Aerobic exercise alleviates statin-induced PCSK9 upregulation by increasing epoxyeicosatrienoic acid levels through the FoxO3a–Sirt6 axis by Jiahui Hu, Hao Lei, Jingyuan Chen, Leiling Liu, Yajun Gui, Kaijun Sun, Danyan Xu

“…Results: Aerobic exercise effectively alleviated statin-induced PCSK9 upregulation in human patients with CHD and hypercholesterolemic ICR mice (all p < 0.05). …”
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Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP by Song Guo, Song Guo, Qihao Pan, Qihao Pan, Baokang Chen, Baokang Chen, Yijuan Huang, Yijuan Huang, Si Li, Si Li, Chenyu Gou, Chenyu Gou, Yu Gao, Yu Gao

“…Therefore, this study explored the relationship between trophoblast cell aging and oxidative injury and YAP in AMA pregnancy, which not only provided an insight into the mechanisms of trophoblast cell aging, but also provide valuable directions for healthcare during AMA pregnancy.MethodsIn this study, human term placentas were collected from AMA and normal pregnancies for the analysis of aging, oxidative damage and YAP level. …”
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Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses by Sarah Buddle, Leysa Forrest, Naomi Akinsuyi, Luz Marina Martin Bernal, Tony Brooks, Cristina Venturini, Charles Miller, Julianne R. Brown, Nathaniel Storey, Laura Atkinson, Timothy Best, Sunando Roy, Sian Goldsworthy, Sergi Castellano, Peter Simmonds, Heli Harvala, Tanya Golubchik, Rachel Williams, Judith Breuer, Sofia Morfopoulou, Oscar Enrique Torres Montaguth

“…We tested samples consisting of a dilution series of a six-virus mock community in a human DNA/RNA background, designed to resemble clinical specimens with low microbial abundance and high host content. …”
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Glioma Image-Level and Slide-Level Gene Predictor (GLISP) for Molecular Diagnosis and Predicting Genetic Events of Adult Diffuse Glioma by Minh-Khang Le, Masataka Kawai, Kenta Masui, Takashi Komori, Takakazu Kawamata, Yoshihiro Muragaki, Tomohiro Inoue, Ippei Tahara, Kazunari Kasai, Tetsuo Kondo

“…The accuracy in diagnosing IDH-mutant astrocytoma, oligodendroglioma, and IDH-wild-type glioblastoma was 0.66, surpassing the human pathologist average of 0.62 (0.54–0.67). In conclusion, GLISP is a two-stage AI framework for histology-based prediction of genetic events in adult gliomas, which is helpful in providing essential information for WHO 2021 molecular diagnoses.…”
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A phase Ia study of a novel anti-HER2 antibody–drug conjugate GQ1001 in patients with previously treated HER2 positive advanced solid tumors by Chenfei Zhou, Bin Wang, Christina Teng, Hui Yang, Sarina A. Piha-Paul, Gary Richardson, Ashanya Malalasekera, Yajun Sun, Wei Wang, Jieqiong Liu, Yan Shi, Xianbao Zhan, Charlotte Lemech

“…Abstract Background A novel anti-human epidermal growth factor receptor 2 (HER2) antibody–drug conjugate (ADC) GQ1001 was assessed in patients with previously treated HER2 positive advanced solid tumors in a global multi-center phase Ia dose escalation trial. …”
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Optimization and characterization studies of poultry waste valorization for peptone production using a newly Egyptian Bacillus subtilis strain by Hajar Saeed, Anthony Ragaey, Ziad Samy, Viola Ashraf, Aly ElMostafa, Norhan Ahmad, Enjy Bebawy, Nour ElHoda M. Sorour, Salwa M. El-Sayed, Ashraf Bakry, Naglaa Ebeed, Hesham Elhariry, Thanaa El-Noby, Samah H. Abu-Hussien

“…The produced peptone exhibited minimal cytotoxicity at lower concentrations (≤ 1 mg/mL), with cell viability exceeding 94% against normal human skin fibroblast (HSF) cells. However, higher concentrations (≥ 3 mg/mL) displayed increased cytotoxic effects. …”
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Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury by Fei Yuan, Jie Liu, Liang Zhong, Pengtao Liu, Ting Li, Kexin Yang, Wei Gao, Guangyuan Zhang, Jie Sun, Xiangyu Zou

“…In this study, we investigated the alterations occurring in MSCs and the production of MSC-EVs following hypoxia pre-treatment, and further explored the key intrinsic mechanisms underlying the therapeutic effects of hypoxic MSC-EVs in the treatment of renal IRI. Methods Human umbilical cord MSCs were cultured under normoxic and hypoxic conditions. …”
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Environmental and health risk assessment of polycyclic aromatic hydrocarbons and toxic elements in the red sea using Monte Carlo simulation by F. Alshaima Sayed, Mohamed Hamdy Eid, Ahmed M. El-Sherbeeny, Gouda Ismail Abdel-Gawad, Essam A. Mohamed, Mostafa R. Abukhadra

“…The study evaluated environmental and human health risks using a multifaceted approach, including cluster analysis, principal component analysis, and various indices (HPI, RI, MI, HQ, HI, and CR). …”
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Development of Cephradine-Loaded Gelatin/Polyvinyl Alcohol Electrospun Nanofibers for Effective Diabetic Wound Healing: In-Vitro and In-Vivo Assessments by Anam Razzaq, Zaheer Ullah Khan, Aasim Saeed, Kiramat Ali Shah, Naveed Ullah Khan, Bouzid Menaa, Haroon Iqbal, Farid Menaa

