Alleviating effect of intranasal zinc on symptoms of allergic rhinitis by Huadong Xu, PhD, Keming Tong, BS, Naruhito Iwasaki, MD, PhD, Nobutaka Ohgami, PhD, Akira Tazaki, PhD, Takumi Kagawa, MMSc, Yanjun Gao, MMSc, Delgama A.S.M. Nishadhi, MMSc, Akihito Harusato, MD, PhD, Masafumi Sakashita, MD, PhD, Kazuhiro Ogi, MD, PhD, Shigeharu Fujieda, MD, PhD, Shogo Sumiya, MD, Shinichi Iwasaki, MD, PhD, Masashi Kato, MD, PhD

“…The mouse interventional study showed that the symptoms of mice with provocative JCP were significantly improved by treatment with the putative human-equivalent dose of Zn. The relative number of mucin-secreting goblet cells, a sign of provocative allergic rhinitis, in the mice was decreased by intranasal treatment with Zn. …”
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Medical Jousting: Going for the kill! by Dr.Fuad Ahmed Khan Niazi

“…It emanates from the deep-rooted instinct of us humans to survive and feel jealous or intimidated by an equal or someone who shares the same goals and targets. …”
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NL-Augmenter: A Framework for Task-Sensitive Natural Language Augmentation by Kaustubh Dhole, Varun Gangal, Sebastian Gehrmann, Aadesh Gupta, Zhenhao Li, Saad Mahamood, Abinaya Mahadiran, Simon Mille, Ashish Shrivastava, Samson Tan, Tongshang Wu, Jascha Sohl-Dickstein, Jinho Choi, Eduard Hovy, Ondřej Dušek, Sebastian Ruder, Sajant Anand, Nagender Aneja, Rabin Banjade, Lisa Barthe, Hanna Behnke, Ian Berlot-Attwell, Connor Boyle, Caroline Brun, Marco Antonio Sobrevilla Cabezudo, Samuel Cahyawijaya, Emile Chapuis, Wanxiang Che, Mukund Choudhary, Christian Clauss, Pierre Colombo, Filip Cornell, Gautier Dagan, Mayukh Das, Tanay Dixit, Thomas Dopierre, Paul-Alexis Dray, Suchitra Dubey, Tatiana Ekeinhor, Marco Di Giovanni, Tanya Goyal, Rishabh Gupta, Louanes Hamla, Sang Han, Fabrice Harel-Canada, Antoine Honoré, Ishan Jindal, Przemysław Joniak, Denis Kleyko, Venelin Kovatchev, Kalpesh Krishna, Ashutosh Kumar, Stefan Langer, Seungjae Ryan Lee, Corey James Levinson, Hualou Liang, Kaizhao Liang, Zhexiong Liu, Andrey Lukyanenko, Vukosi Marivate, Gerard de Melo, Simon Meoni, Maxine Meyer, Afnan Mir, Nafise Sadat Moosavi, Niklas Meunnighoff, Timothy Sum Hon Mun, Kenton Murray, Marcin Namysl, Maria Obedkova, Priti Oli, Nivranshu Pasricha, Jan Pfister, Richard Plant, Vinay Prabhu, Vasile Pais, Libo Qin, Shahab Raji, Pawan Kumar Rajpoot, Vikas Raunak, Roy Rinberg, Nicholas Roberts, Juan Diego Rodriguez, Claude Roux, Vasconcellos Samus, Ananya Sai, Robin Schmidt, Thomas Scialom, Tshephisho Sefara, Saqib Shamsi, Xudong Shen, Yiwen Shi, Haoyue Shi, Anna Shvets, Nick Siegel, Damien Sileo, Jamie Simon, Chandan Singh, Roman Sitelew, Priyank Soni, Taylor Sorensen, William Soto, Aman Srivastava, Aditya Srivatsa, Tony Sun, Mukund Varma, A Tabassum, Fiona Tan, Ryan Teehan, Mo Tiwari, Marie Tolkiehn, Athena Wang, Zijian Wang, Zijie Wang, Gloria Wang, Fuxuan Wei, Bryan Wilie, Genta Indra Winata, Xinyu Wu, Witold Wydmanski, Tianbao Xie, Usama Yaseen, Michael Yee, Jing Zhang, Yue Zhang

“…The transformations incorporate noise, intentional and accidental human mistakes, socio-linguistic variation, semantically-valid style, syntax changes, as well as artificial constructs that are unambiguous to humans. …”
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Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta by Alessia Gallo, Josè Camilla Sammartino, Roberta Vazzana, Roberto Giambruno, Claudia Carcione, Nicola Cuscino, Salvatore Castelbuono, Vitale Miceli, Matteo Bulati, Daniele Lilleri, Irene Cassaniti, Pier Giulio Conaldi, Fausto Baldanti

