Neuroprotective role of epigallocatechin-3-gallate, albeginin and melanoxetin in alzheimer's disease by Arif Malik, Mehreen Hassan, Sulayman Waquar, Muhammad Wasim, Anam Naz, Faryal M. Awan, Muhammad T. Khan, Ali I. Khawaja, Sumera Zaib, Jamshed Iqbal, Ayesha Zahid, Marvi Marvi, Javeid Iqbal, Heng Wang, Dong-Qing Wei

“…Purpose: EGCG, is an antioxidant/anti-inflammatory that lowers amyloid-b and tau aggregation in AD models and improves cognition at preclinical dosages of 25–100 mg/kg/day and clinical doses of 200–800 mg/ Albeginin, a new flavonoid, reduces neuroinflammation in rats at 10–50 mg/kg/day, equal to 100–200 mg/day in humans. Melanoxetin, a phenolic molecule, chelates toxic metals, lowers ROS, and protects neurons at 15–40 mg/kg/day in animal models and 50–150 mg/day in humans. …”
Get full text

Evaluation of willingness to pay and challenges to community empowerment in urban drinkable water by N.I.D. Arista, H.A. Negoro, D.E. Purba

“…BACKGROUND AND OBJECTIVES: Environmental degradation, especially that related to water, has the potential to result in an unhealthy life. Humans drinkable water for basic needs, but poor water quality can cause disease. …”
Get full text

Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder by Jie Wang, Qing Xue, Wenfeng Zhao, Huang Wang, Haixia Leng, Mao Peng, Xiukun Jin, Liucen Tan, Keming Gao, Hongxing Wang, Baoquan Min

“…Background Although 15 mA transcranial alternating current stimulation (tACS) has a therapeutic effect on depression, the activations of brain structures in humans accounting for this tACS configuration remain largely unknown.Aims To investigate which intracranial brain structures are engaged in the tACS at 77.5 Hz and 15 mA, delivered via the forehead and the mastoid electrodes in the human brain.Methods Actual human head models were built using the magnetic resonance imagings of eight outpatient volunteers with drug-naïve, first-episode major depressive disorder and then used to perform the electric field distributions with SimNIBS software.Results The electric field distributions of the sagittal, coronal and axial planes showed that the bilateral frontal lobes, bilateral temporal lobes, hippocampus, cingulate, hypothalamus, thalamus, amygdala, cerebellum and brainstem were visibly stimulated by the 15 mA tACS procedure.Conclusions Brain-wide activation, including the cortex, subcortical structures, cerebellum and brainstem, is involved in the 15 mA tACS intervention for first-episode major depressive disorder. …”
Get full text

Risk Analysis of Groundwater Contaminant in Rural Areas Using Spatial Distribution by Herawati Herawati, Maria Kanan, Anwar Mallongi, Ramli Bidullah, Sandy N. Sakati, Dwi Wahyu Balebu

“…Groundwater is an important resource for humans, especially in rural areas that depend on Groundwaters as the main source of clean water. …”
Get full text

Molecular study of the status of Angiostrongylus cantonensis in rats in Haiti by Fedna Jimmy, Borne Romain, Rieffel Dominique, Bornette Gudrun, Henrys Jean-Hugues, Grenouillet Frédéric, Raoul Francis

“…Angiostrongylus cantonensis, commonly known as the rat lungworm, causes Eosinophilic meningitis in humans. Our study aimed to investigate the prevalence and distribution of this parasite in rats in Haiti. …”
Get full text

Second-Hand Smoke Increases Bronchial Hyperreactivity and Eosinophilia in a Murine Model of Allergic Aspergillosis by Brian W. P. Seymour, Edward S. Schelegle, Kent E. Pinkerton, Kathleen E. Friebertshauser, Janice L. Peake, Viswanath P. Kurup, Robert L. Coffman, Laurel J. Gershwin

