“Old” and “New” Trust in Higher Education by P. A. Ambarova, G. E. Zborovsky, N. V. Shabrova

“…They are important to design various academic practical experience oriented on the use of resource properties of trust with a view to developing the social and human capital of high school communities as well as to elaborate new social technologies for managing the processes of trust formation in the university.…”
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Comparative efficacy of repurposed drugs lopinavir-ritonavir and darunavir-ritonavir in hospitalised COVID-19 patients: insights from a tertiary centre cohort by Dóra Paróczai, Dóra Paróczai, András Bikov, András Bikov, Andreea Blidaru, Emanuel Bobu, Ana Lascu, Ana Lascu, Cristian Ion Mot, Cristian Ion Mot, Stefan Mihaicuta, Stefan Mihaicuta, Stefan Frent, Stefan Frent

“…Although lopinavir-ritonavir (LPV/r) and darunavir-ritonavir (DRV/r) have shown in vitro efficacy against COVID-19, the results in human studies have been inconsistent. Therefore, our objective was to compare the efficacy of LPV/r and DRV/r in COVID-19 patients admitted to a tertiary centre in Romania.Research design and methodsA clinical dataset from 417 hospitalised patients was analysed. …”
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High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone by Daejin Kim, Byul-Nim Ahn, YeongSeok Kim, Dae Young Hur, Jae Wook Yang, Ga Bin Park, Jung Eun Jang, Eun Ju Lee, Min Jeong Kwon, Tae Nyun Kim, Mi Kyung Kim, Jeong Hyun Park, Byoung Doo Rhee, Soon Hee Lee

“…The cells derived from human bladder epithelial cells (HBlEpCs) were treated with metformin or pioglitazone with high glucose and insulin. …”
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Importance and fitness of family medicine milestone project from America to Taiwan by Shih-Ming Li, Yaw-Wen Chang, Ming-Nan Lin, Chi-Wei Lin, Chyi-Her Lin, Cheng-Chieh Li, Ming-Hwai Lin, Yin-Fan Chang, Zih-Jie Sun, Fang-Yih Liaw, Jaw-Shiun Tsai, Shinn-Jang Hwang, Li-Kuang Chen, Jin-Shang Wu

“…Results In IPA, a total of 72.7% (16/22) of the sub-competencies exhibited high importance and fitness, with a mean score ≥ 4.7; the exceptions were PC-1 (cares for acutely ill or injured patients), MK-2 (critical thinking skills in patient care), SBP-1 (cost-conscious medical care), PBLI-3 (improves systems), PROF-3 (humanism/cultural proficiency), and ICS-4 (utilizes technology). …”
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Toxicity, antifeedant and repellent activities of five essential oils on adult Cassida vittata Vill. (Coleoptera: Chrysomelidae) by Achraf Charkaoui, Rachid Jbilou, Houssam Annaz, Kacem Rharrabe

“…Chemical pesticides are considered the most common strategy to control this pest, and their use is extremely harmful to human health and the environment. In this context, the adults of C. vittata were exposed to five essential oils (EOs) obtained from: Artemisia herba alba Asso. …”
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Bradykinin B1 receptor signaling triggers complement activation on endothelial cells by Ingrid Lopatko Fagerström, Alexandra Gerogianni, Markus Wendler, Ida Arvidsson, Ashmita Tontanahal, Ann-Charlotte Kristoffersson, Fatimunnisa Qadri, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Diana Karpman

“…This study investigated if KKS activation induced complement activation on endothelial cells, and if activation was dependent on bradykinin B1 receptor (B1R) signaling.MethodsKKS was activated in normal human serum by kaolin or activated factor XII (FXIIa). …”
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Screening for schistosomiasis in a non-endemic setting: Accuracy of a rapid antibody test using finger prick blood by Margherita Ortalli, Bianca Granozzi, Michele Bacchiega, Concettina Di Lillo, Greta Roncarati, Silvia Stefania Longoni, Cristina Mazzi, Elisa Vanino, Zeno Bisoffi, Stefania Varani

“…Human schistosomiasis is a chronic neglected tropical disease caused by blood flukes of the genus Schistosoma, infecting 250 million people worldwide, mostly in sub-Saharan Africa. …”
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Design and assembly of plant-based COVID-19 candidate vaccines: reсent development and future prospects by E. A. Uvarova, P. A. Belavin, E. V. Deineko

“…This variant of the virus is characterized by a high degree of variability and, as the current situation with its spread across different regions of the globe shows, it can lead to a progressive spread of infection among the human population and become the cause of a pandemic. …”
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Comparative Effects of Crocin and Losartan on RAGE, TGF‐β, TNF‐α Gene Expression and Histopathological Changes of the Liver Tissue in Rats With Diabetes by Shahnaz Rajabi, Yaser Mohammadi, Hamid Kabiri‐rad, Mahdiyeh Rajabi‐moghaddam, Azam Rezaei Farimani

“…Conclusion Crocin may be a feasible therapeutic agent for treating diabetes and its symptoms when combined with pharmaceutical medications. Human research is still needed to reach clear conclusions.…”
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Marker-assisted breeding of hybrid lines of <i>Triticum dicoccon</i> (Schrank) Schuebl. × <i>Triticum aethiopicum</i> Jakubz. with purple grain by P. I. Stepochkin, E. I. Gordeeva, Е. K. Khlestkina

