A Novel Liposome Formulation Carrying Both an Insulin Peptide and a Ligand for Invariant Natural Killer T Cells Induces Accumulation of Regulatory T Cells to Islets in Nonobese Dia... by Hidetoshi Akimoto, Emi Fukuda-Kawaguchi, Omar Duramad, Yasuyuki Ishii, Kazunari Tanabe

“…Antigen-specific therapies using islet autoantigens for restoring immune tolerance have emerged as promising approaches for the treatment of T1D but have been unsuccessful in humans. Herein, we report that RGI-3100-iB, a novel liposomal formulation carrying both α-galactosylceramide (α-GalCer), which is a representative ligand for invariant natural killer T (iNKT) cells, and insulin B chain 9–23 peptide, which is an epitope for CD4+ T cells, could induce the accumulation of regulatory T cells (Tregs) in islets in a peptide-dependent manner, followed by the remarkable prevention of diabetes onset in nonobese diabetic (NOD) mice. …”
Get full text

Penentuan Jarak Karakter Pemain dengan Karakter Bukan Pemain yang Harus Mengikuti Pemain pada Pengembangan Game Simulasi Mitigasi Bencana Erupsi Gunung by Henny Widowati, Rachma Putri Widhowati, Sulistyo Puspitodjati, D.L. Crispina Pardede

“…NPC's animation: the character of cows and humans following players is part of the development of mitigation simulation games for volcanic eruptions. …”
Get full text

Peripheral Mononuclear Cell Resistin mRNA Expression Is Increased in Type 2 Diabetic Women by Panayoula C. Tsiotra, Constantine Tsigos, Eleni Anastasiou, Eleni Yfanti, Eleni Boutati, Emmanouil Souvatzoglou, Ioannis Kyrou, Sotirios A. Raptis

“…Resistin has been shown to cause insulin resistance and to impair glucose tolerance in rodents, but in humans its physiological role still remains elusive. …”
Get full text

Protective effects of wogonin in the treatment of central nervous system and degenerative diseases by Qingan Fu, Qingyun Yu, Hongdan Luo, Zhekang Liu, Xiaowei Ma, Huijian Wang, Zhijuan Cheng

“…Despite extensive preclinical evidence, further clinical studies are warranted to confirm its efficacy and safety in humans. This review highlights the great therapeutic potential of wogonin in terms of CNS protection. …”
Get full text

Experimental opisthorchiasis: a study of blood cells, hematopoiesis and startle reflex in laboratory animals by D. F. Avgustinovich, I. A. Orlovskaya, L. B. Toporkova, G. B. Vishnivetskaya, A. V. Katokhin, M. N. Lvova, E. V. Kashina, N. P. Bondar, N. A. Feofanova, V. A. Mordvinov

“…One of the species of the family Opisthorchiidae, Opisthorchis felineus (O. felineus), causes severe disturbances in humans and animals, and so it is the subject of important research studies. …”
Get full text

Salutogenic Environmental Health Model—proposing an integrative and interdisciplinary lens on the genesis of health by Jule Anna Pleyer, Laura Dominique Pesliak, Annette Konstanze Fides Malsch, Annette Konstanze Fides Malsch, Timothy McCall, Timothy McCall

“…The objective of this study is to address this gap by extending Antonovsky’s model to encompass environmental dimensions, that is, the interactions between humans and their environment. Furthermore, the study will integrate examples of models and theories from various disciplines to illustrate how a more comprehensive and holistic explanation of health development can be provided from an interdisciplinary environmental public health perspective.MethodologyAs part of a three-step approach, a Basic Model was first developed that integrates the five environmental dimensions—Natural, Built-Material, Socio-Cultural, Psycho-Social, and Individual—into the Salutogenic Model. …”
Get full text

New insights in the low-temperature-dependent formation of amorphous titania-coated magnetic polydopamine nanocomposites for the adsorption of methylene blue by Jiangqun Zhang, Xingyu Long, Meng Hu, Wanli Wei, Jiangning Gong, Chun Yang, Pinhua Xia, Anping Wang

“…Abstract Removal of accumulated dyes from the environment water bodies is essential to prevent further harm to humans. The development and design of new alternative nanoadsorbents that can conveniently, quickly, and efficiently improve the adsorption and removal efficiency of dyes from wastewater remains a huge challenge. …”
Get full text

Development of a neural network for diagnosing the risk of depression according to the experimental data of the stop signal paradigm by M. O. Zelenskih, A. E. Saprygin, S. S. Tamozhnikov, P. D. Rudych, D. A. Lebedkin, A.  N. Savostyanov

“…An architecture was developed and a system was implemented for testing motor control indicators in humans, then it was tested in real experiments. A comparison of neural network technologies and methods of mathematical statistics was carried out. …”
Get full text

FASILITAS KHUSUS PENYANDANG DISABILITAS DAN LANSIA PADA MASJID RAYA MAKASSAR by Irma Rahayu

“…Special facilities for the disabilities and the elderly people in this mosque need to be considered to fulfill their rights like normal humans in general. This study aimed to determine the extent of accessible facilities for the disabilities and the elderly people at the Makassar Raya Mosque. …”
Get full text

