Malik, Krystal Song, Stefanie Marcella, Catherine Voutier, Fary Khan

“…The findings suggest: moderate-quality evidence for exercise interventions for improving physical fitness and quality of life; high-quality evidence for nutritional interventions in reducing postoperative infections; high-quality evidence for multimodal prehabilitation for improved preoperative functional capacity; moderate-quality evidence for nutritional interventions for improving humoral immunity, reducing inflammation, and length of stay; moderate-quality evidence for acupuncture in improving gastrointestinal functional recovery; psychosocial interventions in improving short-term quality of life and mental health, and lifestyle interventions for improved quality of life. …”
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Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I by Yukitoshi Takahashi, Kazumi Matsuda, Yuko Kubota, Jiro Shimomura, Etsuko Yamasaki, Tatsuya Kudo, Katsuyuki Fukushima, Hitoshi Osaka, Noriyuki Akasaka, Atsushi Imamura, Shinji Yamada, Naomi Kondo, Tateki Fujiwara

“…Rasmussen syndrome is an intractable epilepsy with a putative causal relation with cellular and humoral autoimmunity. Almost half of the patients have some preceding causative factors, with infections found in 38.2%, vaccinations in 5.9% and head trauma in 8.9% of Japanese patients. …”
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A Precocious Cerebellar Ataxia and Frequent Fever Episodes in a 16-Month-Old Infant Revealing Ataxia-Telangiectasia Syndrome by Luigi Nespoli, Annapia Verri, Silvia Tajè, Francesco Paolo Pellegrini, Maddalena Marinoni

“…Immunodeficiency which includes both cellular and humoral arms has variable severity. Since the clinical presentation is extremely variable, a high clinical suspicion will allow an early diagnosis. …”
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Proceedings of the 14th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals by Sophie Tourdot, Daniel Baltrunkonis, Sofie Denies, Viswanath Devanarayan, Joanna Grudzinska-Goebel, Arno Kromminga, Gregor P. Lotz, Laurent Malherbe, Lydia Michaut, Karin N. Weldingh, Joao A. Pedras-Vasconcelos, Laura. I. Salazar-Fontana, Sebastian Spindeldreher, Zuben Sauna, Veerle Snoeck, Daniela Verthelyi, Daniel Kramer

“…However, the development of unwanted immune responses directed against these drugs, humoral and/or cellular, can hinder their efficacy and have safety consequences with various degrees of severity. …”
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Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B by Ashraf Mohamadkhani, Elnaz Naderi, Masoud Sotoudeh, Aezam Katoonizadeh, Ghodratollah Montazeri, Hossein Poustchi

“…Humoral immunity constitutes major defense mechanism against viral infections. …”
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Late Onset Graft Plasmacytoma-Like PTLD Presenting as Acute Hyperglycemia in a Kidney-Pancreas Transplant Recipient by P. Ventura-Aguiar, M. T. Cibeira, A. Martinez, M. Cuatrecasas, M. Aymerich, J. Ferrer, J. Blade, F. Diekmann, M. J. Ricart

“…Plasma cells are often observed in humoral rejection biopsies, but graft infiltration by plasmacytoma-like PTLD is rare. …”
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Social criticism and tricky irony in Sanai's mind and language by Rouholah Hadi, Mitra Golchin, Mohammadreza Torki, Sima Rahmanifar

“…The heterogeneous experiences of the poet from his world lead to the emergence of apparently more controversial issues in his poetry. The poet's humorous awareness of the existing contradictions brings the text into an irony, can make reading the poet more of an intellectual challenge, and gives readers a wider view. …”
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Hyperglycemia Inhibits Complement-Mediated Immunological Control of S. aureus in a Rat Model of Peritonitis by Clifford T. Mauriello, Pamela S. Hair, Reuben D. Rohn, Nicholas S. Rister, Neel K. Krishna, Kenji M. Cunnion

“…These results suggest that hyperglycemia inhibited humoral effector recruitment, anaphylatoxin generation, and complement-mediated opsonization of S. aureus, suggesting that hyperglycemic inhibition of complement effectors may contribute to the increased risk and severity of S. aureus infections in diabetic patients.…”
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Scanning electron and light microscopic investigation of bursa fabricius in turkey (meleagris gallopavo) by Murat Erdem Gultiken, Dincer Yildiz, Siyami Karahan, Durmus Bolat

“…<p> <b>Conclusion:</b> It was concluded that the results may contribute to the researches which relate to humoral immunity formation and effectiveness of vaccination programme.…”
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Dermatological Disorders following Liver Transplantation: An Update by Dipesh Kumar Yadav, Xue li Bai, Tingbo Liang

“…The liver is considered as an immune privileged organ since it has a low prevalence of humoral rejection in contrast to other SOT, and thus, LT requires a minimal amount of immunosuppressants compared to other SOT recipients. …”
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Immunoprotective Effect of Seabuckthorn (Hippophae rhamnoides) and Glucomannan on T-2 Toxin-Induced Immunodepression in Poultry by T. Ramasamy, C. Varshneya, V. C. Katoch

“…The immunoprotective effects of seabuckthorn and glucomannan were assessed by evaluating humoral immune reaction against NCD vaccine (haemagglutination test and immunoglobulin estimation), serum immunoglobulin levels, phagocytic index, and DTH reaction against DNFB between day 25 and day 28 of experiment. …”
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