Predicting the impact of missense mutations on an unresolved protein’s stability, structure, and function: A case study of Alzheimer’s disease-associated TREM2 R47H variant by Joshua Pillai, Kijung Sung, Chengbiao Wu

“…We believe that the in-silico mutagenesis methods described here can be applied broadly to evaluate the ever-growing numbers of protein mutations/variants discovered in human genetics study for their potential in diseases, ultimately facilitating personalized medicine.…”
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Protocol for a randomised ‘screen-and-treat’ Helicobacter pylori eradication trial in 14–18-years-old adolescents residing in three regions of Chile: effectiveness and microbiologi... by Ximena Aguilera, Camila Cabrera, Sergio George, Yalda Lucero, Beatriz Zabala Torres, Lilian Fernández, Nora Mamani, Anne Lagomarcino, Miguel O'Ryan

“…The gut microbiome will be characterised by amplifying and sequencing the 16S rRNA gene from stool samples, followed by bioinformatics analysis.Ethics and dissemination Approved by the Human Research Ethics Committee at the Faculty of Medicine, University of Chile (073–2022). …”
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Protocol on establishing a prospective enhanced surveillance of vaccine preventable diseases in residential aged care facilities in Central Queensland, Australia: an observational... by Mohammad Rashidul Hashan, Robert Booy, Michael Kirk, Gulam Khandaker, Gwenda Chapman, Jacina Walker, Sonya Jayne Davidson, Jill Auriac, Nicolas Smoll, Delwar Akbar

“…Descriptive statistics, univariate and multivariate regression analysis will be conducted to identify the predictors of morbidity and clinical outcomes following infection.Ethics and dissemination The study has been approved by the CQHHS Human Research Ethics Committee (HREC) (reference number HREC/2021/QCQ/74305). …”
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Scenario Simulation of Ecosystem Services Based on Land Use/Land Cover Change in the Bailong River Basin, in China by Shuangying Li, Yanyan Zhou, Dongxia Yue, Zhongling Guo, Zhi Li

“…Studying LUCC and its impact on ESs is crucial for a comprehensive understanding of the impact of human activities on ecosystems. The InVEST model coupled with the predicted land use data were used to analyze the spatiotemporal characteristics of four ESs (soil conservation (SC), water yield (WY), carbon storage (CS), and habitat quality (HQ)) under three scenarios from 2040 to 2100 and quantified trade-offs/synergies and bundles of these ESs within the Bailong River Basin (BRB). …”
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Unleashing the potential of geostationary satellite observations in air quality forecasting through artificial intelligence techniques by C. Zhang, X. Niu, H. Wu, Z. Ding, K. L. Chan, J. Kim, T. Wagner, C. Liu, C. Liu, C. Liu

“…Our findings demonstrate the significant potential of geostationary satellite observations in artificial-intelligence-based air quality forecasting, with implications for early warning of air pollution events and human health exposure.</p>…”
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Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1 by Cunru Zou, Yu Zhang, Chengyue Liu, Yaxin Li, Congjie Lin, Hao Chen, Jiangping Hou, Guojun Gao, Zheng Liu, Qiupeng Yan, Wenxia Su

“…FGL1, important components of ECM signalling and immune checkpoint ligand of LAG3, were downregulated following CENPM silence, overexpressed in human advanced ACC samples, and colocalized with CENPM. …”
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Technical efficiency of public hospitals in east Africa: a systematic review and meta-analysis by Anteneh Lamesgen, Bekalu Endalew, Aysheshim Belaineh Haimanot, Tigabu Kidie Tesfie, Elyas Melaku Mazengia, Mulat Belay Simegn, Werkneh Melkie Tilahun, Molla Yigzaw Birhanu, Lakew Asmare, Habtamu Geremew, Muluye Gebrie Mengie

“…Abstract Background Hospitals usually encounter human, capital, and financial resource constraints which alerts the efficient use of allocated resources more than ever. …”
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Performance evaluation of the smartphone-based AI cough monitoring app - Hyfe Cough Tracker against solicited respiratory sounds [version 2; peer review: 1 approved, 2 approved wit... by Isabel Blavia, Juliane Chaccour, Eric M. Keen, Virginia Orrillo, Mindaugas Galvosas, Matthew Rudd, Juan C. Gabaldón-Figueira, Simon Grandjean Lapierre, Carlos Chaccour, Peter M. Small, Gerard Giménez

