Assessing cell lines with inducible depletion of cohesin and condensins components through analysis of metaphase chromosome morphology by A. M. Yunusova, A. V. Smirnov, I. E. Pristyazhnuk, T. A. Shnaider, E. K. Maltseva, S. D.  Afonnikova, O. A. Gusev, N.  R. Battulin

“…In this work, we obtained a series of clones of human HAP1 cells carrying the necessary genetic constructs for inducible depletion of RAD21 and SMC2. …”
Get full text

Effects of Functional Red Pine Seed Direct-Drinking Oil on Constipation and Intestinal Barrier Function in Mice by Jie Li, Haonan Zheng, Jiahui Liu, Jie Ding, Qingqi Guo, Na Zhang

“…Constipation is a prevalent global health issue that greatly affects human well-being. However, many existing treatments are associated with side effects, necessitating the development of alternative approaches. …”
Get full text

Ultrasonic-assisted adsorption of methylene blue using shrimp shells as a low-cost adsorbent: Evaluation on the adsorption isotherm, kinetics, and thermodynamics by Erni Misran, Wahyu Pratama, Kanzi Insan Kasyidi Napitupulu, Muhammad Dani Supardan, Dewi Agustina Iryani, Viqry Pramananda

“…However, its presence in wastewater negatively affects the environment, human health, and aquatic life. Adsorption is recognized as an effective and economical method for removing methylene blue from wastewater. …”
Get full text

A genomic duplication spanning multiple P450s contributes to insecticide resistance in the dengue mosquito Aedes aegypti by Bacot, Tiphaine, Haberkorn, Chloe, Guilliet, Joseph, Cattel, Julien, Kefi, Mary, Nadalin, Louis, Filee, Jonathan, Boyer, Frederic, Gaude, Thierry, Laporte, Frederic, Tutagata, Jordan, Vontas, John, Dusfour, Isabelle, Bonneville, Jean-Marc, David, Jean-Philippe

“…Resistance of mosquitoes to insecticides is one example of rapid adaptation to anthropogenic selection pressures having a strong impact on human health and activities. Target-site modification and increased insecticide detoxification are the two main mechanisms underlying insecticide resistance in mosquitoes. …”
Get full text

Regulatory factor X‐5/SCL/TAL1 interruption site axis promotes aerobic glycolysis and hepatocellular carcinoma cell stemness by Zhi‐Zhong Zhang, Zi‐Ming Wang, Hao‐Wen Zhang, Yan‐Xin Gong, Hao‐Ran Sun, Wei Zhang

“…Although research has revealed how important SCL/TAL1 interruption site (STIL) is in many human tumors, the impact of STIL on HCC stem cells is poorly understood. …”
Get full text

“Equity” in genomic health policies: a review of policies in the international arena by Prabhathi Basnayake Ralalage, Prabhathi Basnayake Ralalage, Tala Mitchell, Claire Zammit, Gareth Baynam, Gareth Baynam, Emma Kowal, Libby Masey, Julie McGaughran, Tiffany Boughtwood, Misty Jenkins, Gregory Pratt, Angeline Ferdinand

“…In addition, General and Specific Policy Repositories, Global Consortia in Genomic Medicine, WHO Collaborating Centers in Genomics, Australian Genomics, Public Policy Projects, Global Genomic Medicine Consortium (G2MC), G2MC conference Oct 2023 and National Human Genome Research Institute databases were searched using the inclusion and exclusion criteria. …”
Get full text

Iterative delivery of an implementation support package to increase and sustain the routine provision of antenatal care addressing alcohol consumption during pregnancy: study proto... by John Attia, Luke Wolfenden, Nicole Nathan, Melanie Kingsland, Olivia Wynne, Penny Reeves, Alix Hall, John Wiggers, Elizabeth J Elliott, Tameka McFadyen, Tracey W Tsang, Emma Doherty, Belinda Tully, Adrian John Dunlop, Ian Symonds