“…Cereals whose grain contains antioxidants salutary for human health are promising for functional nutrition. …”
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Development of a non-specialist worker delivered psychological intervention to address alcohol use disorders and psychological distress among conflict-affected populations in Ugand... by Abhijit Nadkarni, Alessandro Massazza, Wietse A. Tol, Sergiy Bogdanov, Lena S. Andersen, Quincy Moore, Bayard Roberts, Helen A. Weiss, Soumya Singh, Melissa Neuman, Carl May, Daniela C. Fuhr

“…A key barrier to care is the lack of contextually relevant interventions and adequately skilled human resources to deliver them. This paper describes the systematic development of the CHANGE intervention, a potentially scalable psychological intervention for people with co-existing AUD and psychological distress in conflict-affected populations, delivered by non-specialist workers (NSWs). …”
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GRK6 palmitoylation dictates triple-negative breast cancer metastasis via recruiting the β-Arrestin 2/MAPKs/NF-κB signaling axis by Wen-Ke Wang, Hui-Yu Lin, Che-Hsuan Lin, Hsun-Hua Lee, Yen-Lin Chen, Yu-Hsien Kent Lin, Hui-Wen Chiu, Shry-Ming Sheen-Chen, Yuan-Feng Lin

“…RT-PCR assays were used to test the GRK6 expression in human BC tissues and cell lines. The in vitro cellular migration and in vivo lung colony-forming assays were established to estimate the metastatic potentials of TNBC cells. …”
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Digital intervention promoting physical activity among obese people (DIPPAO) randomised controlled trial: study protocol by Bruno Pereira, Martine Duclos, Alexandre Mazéas, Aïna Chalabaev, Marine Blond

“…A mixed-model approach will be used to analyse the change in outcomes over time.Ethics and dissemination The research protocol has been reviewed and approved by the Local Human Protection Committee (CPP Ile de France XI, No 21 004-65219). …”
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Biogenic Amines and Aflatoxins in Some Imported Meat Products: Incidence, Occurrence, and Public Health Impacts by Fahad Dhafer Algahtani, Alaa Eldin Morshdy, Mohamed A. Hussein, Essam Said Abouelkheir, Adeniyi Adeboye, Andrea Valentine, Mohamed Tharwat Elabbasy

“…Since the beginning of humanity, the global burden of foodborne disease has had a decimating effect on populations, with biogenic amines (BAs) and aflatoxins in meat products implicated. …”
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Spatio-temporal changes of water quality variables in a highly disturbed river by Z. Abdollahi, A. Kavian, S.H.R. Sadeghi

“…Zanjanrud River, located in Zanjan Province, Iran, where recently faced human intervention needs a regular monitoring from upstream to downstream for sustainable management. …”
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Contribution of Aerosol Species to the 2019 Smoke Episodes over the East Coast of Peninsular Malaysia by Nur Nazmi Liyana Mohd Napi, Maggie Chel Gee Ooi, Mohd Talib Latif, Liew Juneng, Mohd Shahrul Mohd Nadzir, Andy Chan, Li Li, Samsuri Abdullah

“…Abstract Large-scale biomass burning (BB) emits large amounts of aerosols that lead to transboundary smoke events and adversely impacts human health, whilst causing societal and environmental issues. …”
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Computer-assisted discovery of natural inhibitors for platelet-derived growth factor alpha as novel therapeutics for thyroid cancer by Hira Khalid, Farah Sattar, Iqra Ahmad, Valdir Ferreira de Paula Junior, Valdir Ferreira de Paula Junior, Umar Nishan, Umar Nishan, Riaz Ullah, Hanna Dib, Khaled W. Omari, Mohibullah Shah, Mohibullah Shah

“…These drug candidates were further characterized to predict their biological activity spectra in the human body and medicinal characteristics to know their extensive behavior in laboratory testing. …”
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Antimicrobial and ADME properties of methoxylated, methylated and nitrated 2-hydroxynaphthalene-1 carboxanilides by Lucia Vrablova, Tomas Gonec, Tereza Kauerova, Michal Oravec, Izabela Jendrzejewska, Peter Kollar, Alois Cizek, Josef Jampilek

“…All the compounds were evaluated for antibacterial activities against Gram-positive and Gram-negative bacteria and mycobacteria. Cytotoxicity on human cells was also tested. Key results: Three compounds showed activity comparable to clinically used drugs. …”
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Elucidation of α-glucosidase inhibitory activity and UHPLC-ESI-QTOF-MS based metabolic profiling of endophytic fungi Alternaria alternata BRN05 isolated from seeds of Swietenia mac... by Piyush Kumar, Sai Anand Kannakazhi Kantari, Ranendra Pratap Biswal, Prasanth Ghanta, Malleswara Dharanikota

“…Molecular Dynamics (MD) simulations of 3’,4’,7-trihydroxyisoflavanone (THF) and alternariol 9-methyl ether (AME) from EQS, exhibiting high binding energies (-7.5 and -7 kcal/mol, respectively), were performed to investigate their interactions with human intestinal α-glucosidase. Results suggest THF possesses strong inhibitory potential, making it a promising candidate for diabetes management.…”
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USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression by Shaoxuan Cheng, Zhiyuan Qiu, Ziyi Zhang, Yuxuan Li, Yue Zhu, Yuxin Zhou, Yinghui Yang, Yaowen Zhang, Dian Yang, Yingqiu Zhang, Han Liu, Zhaoxia Dai, Shu-Lan Sun, Shuyan Liu

“…Deubiquitylating enzymes (DUBs) emerge as novel therapeutic targets against human cancers. However, the nucleolar phase separation of DUBs and association with lung cancer development have remained incompletely investigated till now. …”
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