Anti-inflammatory effect of sea buckthorn in an HCl-induced cystitis rat model by Hyun Suk Yoon, Juyeon Yu, Shinhoon Kang, Hana Yoon

“…In addition, intravesical application of hydrochloric acid (HCl) in rats induces histological changes similar to those observed in humans with IC. Therefore, the aim of this study was to evaluate the anti-inflammatory effects of SB in an HCl-induced rat cystitis model. …”
Get full text

Trends in vegetation cover changes in Bonny area of the Niger Delta by A Adoki

“…This increment is attributed to influx of humans into the area as a result of increase in Oil and Gas industry activities. …”
Get full text

Efficacy of hyperimmunized egg yolk antibodies (IgY) against Campylobacter jejuni: In Vitro and In Vivo evaluations by Nazanin Soltani, Shaban Rahimi, Pejvak Khaki, Mohammad Amir Karimi Torshizi, Bahareh Eskandari, Jesse Grimes

“…Campylobacter infections are a prevalent cause of diarrheal disease in humans and are the most significant zoonotic pathogens worldwide. …”
Get full text

Ticks and Tick-Borne Pathogens in Wild Animals and Birds from Two Rehabilitation Facilities in Greece by Dimitrios Vourvidis, Georgia Tzouganatou, Sokratis Perdikaris, Evangelia Kofidou, Beatriz Martinez-Gonzalez, Mary Emmanouil, Emmanouil Papadogiannakis, Anastasia Komnenou, Emmanouil Angelakis

“…Ticks are temporary ectoparasites that serve as vectors for a wide range of pathogens affecting both wildlife and humans. In Greece, research on the prevalence of tick-borne pathogens in wildlife is limited. …”
Get full text

A basis water quality monitoring plan for rehabilitation and protection by M. Enriquez, R. Tanhueco

“…BACKGROUND AND OBJECTIVES: Safeguarding water resources became a major concern in many parts of the world as it aims to provide safe and healthy water for humans. Water quality monitoring is a popular tool in ensuring water quality is safe and within the allowable limits and standards for the health of the community. …”
Get full text

Fecal microbiota transplantation modulates jejunal host-microbiota interface in weanling piglets by Shankumar Mooyottu, Muhammed Shafeekh Muyyarikkandy, Farnaz Yousefi, Ganwu Li, Orhan Sahin, Eric Burrough, Joy Scaria, Brett Sponseller, Alejandro Ramirez

“…In addition, the results suggest that FMT could be considered a potential strategy to address conditions associated with small intestinal dysbiosis in swine and other monogastric species with similar gut anatomy and physiology, such as humans. Video Abstract…”
Get full text

Multi-scale feature fusion of deep convolutional neural networks on cancerous tumor detection and classification using biomedical images by U. M. Prakash, S. Iniyan, Ashit Kumar Dutta, Shtwai Alsubai, Janjhyam Venkata Naga Ramesh, Sachi Nandan Mohanty, Khasim Vali Dudekula

“…Abstract In the present scenario, cancerous tumours are common in humans due to major changes in nearby environments. …”
Get full text

Antimicrobial Resistance Profile of E. coli Isolated from Raw Cow Milk and Fresh Fruit Juice in Mekelle, Tigray, Ethiopia by Haftay Abraha Tadesse, Netsenet Berhe Gidey, Kidane Workelule, Hagos Hailu, Seyfe Gidey, Abrha Bsrat, Habtamu Taddele

“…They cause great suffering and are transmitted directly or indirectly between animals and humans and circulate in the global environment. E. coli are among them, causing a major public health problem. …”
Get full text

CAPTCHA as a Visual Performance Metric in Active Macular Disease by Gautam Vangipuram, Aaron Y. Lee, Kasra A. Rezaei, Lisa C. Olmos De Koo, Yewlin E. Chee, Jennifer R. Chao, Catherine Egan, Cecilia S. Lee

“…CAPTCHA (completely automated public turing test to tell computers and humans apart) was designed as a spam prevention test. …”
Get full text

A Toxicological Evaluation of Methylliberine (Dynamine®) by Timothy S. Murbach, Róbert Glávits, John R. Endres, Amy E. Clewell, Gábor Hirka, Adél Vértesi, Erzsébet Béres, Ilona Pasics Szakonyiné

“…Future studies are encouraged to corroborate the safety, and assess efficacy, of methylliberine in humans.…”
Get full text

Mycotoxicological Assessment of Broiler Compound Feed: A Multi-Year Analysis of Five Mycotoxins in a Romanian Feed Mill by Dragoș Mihai Lăpușneanu, Silvia-Ioana Petrescu, Cristina-Gabriela Radu-Rusu, Mădălina Matei, Ioan Mircea Pop

“…Mycotoxins are secondary metabolites of filamentous fungi that cause massive agricultural losses worldwide and constitute a significant health problem for humans and animals. The aim of this five-year study was to investigate the contamination of compound feed for broiler chickens at all stages (starter, grower and finisher) from a feed mill in Romania with mycotoxins such as total aflatoxins (AFT), deoxynivalenol (DON), fumonisins (FUMs), ochratoxin A (OTA) and zearalenone (ZEN). …”
Get full text