Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1–7) and Bradykinin by Nádia Bertoncello, Roseli Peres Moreira, Danielle Yuri Arita, Danielle S. Aragão, Ingrid Kazue Mizuno Watanabe, Patricia S. Dantas, Ralmony Santos, Rodolfo Mattar-Rosa, Rodrigo Yokota, Tatiana Sousa Cunha, Dulce Elena Casarini

“…Population studies have shown an association between diabetic nephropathy (DN) and insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene (ACE in humans, Ace in mice). The aim was to evaluate the modulation of Ace copies number and diabetes mellitus (DM) on renal RAS and correlate it with indicators of kidney function. …”
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Microbiological Safety of Leafy Vegetables Produced at Houeyiho and Sèmè-Kpodji Vegetable Farms in Southern Benin: Risk Factors for Campylobacter spp. by Sylvain Daton Kougblénou, Alidéhou Jerrold Agbankpé, Justin Gbèssohélé Béhanzin, Tamègnon Victorien Dougnon, Alidah Victonie Aniambossou, Lamine Baba-Moussa, Honoré Sourou Bankolé

“…Foodborne infections, mainly those attributable to Campylobacter, are one of the most common causes of intestinal diseases, of bacterial origin in humans. Although the vehicle of transmission is not always identified, the most common vehicles are poultry, poultry products, and contaminated water. …”
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Rural and remote health care: the case for spatial justice by Karen Hayes, Kristy Coxon, Rosalind Bye

“…To critical geographers, places are not static; humans both respond to geography and shape it based on decisions influenced by contemporary social ideologies. …”
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A systematic review of One Health perspective on the use of antimicrobials in Nigeria by Umulkhairah Onyioiza Arama, Malik Olatunde Oduoye, Bolanle Akanbi-Hakeem, Misha Khan, Polyne Wechuli, Amina Aliyu

“…This article aims to highlight the need for all sectors in One Health, including human and animal health, to work together in reducing the misuse of antimicrobials in Nigeria. …”
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Near telomere-to-telomere genome assemblies of Silkie Gallus gallus and Mallard Anas platyrhynchos restored the structure of chromosomes and “missing” genes in birds by Qiangsen Zhao, Zhongtao Yin, Zhuocheng Hou

“…Abstract Background Chickens and ducks are vital sources of animal protein for humans. Recent pangenome studies suggest that a single genome is insufficient to represent the genetic information of a species, highlighting the need for more comprehensive genomes. …”
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Homo erectus adapted to steppe-desert climate extremes one million years ago by Julio Mercader, Pamela Akuku, Nicole Boivin, Alfredo Camacho, Tristan Carter, Siobhán Clarke, Arturo Cueva Temprana, Julien Favreau, Jennifer Galloway, Raquel Hernando, Haiping Huang, Stephen Hubbard, Jed O. Kaplan, Steve Larter, Stephen Magohe, Abdallah Mohamed, Aloyce Mwambwiga, Ayoola Oladele, Michael Petraglia, Patrick Roberts, Palmira Saladié, Abel Shikoni, Renzo Silva, María Soto, Dominica Stricklin, Degsew Z. Mekonnen, Wenran Zhao, Paul Durkin

“…These findings suggest archaic humans possessed an ecological flexibility previously attributed only to later hominins. …”
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Acrylamide Induces Antiapoptotic Autophagy and Apoptosis by Activating PERK Pathway in SH-SY5Y Cells by Yiqi Wang, Ying Liu, Xing Zhang, Yang Jiao, Lian Duan, Ruijie Cheng, Ning Yang, Hong Yan

“…Acrylamide (ACR) is a commonly used organic compound that exhibits evident neurotoxicity in humans. Our previous studies showed that the mechanisms of ACR-caused neurotoxicity included apoptosis, PERK-mediated endoplasmic reticulum stress, and autophagy, but the relationships among them were still unclear. …”
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Isoleucine at position 137 of haemagglutinin acts as a mammalian adaptation marker of H9N2 avian influenza virus by Weiwei Ma, Chenyang Ren, Lin Shi, Bo Meng, Yali Feng, Ying Zhang

“…The H9N2 subtype of avian influenza virus (AIV) is widely distributed among poultry and wild birds and is also a threat to humans. During AIV active surveillance in Liaoning province from 2015 to 2016, we identified 10 H9N2 strains exhibiting different lethality to chick embryos. …”
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Socio-economic assessment of dog population management systems: a scoping review by Rabina Ghimire, Parimala Mohanty, Elly Hiby, Andrew Larkins, Andrew Larkins, Salome Dürr, Sonja Hartnack

“…IntroductionDog Population Management (DPM) systems primarily aim to reduce the free-roaming dog population, improve the health and welfare of humans and dogs, and foster their peaceful coexistence. …”
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Effects of water stably-enriched with oxygen as a novel method of tissue oxygenation on mitochondrial function, and as adjuvant therapy for type 2 diabetes in a randomized placebo-... by Joan Khoo, Christoph E Hagemeyer, Darren C Henstridge, Sumukh Kumble, Ting-Yi Wang, Rong Xu, Linsey Gani, Thomas King, Shui-Boon Soh, Troy Puar, Vanessa Au, Eberta Tan, Tunn-Lin Tay, Carmen Kam, Eng-Kiong Teo

“…Mitochondrial stress testing, and flow cytometry analysis of mitochondrial mass and membrane potential, were performed on human HepG2 cells cultured in four Dulbecco's Modified Eagle Medium media, made with ELO water or regular (control) water, at normal (5.5 mM) or high (25 mM) glucose concentrations. …”
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Use of Garden Design to Enhance Mental Health Among the Selected Health Facilities in Kabale Town: A Case Study of Makanga Health Facility. by Nayebare, Maria