“…LNFs were further characterized biologically by in-vitro assessment of their potency against <i>S. aureus</i> clinical strains (<i>N</i> = 16) using the Kirby–Bauer test and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, by <i>ex-vivo</i> assessment to evaluate their cytotoxicity against primary human epidermal keratinocytes using MTT assay, and by in-vivo assessment to estimate their diabetic chronic wound-healing efficiency using NcZ10 diabetic/obese mice (<i>N</i> = 18). …”
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Exploring the multifaceted roles of Sonneratia apetala and Nipa fruticans in coastal habitat restoration and bioactive properties discovery by Sabina Yasmine, Rezwana Zaman Proma, Md. Ripaj Uddin, Mohammad Saydur Rahman, Md. Hamedul Islam, Muhammad Abdullah Al Mansur, AHM Shofiul Islam Molla Jamal, Abu Yousuf, Md. Hasnain Mustak, Sarker Kamruzzaman, M. Mahboob Ali Siddiqi

“…This comprehensive analysis underscores S. apetala's and N. fruticans broad nutritional and phytochemical significance, making it a valuable subject in studies of natural products and human health.…”
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Artificial-Intelligence-Based Investigation on Land Use and Land Cover (LULC) Changes in Response to Population Growth in South Punjab, Pakistan by Tanweer Abbas, Muhammad Shoaib, Raffaele Albano, Muhammad Azhar Inam Baig, Irfan Ali, Hafiz Umar Farid, Muhammad Usman Ali

“…Land use and land cover (LULC) changes are significantly impacting the natural environment. Human activities and population growth are negatively impacting the natural environment. …”
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Predicting pediatric patient rehabilitation outcomes after spinal deformity surgery with artificial intelligence by Wenqi Shi, Felipe O. Giuste, Yuanda Zhu, Ben J. Tamo, Micky C. Nnamdi, Andrew Hornback, Ashley M. Carpenter, Coleman Hilton, Henry J. Iwinski, J. Michael Wattenbarger, May D. Wang

“…Moreover, we enable responsible AI by calibrating model confidence for human intervention and mitigating health disparities for algorithm fairness. …”
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Post Covid-19 Syndromes, The Time line of Covid by Nadia Shams, Zaid Umar, Lubna Meraj, Neelam Ayub, Muhammad Waseem, Kazim Abbas Virk

“…Timeline of long-term complications and effects on humanity are yet to be explored. Current study aims to evaluate the spectrum of post Covid syndromes in our Covid survivors. …”
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Targeted Delivery of BMS-1166 for Enhanced Breast Cancer Immunotherapy by Yu Z, Zhou Z, Zhao Y

“…Drug encapsulation efficiency, loading degree, and release profile were examined by high-performance liquid chromatography. Human breast cancer MDA-MB-231 was used to test the cytotoxicity. …”
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“A quality of heart, of presence, and of really caring”: toward affirmative intersex health communication in Canada by Terese Knoppers, Angelica Voutsinas, Nicole Palmour, Kaleb Saulnier, Kaleb Saulnier, Morgan Holmes, Marilou Charron, Hortense Gallois, Hortense Gallois, Narges Jamali, Narges Jamali, Leslie Ordal, Yann Joly

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Investigation of the Mechanism Underlying Calcium Dobesilate-Mediated Improvement of Endothelial Dysfunction and Inflammation Caused by High Glucose by Yijun Zhou, Chaojun Qi, Shu Li, Xinghua Shao, Zhaohui Ni

“…The aim of this study was to elucidate the molecular and cellular mechanisms underlying the protective effects of CaD. Methods. Human umbilical vein endothelial cells (HUVECs) were cultured with different D-glucose concentrations to determine the effects of high glucose on HUVEC gene expression. …”
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Functional Fitness and Self-Reported Quality of Life of Older Women Diagnosed with Knee Osteoarthrosis: A Cross-Sectional Case Control Study by Paula Andréa Malveira Cavalcante, Márcio Roberto Doro, Frank Shiguemitsu Suzuki, Roberta Luksevicius Rica, Andrey Jorge Serra, Francisco Luciano Pontes Junior, Alexandre Lopes Evangelista, Aylton José Figueira Junior, Julien Steven Baker, Danilo Sales Bocalini

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Feasibility and therapeutic efficacy of a two-week low-level laser acupuncture therapy for shoulder and neck pain in office workers: Protocol for a pilot, single-blind, double-arme... by Carol Chunfeng Wang, Lisa Whitehead, Travis Cruickshank, Johnny Lo, Jianhong Cecilia Xia, Jun Wen

“…This study was approved by Edith Cowan University's Human Research Ethics Committee (No. 2021-02225-WANG).…”
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Effect of diet containing alfalfa (Medicago sativa) powder and leaf extract on hemolymph factors of western whiteleg shrimp (Litopenaeus vannamei) under low salinity stress by Kobra Babanejad Abkenar, Arash Akbarzadeh, Ahmad Noori, Mohammad Niroomand

“…Alfalfa, Medicago sativa leaves are used in animal and human diets due to high protein content and nutritional value. …”
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Effects of Dual-Site Anodal Transcranial Direct Current Stimulation on Attention, Decision-Making, and Working Memory during Sports Fatigue in Elite Soccer Athletes by Fengxue Qi, Na Zhang, Michael A. Nitsche, Longyan Yi, Yingqiu Zhang, Tian Yue

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