“…Abstract Background Since the breakout of COVID-19, the mutated forms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have shown enhanced rates of transmission and adaptation to humans. The variants of concern (VOC), designated Alpha, Beta, Gamma, Delta, and Omicron emerged independent of one another, and in turn rapidly became dominant. …”
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CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models by Felipe Saceanu Leser, Flavio de Souza Júnyor, Iohanna Bianca Pagnoncelli, Anna Beatriz Delgado, Isabelle Medeiros, Ana Clara Campanelli Nóbrega, Brenda da Silva Andrade, Maiara Nascimento de Lima, Nícolas Emanoel da Silva, Laurent Jacob, Kevin Boyé, Luiz Henrique Medeiros Geraldo, Alessandra Mendonça Teles de Souza, Tatiana Maron-Gutierrez, Hugo Castro-Faria-Neto, Cristian Follmer, Carolina Braga, Gilda Angela Neves, Anne Eichmann, Luciana Ferreira Romão, Flavia Regina Souza Lima

“…Herein, we identified the neuronal chemokine CCL21 as a major cause of microglial cell imbalance through the CCR7 receptor pathway with therapeutic implications for PD. In humans, we found that CCL21 transcript expression was increased in dopaminergic neurons (DANs) of the substantia nigra in PD patients. …”
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Biallelic SLC13A1 loss-of-function variants result in impaired sulfate transport and skeletal phenotypes, including short stature, scoliosis, and skeletal dysplasia by Christina G. Tise, Katie Ashton, Lachlan de Hayr, Kun-Di Lee, Omkar L. Patkar, Emma Krzesinski, Jennifer A. Bassetti, Erin M. Carter, Cathleen Raggio, Andreas Zankl, Anas M. Khanshour, Kristhen N. Atala, Jonathan J. Rios, Carol A. Wise, Ying Zhu, Futao Zhang, Tony Roscioli, Michael Buckley, Robert J. Harvey, Paul A. Dawson

“…Conclusion: Biallelic loss-of-function variants in SLC13A1 are a novel cause of skeletal phenotypes in humans with a measurable biomarker. Sulfate measurements should be considered in the clinical interpretation of variants identified in SLC13A1.…”
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Flood susceptibility mapping based on watershed geomorphometric characteristics and land use/land cover on a small island by B.H. Narendra, O. Setiawan, R.A. Hasan, C.A. Siregar, , Pratiwi, N. Sari, A. Sukmana, I.W.S. Dharmawan, R. Nandini

“…BACKGROUND AND OBJECTIVES: Flooding is the most frequent hydrological disaster which greatly impacts humans and the environment. Lombok, a small tropical island, experiences severe flooding almost yearly. …”
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The novel H10N3 avian influenza virus acquired airborne transmission among chickens: an increasing threat to public health by Xiaoquan Wang, Huiyan Yu, Yahao Ma, Pinghu Zhang, Xiyue Wang, Jianyu Liang, Xiuling Zhang, Ruyi Gao, Xiaolong Lu, Wenhao Yang, Yu Chen, Min Gu, Jiao Hu, Xiaowen Liu, Shunlin Hu, Daxin Peng, Xian Qi, Changjun Bao, Kaituo Liu, Xiufan Liu

“…Serological studies conducted among poultry workers suggest that while the human population was largely naïve to H10N3 infection, sporadic and undetected human infections did occur, indicating a potential increasing trend. …”
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Editorial by Jörg Tremmel, Edward Page, Konrad Ott

“…Combined with other inertias integral to the climate system, the bulk of the expected harm to humans from climate change will be felt by future generations…”
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BPZ inhibits early mouse embryonic development by disrupting maternal-to-zygotic transition and mitochondrial function by Zhiming Ding, Huilei Chen, Huiru Cheng, Caiyun Wu, Hongzhen Ruan, Bingjing Zhu, Ping Zhou, Zuying Xu, Huifen Xiang

“…Bisphenol Z (BPZ) is used as an alternative to BPA, and humans are widely exposed to BPZ through various routes. …”
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Therapeutic efficacy of LysGH15 against necrotising pneumonia caused by Staphylococcus aureus in a rabbit model by Bowei Zhang, Liran Song, Yongran Wang, Meimei Zhang, Chong Chen, Hui Ning, Li Wang, Cao Qiu, Xinwu Wang, Changjiang Sun, Xin Feng, Wenyu Han, Wenyu Han, Bin Wang, Yalu Ji, Jingmin Gu, Jingmin Gu

