A prospective study to evaluate the clinical specificity of the cobas® MPX test kit for screening for HIV RNA, HCV RNA, and HBV DNA in blood donation samples using the cobas® 6800... by Lei Zhou, Lin Wang, Xiaofang Gong, Xiaochun Liu, Yaxuan Zou, Yingying Wang, Jinfeng Zeng, Liang Zang

“…Roche's advanced cobas® MPX assay detects human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV) using the cobas® 6800/5800 Systems, based on real-time PCR technology, providing improved sensitivity. …”
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Ecological security driving mechanisms and optimization of zoning in Chinese urban agglomerations: A case study of the central plains urban agglomeration by Jinyuan Zhang, Xuning Qiao, Yongju Yang, Liang Liu, Yalong Li, Shengnan Zhao

“…Spatial disparities in ecological security were relatively small, and counties with lower ecological security levels tended to show greater clustering; (2) The explanatory power of the driving factors is ranked as follows: human factors > natural factors > landscape factors. …”
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Optimization of the Solid-state Fermentation Process for Morchella esculenta Fermented Wheat and Analysis of Its Nutritional Components, Physicochemical Properties and Antioxidant... by Dandan GU, Xue DONG, Jinxiu ZHANG, Xiaoru WANG, Zongshuo ZHAO, Li'an WANG

“…Under simulated conditions of the human stomach and intestine, the cholesterol adsorption rate increased by 86.29% and 290.14%, respectively. …”
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The paediatric liver transplant experience in Johannesburg, South Africa: A broad overview and update by K Kinandu, A Beeton, M Beretta, S Berkenfeld, L Brannigan, R Britz, D Demopoulos, L Doedens, M Duncan, P Gaylard, C Hajinicolaou, W Lowman, H Maher, T De Maayer, V Mudau, S Rambarran, M Reynders, F van der Schyff, B Ströbele, S Tager, E Wessels, J Fabian, J Loveland

“…Data were accessed from the Wits Donald Gordon Medical Centre Paediatric Liver Transplant Research Database (University of the Witwatersrand Human Research Ethics approval: M190749). The following data were collected: donor and recipient sociodemographic and clinical characteristics, details of transplant procedures, donor grafts and recipient outcomes (post-operative complications, graft and recipient survival).   …”
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Entre la creatividad y el recuerdo: el espacio de juego en el arte de instalación de Carsten Höller y Gelitin by Javier Gómez Chozas, Vanesa Cejudo Mejías, Arturo Franco Díaz

“…Tomando como ejemplo las obras Test Site (2006), del artista alemán Carsten Höller, y Human Elevator (1999-2016), del colectivo austríaco Gelitin, se comparan las obras para llegar a diversas conclusiones acerca de la inserción del juego infantil en la programación de exposiciones en las instituciones artísticas. …”
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Cell culture expansion media choice affects secretory, protective and immuno-modulatory features of adipose mesenchymal stromal cell-derived secretomes for orthopaedic applications by Enrico Ragni, Andrea Papait, Michela Maria Taiana, Paola De Luca, Giulio Grieco, Elsa Vertua, Pietro Romele, Cecilia Colombo, Antonietta Rosa Silini, Ornella Parolini, Laura de Girolamo

“…In addition to standard supplementation given by foetal bovine serum (FBS) or human platelet lysate (hPL), new good manufacturing practice (GMP)-compliant serum/xeno (S/X)-free media formulations have been proposed, although their influence on MSCs phenotype and potential is scarcely described. …”
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Predictors of treatment failure of tubal pregnancy with single-dose methotrexate regimen – a systematic review and meta-analysis by Lili Tang, Sipei Nie, Ling Ling, Qian Zhu