“…The research emphasizes the importance of reconnecting humans with their environment and highlights the therapeutic potential of nature. …”
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Molecular detection of parasites and host preference in wild-caught Culicoides biting midges (Diptera: Ceratopogonidae) in Chiang Mai and Nakhon Si Thammarat Provinces, Thailand by Kyi Soe Baby, Kaewmee Saowalak, Mano Chonlada, Pattanawong Urassaya, Tipparawong Nopporn, Siriyasatien Padet, Gatherer Derek, Urbaniak Michael D., Bates Paul A., Jariyapan Narissara

“…Blood meal analysis revealed that Culicoides primarily fed on cattle (17/29, 58.6%), followed by chickens (10/29, 34.5%), and humans (2/29, 6.9%). Our findings confirmed the existence of several Culicoides species in Thailand, which might be potential vectors for transmission of haemosporidians (Leucocytozoon and Plasmodium). …”
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Terrain Irregularity Sensing by Evaluating Feet Coordinate Standard Deviation by Tomas Luneckas, Mindaugas Luneckas, Dainius Udris

“…Our proposed terrain roughness method is inspired by the observation that humans can sense their limb position in space without looking at them, which allows us to estimate obstacle heights. …”
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Techno-Functional and Bioactive Properties and Chemical Composition of Guava, Mamey Sapote, and Passion Fruit Peels by Leticia X. López-Martínez, Mónica A. Villegas-Ochoa, J. Abraham Domínguez-Avila, Elhadi M. Yahia, Gustavo A. Gonzalez-Aguilar

“…The chemical composition and properties reported in the present work suggest that peel powders of these guava, mamey sapote, and passion fruit could be used as constituents in different foods, such as bakery and meat goods, with beneficial health effects like control of hyperglycemia, improved intestinal function, and control of overweight; however, more studies are necessary for animal models and humans to confirm these bioactivities conclusively.…”
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Association of per- and polyfluoroalkyl substances with gout risk: a cross-sectional analysis of NHANES 2007–2018 data emphasizing mixture effects by Haixin Feng, Siran Li, Shiqing Huang, Linxi He, Ruihao Huang, Renhuizi Wei, Xin Peng, Haiyi Yan, Chongxiang Xiong, Bingsong Zhang

“…PFHxS has the longest metabolic half-life in humans (7.3 years) and bioaccumulates in the endocrine, immune, nervous, and reproductive systems. …”
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Cause-Effect Relationships between Painful TMD and Postural and Functional Changes in the Musculoskeletal System: A Preliminary Report by Adam Andrzej Garstka, Monika Brzózka, Aleksandra Bitenc-Jasiejko, Roman Ardan, Helena Gronwald, Piotr Skomro, Danuta Lietz-Kijak

“…A number of scientific publications indicated the relationship between the presence of postural dysfunctions and functional disorders of the masticatory system in humans. Nevertheless, dental procedures still very rarely include comprehensive diagnostics and procedures aimed at the normalization of the locomotor system related to TMD. …”
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Serological cross-reactivity between Crimean-Congo haemorrhagic fever virus and Nairobi sheep disease virus glycoprotein C by Emmanuel A. Maze, George Booth, Georgina Limon, Sandra Belij-Rammerstorfer, Simona R. Tchakarova, Tsviatko Alexandrov, Clare Browning, Ginette Wilsden, Anna B. Ludi, Bryan Charleston, Teresa Lambe, Teresa Lambe

“…IntroductionCrimean-Congo haemorrhagic fever virus (CCHFV) and Nairobi sheep disease virus (NSDV) are orthonairoviruses of concern, able to cause haemorragic fever disease in humans and sheep, respectively. CCHFV and NSDV cocirculating in small ruminant populations across South Asia and East Africa. …”
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Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models by Carol Milligan, Dale O. Cowley, William Stewart, Alyson M. Curry, Elizabeth Forbes, Brian Rector, Annette Hastie, Liang Liu, Gregory A. Hawkins

“…<b>Methods:</b> We leveraged unique mouse models of IL6 trans-signaling that we developed that recapitulate the production of active sIL6R in a genotypic and quantitative fashion observed in humans. Given that the SOD1 transgenic mouse is one of the most highly studied and characterized models of ALS, we bred <i>SOD1^G93A</i> mice with IL6R trans-signaling mice to determine how enhanced trans-signaling influenced symptom onset and pathological processes, including neuromuscular junction (NMJ) denervation, glial activation and motoneuron (MN) survival. …”
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Identifikasi Carrier Bakteri Streptococcus β hemolyticus Group A pada Murid SD Negeri 13 Padang Berdasarkan Perbedaan Umur dan Jenis Kelamin by Fadhila Aini, Aziz Djamal, Elly Usman

“…</p><p><strong>Kata kunci:</strong> carrier, streptococcus β hemolyticus grup A, umur, jenis kelamin</p><p> </p><p><strong><em>Abstract</em></strong></p><p><em>Group A Streptococcus β hemolyticus or also called Streptococcus pyogenes is one of many pathogenic bacteria that infect humans. These bacteria can be found as a carrier in the respiratory tract especially in children, do not cause disease but can be a risk for spreading the disease. …”
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Quantification of Volatile Acetone Oligomers Using Ion-Mobility Spectrometry by Tobias Hüppe, Dominik Lorenz, Felix Maurer, Tobias Fink, Ramona Klumpp, Sascha Kreuer

“…The ratio of acetone monomer and dimer is inconsistent and varies in ambient air from place-to-place and across individual humans and rats. Monomers and dimers must therefore be considered when quantifying acetone. …”
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