“…Antibodies to fungal antigens such as Aspergillus fumigatus (Af) cause an allergic lung disease in humans. This study was carried out to determine the effect of environmental tobacco smoke (ETS) on a murine model of allergic bronchopulmonary aspergillosis (ABPA). …”
Get full text

Age and diet affect self-resilience of intestinal microbiome in mice by Chenyi Shao, Shenmin Chen, Huan Yang, Mufan Li, Yinhui Liu, Shu Wen, Jing Xiao, Li Tang

“…BackgroundGut microbiota contributes to human health. Little is known about the self-resilience of the gut microbiota after dysbiosis. …”
Get full text

Production of Hydrophobic Microparticles at Safe-To-Inject Sizes for Intravascular Administration by Francisca L. Gomes, Francisco Conceição, Liliana Moreira Teixeira, Jeroen Leijten, Pascal Jonkheijm

“…<b>Results:</b> We achieve a PCL MP size distribution of 99.8% below this size limit, and prove that these particles can flow without obstruction through a microfluidic model emulating a thin human blood capillary (4.1 µm × 3.0 µm width × heigh). …”
Get full text

Infected burn wound healing using Hydroxy-propyl-methyl cellulose gel containing bacteriophages against Pseudomonas aeruginosa and Klebsiella pneumoniae by Meysam Adibi, Kazem Javanmardi, Noor Al-Huda Ali A.H. Saeed, Mohammad Ali Mobasher, Javad Jokar, Abdolmajid Ghasemian, Niloofar Rahimian, Ava Soltani Hekmat

“…Meanwhile, the complications due to their widespread use in humans should be investigated in more details. …”
Get full text

Drosophila Cul3 contributes to Diap2-mediated innate immune signaling for antimicrobial defense by Fanrui Kong, Zixuan Wang, Chuchu Zhang, Yihua Xiao, Muhammad Abdul Rehman Saeed, Weini Li, Akira Goto, Qingshuang Cai, Shanming Ji

“…Taken together, our findings highlight a previously unrecognized regulatory axis of Cul3/Diap2/Dredd in the fly antimicrobial immune defense, providing potential insights into therapeutic strategies for combating bacterial infections in humans.…”
Get full text

Evaluation of various RNA-seq approaches for identification of gene outrons in the flatworm Opisthorchis felineus by N. I. Ershov, D. E. Maslov, N. P. Bondar

“…The parasitic flatworm Opisthorchis felineus is one of the causative agents of opisthorchiasis in humans. Recently, we assembled the O. felineus genome, but the correct genome annotation by means of standard methods was hampered by the presence of spliced leader trans-splicing (SLTS). …”
Get full text

Global avian influenza situation (2019–2022). Host range expansion asevidence of high pathogenicity avian influenza virus evolution by M. V. Zhiltsova, T. P. Akimova, A. V. Varkentin, M. N. Mitrofanova, A. V. Mazneva, V. P. Semakina, E. S. Vystavkina

“…Changes in the habitats of both migratory birds and mammals, including due to some human economic activities, add an ecological and urban component to the complex task of the control and prevention of the epidemic, also posing a potential threat to humans.…”
Get full text

Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders by Hanyang Ruan, Geya Tong, Minghui Jin, Kathrin Koch, Zhen Wang

“…In this review, we provide an overview across studies investigating the effects of NAc DBS in humans and animals and discuss potential mechanisms underlying its clinical efficacy. …”
Get full text

Development and Validation of Rabies Health Education Module (RaHEM) for Dog Owners in Kelantan, Malaysia: An ADDIE Model by Mohammad Fazrul Mohammad Basir, Suhaily Mohd Hairon, Mohd Ismail Ibrahim, Wan Mohd Zahiruddin Wan Mohamad, Nik Mohd Hafiz Mohd Fuzi, Ainin Syakirah Rosli, Mohammad Sabri Abdul Rahman, Anas Rosedi