“…This meta-analysis aimed to identify early predictors for single-dose methotrexate (MTX) treatment failure in tubal pregnancies.Methods A literature search was conducted across several databases from their inception to December 2023, with references in the selected studies manually reviewed. 14 studies involving 2,804 patients were included in this meta-analysis.Results The results revealed that higher serum beta-human chorionic gonadotropin (β-hCG) levels on Day 1 (SMD = 1.25, 95% CI 0.73–1.77), foetal cardiac activity presence (OR = 12.64, 95% CI 3.15–50.75), adnexal mass presence (OR = 4.66, 95% CI 2.02–10.74), yolk sac presence (OR = 5.35, 95% CI 2.33–12.27), thicker endometrium (MD = 1.74, 95% CI 0.30–3.19), more number of previous ectopic pregnancies (MD = 0.21, 95% CI 0.13–0.30), history of pelvic inflammatory disease (PID) (OR = 3.97, 95% CI 2.02–7.79), higher progesterone levels on Day 1 (SMD = 0.22, 95% CI 0.07–0.36), a higher 48-hour pre-treatment increment in serum β-hCG percentage (MD = 11.46, 95% CI 2.95–19.98), and a higher percentage of serum β-hCG change from Day 4 to Day 0/1 (SMD = 2.58, 95% CI 1.02–4.14) were early predictive factors for treatment failure of tubal pregnancy with the MTX single-dose regimen.Conclusions This review clarifies early predictive factors for treatment failure with the MTX single-dose regimen in tubal pregnancies. …”
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Shenshuaikang enema restores the intestinal barrier and microbiota-gut-kidney axis balance to alleviate chronic kidney disease via NF-κB pathway by Yan Ye, Yan Ye, Xiaopeng Huang, Xiaopeng Huang, Xiaopeng Huang, Xueying Li, Xueying Li, Fei Gao, Wenzhen Zhong, Anqi Tang, Anqi Tang, Liangbin Zhao, Dengpiao Xie, Naijing Ye, Naijing Ye

“…It has become a significant public health problem, posing a threat to human health worldwide. Shenshuaikang enema (SSKE) has demonstrated notable efficacy and safety in treating CKD, although its mechanism of action remains unclear.MethodsThe CKD rat model was induced using 2.5% adenine, and the effect of SSKE was evaluated by detecting uremic toxins, inflammatory cytokines, and renal function. …”
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Concept of a geoinformation platform for landmines and other explosive objects detection and mapping with UAV by Mykhailo Popov, Sergey Stankevich, Sergey Mosov, Stanislav Dugin, Stanislav Golubov, Artem Andreiev, Artur Lysenko, Ievgen Saprykin

“…Undetected explosives threaten business (agriculture, logistics, etc.) and human lives. The problem becomes more acute with the rapid extension of minefield areas, which requires significant time and resources and carries high risks. …”
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Comparative evaluation of various DNA extraction methods and analysis of DNA degradation levels in commercially marketed Chestnut rose juices and beverages by Yongchao Ren, Yunlong Ma, Yanqi Li, Yun Song, WeiWei Zhao, Xuncai Huang, Danmin Yu, Jian Li, Zuogang Xu, Wenjun Zhao

“…Abstract Background Food safety is a significant global study subject that is strongly intertwined with human life and well-being. The utilization of DNA-based methods for species identification is a valuable instrument in the field of food inspection and regulation. …”
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Contribution of the Geodiversity knowledge to social, economic, and environmental health development by Cassio Silva, Edson Farias Mello, Gilberto Dias Calaes, Patricia Duringer Jacques, André Luiz Invernizzi

“…These include mining, where knowledge and proper utilization of essential mineral resources are crucial for human survival and quality of life; energy, which relies on petroleum, gas, coal, peat, and other minerals for nuclear energy generation, as well as for renewable energy sources like wind and solar power. …”
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Study protocol of a pilot randomised controlled trial assessing the feasibility and acceptability of RecoverEsupport: a digital health intervention to enhance recovery in women und... by Christopher Oldmeadow, Mitch J Duncan, Penny Reeves, Priscilla Viana da Silva, Rebecca Wyse, Helen Moore, Alison Zucca, Sancha Robinson, Stephen Ridley Smith, Emma Sansalone, Owen Morris, Rebecca Chenery, Lara Riley, Anna Palazzi-Parsons

“…Data regarding patient behaviours related to patient-managed ERAS recommendations, Quality of Life, European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), Quality of Recovery (QOR-15), Anxiety (Hospital Anxiety and Depression Scale), hospital readmissions, emergency department presentations and health service utilisation postdischarge will also be collected.Ethics and dissemination This study has been approved by the Human Research Ethics Committees of the Hunter New England Local Health District (2022/ETH02010), the University of Newcastle (H-2023–0298) and the Calvary Mater Newcastle (2022/STE03757). …”
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Greenness and averted mortality in 390 cities in China (2000–2020)Research in context by John S. Ji, Zheng Tao, Hui Miao, Tom Cole-Hunter, Xuecao Li, David Rojas-Rueda, Wenjia Cai