“…Results: Hyfe Cough Tracker app showed sensitivity of 91% and specificity of 98% with a very high correlation between the cough rate measured by Hyfe and that of human annotators (Pearson correlation of 0.968). …”
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Advancements in end treatment techniques and applications of acid mine drainage in coal mines: A research review by Qiaohui CHE, Song DU, Degao ZHANG, Yinglin FAN, Xiao ZHANG, Fengli WANG

“…Acid mine drainage(AMD) from coal mines contains elevated concentrations of heavy metals and sulfates, rendering it highly corrosive and posing a persistent threat to both the ecological environment and human health. Consequently, it has emerged as a pervasive environmental predicament in the coal mining process. …”
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NORDIC denoising on VASO data by Lasse Knudsen, Lasse Knudsen, Luca Vizioli, Federico De Martino, Lonike K. Faes, Daniel A. Handwerker, Steen Moeller, Peter A. Bandettini, Peter A. Bandettini, Laurentius Huber

“…The use of submillimeter resolution functional magnetic resonance imaging (fMRI) is increasing in popularity due to the prospect of studying human brain activation non-invasively at the scale of cortical layers and columns. …”
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Particle emission and thermal efficiency analysis of a diesel vehicle using biodiesel and a platinum metallic partial-flow particulate filter by Huy Quang Dang, Mi Zwe Mon Phyo, Poonnut Thaeviriyakul, Plan Teekatasn Cosh, Mek Srilomsak, Therdsak Petblengsri, Ittipol Pawarmart, Sompong Srimanosaowapak, Hidenori Kosaka, Preechar Karin

“…Harmful emissions from diesel vehicles, particularly unmodified ones, pose significant concerns for human health and the environment, underscoring the urgency to address these issues. …”
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The role of hospital pharmacists in supporting the appropriate and safe use of CGT/ATMPs: a scoping review of current insights by Junnan Shi, Xianwen Chen, Hao Hu, Carolina Oi Lam Ung

“…Of 26 studies, the perspectives assuming their roles in CGT/ATMPs management were categorized when patients receiving ATMPs (n = 2), HSCT and cellular-based therapy (n = 12), gene therapy (n = 6), and the chimeric antigen receptor (CAR) T-cell therapy (n = 6), mainly covering procurement, influences on prescribing, preparation and delivery, administration, monitoring of medicines use, human resources, training and development. The anticipated impact was primarily intended to promote pharmacy practice, multidisciplinary collaboration and improve patient clinical outcomes. …”
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Herpes Simplex Virus Type 2 (HSV-2) and Cytomegalovirus (CMV) among Women with Macerated Stillbirth: A Cross-Sectional Hospital-Based Study from Mwanza, Tanzania by Helmut A. Nyawale, Elieza Chibwe, Fridolin Mujuni, Lidya Maiga, Albert Silvin, Alda Ester Chongo, Bertrand Msemwa, Vitus Silago, Mtebe Majigo, Doreen Kamori, Stephen E. Mshana, Mariam M. Mirambo

“…This study investigated the magnitude of herpes simplex 2 virus (HSV-2) and human cytomegalovirus (HCMV) among women with macerated stillbirth. …”
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A mixed method exploration of job morale of physicians working in public healthcare settings in Kazakhstan during the COVID-19 pandemic by Alina Kuandyk, Mariya Dmitriyeva, Nazerke Toleukhanova, Maev Conneely, Timur Suleimenov, Dauren Sarssenov, Raimzhan Mamytkhan, Madiyar Sakhayev, Arman Tleubergenov, Medet Toleubayev

“…The Warr-Cook-Wall scale, Maslach Burnout Inventory Human Services Survey for Medical Personnel, and Beck Depression Inventory were used to measure job morale indicators. …”
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Narrow Dietary Niche With High Overlap Between Snow Leopards and Himalayan Wolves Indicates Potential for Resource Competition in Shey Phoksundo National Park, Nepal by Sandesh Lamichhane, Bikram Shrestha, Bhumi Prakash Chaudhary Tharu, Raj Kumar Koirala, Bishnu Prasad Bhattarai, Pratigyan Poudel, Binaya Adhikari, Gopal Khanal