“…Economic and process evaluation measures will also be reported.Ethics and dissemination Ethical approval was obtained through the Hunter New England (16/11/16/4.07, 16/10/19/5.15) and University of Newcastle Human Research Ethics Committees (H-2017-0032, H-2016-0422) and the Aboriginal Health and Medical Research Council (1236/16). …”
Get full text

Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure by Rima Kamel, Aurélia Bourcier, Jean Piero Margaria, Valentin Jin, Audrey Varin, Agnès Hivonnait, Françoise Mercier‐Nomé, Delphine Mika, Alessandra Ghigo, Flavien Charpentier, Vincent Algalarrondo, Emilio Hirsch, Rodolphe Fischmeister, Grégoire Vandecasteele, Jérôme Leroy

“…Background PDE2 (phosphodiesterase 2) is upregulated in human heart failure. Cardiac PDE2‐transgenic mice are protected against contractile dysfunction and arrhythmias in heart failure but whether an acute elevation of PDE2 could be of therapeutic value remains elusive. …”
Get full text

Clinical and ultrasound assessment of body composition in preterm infants at discharge: an observational study by Beatriz del Rey Hurtado de Mendoza, Montserrat Izquierdo Renau, Elsa García González, Carla Balcells-Esponera, Emilio J Inarejos Clemente, Isabel Iglesias-Platas

“…Higher nutritional support during the first 2 weeks of life was related to a lower loss of length z-scores, and exclusive human milk feeding correlates with arm fat-to-circumference ratio.Conclusions Growth and BC of VPIs can be approached using simpler measures in clinical practice. …”
Get full text

Brodalumab: Six-Year US Pharmacovigilance Report by Mark G. Lebwohl, John Y. Koo, April W. Armstrong, Bruce E. Strober, Soo Han Yoon, Nicole N. Rawnsley, Earl L. Goehring, Gina D. Mangin, Abby A. Jacobson

“…Abstract Introduction Brodalumab is a human interleukin-17 receptor A antagonist indicated for the treatment of moderate-to-severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy and have failed to respond or have lost response to other systemic therapies. …”
Get full text

Preliminary Exploration of Natural Polyphenols and/or Herbal Mix Replacing Sodium Nitrate to Improve the Storage Quality of Pork Sausage by Angeliki-Niki Kaloudi, Agori Karageorgou, Michael Goliomytis, Panagiotis Simitzis

“…However, these compounds can be harmful to human health, due to their carcinogenic potential. …”
Get full text

Implications of the Improvement in Atmospheric Fine Particles: A Case Study of COVID-19 Pandemic in Northern Taiwan by Chuan-Hsiu Huang, Yi-Ru Ko, Tzu-Chi Lin, Yu-Hsiang Cheng, Yu-Cheng Chen, Yu-Chieh Ting

“…This study investigated the variations in sources, chemical characteristics and human health risks of PM2.5 comprehensively. The PM2.5 mass concentrations decreased from pre-alert to Level 3 alert by 49.4%, and the inorganic ions, i.e., NH4+, NO3− and SO42−, dropped even more by 71%, 90% and 52%, respectively. …”
Get full text

Self-Assembled Peptide Hydrogels PPI45 and PPI47: Novel Drug Candidates for <i>Staphylococcus aureus</i> Infection Treatment by Quanlong Wu, Mengyin Deng, Ruoyu Mao, Na Yang, Ya Hao, Manli Cao, Da Teng, Jianhua Wang

“…In vitro safety assessments indicated minimal hemolytic activity on murine red blood cells and low cytotoxicity on human immortalized epidermal cells (HaCaT). In summary, this work lays a valuable cornerstone for the future design and characterization of self-assembling antimicrobial peptides hydrogels to combat <i>S. aureus</i> infection.…”
Get full text

Brief exposure to (-) THC affects zebrafish embryonic locomotion with effects that persist into the next generation by Md Ruhul Amin, Lakhan Khara, Joshua Szaszkiewicz, Andrew M. Kim, Trevor J. Hamilton, Declan W. Ali