“…Despite the availability of effective vaccines for both humans and animals, the persistence of rabies-related fatalities underscores the need for enhanced public education strategies. …”
Get full text

Positive Correlation Between Serum Limonene Levels and Muscle Health in a Representative Adult Population in the United States by Chang-Chin Wu, Yu-Wei Fang, Chikang Wang, Chien-Yu Lin

“…However, the impact of monoterpene exposure on muscle strength and mass in humans remains unclear. <b>Methods</b>: To explore this relationship, we analyzed data from 1202 adults (aged ≥ 18 years) who participated in the 2013–2014 National Health and Nutrition Examination Survey (NHANES), focusing on serum levels of three specific monoterpenes—α-pinene, β-pinene, and limonene—and their association with hand grip strength and lean muscle mass. …”
Get full text

Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis by Fenli Shao, Qianqian Liu, Yuyu Zhu, Zhidan Fan, Wenjun Chen, Shijia Liu, Xiaohui Li, Wenjie Guo, Gen-Sheng Feng, Haiguo Yu, Qiang Xu, Yang Sun

“…It is worth emphasizing that such pathological thickness of growth plates was evident in adolescent humans with enthesitis-related arthritis, which could progress to AS in adulthood. …”
Get full text

Knowledge, Attitude, Awareness, and Practice Regarding Demodex Mites Among the Thai Population by Paichitrojjana A, Paichitrojjana A

“…Anon Paichitrojjana,1 Anand Paichitrojjana2 1School of Anti-Aging and Regenerative Medicine, Mae Fah Luang University, Bangkok, Thailand; 2Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Anon Paichitrojjana, Email anonpaic@gmail.comBackground: Demodex mites are common ectoparasites in humans and can cause various skin disorders known as demodicosis, ranging from nonspecific facial dermatitis to conditions resembling eczema, seborrheic dermatitis, folliculitis, and acne. …”
Get full text

Impact of Combined Acidic and Hyperosmotic Shock Conditions on the Proteome of Listeria monocytogenes ATCC 19115 in a Time-Course Study by Dong Lai Zhang, Ya Long Bai, John P. Bowman

“…Listeria monocytogenes can cause listeriosis in humans through consumption of contaminated food and can adapt to and grow under a wide array of physiochemical stresses. …”
Get full text

Retrieval of NO2 Columns by Exploiting MAX-DOAS Observations and Comparison with OMI and TROPOMI Data during the Time Period of 2015–2019 by Ahmad Iqbal, Naveed Ahmad, Hassan Mohy ud Din, Michel Van Roozendael, Muhammad Shehzaib Anjum, Muhammad Zeeshan Ali Khan, Muhammad Fahim Khokhar

“…Exposure to high concentrations of NO2 has been reported to cause various health issues in humans. This study presents an intercomparison of NO2 retrieval settings using the Differential Optical Absorption Spectroscopy (DOAS) and based on the literature published over the last 20 years. …”
Get full text

Natural exposure to Chikungunya virus in golden-headed lion tamarin (Leontopithecus chrysomelas, Kuhl, 1820) from non-protected areas in southern Bahia, Brazil: Implications and si... by Sofía Bernal-Valle, María Angélica Monteiro de Mello Mares-Guia, Filipe Vieira Santos de Abreu, Fabrício Souza Campos, Cirilo Henrique de Oliveira, Antônio Victor Veloso Ramos, Reizane Pereira Lordelo, Kristel De Vleeschouwer, Leonardo de Carvalho Oliveira, Hllytchaikra Ferraz Fehlberg, Ana Maria Bispo Filippis, Bergmann Morais Ribeiro, Paulo Michel Roehe, Anaiá da Paixão Sevá, Danilo Simonini-Teixeira, George Rego Albuquerque

“…Chikungunya virus (CHIKV) is primarily associated with non-human-primates (NHPs) in Africa, which also infect humans. …”
Get full text