“…Methods: In China, we mapped the urban human population distribution aged 20 and above with a 1 km grid (30 arc-second) and used satellite-based remote sensing to measure green space over time to create population-weighted normalized difference vegetation index (NDVI). …”
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Accuracy of screening tests for cervical precancer in women living with HIV in low-resource settings: a paired prospective study in Lusaka, Zambia by Nicola Low, Partha Basu, Andreas Limacher, Katayoun Taghavi, Misinzo Moono, Mulindi Mwanahamuntu, Herbert Kapesa, Albert Manasyan, Julia Bohlius, Marie Roumet, Thamsanqa Madliwa, Anne Rutjes

“…The index tests were high-risk human papillomavirus detection (hrHPV, Xpert HPV, Cepheid), portable colposcopy (Gynocular, Gynius) and visual inspection with acetic acid (VIA). …”
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Generation and miRNA Characterization of Equine Induced Pluripotent Stem Cells Derived from Fetal and Adult Multipotent Tissues by Laís Vicari de Figueiredo Pessôa, Pedro Ratto Lisboa Pires, Maite del Collado, Naira Caroline Godoy Pieri, Kaiana Recchia, Aline Fernanda Souza, Felipe Perecin, Juliano Coelho da Silveira, André Furugen Cesar de Andrade, Carlos Eduardo Ambrosio, Fabiana Fernandes Bressan, Flavio Vieira Meirelles

“…We were able to generate bFGF-dependent iPSCs from eADmsc, eUCmsc, and eFibros with human OSKM, and the miRNA profile revealed that clonal lines may respond differently to the reprogramming process.…”
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Novel Prognostic Factors Associated with Cell Cycle Control in Sporadic Medullary Thyroid Cancer Patients by Raffaele Pezzani, Loris Bertazza, Elisabetta Cavedon, Simona Censi, Jacopo Manso, Sara Watutantrige-Fernando, Gianmaria Pennelli, Francesca Galuppini, Susi Barollo, Caterina Mian

“…Seventy-one sporadic MTC human samples were analyzed for RET mutations and by qPCR for PTTG1 and AURKA (Aurora kinase A) expression. …”
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The microbial mechanism of maize residue decomposition under different temperature and moisture regimes in a Solonchak by Fan Huang, Wan Zhang, Lihua Xue, Bahar Razavi, Kazem Zamanian, Xiaoning Zhao

“…Abstract Soil salinization becomes serious under climate change and human activities. Although the residue decomposition contributes lots to soil carbon storage and fertility, the decomposition process and microbial mechanisms on saline-alkali soils are still vague facing climate change. …”
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Examining the impact of probiotic Lactiplantibacillus pentosus 6MMI on inhibiting biofilm formation, adhesion, and virulence gene expression in Listeria monocytogenes ATCC 19115 by Behrooz Alizadeh Behbahani, Mostafa Rahmati-Joneidabad, Morteza Taki

“…Probiotic bacteria improve human health by secreting pro-microbial substances, balancing intestinal flora, binding to the mucous membrane and epithelium, strengthening the intestinal epithelial barrier, and creating interactions between the gastrointestinal microbiota and the immune system. …”
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Clinicopathological Significance of FOXO4 Expression and Correlation with Prx1 in Head and Neck Squamous Cell Carcinoma by Yunping Lu, Yajun Shen, Lingyu Li, Min Zhang, Min Wang, Lihua Ge, Jing Yang, Xiaofei Tang

“…The function of FOXO4 correlation with HNSCC prognosis was analyzed via ONCOMINE, UALCAN, Human Protein Atlas, and cBioPortal. The expression of FOXO4 was detected in Prx1 silenced CaL27 and SCC9 cell lines by Western blot. …”
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Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia by Shuwen Zheng, Yingying Wang, Chuxuan Ni, Rui Guo, Xunan Qiu, Jijun Chen, Lu Wang, Xiaohu Sun, Moye Chen, Yunen Liu, Yuan Yuan, Yuehua Gong

“…Immunohistochemistry staining was conducted to validate hnRNPK, TPT1, OCT1, and CDX2 expression in gastric tissue samples from both human and Mongolian gerbils. Results H. pylori SlyD upregulates TPT1 and induces the expression of GIM markers through hnRNPK. …”
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