“…Abstract Cannabis is one of the most widely used drugs, and yet an understanding of its impact on the human brain and body is inconclusive. Medicinal and recreational use of cannabis has increased in the last decade with a concomitant increase in use by pregnant women. …”
Get full text

Comparing the Critical Thinking Skills of Dentistry, Engineering, and Law Students: A Cross-Sectional Study in Mashhad, Iran by Mohammad Hosein Sadeghi, Ali Kazemian, Maryam Mehrabkhani

“…This problem shows that certain educational practices need to be reviewed, and more attention should be paid to training human and conceptual skills as part of education planning.…”
Get full text

WT1 Peptide Cancer Vaccine for Patients with Hematopoietic Malignancies and Solid Cancers by Yoshihiro Oka, Akihiro Tsuboi, Olga A. Elisseeva, Hiroko Nakajima, Fumihiro Fujiki, Manabu Kawakami, Toshiaki Shirakata, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Ichiro Kawase, Haruo Sugiyama

“…Wild-type Wilms' tumor gene WT1 is expressed at a high level in hematopoietic malignancies including acute leukemia, chronic myelogenous leukemia, and myelodysplastic syndromes, as well as in various kinds of solid cancers. Human cytotoxic T lymphocytes (CTLs), which could specifically lyse WT1-expressing tumor cells with HLA class I restriction, were generated in vitro. …”
Get full text

Neurofilament light chain (Nf-L) in cerebrospinal fluid and serum as a potential biomarker in the differential diagnosis of neurological diseases in cattle by Giorgia Di Muro, Carlotta Tessarolo, Giulia Cagnotti, Alessandra Favole, Sara Ferrini, Ugo Ala, Claudio Bellino, Giuliano Borriello, Marina Gallo, Giulia Iamone, Barbara Iulini, Marzia Pezzolato, Cristina Casalone, Maria Caramelli, Lorenzo Capucci, Patrizia Cavadini, Cristiano Corona, Antonio D’Angelo

“…Abstract Neurofilament light chain (Nf-L) is a biomarker for axonal damage in human neurology but is understudied in cattle. With this study we wanted to determine Nf-L stability at two different storage temperatures and Nf-L levels in healthy cattle and the relationship with age, evaluate whether Nf-L holds diagnostic potential for neurological disorders, and whether an association exists between Nf-L in serum and in cerebrospinal fluid (CSF). …”
Get full text

Spatiotemporal Changes in Evapotranspiration and Its Influencing Factors in the Jiziwan Region of the Yellow River from 1982 to 2018 by Wenting Liu, Rong Tang, Ge Zhang, Jiacong Xue, Baolin Xue, Yuntao Wang

“…Moreover, the influence of human activities on total ET and its components is also high. …”
Get full text

3,5,6,7,8,3’,4’- Heptamethoxyflavonoid inhibits TGF-β1-induced epithelial–mesenchymal transition by regulating oxidative stress and autophagy through MEK/ERK/PI3K/AKT/mTOR signalin... by Yiting Wang, Zhiheng Ma, Weiwen Peng, Qinglian Yu, Wenjie Liang, Liu Cao, Zhuqiang Wang

“…The objective of this study was to investigate the impact of HMF on TGF-β1-induced EMT in human alveolar Type II epithelial cells (A549) and its underlying mechanism. …”
Get full text

Taxonomic composition and biodiversity of the gut microbiome from patients with irritable bowel syndrome, ulcerative colitis, and asthma by A. Y. Tikunov, A. N. Shvalov, V. V. Morozov, I. V. Babkin, G. V. Seledtsova, I. O. Voloshina, I. P. Ivanova, A. V. Bardasheva, V. V. Morozova, V. V. Vlasov, N. V. Tikunova

“…To date, the association of an imbalance of the intestinal microbiota with various human diseases, including both diseases of the gastrointestinal tract and disorders of the immune system, has been shown. …”
Get full text