“…Nevertheless, the region's low prey richness means that, with increasing human influence, any reduction in wild prey or increase in livestock could intensify competition between snow leopards and wolves, which could have implications for livestock depredation.…”
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Integrated assessment of carbon dioxide removal portfolios: land, energy, and economic trade-offs for climate policy by Solene Chiquier, Angelo Gurgel, Jennifer Morris, Yen-Heng Henry Chen, Sergey Paltsev

“…Moreover, we highlight the importance of nature-based removals, especially in Brazil, Latin America, and Africa, where potentials for avoided deforestation are the greatest, emphasizing their substantial benefits, not only for carbon sequestration, but also for preserving planetary well-being and human health. Finally, this study reveals that incentivizing timely and large-scale CDR deployment by policy and financial incentives could reduce the risk of deterring climate change mitigation, notably by minimizing carbon prices.…”
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Immunogenicity and protective efficacy of a multi-antigenic adenovirus-based vaccine candidate against Mycobacterium tuberculosis by Jin-Seung Yun, Jin-Seung Yun, Eunkyung Shin, Young-Ran Lee, Jung-Ah Lee, Hyeokjin Lee, Jong-Seok Kim, Sung Jae Shin, Sang-Jun Ha, Sang-Won Lee, Dokeun Kim, Jung-Sik Yoo, Hye-Sook Jeong

“…IntroductionThe inadequate efficacy of the Bacillus Calmette–Guérin (BCG) vaccine against adult pulmonary tuberculosis (TB) necessitates the development of new and effective vaccines. Human adenovirus serotype 5 (Ad5), which induces T-cell response, is a widely used viral vector. …”
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Innovative Solid Lipid Nanoparticle-Enriched Hydrogels for Enhanced Topical Delivery of L-Glutathione: A Novel Approach to Anti-Ageing by Mengyang Liu, Manisha Sharma, Guoliang Lu, Zhiwen Zhang, Wenting Song, Jingyuan Wen

“…The hydrogel significantly improved antioxidant capacity, protecting human fibroblasts from UVA-induced oxidative stress and enhancing cell viability. …”
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Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours by Surbhi Mishra, Mysore Vishakantegowda Tejesvi, Jenni Hekkala, Jenni Turunen, Niyati Kandikanti, Anna Kaisanlahti, Marko Suokas, Sirpa Leppä, Pia Vihinen, Hanne Kuitunen, Kaisa Sunela, Jussi Koivunen, Arja Jukkola, Ilja Kalashnikov, Päivi Auvinen, Okko-Sakari Kääriäinen, T. Peñate Medina, O. Peñate Medina, Juha Saarnio, Sanna Meriläinen, Tero Rautio, Raila Aro, Reetta Häivälä, Juho Suojanen, Mikael Laine, Pande Putu Erawijattari, Leo Lahti, Peeter Karihtala, Terhi S. Ruuska, Justus Reunanen

“…Introduction: Gut microbiome–derived nanoparticles, known as bacterial extracellular vesicles (bEVs), have garnered interest as promising tools for studying the link between the gut microbiome and human health. The diverse composition of bEVs, including their proteins, mRNAs, metabolites, and lipids, makes them useful for investigating diseases such as cancer. …”
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Pharmacological Vitamin C-induced high H2O2 generation mediates apoptotic cell death by caspase 3/7 activation in breast cancer tumor spheroids by Ali Mussa, Mahasin Hamid, Khalid Hajissa, Ahmad Hafiz Murtadha, Mohammad A. I. Al-Hatamleh, Noor Fatmawati Mokhtar, Vuk Uskoković, Magdalena Plebanski, Rohimah Mohamud, Rosline Hassan

“…However, the anticancer activity of Vit-C has not been investigated in realistic 3D models of human cancers, especially with respect to breast cancer (BC), and its potential benefits remain under debate. …”
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