“…IntroductionStaphylococcus aureus (S. aureus) is one of the most important zoonotic pathogens and can be transmitted to humans through the meat diet routes, causing necrotising pneumonia.MethodsThis study investigated the therapeutic effect of bacteriophage lysin LysGH15 on necrotising pneumonia in rabbit model caused by S. aureus.ResultsIn the in vitro experiments, 50 μg/mL LysGH15 not only significantly reduced the viable count (approximately 3.24 × 106 CFU/g) of chicken meat stored at 4°C for 48 h but also effectively reduced the viable count of chicken meat thawed at 4°C and 30°C, with reductions of approximately 1.42 × 106 CFU/g and 2.78 × 106 CFU/g, respectively. …”
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“Restoration of the Past Scenery-Realm”: A Research on the Scenery-Realm Restoration of Jiang’s Fu Garden During Qing Dynasty in the Historical Revolution of the Humble Administrat... by Qian BIAN

“…These include the natural positioning and appropriate utility of the garden’s architectures, the continuous fragrance and seasonal scenery of flowers and trees, and the scene where animals, like birds and fish, return to their dwellings and are naturally drawn toward humans. In terms of realm experience, the research analyzes the generation of typical comprehensive experience and emotional activities in the garden from the perspectives of “Dong You Jian Jing Can” (roaming in motion and meditation in stillness) and “Ya Ji Yu Yuan Ju” (elegant gathering and garden dwelling), pointing out that the former, in short-term composite perceptions, is more likely to form differentiated results due to changes in mood, season, and combinations of dynamic and static appreciation, while the latter, through long-term interactive attachment and more nuanced examinations over time, can make the emotional sustenance of guests in the garden more genuine and varied. 2) In response to the question of what qualified the garden as a restoration of the past scenery-realm, the focus is on the “Yuanxiang Hall” area as a clue to explore the value orientation of the Fu Garden’s restoration. …”
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Integrated Framework and Technical Path for Multi-level Nested Assessment of Landscape Character by Yuncai WANG, Qizhen DONG

“…Landscape personality is formed by highly condensed landscape character with inherent attributes that are perceived by humans, and LCA is the foundation of LPA formation. …”
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Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response by Wazim Mohammed Ismail, Jenna A. Fernandez, Moritz Binder, Terra L. Lasho, Minsuk Kim, Susan M. Geyer, Amelia Mazzone, Christy M. Finke, Abhishek A. Mangaonkar, Jeong-Heon Lee, Liguo Wang, Kwan Hyun Kim, Vernadette A. Simon, Fariborz Rakhshan Rohakthar, Amik Munankarmy, Seul Kee Byeon, Susan M. Schwager, Jonathan J. Harrington, Melissa R. Snyder, Keith D. Robertson, Akhilesh Pandey, Eric D. Wieben, Nicholas Chia, Alexandre Gaspar-Maia, Mrinal M. Patnaik

“…Although individual impacts on the epigenome have been described using different model systems, the phenotypic complexity in humans remains to be elucidated. Here, we make use of a natural inflammatory response occurring during coronavirus disease 2019 (COVID-19), to understand the association of these mutations with inflammatory morbidity (acute respiratory distress syndrome [ARDS]) and mortality. …”
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Visual Environment Factors Influencing Staying Behaviors During Cycling on Countryside Greenways by Ting WEN, Yun ZHANG, Ming DU

“…Since visual perception accounts for 80%-90% of the information humans receive from their environment, it exerts a profound influence on human behavior and environmental experiences. …”
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Fálétí’s Philosophical Sensibility by Adeshina Afolayan

“…While it may be misplaced to draw a comparison between Fágúnwà and Fálétí, there is a sense in which Fálétí’s demonstrates a more robust literary sensibility that goes beyond the allegorical into a realistic assessment of human relationship and sociality within the context of the Yorùbá cultural template. …”
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Transfer of aflatoxin M1 and sterigmatocystin from buffalo milk to soft cheeses by Maurizio Cossu, Andrea Sanna, Giannina Chessa, Stefano Sdogati, Ivan Pecorelli, Ilaria Di Marco Pisciottano, Sara Lambiase, Pasquale Gallo, Stefania Massafra, Elena Torres, Marilena Gili, Giovanni Lo Cascio, Antonio Vella, Roberto Condoleo, Bruno Neri, Guglielmo Militello, Gilberto Giangolini, Carlo Boselli

“…AFM1 is a toxic molecule classified by the IARC as “potentially carcinogenic to humans” in Group 1. In addition to the four aflatoxins (AFB1, AFB2, AFG1, and AFG2), these fungi also produce other toxins such as Sterigmatocystin (STC), while Aflatoxicol (AFL) is a metabolite of AFB1. …”
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